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World Journal of Clinical Cases 2024年第20期12卷 4405-4411页

作者： Xing-Zu Ji Zhong-Da Liu Yi-Ping Ye Quan Li Xiao-Jing Liu min-hua zhou Yi Jin Department of Respiratory and Critical Care Medicine Lishui Hospital of Traditional Chinese MedicineLishui 323000Zhejiang ProvinceChina Traditional Chinese Medicine Oncology Lishui Hospital of Traditional Chinese MedicineLishui 323000Zhejiang ProvinceChina Department of Emergency Medicine Lishui People's HospitalLishui 323000Zhejiang ProvinceChina

BACKGROUND Epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs)significantly improve the survival of patients with Epidermal growth factor receptor(EGFR)sensitive mutations in non-small cell lung cancer(NSCLC).CASE SUMMARY A 67-year-old female patient in advanced lung adenocarcinoma suffered from drug resistance after EGFR-TKIs *** pathological tissue biopsy confirmed squamous cell carcinoma(SCC)*** inevitably encountered drug resistance issues after receiving EGFR-TKIs treatment for a certain period of time,while EGFR-TKIs can significantly improve the survival of patients with EGFR-sensitive mutations in ***,EGFR-TKIs resistance includes primary and *** transformation is one of the mechanisms of acquired resistance in EGFR-TKIs,with SCC transformation being relatively *** results provide more detailed results of the patient’s diagnosis and treatment process on SCC transformation after EGFR-TKIs treatment for lung *** Squamous cell carcinoma transformation is one of the acquired resistance mechanisms of EGFR-TKIs in advanced lung adenocarcinoma with EGFR mutations.

关键词： Lung adenocarcinoma Squamous cell carcinoma Pathological histological transformation Epidermal growth factor receptor tyrosine kinase inhibitors Drug resistance Case report

Structure and 2p decay mechanism of^(18)Mg

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Nuclear Science and Techniques 2024年第6期35卷 145-154页

作者： Long zhou De-Qing Fang Si-min Wang Hui hua Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan UniversityShanghai 200438China School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China

The recently discovered,extremely proton-rich nuclide 18 Mg exhibits ground-state decay via two sequential two-proton(2p)emissions through the intermediate nucleus,*** study investigates the structure and the initial 2p decay mechanism of^(18)Mgby examining the density and correlations of the valence protons using a three-body Gamow coupled-channel *** results show that the ground state of^(18)Mgis significantly influenced by the continuum,resulting in a significant s-wave ***,based on the current framework,this does not lead to a significant deviation in mirror symmetry in either the structure or spectroscopy of the 18Mg-18C ***,the time evolution analysis of the^(18)Mgground state suggests a simultaneous 2p emission during the first step of *** observed nucleon-nucleon correlations align with those of the light-mass 2p emitters,indicating a consistent decay behavior within this nuclear region.

关键词： Structure of^(18)Mg Two-proton decay Proton-proton correlation

The composite X-ray spectra of radio-loud and radio-quiet SDSS quasars

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Research in Astronomy and Astrophysics 2021年第1期21卷 33-44页

作者： min-hua zhou min-Feng Gu Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy ofSciences80 Nandan RoadShanghai 200030China University of Chinese Academy of Sciences 19A Yuquan RoadBeijing 100049China

We present a study of the X-ray emission for a sample of radio-detected quasars constructed from the cross-matches between SDSS,FIRST catalogs and XMM-Newton archives.A sample of radio-quiet SDSS quasars without FIRST radio detection is also assembled for *** construct the optical and X-ray composite spectra normalized at rest frame 4215 A(or 2200 A)for both radio-loud quasars(RLQs)and radio-quiet quasars(RQQs)at z≤3.2,with matched X-ray completeness of 19%,redshift and optical *** the optical composite spectrum of RLQs is similar to that of RQQs,we find that RLQs have a higher X-ray composite spectrum than RQQs,consistent with previous studies in the *** dividing the radio-detected quasars into radio loudness bins,we find the X-ray composite spectra are generally higher with increasing radio ***,a significant correlation is found between the optical-to-X-ray spectral index and radio loudness,and there is a unified multi-correlation between the radio and X-ray luminosities and radio loudness in radio-detected *** results could be possibly explained with the corona-jet model,in which the corona and jet are directly related.

关键词： methods:statistical catalogs quasars:general X-rays:general

Quantum Neural Network for Quantum Neural Computing

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Research 2024年第1期2023卷 71-80页

作者： min-Gang zhou Zhi-Ping Liu hua-Lei Yin Chen-Long Li Tong-Kai Xu Zeng-Bing Chen National Laboratory of Solid State Microstructures School of PhysicsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China MatricTime Digital Technology Co.Ltd. Nanjing 211899China

Neural networks have achieved impressive breakthroughs in both industry and *** to effectively develop neural networks on quantum computing devices is a challenging open ***,we propose a new quantum neural network model for quantum neural computing using(classically controlled)single-qubit operations and measurements on real-world quantum systems with naturally occurring environment-induced decoherence,which greatly reduces the difficulties of physical *** model circumvents the problem that the state-space size grows exponentially with the number of neurons,thereby greatly reducing memory requirements and allowing for fast optimization with traditional optimization *** benchmark our model for handwritten digit recognition and other nonlinear classification *** results show that our model has an amazing nonlinear classification ability and robustness to ***,our model allows quantum computing to be applied in a wider context and inspires the earlier development of a quantum neural computer than standard quantum computers.

关键词： quantum thereby breakthrough

Learnware:small models do big

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Science China(Information Sciences) 2024年第1期67卷 39-50页

作者： Zhi-hua zhou Zhi-Hao TAN National Key Laboratory for Novel Software Technology Nanjing University

There are complaints about current machine learning techniques such as the requirement of a huge amount of training data and proficient training skills,the difficulty of continual learning,the risk of catastrophic forgetting,and the leaking of data privacy/*** research efforts have been focusing on one of those concerned issues separately,paying less attention to the fact that most issues are entangled in *** prevailing big model paradigm,which has achieved impressive results in natural language processing and computer vision applications,has not yet addressed those issues,whereas becoming a serious source of carbon *** article offers an overview of the learnware paradigm,which attempts to enable users not to need to build machine learning models from scratch,with the hope of reusing small models to do things even beyond their original purposes,where the key ingredient is the specification which enables a trained model to be adequately identified to reuse according to the requirement of future users who know nothing about the model in advance.

关键词： artificial intelligence machine learning learnware

Vibration Control of A Flexible Marine Riser System Subject to Input Dead Zone and Extraneous Disturbances

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China Ocean Engineering 2024年第2期38卷 271-284页

作者： zhou Li WANG Guo-rong WAN min School of Mechatronic Engineering Southwest Petroleum UniversityChengdu 610500China Energy Equipment Institute Southwest Petroleum UniversityChengdu 610500China National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China

An observer-based adaptive backstepping boundary control is proposed for vibration control of flexible offshore riser systems with unknown nonlinear input dead zone and uncertain environmental *** control algorithm can update the control law online through real-time data to make the controller adapt to the environment and improve the control ***,based on the adaptive backstepping framework,virtual control laws and Lyapunov functions are designed for each *** direction interference observers are designed to track the timevarying boundary *** this basis,the inverse of the dead zone and linear state transformation are used to compensate for the original system and eliminate the adverse effects of the dead *** addition,the stability of the closed-loop system is proven by Lyapunov stability *** the system states are bounded,and the vibration offset of the riser converges to a small area of the initial ***,four examples of flexible marine risers are simulated in MATLAB to verify the effectiveness of the proposed controller.

关键词： adaptive backstepping control disturbance observer flexible marine riser input dead zone vibration control

Automated process parameters tuning for an injection moulding machine with soft computing

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第3期12卷 201-206页

作者： Peng ZHAO Jian-zhong FU hua-min zhou Shu-biao CUI State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China State Key Laboratory of Material Processing and Die & Mould Technology Huazhong University of Science and Technology Wuhan 430074 China

In injection moulding production,the tuning of the process parameters is a challenging job,which relies heavily on the experience of skilled *** this paper,taking into consideration operator assessment during moulding trials,a novel intelligent model for automated tuning of process parameters is *** consists of case based reasoning (CBR),empirical model (EM),and fuzzy logic (FL) *** and EM are used to imitate recall and intuitive thoughts of skilled operators,respectively,while FL is adopted to simulate the skilled operator optimization ***,CBR is used to set up the initial process *** CBR fails,EM is employed to calculate the initial ***,a moulding trial is performed using the initial *** FL is adopted to optimize these parameters and correct defects repeatedly until the moulded part is found to be *** on the above methodologies,intelligent software was developed and embedded in the controller of an injection moulding *** results show that the intelligent software can be effectively used in practical production,and it greatly reduces the dependence on the experience of the operators.

关键词： Injection moulding machine (IMM) Process parameters Case based reasoning (CBR) Empirical model (EM) Fuzzy logic (FL)

Physiological and pathological functions of circular RNAs in the nervous system

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Neural Regeneration Research 2024年第2期19卷 342-349页

作者： min zhou Shi Li Chuan huang School of Life Sciences Chongqing UniversityChongqingChina

Circular RNAs(circRNAs)are a class of covalently closed single-stranded RNAs that are expressed during the development of specific cells and *** play crucial roles in physiological and pathological processes by sponging microRNAs,modulating gene transcription,controlling the activity of certain RNA-binding proteins,and producing functional peptides.A key focus of research at present is the functionality of circRNAs in the nervous system and several advances have emerged over the last 2 ***,the precise role of circRNAs in the nervous system has yet to be comprehensively *** this review,we first summarize the recently described roles of circRNAs in brain development,maturity,and ***,we focus on the involvement of circRNAs in various diseases of the central nervous system,such as brain cancer,chronic neurodegenerative diseases,acute injuries of the nervous system,and neuropathic pain.A better understanding of the functionality of circRNAs will help us to develop potential diagnostic,prognostic,and therapeutic strategies to treat diseases of the nervous system.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis brain development circRNAs neuropathic pain Parkinson’s disease

An Environment‑Tolerant Ion‑Conducting Double‑Network Composite Hydrogel for High‑Performance Flexible Electronic Devices

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Nano-Micro Letters 2024年第5期16卷 352-369页

作者： Wenchao Zhao Haifeng zhou Wenkang Li Manlin Chen min zhou Long Zhao State Key Laboratory of Advanced Electromagnetic Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China School of Chemistry and Chemical Engineering Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China

High-performance ion-conducting hydrogels(ICHs)are vital for developing flexible electronic ***,the robustness and ion-conducting behavior of ICHs deteriorate at extreme tempera-tures,hampering their use in soft *** resolve these issues,a method involving freeze–thawing and ionizing radiation technology is reported herein for synthesizing a novel double-network(DN)ICH based on a poly(ionic liquid)/MXene/poly(vinyl alcohol)(PMP DN ICH)*** well-designed ICH exhibits outstanding ionic conductivity(63.89 mS cm^(-1) at 25℃),excellent temperature resistance(-60–80℃),prolonged stability(30 d at ambient temperature),high oxidation resist-ance,remarkable antibacterial activity,decent mechanical performance,and ***,the ICH performs effectively in a flexible wireless strain sensor,thermal sensor,all-solid-state supercapacitor,and single-electrode triboelectric nanogenerator,thereby highlighting its viability in constructing soft electronic *** highly integrated gel structure endows these flexible electronic devices with stable,reliable signal output *** particular,the all-solid-state supercapacitor containing the PMP DN ICH electrolyte exhibits a high areal specific capacitance of 253.38 mF cm^(-2)(current density,1 mA cm^(-2))and excellent environmental *** study paves the way for the design and fabrication of high-performance mul-tifunctional/flexible ICHs for wearable sensing,energy-storage,and energy-harvesting applications.

关键词： Ionic liquids Double-network hydrogels Temperature tolerance Multifunctionality Flexible electronic devices

Astrocyte syncytium:from neonatal genesis to aging degeneration

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Neural Regeneration Research 2024年第2期19卷 395-396页

作者： min zhou Shiying Zhong Alexei Verkhratsky Department of Neuroscience Ohio State University Wexner Medical CenterColumbusOHUSA Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Achücarro Basque Center for Neuroscience IKERBASQUEBasque Foundation for ScienceBilbaoSpain Department of Neurosciences University of the Basque Country UPV/EHU and CIBERNEDLeioaSpain

Modern neuroscience began from all reaching and fierce conflict between“neuronismo and reticulismo”——between neuronal and reticular theories of the organization of the nervous system;the conflict culminated in December of 1906 in Stockholm where Santiago Ramon y Cajal(the proponent of the neuronal doctrine)and Camillo Golgi(who advocated the syncytial reticular organization of neural networks)delivered their Noble prize lectures(Verkhratsky,2009).

关键词： degeneration neonatal aging