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Shear stress induces synthetic-to-contractile phenotypic modulation in smooth muscle cells via PPAR-alpha/delta activations by prostacyclin released by sheared endothelial cells

Shear stress induces synthetic-to-contractile phenotypic mod...

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第七届海峡两岸心血管科学研讨会

作者： min-chien tsai Shu chien Jeng-Jiann Chiu Division of Medical Engineering Research National Health Research InstitutesMiaoliTaiwan

Phenotypic modulation of smooth muscle cells(SMCs),which are located in close proximity to endothelial cells(ECs),is critical in regulating vascular *** investigated the role of flow-induced shear stress on ECs in modulating SMC phenotype and its underlying mechanism,using our newly developed EC/SMC co-culture flow system in which ECs and SMCs were separated by a porous *** of shear stress(12 dynes/ cm)to EC/SMC modulated SMC phenotype from synthetic to contractile state,with up-regulation of contractile markers,down-regulation of pro-inflammatory genes,and decreased percentage of cells in the synthetic phase. Treating SMCs with media from sheared ECs induced peroxisome proliferator-activated receptor(PPAR)-α,-δ, and-γligand binding activities;transfecting SMCs with specific small interfering RNAs(siRNAs)of PPAR-αand-δ, but not-γ,inhibited shear-induction of contractile *** exposed to shear stress released prostacyclin (PGI).Transfecting ECs with PGI synthase-specific siRNA inhibited shear-induced activation of PPAR-α/δ,up-regulation of contractile markers,down-regulation of pro-inflammatory genes,and decrease in percentage of SMCs in synthetic *** with PPAR-αdeficiency showed altered SMC phenotype toward a synthetic state,with increased arterial contractility in response to angiotensinⅡ,as compared with control *** results indicate that laminar shear stress induces synthetic-to-contractile phenotypic modulation in SMCs through the activation of PPAR-α/δby the EC-released *** findings provide insights into the mechanisms underlying the interplays of ECs with SMCs and the protective homeostatic function of laminar shear stress in modulating SMC phenotype.

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Protein kinase C-δ and -β coordinate flow-induced directionality and deformation of migratory human blood T-lymphocytes

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Journal of Molecular Cell Biology 2014年第6期8卷 458-472页

作者： Shu-Yi Wei Ting-Er Lin Wei-Li Wang Pei-Ling Lee min-chien tsai Jeng-Jiann Chiu Institute of Cellular and System Medicine 'National' Health Research Institutes Miaoli 350 Department of Physiology and Biophysics 'National' Defense Medical Center Taipei 114 Institute of Biomedical Engineering 'National' Tsing Hua University Hsinchu 300 Institute of Biomedical Engineering 'National' Cheng Kung University Tainan 701

T-tym phocyte migration under flow is critical for immune responses, but the mechanisms by which flow modulates the migratory beha- viors of T-lymphocytes remain unclear. Human peripheral blood T-lymphocytes （PBTLs）, when stimulated with phorboL 12-myristate 13-acetate （PMA）, stretched their ceU bodies dramatically and moved alongthe flow direction. In contrast, stromal ceil-derived factor- lα-stimulated PBTI.s deformed and migrated in a random manner. Here we elucidated the molecular mechanisms underlying flow- induced directionality and deformation of PMA-stimulated PBTLs. PMA primed PBTLs for polarization under flow, with protein kinase C （PKC）-δ enriched in the leading edge, PKC-β1 in the microtubuie organizing center, and PKC-1311 in the uropod and peripheral region. PKC-δ regulated cell protrusions in the leading edge through Tiaml/Racl/caLmoduUn, whereas PKC-β regulated RhoA/Rho- associated kinase activity and microtubule stability to modulate uropod contractility and detachment. Our findings indicate that PKC-δ and -β coordinate in the cell Leading edge and uropod, respectively, to modu｜ate the directionality and deformability of migratory T-Lymphocytes under flow.

关键词： deformability directionality migration PKCs T-lymphocyte

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Hepatitis B reactivation in chronic myeloid leukemia patients receiving tyrosine kinase inhibitor

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World Journal of Gastroenterology 2013年第8期19卷 1318-1321页

作者： Guan-min Lai Sheng-Lei Yan Cheng-Shyong Chang chien-Yu tsai Division of Hemato-Oncology Department of Internal MedicineChanghua Christian Hospital Division of Gastroenterology Department of Internal MedicineChang-BingShow Chwan Memorial Hospital

Hepatitis B virus(HBV) reactivation is a well-recognized complication in patients with chronic HBV infection receiving cytotoxic or immunosuppressive *** mesylate and nilotinib are selective Bcr/Abl tyrosine kinase inhibitors,which are now widely used in the treatment of patients with chronic myeloid *** HBV reactivation induced by imatinib mesylate has been reported,nilotinib-related HBV reactivation has not been reported in the English *** report here 2 cases of HBV reactivation in chronic myeloid leukemia patients receiving imatinib mesylate and a novel case of nilotinib related HBV reactivation.

关键词： Hepatitis B virus Chronic myeloid leukemia Imatinib mesylate Nilotinib Tyrosine kinase inhibitor

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Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo min Song Lulu An Xiao Huang Qian Zhang Chenhao Zhang Tao Shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Electrolytic reduction

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-min Qin Zhongliang Li Wen‑Xia Su Jia‑min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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Chest pain in a heart transplant recipient:A case report

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World Journal of Clinical Cases 2021年第16期9卷 3966-3970页

作者： Yu-Jen Chen chien-Sung tsai tsai-Wang Huang Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Cardiovascular Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan

BACKGROUND Heart transplantation is recommended for the treatment of patients with refractory heart *** pain after heart transplantation is usually considered noncardiac owing to the denervated ***,data from case reports on tacrolimus-induced achalasia after heart transplantation are *** aimed to present a case of tacrolimus-induced achalasia that developed after heart tran-splantation,which was successfully relieved by laparoscopic Heller *** SUMMARY A 67-year-old man with a history of Type 2 diabetes mellitus,hyperlipidemia,and dilated cardiomyopathy had congestive heart failure following orthotopic heart transplantation with tacrolimus treatment 12 years *** the 10-year follow-up after the heart transplantation,the patient presented with persistent cough,dysphagia,heartburn,and retrosternal chest pain lasting for 2 *** endoscopy revealed no specific *** years later,the patient experienced the same symptoms,including chest pain lasting for 4 *** and manometry confirmed the presence of *** reports showed that discontinuing calcineurin inhibitor(CNI)treatment and endoscopic botulinum toxin injection could treat CNI-induced *** to the risk of rejection of the transplanted heart and considering the temporary benefits of botulinum toxin injection in achalasia,the patient underwent laparoscopic Heller *** was relieved without *** months later,he had no signs of recurrence of the *** In transplant patients with chest pain and gastrointestinal symptoms, CNIinducedachalasia may be one of the differential diagnoses. Esophagogram/manometry is useful for diagnosis.

关键词： Heart transplantation Refractory heart failure Chest pain Achalasia Esophagogram Case report

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SPIN WAVES IN MAGNETIC SUPERLATTICES

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Chinese Physics Letters 1984年第2期1卷 92-94页

作者： MA Hong-ru tsai chien-hua Institute of Solid State Physics Nanjing UniversityNanjing Institute of Solid State Physics Nanjing UniversityNanjingand Department of PhysicsChiao-tung UniversityShanghai

We discuss,in terms of a simple model,the spin wave excitations,spontaneous magnetization and response to alternating fields of magnetic superlattices.

关键词： excitation magnetization alternating

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Teriparatide as nonoperative treatment for femoral shaft atrophic nonunion: A case report

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World Journal of Clinical Cases 2019年第18期7卷 2838-2842页

作者： Meng-Huan tsai Chih-chien Hu College of Medicine Chang Gung UniversityTaoyuan 33305Taiwan Department of Joint Reconstruction Orthopedic SurgeryBone and Joint Research CenterChang Gung Memorial HospitalLin-Kou Medical CenterTaoyuan 33305Taiwan

BACKGROUND Femoral shaft fractures are a common type of fracture among adults and have high union rates. However, clinical decisions are difficult to make because of the different types of nonunions. Atrophic nonunion usually requires revision surgery combined with bone grafting. Furthermore, no study of teriparatide administration for femoral atrophic nonunion have been previously reported. CASE SUMMARY A 60-year-old woman had a right femoral shaft fracture due to a traffic accident, and she immediately underwent closed reduction and internal fixation surgery with an intramedullary nailing. However, after 6 mo of rehabilitation, the fracture site showed no signs of healing, and her condition was diagnosed as atrophic nonunion. Subsequently, teriparatide was administered for 6 mo. Complete union was observed at the fracture site 6 mo after teriparatide discontinued. CONCLUSION The use of teriparatide can be a promising treatment to improve the healing of nonunion fractures.

关键词： Teriparatide Nonunion Femoral fractures Case report

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Real-Time Human Body Motion Capturing System

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Journal of Electronic Science and Technology 2017年第2期15卷 115-122页

作者： Chung-Lin Huang chien-Wei Hsu Zhi-Ren tsai Department of M-Commerce and Multimedia Applications Asia UniversityTaichung 41354 MediaTek Inc.Hsinchu department of computer science and information engineering Asia UniversityTaichung 41354

This paper proposes a human body motion capturing system using the depth images. It consists of three processes to estimate the human pose parameters. First, we develop a pixel-based body part classifier to segment the human silhouette into different body part sub-regions and extract the primary joints. Second, we convert the distribution of the joints to the feature vector and apply the regression forest to estimate human pose parameters. Third, we apply the temporal constraints mechanism to find the best human pose parameter with the minimum estimation error. In experiments, we show that our system can operate in real-time with sufficient accuracy.

关键词： Index Terms-Motion capturing random forest classifier regression forest.

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Diagnosis and management of glandular papilloma of lung:A case report

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World Journal of Clinical Cases 2020年第6期8卷 1104-1115页

作者： chien-Wei Wu Ann Chen tsai-Wang Huang Department of Surgery Tri-Service General HospitalTaipei 114Taiwan Department of Pathology Tri-Service General HospitalTaipei 114Taiwan Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalTaipei 114Taiwan

BACKGROUND Solitary respiratory papilloma is a rare epithelial tumor that can be categorizedinto multiple subtypes depending on tumor location,histological presentationand *** glandular type is the rarest,with only 30 cases available withinthe ***,information on its identification and treatment is *** thisreport,we discuss the diagnostic strategy and management of glandularpapilloma,along with a review of the *** SUMMARY We describe a male 44-year-old nonsmoker who presented with a persistentcough and recurrent pneumonia,which he had experienced for over 2 *** pulmonary nodule with an endobronchial lesion was found via computedtomography of the *** a biopsy was obtained,no definite diagnosiscould be *** papilloma of the lung was confirmed via videoassistedthoracoscopic anatomic resection of the right lower lobe of the *** remained disease-free after 6 mo follow *** minimally invasive surgery is feasible for the surgical resection of endobronchialglandular *** rare,glandular papilloma should be consideredin patients with infection or endobronchial lesions.

关键词： Papilloma Lung Treatment minimal invasive surgery Diagnosis Case report

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