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Chinese Journal of Natural Medicines 2021年第1期19卷 56-62页

作者： lim Seong-min Park Hae-Bin Jin Jun-O Department of Medical Biotechnology Yeungnam UniversityGyeongsan 38541South Korea Shanghai Public Health Clinical Center Shanghai Medical CollegeFudan UniversityShanghai201508China

Astragalus membranaceus(***)is a widely used traditional herb in China and *** polysaccharides(AMP),which make up a major part of the root extract,have been shown to modulate immune modulations,especially activation of bone marrow-derived dendritic cells(BMDCs)and T ***,the immune stimulatory effect of AMP in the mouse in vivo and human peripheral blood DCs(PBDCs)has not been well *** this study,we found that intravenous(i.v.)injection of AMP in C57 BL/6 mice induced remarkable elevations in co-stimulatory and MHC class I and II molecule levels in the splenic DCs and its *** stimulatory effect of DCs by AMP was elevated 6 h after treatment,which rapidly decreased 18 h after ***,AMP promoted intracellular production of pro-inflammatory cytokines in spleen DC subsets,which contributed elevation of serum cytokine ***,the AMP promoted PBDC ***,these results demonstrate that AMP can be used as an immune stimulatory molecules in human and mouse.

关键词： Astragalus membranaceus polysaccharide Spleen dendritic cell Human peripheral blood dendritic cell

Cholecystocolic fistula caused by gallbladder carcinoma:Preoperatively misdiagnosed as hepatic colon carcinoma

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World Journal of Gastroenterology 2015年第15期21卷 4765-4769页

作者： gi Won Ha min Ro Lee Jong Hun Kim Research Institute of Clinical Medicine Chonbuk National University Medical School

Cholecystocolic fistula secondary to gallbladder carcinoma is extremely rare and has been reported in very few studies. Most cholecystocolic fistulae are late complications of gallstone disease, but can also develop following carcinoma of the gallbladder when the necrotic tumor penetrates into the adjacent colon. Although no currently available imaging technique has shown great accuracy in recognizing cholecystocolic fistula, abdominopelvic computed tomography may show fistulous communication and anatomical *** we report an unusual case of cholecystocolic fistula caused by gallbladder carcinoma, which was preoperatively misdiagnosed as hepatic flexure colon carcinoma.

关键词： Cholecystocolic fistula Gallbladder carcinoma Misdiagnosed Hepatic colon carcinoma Abdominopelviccomputed tomography

Effectiveness of bee venom acupuncture in alleviating post-stroke shoulder pain: a systematic review and meta-analysis

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Journal of Integrative Medicine 2015年第4期13卷 241-247页

作者： Sung min lim Sook-Hyun Lee Department of Clinical Research on Rehabilitation Korea National Rehabilitation Research Institute

BACKGROUND：Shoulder pain is a common complication of *** venom acupuncture（BVA）is increasingly used in the treatment of post-stroke shoulder ***：To summarize and evaluate evidence on the effectiveness of BVA in relieving shoulder pain after *** STRATEGY：Nine databases,namely MEDLINE,EMBASE,the Cochrane Library,the China National Knowledge Infrastructure（CNKI）,the Japan Science and Technology Information Aggregator,Electronic（J-STAGE）,and four Korean medical databases,namely,the National Assembly Library,the Research Information Service System,the National Discovery for Science Leaders,and OASIS,were searched from their inception through August 2014 without language *** CRITERIA：Randomized controlled trials（RCTs）were included if BVA was used at acupoints as the sole treatment,or as an adjunct to other treatments,for shoulder pain after *** EXTRACTION AND ANALYSIS：Two review authors independently selected trials for inclusion,assessed methodological quality and extracted ***：A total of 138 potentially relevant articles were identifi ed,4 of which were RCTs that met our inclusion *** quality of studies included was generally low,and a preponderance of positive results was *** four trials reported favorable effects of BVA on shoulder pain after *** RCTs assessing the effects of BVA on post-stroke shoulder pain,as opposed to saline injections,were included in the *** was signifi cantly lower for BVA than for saline injections（standardized mean difference on 10-cm visual analog scale：1.46 cm,95%CI=0.30–2.62,P=0.02,n=86）CONCLUSION：This review provided evidence suggesting that BVA is effective in relieving shoulder pain after ***,further studies are needed to confi rm the role of BVA in alleviating post-stroke shoulder *** studies should be conducted with large samples and rigorous study designs.

关键词： bee venoms acupuncture therapy stroke shoulder pain meta-analysis systematic review

High prevalence of osteoporosis in patients with gastric adenocarcinoma following gastrectomy

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World Journal of Gastroenterology 2007年第48期13卷 6492-6497页

作者： Jung Sub lim Sang Bum Kim Ho-Yoon Bang gi Jeong Cheon Jong-Inn Lee Department of Pediatrics Korea Cancer Center Hospital Department of Surgery Korea Cancer Center Hospital Department of Nuclear Medicine Korea Cancer Center Hospital

AIM： To evaluate the prevalence and predictive factors of osteoporosis in patients with gastric adenocarcinoma alter gastrectomy.METHODS： The study included 133 patients diagnosed with gastric adenocarcinoma but who did not undergo prior diagnostic work-up for osteoporosis. Bone mineral density （BMD） was measured by dual-energy X-ray absorptiometry （DXA） and vertebral deformity was assessed by plain X-rays. We evaluated the effects of age, sex, body mass index （BMI）, anemia, back pain, vertebral deformity, tumor staging, reconstruction type, and past medical history to determine predictive factors of osteoporosis in these patients.RESULTS： The prevalence of osteoporosis in the lumbar spine was 38.3% （male, 28.9%; female, 54.0%）, and 15.0% in the femoral neck （male, 10.8%; female, 22.0%）. The vertebral deformity rate was 46.6% （male, 43.4%; female, 52.0%）. Age, BMI and hemoglobin correlated with BMD （P 〈 0.01）. In males, anemia and age 〉 64 years were independent predictive factors of osteoporosis in multivariate analysis. In females, back pain was an independent factor for osteoporosis.CONCLUSION： The results of this study revealed that prevalence of osteoporosis and vertebral bone deformity rate were high in gastric cancer patients, regardless of post-gastrectomy duration and operation type. Early diagnosis and a proper management plan must be established in these patients.

关键词： Gastric adenocarcinoma Gastrectomy Bone mineral density Osteoporosis Vertebral deformity Anemia Back pain

Applicability of cement-based grout for ground heat exchanger considering heating-cooling cycles

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Science China(Technological Sciences) 2011年第7期54卷 1661-1667页

作者： Moonseo PARK Sunhongmin Jeehee lim Jong min CHOI Hangseok CHOI School of civil Environmental and Architectural Engineering Korea University Seoul Republic of Korea Department of Mechanical Engineering Hanbat National University Daejeon Republic of Korea

The applicability of cement grout （or cement-based grout） has been considered as an alternative to bentonite grout commonly used to backfill closed-loop vertical ground heat exchangers. In a geothermal heat pump system, repeated heating-cooling cycles may cause adverse effects on the integrity of cement grout in the ground heat exchanger. To account for the temperature cycling effect, the strength degradation of cement grout due to temperature cycling has been examined by measuring the unconfined compression strength of cured specimens in a humidity-temperature controlling chamber with applying temperature cycles between -5℃ and 50℃. There is a tendency that the unconfined compression strength decreases with an increase in the number of temperature cycles. On the other hand, an equivalent hydraulic conductivity of a pipe-embedded cement grout specimen was evaluated by carrying out a modified flexible wall permeameter test equipped with a water circulating system to control temperature inside the pipe section. The applied operating temperature range was from 5 to 35℃. After three cycles of heating-cooling circulation, the equivalent hydraulic conductivity becomes asymptotic to a constant value, which implies there is no severe detachment of the pipe from the cement grout.

关键词： cement grout bentonite grout thermal conductivity workability equivalent permeability coefficient

Massive retroperitoneal hematoma as an acute complication of retrograde intrarenal surgery:A case report

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World Journal of Clinical Cases 2021年第16期9卷 3914-3918页

作者： Taesoo Choi Jeonghyouk Choi Gyeong Eun min Dong-gi Lee Department of Urology School of MedicineKyung Hee UniversitySeoul 05278South Korea

BACKGROUND Retrograde intrarenal surgery(RIRS)has been proven to be a safe and effective treatment modality in large-scale quantitative ***,although its safety profile has been established,it also has a potential risk of life-threatening *** here describe our experience with a patient who developed a huge periureteral hematoma after RIRS with holmium laser *** SUMMARY A 73-year-old woman visited our center with a complaint of gross *** enhanced computed tomography(CT)scan revealed a 1.5-cm left renal pelvis stone with *** patient underwent *** the surgery,a 12/14-Fr ureteral access sheath was applied and a 6-Fr ureteral catheter was indwelled *** postoperative day 1,she experienced aggravated left flank pain and left lower-quadrant tenderness without rebound tenderness.A follow-up CT scan was taken,which revealed a huge hematoma in the periureteral space,not in the perirenal space,with suspicious contrast medium *** angiography was performed;however,it showed no evidence of active *** was conservatively managed with hydration and antibiotic and nonsteroidal anti-inflammatory drug therapy,and was discharged on postoperative day ***,she visited our outpatient department with recurrent left flank pain at 5 d from *** confirmed that the double J-stent was *** rule out stent malfunction,the stent was *** size of the hematoma was observed in the imaging studies,and conservative management for candiduria was performed for 1 *** Although RIRS is an effective and safe procedure for the management of renal stones,clinicians should be aware of its potential complications.

关键词： Retroperitoneal hematoma Ureteral access sheath Retrograde intrarenal surgery Acute complication Case report

Factors associated with use of gastric cancer screening services in Korea

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World Journal of Gastroenterology 2009年第29期15卷 3653-3659页

作者： Young min Kwon Hyung Taek lim Kiheon Lee Be Long Cho min Sun Park Ki Young Son Sang min Park Department of Family Medicine Seoul National University Hospital Seoul National University College of Medicine 28 Yunkeon-dong Jongro-gu Seoul 110-744 South Korea Department of Medicine Yonsei University College of Medicine 134 Shinchon-dong Seodaemun-gu Seoul 120-752 South Korea Department of Family Medicine Seoul National University Bundang Hospital and Department of the History of Medicine and Medical Humanities Seoul National University College of Medicine 166 Gumi-ro Bundang-gu Seongnam-si Gyeonggi-do 463-707 South Korea

AIM: To identify the factors associated with participation in gastric cancer screening programs. METHODS: Using data from the Korea National Health and Nutrition Examination Survey 2005 (KNHANES Ⅲ), a nationwide health-related surveyin Korea, a cross-sectional study was performed to investigate the multiple factors associated with gastric cancer screening attendance among persons aged at least 40 years. The study population included 4593 individuals who completed a gastric cancer screening questionnaire and had no previous cancer history. Four groups ofindividual-level or environmental level covariates were considered as potential associated ***: Using KNHANES Ⅲdata, an estimated31.71% of Korean individuals aged at least 40 years adhered to gastric cancer screening recommendations. Subjects who graduated from elementary school[adjusted odds ratio (aOR), 1.66; 95% CI: 1.21-2.26], middle/high school (aOR, 1.38; 95% CI: 1.01-1.89), and university or higher (aOR, 1.64; 95% CI: 1.13-2.37) were more likely to undergo gastric cancer screening than those who received no formal education at all. The population with the highest income tertile had more attendance at gastric screening compared to those with the lowest income tertile (aOR, 1.36; 95% CI: 1.06-1.73). Gastric screening was also negatively associated with excessive alcohol consumption (aOR, 0.71; 95% CI: 0.53-0.96). A positive attitude to preventive medical evaluation was significantly associated with better participation in gastric cancer screening programs (aOR, 5.26; 95% CI: 4.35-6.35). CONCLUSION: Targeted interventions for vulnerable populations and public campaigns about preventive medical evaluation are needed to increase gastric cancer screening participation and reduce gastric cancer mortality.

关键词： Socioeconomic factors Health behavior Health status disparity Mental health Early detectionof cancer

Examination of in vivo mutagenicity of sodium arsenite and dimethylarsinic acid in gpt delta rats

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Journal of Environmental Sciences 2016年第11期28卷 125-130页

作者： Masaki Fujioka min gi Satoko Kawachi Kumiko Tatsumi Naomi Ishii Kenichiro Doi Anna Kakehashi Hideki Wanibuchi Department of Molecular Pathology Osaka City University Graduate School of Medicine

Arsenic is a well-known human bladder and liver carcinogen, but its exact mechanism of carcinogenicity is not fully understood. Dimethylarsinic acid（DMAV） is a major urinary metabolite of sodium arsenite（i As~Ⅲ） and induces urinary bladder cancers in rats. DMAVand i As~Ⅲare negative in in vitro mutagenicity tests. However, their in vivo mutagenicities have not been determined. The purpose of present study is to evaluate the in vivo mutagenicities of DMAVand i As~Ⅲin rat urinary bladder epithelium and liver using gpt delta F344 ***-week old male gpt delta F344 rats were randomized into 3 groups and administered 0,92 mg/L DMAV, or 87 mg/L i As~Ⅲ（each 50 mg/L As） for 13 weeks in the drinking water. In the mutation assay, point mutations are detected in the gpt gene by 6-thioguanine selection（gpt assay） and deletion mutations are identified in the red/gam genes by Spi-selection（Spi-assay）. Results of the gpt and Spi-assays showed that DMAVand i As~Ⅲhad no effects on the mutant frequencies or mutation spectrum in urinary bladder epithelium or liver. These findings indicate that DMAVand i As~Ⅲare not mutagenic in urinary bladder epithelium or liver in rats.

关键词： Dimethylarsinic acid Sodium arsenite In vivo mutagenicity Urinary bladder epithelium gpt delta rat

A Study of the Gas Flow through Air Jet Loom

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Journal of Thermal Science 2007年第2期16卷 159-163页

作者： Heuy-Dong Kim Chae-min lim Ho-Joon Lee Doo-Hwan Chun School of Mechanical Engineering Andong National University388Songcheon-dongAndong 760-749KoreaE-mail:kimhd Korea Textile Machinery Research Institute 300Sampoong-dongKyeongsan 712-210Korea

Air jet loom, as one of the shuttleless looms, transports a yam into warps using viscosity and kinetic energy of an air jet. Performance of this picking system depends on the ability of instantaneous inhalation/exhaust, configuration of nozzle, operation characteristics of a check valve, etc. In the recent past, many studies have been reported on the air jet discharged from a nozzle exit, but studies for understanding the flow field characteristics associated with shear layer and shock wave/boundary layer interaction in the nozzle were not conducted enough. In this paper, a computational study was performed to explain the flow field in the air jet nozzle with an acceleration tube and validated with previous experimental data available. The results obtained from the computational study show that, in the supersonic flow regime, the flow field depends significantly on the length of acceleration tube. As nozzle pressure ratio increases, drag force acting on the string also increases. For a longer acceleration tube, the total pressure loss is large, owing to the frictional loss.

关键词： compressible flow nozzle shear layer shock wave air jet loom shuttleless loom

Molecular mechanisms of chemopreventive phytochemicals against gastroenterological cancer development

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World Journal of Gastroenterology 2013年第7期19卷 984-993页

作者： min-Yu Chung Tae Gyu lim Ki Won Lee WCU Biomodulation Major Center for Food and BioconvergenceDepartment of Agricultural BiotechnologySeoul National UniversitySeoul 151-742South Korea Advanced Institutes of Convergence Technology Seoul National UniversitySuwon 443-270South Korea

Cancer is one of the leading causes of death *** used cancer treatments,including chemotherapy and radiation therapy,often have side effects and a complete cure is sometimes ***,prevention,suppression,and/or delaying the onset of the disease are *** onset of gastroenterological cancers is closely associated with an individual's ***,changing lifestyle,specifically the consumption of fruits and vegetables,can help to protect against the development of gastroenterological *** particular,naturally occurring bioactive compounds,including curcumin,resveratrol,isothiocyanates,(-)-epigallocatechin gallate and sulforaphane,are regarded as promising chemopreventive ***,regular consumption of these natural bioactive compounds found in foods can contribute to prevention,suppression,and/or delay of gastroenterological cancer *** this review,we will summarize natural phytochemicals possessing potential antioxidant and/or anti-inflammatory and anti-carcinogenic activities,which are exerted by regulating or targeting specific molecules against gastroenterological cancers,including esophageal,gastric and colon cancers.

关键词： Curcumin Resveratrol (-)-Epigallocatechin gallate Isothiocyanates Sulforaphane Gastroenterological cancers Molecular target