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A novel molecular mechanism for nitrated α-synuclein-induced cell death

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Journal of Molecular Cell Biology 2011年第4期3卷 239-249页

作者： Yanying Liu min qiang Yan Wei Rongqiao He State Key Laboratory of Brain and Cognitive Sciences Institute of BiophysicsChinese Academy of Sciences15 Datun RoadChaoyang DistrictBeijing 100101China Key Laboratory of Mental Health Institute of PsychologyChinese Academy of Sciences15 Datun RoadChaoyang DistrictBeijing 100101China

Although previous studies have demonstrated the involvement of nitrated a-synuclein in neurodegenerative disorders(synucleinopathies),the effects of nitrated α-synuclein and the molecular mechanisms underlying its toxicity are still *** the present study,nitrated α-synuclein with four 3-nitrotyrosines(Tyr^(39),Tyr^(125),Tyr^(133),and Tyr^(136))was obtained non-enzymatically by incubation with *** nitrated protein existed as a mixture of monomers,dimers,and polymers in *** nitrated a-synuclein could induce cell death in a time-and concentration-dependent manner when SH-SY5Y cells(a human neuroblastoma cell line)were incubated with the dimers and *** with anti-integrin α5β1 antibody partially rescued the SH-SY5Y cells from the cell *** blotting and immunoprecipitation revealed that the nitrated protein bound to integrin on the cell *** of nitric oxide(NO)and calcium-independent inducible NO synthase(iNOS)activity increased during the initial stages of the *** expression of phosphorylated focal adhesion kinase(FAK)decreased in the ***,an increase in caspase 3 activity was observed in SH-SY5Y *** results demonstrate that activation of iNOS and inhibition of FAK may both be responsible for the cell death induced by nitrated α-*** data suggest that the cytotoxicity of nitrated a-synuclein is mediated via an integrin-iNOS/-FAK signaling pathway,and that the nitration of α-synuclein plays a role in neuronal degeneration.

关键词： nitric oxide nitration neuronal death toxicity focal adhesion kinase calcium-independent inducible nitric oxide synthase

Micro-mechanism of metal magnetic memory signal variation during fatigue

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International Journal of minerals,Metallurgy and Materials 2014年第3期21卷 259-265页

作者： ming-xiu Xu Zhang-hua Chen min-qiang Xu School of Mathematics and Physics University of Science and Technology Beijing Division of Vehicle Dynamics & Control Harbin Institute of Technology

Tensile fatigue tests were designed to study the relation between the tangential magnetic memory signal and dislocations. According to experimental results, in the early stage of fatigue, the magnetic signal and the dislocation density rapidly increase; while in the middle stage, the magnetic signal gradually increases, the dislocation density remains steady, and only the dislocation structure develops. On the other hand, in the later stage, the magnetic signal once again increases rapidly, the dislocation structure continues to develop, and microscopic cracks are formed. Analysis reveals that the dislocations block the movement of the domain wall, and the area of dislocation accumulation thus becomes an internal magnetic source and scatters a field outward. In addition, the magnetic memory field strengthens with increasing dislocation density and complexity of the dislocation structure. Accordingly, the dislocation pinning factor related with the dislocation density and the dislocation structure has been proposed to characterize the effect of dislocations on the magnetic memory signal. The magnetic signal strengthens with an increase in the dislocation pinning factor.

关键词： fatigue of materials metal magnetic memory dislocations magnetic fields

A brief review on current progress in neuroscience in China

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Science China(Life Sciences) 2011年第12期54卷 1156-1159页

作者： qiang min WU BeiBei LIU Ying State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China

Neuroscience has been undergoing a rapid development in China since the beginning of the 21st century. Chinese sci- entists are working on neuroscience and getting more and more important results. As described by Poo Mu-ming [1], the increasing funding support, the flood of returning over- seas researchers and numerous international conferences held in China give birth to the springtime of neuroscience in China.

关键词：神经科学中国国际会议研究人员资金支持科学家

Investigation of Inclusion Complexes Between α-Cyclodextrin and Ferrocene by ESI-MSn and Cyclic Voltammetry

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Chemical Research in Chinese Universities 2005年第1期21卷 117-118页

作者： GUOLi-min LIUZhi-qiang LIUShu-ying ChangchunInstituteofAppliedChemistry ChineseAcademyofSciencesChangchun130022P.R.China

The inclusion complexes of α-cyclodextrin(α-CD) and FcCO2(CH2)18 (FcSH) and their self-assembled monolayers(SAMs) on gold surface were investigated by electrospray tandem ionization mass spectrometry(ESI-MSn) and cyclic voltammetry, respectively. The interfacial electrochemical response of the SAMs is related to the way in which the inclusion complexes formed.

关键词： Ferrocene α-Cyclodextrin Inclusion complex ESI-MSn Cyclic voltammetry

Dry needling at myofascial trigger points mitigates chronic post-stroke shoulder spasticity

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Neural Regeneration Research 2018年第4期13卷 673-676页

作者： Li Tang Yan Li qiang-min Huang Yang Yang Tong Ren Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Shanghai University of Sport Shanghai China

Post-stroke spasticity is associated with restriction in the range of motion of the *** muscular dystrophy may help relieve muscular dysfunction in patients with post-stroke shoulder *** needle therapy is a method of needling the trigger points using a syringe needle without the use of a *** needle therapy is commonly used for pain at the shoulder,neck,waist,and *** this case study,a 62-year-old male patient affected with cerebral hemorrhage of the right frontal lobe had received rehabilitative treatment for 12 ***,he still experienced shoulder *** patient received daily dry needling at the trigger points of infraspinatus,teres minor,posterior deltoid,and pectoralis major on 9 *** the first and ninth treatment,the Modified Ashworth Scale and the passive range of motion of the shoulder was used to assess the effect of the *** spasticity and range of motion of the shoulder showed obvious *** results indicate that dry needling at the myofascial trigger points can effectively treat chronic poststroke shoulder spasticity.

关键词： nerve regeneration stroke dry needling shoulder spasticity Modified Ashworth Scale passive range of motion neural regeneration

Early Sensor Fault Detection Based on PCA and Clustering Analysis

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Journal of Harbin Institute of Technology(New Series) 2014年第6期21卷 113-120页

作者： Xue-Bing Gong Ri-Xin Wang min-qiang Xu Deep Space Exploration Research Center Harbin Institute of Technology

This paper proposes a novel scoring index for the early sensor fault detection in order to make full use of massive archived spacecraft telemetry *** early detection of sensor faults is made by using the index constructed by the K-means algorithm and PCA *** sensor fault detection includes the learning phase and monitoring *** amplitude of sensor fault has been always increasing when the performance of sensors deteriorates during a *** proposed index can detect the smaller sensor faults than the squared prediction error( SPE) index which means it can discover the sensor faults earlier than the *** simulation results demonstrate the effectiveness and feasibility of the proposed index which can decrease the check-limit as much as 40% than SPE in the same magnitude of bias sensor fault.

关键词： early fault detection PCA K-means algorithm SPE Sensor faults

Clinical significance of peri-appendiceal abscess and phlegmon in acute complicated appendicitis patients undergoing emergency appendectomy

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3123-3132页

作者： Ling-qiang min Jing Lu Hong-Yong He Department of General Surgery/Emergency Surgery Zhongshan HospitalFudan UniversityShanghai 200032China Department of Nursing Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND Although antibiotic therapy has become the primary treatment for acute unco-mplicated appendicitis,the management of acute complicated appendicitis nece-ssitates careful consideration of various treatment *** To analyze the clinical data of patients who underwent emergency appendectomy for acute complicated appendicitis with peri-appendiceal abscess or phlegmon,identify factors influencing the postoperative length of hospital stay(LOS),and improve treatment *** The clinical data of acute complicated appendicitis patients with peri-appendiceal abscess or phlegmon who underwent emergency appendectomy at The Depart-ment of Emergency Surgery,Zhongshan Hospital,Fudan University from January 2016 to March 2023 were retrospectively *** A total of 234 patients were included in our *** duration of symptoms and the presence of an appendicolith were significantly correlated with the occurrence of peri-appendiceal abscess in patients with acute complicated appendicitis(P<0.001 and P=0.015,respectively).Patients with symptoms lasting longer than 72 h had a significantly longer postoperative LOS compared to those with symptoms lasting 72 h or less[hazard ratio(HR),1.208;95%CI:1.107-1.319;P<0.001].Additionally,patients with peri-appendiceal abscesses had a significantly longer postoperative LOS compared to those with phlegmon(HR,1.217;95%CI:1.095-1.352;P<0.001).The patients with peri-appendiceal abscesses were divided into two groups based on the median size of the abscess:Those with abscesses smaller than 5.0 cm(n=69)and those with abscesses 5.0 cm or larger(n=82).Patients with peri-appendiceal abscesses measuring 5.0 cm or larger had a significantly longer postoperative LOS than those with abscesses smaller than 5.0 cm(P=0.038).CONCLUSION The duration of symptoms and the presence of an appendicolith are significant risk factors for the formation of peri-appendiceal abscesses in patients with acute complicated ***

关键词： Acute complicated appendicitis Abscess Phlegmon Appendectomy Appendicolith

Clinical significance of appendicoliths in elderly patients over eighty years old undergoing emergency appendectomy:A single-center retrospective study

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World Journal of Gastrointestinal Surgery 2024年第11期16卷 3453-3462页

BACKGROUND Acute appendicitis with an appendicolith is one of the most common abdominal emergencies in elderly patients and is more likely to progress to gangrene and *** To analyze the clinical data of elderly patients undergoing emergency appende-ctomy for acute appendicitis,aiming to improve treatment *** The clinical data of 122 patients over 80 years old who underwent emergency appendectomy for acute appendicitis at the Department of Emergency Surgery of Zhongshan Hospital,Fudan University from January 2016 to March 2023 were retrospectively *** patients were divided into two groups based on the presence of an appendicolith or not,and clinicopathological and surgery-related features were compared between the two *** The duration of abdominal pain in all 122 patients ranged from 5 to 168 *** patients underwent emergency appendectomy:6 had an open appendectomy,101 had a laparoscopic appendectomy,and 15 required conversion from laparoscopic to open surgery,resulting in a conversion rate of 12.9%(15/116).The patients were divided into two groups:Appendicolith group(n=46)and non-appendi-colith group(n=76).Comparisons of clinicopathological features revealed that patients with appendicoliths were more likely to develop appendiceal gangrene(84.8%vs 64.5%,P=0.010)and perforation(67.4%vs 48.7%,P=0.044),and had a lower surgical conversion rate(2.2%vs 19.7%,P=0.013).The median length of hospital stay was 5.0 d for both groups and there was no significant difference between *** patients were successfully *** Around 40%of patients over 80 years old with acute appendicitis have an appendicolith,increasing their risk of developing appendiceal gangrene and perforation,and therefore should receive timely surgical treatment.

关键词： Elderly patients Acute appendicitis Appendicolith Appendectomy Acute abdomen

A Routing Algorithm in WDM Mesh Networks with Grooming Capacities

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Wuhan University Journal of Natural Sciences 2005年第5期10卷 873-876页

作者： WANG qiang-min RONG Meng-tian ZHU Hong-wen School of Information Security Engineering Shanghai Jiaotong University Shanghai 200030 China Modern Communication Institute Shanghai Jiaotong University Shanghai 200030 China

Most of the work in traffic grooming has been in the area of providing efficient network designs in Wavelength division multiplexing （WDM）. The objective of these traffic grooming algorithms is to reduce the cost of overall networks. In this paper, a routing algorithm based on transiently chaotic neural network is proposed to solve the problem in WDM logical topology. The objectives of the routing algorithm are ac commodating all traffic requirements and using less network resource. The simulation shows that the proposed algorithm is efficient in the routing selection, meanwhile the algorithm can use less network resource.

关键词： wavelength division multiplexing optical communication network traffic grooming routing