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Multi-parameter identification of gratings measurement by Experimental Ray Tracing

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Research in Astronomy and Astrophysics 2021年第11期21卷 119-126页

作者： li-si chen Zhong-Wen Hu Hai-Jiao Jiang hui-min Kang chen-Zhong Wang National Astronomical Observatories/Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China CAS Key Laboratory of Astronomical Optics&Technology Nanjing Institute of Astronomical Optics&TechnologyNanjing 210042China University of Chinese Academy of Sciences Beijing 100049China

A simple method for measuring grating groove density as well as its position and orientation is proposed based on the idea of ERT(Experimental Ray Tracing).Conventional methods only measure grating groove density with accuracy limited by its rotary stage and *** method proposed in the paper utilizes linear guides which could be calibrated to much higher *** is applicable to gratings of arbitrary surface profile or mosaic of a group of various *** measurement error sources are simulated by the Monte Carlo method and the results show high accuracy capability of grating parameters identification.A verification testing is *** accuracy dependency on main configuration parameters is evaluated.A method to expand measurement range by double wavelength is also discussed.

关键词： grating groove density position orientation measurement range

Dose optimization of intrathecal administration of human umbilical cord mesenchymal stem cells for the treatment of subacute incomplete spinal cord injury

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Neural Regeneration Research 2022年第8期17卷 1785-1794页

作者： Ting-Ting Cao Huan chen Mao Pang si-si Xu hui-Quan Wen Bin liu li-min Rong Mang-Mang li Department of Cell Biology School of Basic Medical SciencesSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Spine Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Department of Radiology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Human umbilical cord mesenchymal stem cells(hUC-MSCs)are a promising candidate for spinal cord injury(SCI)repair owing to their advantages of low immunogenicity and easy accessibility over other MSC ***,modest clinical efficacy hampered the progression of these cells to clinical *** discrepancy may be due to many variables,such as cell source,timing of implantation,route of administration,and relevant efficacious cell dose,which are critical factors that affect the efficacy of treatment of patients with ***,we have evaluated the safety and efficacy of 4×10^(6) hUC-MSCs/kg in the treatment of subacute SCI by intrathecal implantation in rat *** search for a more accurate dose range for clinical translation,we compared the effects of three different doses of hUC-MSCs-low(0.25×10^(6) cells/kg),medium(1×10^(6) cells/kg)and high(4×10^(6) cells/kg)-on subacute SCI repair through an elaborate combination of behavioral analyses,anatomical analyses,magnetic resonance imaging-diffusion tensor imaging(MRI-DTI),biotinylated dextran amine(BDA)tracing,electrophysiology,and quantification of mRNA levels of ion channels and neurotransmitter *** study demonstrated that the medium dose,but not the low dose,is as efficient as the high dose in producing the desired therapeutic ***,partial restoration of theγ-aminobutyric acid type A(GABAA)receptor expression by the effective doses indicates that GABAA receptors are possible candidates for therapeutic targeting of dormant relay pathways in injured spinal ***,this study revealed that intrathecal implantation of 1×10^(6) hUC-MSCs/kg is an alternative approach for treating subacute SCI.

关键词： effective dose human umbilical cord mesenchymal stem cells intrathecal implantation ion channels neurotransmitter receptors spinal cord injury subacute spinal cord injury γ-aminobutyric acid type A(GABA_(A))receptors

DeepHBSP:A Deep Learning Framework for Predicting Human Blood-Secretory Proteins Using Transfer Learning

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Journal of Computer Science & Technology 2021年第2期36卷 234-247页

作者： Wei Du Yu sun hui-min Bao liang chen Ying li Yan-Chun liang Key Laboratory of Symbol Computation and Knowledge Engineering of ministry of Education College of Computer Science and TechnologyJilin UniversityChangchun 130012China Department of Computer Science College of EngineeringShantou UniversityShantou 515063China Zhuhai Laboratory of Key Laboratory of Symbol Computation and Knowledge Engineering of ministry of Education Zhuhai College of Jilin University Zhuhai 519041China

The identification of blood-secretory proteins and the detection of protein biomarkers in the blood have an important clinical application *** methods for predicting blood-secretory proteins are mainly based on traditional machine learning algorithms,and heavily rely on annotated protein *** traditional machine learning algorithms,deep learning algorithms can automatically learn better feature representations from raw data,and are expected to be more promising to predict blood-secretory *** present a novel deep learning model(DeepHBSP)combined with transfer learning by integrating a binary classification network and a ranking network to identify blood-secretory proteins from the amino acid sequence information *** loss function of DeepHBSP in the training step is designed to apply descriptive loss and compactness loss to the binary classification network and the ranking network,*** feature extraction subnetwork of DeepHBSP is composed of a multi-lane capsule ***,transfer learning is used to train a highly accurate generalized model with small samples of blood-secretory *** main contributions of this study are as follows:1)a novel deep learning architecture by integrating a binary classification network and a ranking network is proposed,superior to existing traditional machine learning algorithms and other state-of-the-art deep learning architectures for biological sequence analysis;2)the proposed model for blood-secretory protein prediction uses only amino acid sequences,overcoming the heavy dependence of existing methods on annotated protein features;3)the blood-secretory proteins predicted by our model are statistically significant compared with existing blood-based biomarkers of cancer.

关键词： blood-secretory protein deep learning capsule network transfer learning

Hydrogen generation from ammonia electrolysis on bifunctional platinum nanocubes electrocatalysts

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Journal of Energy Chemistry 2020年第8期29卷 234-240,I0009页

作者： hui-Ying sun Guang-Rui Xu Fu-min li Qi ng-li ng Hong Pu-Jun Jin Pei chen Yu chen Key Laboratory of Macromolecular Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid Chemistry(Ministry of Education)Shaanxi Key Laboratory for Advanced Energy DevicesSchool of Materials Science and EngineeringShaanxi Normal UniversityXi'an 710062ShaanxiChina School of Chemistry and Chemical Engineering Shaanxi Normal UniversityXi'an 710062ShaanxiChina

The ammonia electrolysis is a highly efficient and energy-saving method for ultra-pure hydrogen generation, which highly relies on electrocatalytic performance of electrocatalysts. In this work, high-quality platinum(Pt) nanocubes(Pt-NCs) with 4.5 nm size are achieved by facile hydrothermal synthesis. The physical morphology and structure of Pt-NCs are exhaustively characterized, revealing that Pt-NCs with special {100} facets have excellent uniformity, good dispersity and high crystallinity. Meanwhile, the electrocatalytic performance of Pt-NCs for ammonia electrolysis are carefully investigated in alkaline solutions, which display outstanding electroactivity and stability for both ammonia electrooxidation reaction(AEOR) and hydrogen evolution reaction(HER) in KOH solution. Furthermore, a symmetric Pt-NCs||Pt-NCs ammonia electrolyzer based on bifunctional Pt-NCs electrocatalyst is constructed, which only requires 0.68 V electrolysis voltage for hydrogen generation. Additionally, the symmetric Pt-NCs||Pt-NCs ammonia electrolyzer has excellent reversible switch capability for AEOR at anode and HER at cathode, showing outstanding alternating operation ability for ammonia electrolysis.

关键词： Ammonia electrolysis Water electrolysis Ammonia oxidation reaction Hydrogen evolution reaction Platinum nanocubes

Heat stability of winter wheat depends on cultivars, timing and protective methods

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Journal of Integrative Agriculture 2020年第8期19卷 1984-1997页

作者： li Qiang CHANG Xu-hong MENG Xiang-hai li Ding ZHAO ming-hui sun Shu-luan li hui-min QIAO Wen-chen Dryland Farming Institute Hebei Academy of Agriculture and Forestry SciencesHengshui 053000P.R.China Key Lab of Crop Drought Tolerance Research of Hebei Province Hengshui 053000P.R.China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081P.R.China

Heat stress negatively affects wheat production in many regions of the *** present,sensitivity to heat stress remains one of the least understood aspects of wheat genetics and breeding,and measures for preventing heat stress are *** this study,we used three cultivars of winter wheat(GY2018,SL02-1 and SY20)to evaluate the effect of heat stress at different days after anthesis(DAA)on yield and *** stability of the cultivars were analyzed and evaluated for the effects of two kinds of regulators on wheat under heat stress *** treatment at 7 DAA led to the most substantial reduction in yield while GY2018 had the best heat stability with respect to yield,and demonstrated the most positive effects on several quality traits including protein content,sedimentation volume and glutenin and gliadin *** treatment at 14 DAA had the least reduction in yield,while SY20 had the best heat stability with respect to yield and heat treatment had minimal effects on *** treatment at 21 DAA had only a limited effect on yield,while SL02-1 had the best heat stability with respect to yield,but it showed the most negative effects on *** time at 14 DAA and protein content at 21 DAA can be used as indicators for detecting the stability of quality under heat *** the three studied cultivars,SY20 was the most sensitive to heat stress with the stable time decreasing from 26.4 to 9.1 min,a higher sedimentation volume at 7 DAA,and a lowerγ-gliadin content which increased 2.4-fold under high-temperature *** addition of various regulators had different effects:potassium dihydrogen phosphate(KDP)was more protective of yield with heat stress at 7 DAA,while Duntianbao(DTB)had better effects on quality with heat stress at 21 DAA.

关键词： wheat high temperature heat stability yield quality prevention

Evaluation of a new method for quantification of heat tolerance in different wheat cultivars

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Journal of Integrative Agriculture 2018年第4期17卷 786-795页

作者： li Qiang WANG Zheng-rui li Ding WEI Jian-wei QIAO Wen-chen MENG Xiang-hai sun Shu-luan li hui-min ZHAO ming-hui chen Xiu-min ZHAO Feng-wu Dryland Farming Institute Hebei Academy of Agricultural and Forestry Sciences/Key Laboratory of Crop Drought Tolerance Research of Hebei Province

Heat stress seriously affects wheat production in many regions of the world. At present, heat tolerance research remains one of the least understood fields in wheat genetics and breeding and there is a lack of effective methods to quantify heat stress and heat tolerance in different wheat cultivars. The objective of this study was to use various wheat cultivars to evaluate stress intensity(δ) and a new method for quantification of heat tolerance and compare this technique with three other currently utilized methods. This new parameter for heat tolerance quantification is referred to as the heat tolerance index(HTI) and is an indicator of both yield potential and yield stability. Heat treatments were applied in a controlled setting when anthesis had been reached for 80% of the wheat. The stress intensity evaluation indicated heat shock was the main factor associated with kernel weight reduction while grain yield reduction was mainly associated with chronic high temperature. The methods evaluation showed that a temperature difference of 5°C from natural temperatures was a suitable heat treatment to compare to the untreated controls. HTI was positively correlated with yield under heat stress(r=0.8657, δ=0.15, in 2009–2010; r=0.8418, δ=0.20, in 2010–2011; Plidated the use of HTI and temperature difference control for quantifying wheat heat tolerance that included the yield potential and the stability of different wheat cultivars under heat stress. Additionally, 10 wheat cultivars showed high HTI and should be further tested for their heat confirming characteristics for use in wheat heat tolerance breeding.

关键词： wheat breeding heat tolerance quantification HTI temperature difference controlling stress intensity

Real-time frequency transfer system over ground-to-satellite link based on carrier-phase compensation at 10-16 level

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Chinese Physics B 2021年第8期30卷 260-268页

作者： hui-Jian liang Shi-Guang Wang Yu Bai si-chen sun li-Jun Wang Department of Electronic Engineering Tsinghua UniversityBeijing 100084China State Key Laboratory of Precision Measurement Technology and Instruments Tsinghua UniversityBeijing 100084China Department of Precision Instruments Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China

We demonstrate a novel and stable frequency transfer scheme over ground-to-satellite link based on real-time carrier-phase detection and *** performed a zero-baseline measurement with the designed system,an uninterrupted frequency standard signal is recovered in the reception station without additional post-correction of delay error caused in the route,which is because the phase error of the entire route is tracked and compensated continuously in *** achieve this goal,we employed two carriers in the system and the differential signal is transferred in order to eliminate the instability results from the local oscillator at the satellite transponder as well as the common-mode noise induced in the transfer route and microwave *** stability of 3×10^(-16) with an integration time of 1 day was achieved and the time fluctuation during one day was measured to be about±20 *** sources and possible solutions are *** zero-baseline method shows a promising result for real-time satellite-based time and frequency transfer and deserves further research to find whether it works between long-baseline stations.

关键词： frequency transfer ground-to-satellite link carrier-phase compensation

QTL Mapping for Quality Traits of Chinese Dry Noodle

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Agricultural Sciences in China 2009年第4期8卷 394-400页

作者： ZHAO Jing-lan chen min-sheng MA Yan-ming li Rui-jun REN Yong-pan sun Qing-quan li si-shen National Key Laboratory of Crop Biology/College of Agronomy Shandong Agricultural University Tai＇an 271018 P.R.China Taishan Vocational and Technical College Tai＇an 271000 P.R.China

The QTLs for quality traits of Chinese dry noodle （CDN） were mapped based on a population of recombinant inbred lines （RILs） derived from the cross between two Chinese winter wheat varieties, Chuan 35050 and Shannong 483. Sensory quality traits of CDN were tested according to the standard of ministry of Commerce of *** （SB/T 10137-93）, and the textural property traits were detected using a texture analyser （***）. We have obtained 8 putative QTLs for 6 sensory quality traits and 2 QTLs for textural property of CDN with a single QTL explainning 4.07-75.67% of phenotypic variations on chromosomes 1A, 1 D, 3D, 4A, and 6D. A cluster of 3 QTLs for palate, elasticity and smoothness of CDN was found near the Glu-D I locus on chromosome 1D with high contributions, The increasing effect come from Chuan 35050, and the relationship between the QTLs were positive. On chromosome 4A, co-location QTLs for stickiness and total score were detected in the region of Xwmc420-Xswes620-Xswes615. Their contributions were high and the increasing effects come from Shannong 483. A taste QTL ***-4A.1 was obtained in Xsrap18-Xswes624c-Xissr25b-Xissr23b on chromosome 4A with the highest contribution of 75.67%. This QTL was a major gene and the increasing effects come from Shannong 483.

关键词： wheat noodle quality trait textural property QTL RIL

The impact of space environment on gene expression in Arabidopsis thaliana seedlings

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Science China(Technological Sciences) 2017年第6期60卷 902-910页

作者： li HuaSheng LU JinYing ZHAO hui sun Qiao YU FuTong PAN Yi chen Yu SU liang liU min Space Molecular Biological Laboratory China Academy of Space Technology Department of Plant Nutrition China Agricultural University Institute of Genetics and Developmental Biology Chinese Academy of Sciences

One of the important questions in space biology is the mechanisms underlying plant responses to an outer space environment,i.e.,how gene expression is altered in *** this study,the transcriptome of Arabidopsis thaliana seedlings was analyzed as a part of Germany siMBOX(science in microgravity box)spaceflight experiment on Shenzhou 8 *** experiment involved the following treatments:spaceflight with microgravity(Fμg),spaceflight with 1g centrifugal force(F 1g),and ground 1g control(G 1g).Gene chips were used to screen gene expression differences in Arabidopsis thaliana seedlings among these *** analysis revealed that 621 genes were differentially expressed in samples Fμg vs.G 1g,249 genes in samples F 1g vs.G 1g,and 368 genes in samples Fμg vs.F *** ontology analysis indicated that the genes were involved in metabolism of stress response,gravitropic response,and DNA damage and repair,suggesting that plants adjust these metabolic pathways to space environmental stress,microgravity,and radiation.

关键词： Arabidopsis thaliana space flight microgravity microarray gene expression profile