检索结果-南通市图书馆

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

Two schemes of multiparty quantum direct secret sharing via a six-particle GHZ state

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2020年第2期72卷 38-45页

作者： Xin-Wei zha.Ruo-Xu Jiang min-Rui Wang School of Science Xi’an University of Posts and TelecommunicationsXi’an710121China

In this paper,two new efficient multiparty quantum direct secret sharing schemes are proposed via a six-particle GHZ state and Bell *** the first scheme,based on the theory of security cryptanalysis,the secret message of the sender is directly encoded into the transmitted particles,and all the agents can obtain their information by performing bell measurement on the received particles,and then cooperate to recover the information of the *** the second scheme,we define a new secret shared coding method by performing local unitary operations on the transmitted particles,then agents perform Bell measurements on their own particles respectively,and feedback the measurement to the *** the agent’s results are matched with the previous coding method,the protocol will work *** addition,the proposed two schemes have the following common advantages:the sender can send all prepared particles to the receiver,and can send an arbitrary key to the receiver,rather than a random secret key;the proposed schemes do not need to insert any detection sets to detect eavesdropping and can resist both existing attacks and spoofing attacks by dishonest *** sender need not to retain any photons,so the sender’s quantum memory could be omitted here.

关键词： quantum direct secret sharing Bell measurement security cryptanalysis local unitary operation

Surfactant-enhanced electrochemical detection of bisphenol A based on Au on ZnO/reduced graphene oxide sensor

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2023年第4期42卷 1274-1282页

作者： Ai-Yun zha.Qing-Bing zha.Zhi Li Hong-min zha.g Xue-Feng Ma Wen Xie ming-Shan Zhu Department of Nephrology The First Affiliated Hospital of Jinan UniversityGuangzhou510630China Department of Clinical Laboratory The Fifth Affiliated Hospital of Jinan University(Heyuan Shenhe People’s Hospital)Heyuan517000China Department of Obstetrics and Gynecology The First Affiliated Hospital of Jinan UniversityGuangzhou510630China Guangdong Key Laboratory of Environmental Pollution and Health School of EnvironmentJinan UniversityGuangzhou511443China

Bisphenol A(BPA),one of the most commonly used plastic organic monomers,is widely used in manufacturing food packaging and ***,the gradual emissions of BPA from manufacturing plastic products bring great potential in human health threats,which urgently need to develop a simple and rapid method for detecting *** bromide(CTAB),a typical surfactant,is used to enhance the electrochemical detection of trace endocrine disruptors due to the fact that it can effectively enrich and absorb hydrophobic phenolic compounds through the hydrophobicity of its long-chain *** on these,the present study reports a ternary composite of Au on zinc oxide/reduced graphene oxide nanosheets(Au/ZnO/rGO)as electrochemical sensor for detecting BP *** the addition of CTAB,the analytic performances toward BP A detection are significantly improved 3.8 times compared with those without *** pH,accumulation potential and time are ***,the electrochemical activity of CTAB/Au/ZnO/rGO sensor is also evaluated by cyclic voltammetry(CV),electrochemical impedance spectroscopy(EIS),differential pulse voltammetry(DPV)and scan *** sensor displays two linear range from 10to 1340 nmol·L^(-1)and 1340 to 10,000 nmol·L^(-1),and a low detection limit of 4.95 nmol·L^(-1).Lastly,the sensor also exhibits good reproducibility,selectivity and potential practical application for BPA detection in real samples.

关键词： Bisphenol A(BPA) Cetyltrimethylammonium bromide(TAB) Electrochemical detection(ED) Electron transmission

Microstructure evolution and stress rupture properties of K4750 alloys with various B contents during long-term aging

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2021年第14期73卷 108-115页

作者： Xiaoxiao Li Meiqiong Ou min Wang Xiang dong zha.Yingche Ma Kui Liu Institute of Metal Research Chinese Academy of SciencesShenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei230026China

The relationship among B content,microstructure evolution and stress rupture properties of K4750 alloy during long-term aging were *** aging at 800℃for 1000 h,the decomposition degree of MC carbides of K4750 alloys with 0 B,0.007 wt.%B and 0.010 wt.%B were basically identical,which indicated that B has no inhibition on MC carbide decomposition during long-term *** MC carbide decomposition was accompanied by the formation of M_(23)C_(6) carbides and a small number ofηphases,which was controlled by the outward diffusion of C and Ti combined with the inward diffusion of Ni and Cr from theγ*** addition,M_(23)C_(6) carbides in boron-free alloy were in continuous chain and needle-likeηphases were precipitated near them,while M_(23)C_(6) carbides in boron-containing alloys remained in granular distribution and noηphases precipitation around *** B could delay the agglomeration and coarsening of M_(23)C_(6) carbides during long-term aging,which was because the segregation of B at grain boundary retarded the diffusion of alloy elements,thus weakened the local fluctuation of chemical composition near grain *** stress rupture samples of K4750 alloys with various B contents after aging at 800℃for 1000 h were tested at 750℃/380 *** results indicated that the stress rupture properties of bo ron-containing alloys were significantly better than that of boron-free alloy,which could be attributed to the increase of grain boundary cohesion strength and the optimization of M_(23)C_(6) carbide distribution due to the addition of B.

关键词： Nickel-based superalloy Boron additions Long-term aging Grain boundary segregation Stress rupture properties

晋西黄土区不同植被恢复阶段土壤生态化学计量特征

在线全文

学校读者我要写书评

暂无评论

水土保持研究 2025年第1期32卷 30-38+47页

作者：高连炜张红丽查同刚北京林业大学水土保持学院水利部水土保持监测中心

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究，探究植被恢复引起土壤养分变化规律及其作用机制，对认识植被恢复与土壤养分的关系，指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌... 详细信息

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究，探究植被恢复引起土壤养分变化规律及其作用机制，对认识植被恢复与土壤养分的关系，指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌木林、先锋阔叶林、针叶林)的5种林(草)地为研究对象，通过调查采样和室内分析，探究土壤生态化学计量特征随植被恢复的进程变化及其影响因素。[结果](1)随着植被的恢复，先锋阔叶林和针叶林阶段的SOC含量较上一阶段增加19.8%,土壤TN含量较上一阶段增加17.6%,而土壤TP含量较上一阶段减少12.4%;(2)随着植被恢复的发展，土壤C∶P和N∶P显著增加，C∶N的变化无明显规律，在先锋阔叶林和针叶林阶段的土壤C∶P较上一阶段增加26.6%;先锋阔叶林和针叶林阶段在0—40 cm土层的土壤N∶P较上一阶段增加40.2%,40—100 cm土层的土壤N∶P较上一阶段增加35.7%;土壤C∶N在不同植被恢复阶段间的变化未见明显规律，研究区土壤逐渐由C,N的限制转变为P的限制；(3)各植被恢复阶段土壤C∶P和N∶P主要与砂粒含量呈显著负相关，与孔隙度呈显著正相关，土壤C∶N与其他因子的相关性不明显。[结论]植被恢复有利于土壤C,N含量增加，改善土壤理化性质，在植被恢复过程应同时注重P元素的调控，以提高晋西黄土区植被生态恢复水平。

关键词：植被恢复土壤养分生态化学计量特征

Selective laser melted AZ91D magnesium alloy with superior balance of strength and ductility

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2023年第12期11卷 4644-4658页

作者： Xinzhi Li Xuewei Fang Shuaipeng Wang Siqing Wang min zha.Ke Huang State Key Laboratory for Manufacturing Systems Engineering School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049ShaanxiPR China School of Materials Science and Engineering Jilin UniversityChangchunPR China

In the context of global carbon neutrality, the application of lightweight magnesium alloys is becoming increasingly attractive. In this study, selective laser melting(SLM) was employed to achieve nearly full dense and crack-free AZ91D components with fine equiaxed grain structure. The formation mechanism of typical pore defects(gas pore, lack-of-fusion pore and keyhole pore) and melting modes(keyhole mode and conduction mode) were systematically studied by varying the laser power and scanning speed. The morphology and volume fraction of the pores under different processing conditions were characterized. A criterion based on the depth-to-width ratio of the melt pool was established to identify different melting modes. The strength and ductility(tensile strength up to 340 MPa and uniform elongation of 8.9%)of the as deposited AZ91D are far superior to those of the casting components and are comparable to those of its wrought *** superior balance of strength and ductility of SLMed AZ91D, as well as the negligible anisotropic properties are mainly ascribed to the extremely fine equiaxed grain structure(with average grain size of ~1.2 μm), as well as the discontinuous distribution of β-Al_(12)Mg_(17) phases. It thus provides an alternative way to fabricate high-strength magnesium alloys with complex geometry.

关键词： Magnesium alloy Selective laser melting Melting mode Defects Equiaxed grain structure Mechanical properties

Synthesis of a kind of geminal imidazolium ionic liquid with long aliphatic chains

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2007年第1期18卷 48-50页

作者： Yun Sheng Ding min zha.Jun zha.g Seng Shan Wang Department of Polymer Materials and Engineering School of Chemical Engineering Hefei University of Technology Hefei 230009 China CAS Key Laboratory of Engineering Plastics Joint Laboratory of Polymer Science and Materials Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

A novel geminal imidazolium ionic liquid with long hydrocarbon group, 1,4-bis （3-tetradecylimidazolium- 1-yl） butane bromide was synthesized and an efficient synthesized method was introduced detailedly. Its structu... 详细信息

关键词： Geminai imidazolium ionic liquid Long aliphatic chain Physicochemicai properties

Theoretical analysis and application of polymer-matrix field grading materials in HVDC cable terminals

在线全文

学校读者我要写书评

暂无评论

High Voltage 2017年第1期2卷 39-46页

作者： Peng Han Jun-Wei zha.Si-Jiao Wang Zhi-min Dang Department of Polymer Science and Engineering University of Science and Technology BeijingBeijing 100083People’s Republic of China State Key Laboratory of Power System and Department of Electrical Engineering Tsinghua UniversityBeijing 100084People’s Republic of China

The distortion and uneven distribution of electric field in high-voltage direct current(HVDC)terminal insulator is the key problem for stable running of the power transmission *** flexible materials filled polymer-matrix composites with non-linear conductivity have also been considered to modify the distribution of electric field in cable *** factors having influence on the non-linear conductivity will be analysed in this review.

关键词： field conductivity matrix

Effects of Silicon on the Microstructure and Mechanical Properties of 15–15Ti Stainless Steel

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2020年第11期33卷 1583-1590页

作者： Hao-Yu Yi Tian Liang min Wang Xiang-Dong zha.Ying-Che Ma Kui Liu China Nuclear Power Technology Research Institute Shenzhen 518000China Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

Effects of silicon on the microstructure and mechanical properties of 20% cold-worked 15-15 Ti austenitic stainless steels are systemically investigated by uniaxial tensile tests,scanning and transmission electron microscope observations,and strength *** results reveal that a large number of deformation twins are formed in the 20% cold-worked steels with various silicon *** volume fraction of deformation twins and the density of dislocations increase with silicon content,while the twin thickness slightly decreases.A better strength-ductility combination is achieved by silicon addition,since the yield strength of the steel with 2% silicon is 61 MPa higher than that of the steel with 1% silicon,while their uniform elongations are almost both equal to 16%.The yield strength of the 15-15 Ti stainless steels is predominantly contributed by the solid solution,dislocation and deformation twin strengthening effects,which can be enhanced by silicon addition.

关键词： Austenitic stainless steel Silicon Microstructure Mechanical property