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Nelumbo Nucifera leaf extract attenuated pancreatic β-cells toxicity induced by interleukin-1β and interferon-γ, and increased insulin secrection of pancreatic β-cells in streptozotocin-induced diabetic rats

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Journal of Traditional Chinese Medicine 2016年第1期36卷 71-77页

作者： Bhesh Raj Sharma min suk kim Dong Young Rhyu Department of Oriental Medicine Resources and Institute of Korean Medicine Industry Mokpo National UniversityJeonnam 534-729Republic of Korea Department of Environmental and Molecular Toxicology Oregon State UniversityCorvallisOR 97331The United States of America

OBJECTIVE： To evaluate the effect of Nelumbo Nucifera leaf water extract （NNLE） on insulinoma （RIN） cells induced by interleukin-1β （1L-1β） and interferon-g （IFN-γ）, and injured pancreatic β-cells induced by Streptozotocin （STZ） in rats. METHODS： The anti-oxidative effects of NNLE were assessed using 1,1 -diphenyl-2-picryl hydrazyl （DPPH） and nitric oxide （NO） scavenging assays. The inhibitory effect of NNLE on a-glucosidase and DPP （dipeptidyl peptidase）-IV was measured in vitro. Pancreatic 1β-cell protective and insulin secretory effects were assessed, using 1L-1β and IFN-γ-inducedrat RIN cells. STZ-induced diabetic rats were treated with 50, 100, and 400 mg/kg NNLE for 4 weeks. The effects of NNLE on blood glucose （BG）, body weight （BW）, and lipid profiles were measured. RESULTS： NNLE inhibited DPPH, NO, aglucosidase, and DPP-Ⅳ which were directly linked to the function of β-cells. Furthermore, NNLE protected RIN cells from toxicity induced by 11-11β and IFN-γ, decreased NO production, and increased insulin secretion. NNLE caused a significant reduction in blood glucose, triglyceride （TG）, total cholesterol （TC）, blood urea nitrogen （BUN）, and creatinine in STZ-induced diabetic rats. Furthermore, it significantly decreased BW loss in STZ-induced diabetic rats. CONCLUSION： Our results suggest that NNLE reduced the toxicity in insulinoma cells and increased insulin secretion in pancreatic β-cells in STZ-induced diabetic rats.

关键词： Nelumbo Nucifera Diabetes mellitus Insulin Interleukin-lbeta Interferon-gamma Insulin-secreting cells Streptozotocin Glucose

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Flexible thermocouple using a thermoelectric graphene fiber with a seamless junction

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Journal of Materials Science & Technology 2024年第5期172卷 15-22页

作者： Seungwon kim Soomook Lim Myeong Hee Jeong Wonjoon kim Seunghyun Baik Ji Won suk School of Mechanical Engineering Sungkyunkwan UniversitySuwonGyeonggi-do 16419Republic of Korea Department of Smart Fab.Technology Sungkyunkwan UniversitySuwonGyeonggi-do 16419Republic of Korea SKKU Advanced Institute of Nanotechnology(SAINT) Sungkyunkwan UniversitySuwonGyeonggi-do 16419Republic of Korea

Temperature is an important physical variable that indicates the condition of the human body and artificial *** wearable applications require the development of temperature sensors with different form *** this study,a fiber-shaped thermoelectric temperature sensor is fabricated using a continuous graphene fiber whose two halves possess different reduction states.A seamless junction is formed by partially reducing a wet-spun graphene oxide fiber with hydroiodic acid(HI)solutions of different ***-half of the fiber is mildly reduced with 0.97 wt%HI,while the other half is highly reduced with 30.6 wt%*** different reduction states of the graphene composite fiber result in different Seebeck coefficients,allowing for the fabrication of a fiber-shaped graphene thermocou-ple without any laborious *** flexible graphene thermocouple exhibits high sensitivity with a thermopower of 12.5μV K^(-1)in the temperature range of room temperature to∼70℃.Furthermore,it exhibits high linearity with a correlation coefficient exceeding 0.995 and fast response with a time constant of 0.24 *** to its mechanical robustness and flexibility,the stand-alone graphene ther-mocouple can be knitted into a cotton fabric glove,which presents a fast response to environmental changes without any external power *** work offers a unique fabrication method for producing a high-performance,flexible thermocouple that features a seamless and clear junction without the use of additional *** alternative method eliminates the complicated assembly processes typically required for conventional thermocouples.

关键词： Graphene fiber Thermocouple Reduced graphene oxide Flexible temperature sensor Seebeck coefficient

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Retinal artery/arteriole occlusion risks after endovascular treatment for unruptured intracranial aneurysm

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Stroke & Vascular Neurology 2024年第3期9卷 295-305,I0251-I0263页

作者： Hae Rang kim min Jeoung kim Sunyeup kim Myung Soo Chang Dong Joon kim Byung Moon kim Keun Young Park Yong Bae kim Christopher Seungkyu Lee suk Ho Byeon Sung Soo kim Seung Won Lee Yong Joon kim Department of Ophthalmology CHA Bundang Medical CenterCHA University College of MedicineSeongnamKorea(the Republic of) Department of Neurosurgery Severance Stroke CenterSeverance HospitalYonsei University College of MedicineSeoulKorea(the Republic of) Department of Neurosurgery Uijeongbu St.Mary’s HospitalThe Catholic University of Korea College of MedicineUijeongbuKorea(the Republic of) Department of Medical AI Sungkyunkwan University School of MedicineSuwonKorea(the Republic of) Department of Ophthalmology Institute of Vision ResearchYonsei University College of MedicineSeoulKorea(the Republic of) Department of Radiology Severance Stroke CenterSeverance HospitalYonsei University College of MedicineSeoulKorea(the Republic of) Department of Precision Medicine Sungkyunkwan University School of MedicineSuwonKorea(the Republic of)

Background To evaluate the association between retinal artery/arteriole occlusion(RAO)and unruptured intracranial aneurysm(UIA).Methods Incident UIA patients from a nationwide cohort(n=253240)were categorised into three groups based on subsequent treatment:observation(n=208993),microsurgical clipping(n=14168)and endovascular treatment(EVT)groups(n=30079).The incidence and the incident time of RAO were *** of RAO and associated risk factors were ***,a hospital cohort comprising 2569 consecutive UIA patients treated at a tertiary hospital was analysed with detailed clinical information of *** In the nationwide cohort analysis,the incidence of RAO was significantly higher in EVT group than in observation and clipping groups,especially within 60 days(early RAO(within 60 days):HR=4.00,95%CI:2.44 to 6.56);delayed RAO(after 60 days:HR=1.74,95%CI:1.13 to 2.68).Multivariable analysis showed that the presence of chronic kidney disease(p=0.009)and use of a balloon microcatheter during the procedure(p=0.013)were associated with a higher risk of *** hospital cohort analysis,11(0.8%)cases of RAO occurred after EVT,whereas none occurred after microsurgical clipping(pming EVT for UIA may increase the risk of subsequent *** should be taken when treating paraclinoid aneurysms with balloon microcatheters.

关键词： treatment nationwide balloon

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Tracking of horizontal alignment of the long and large diameter uncharged hole in NATM tunnel

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Underground Space 2024年第3期16卷 18-28页

作者： min-Seong kim Sean Seungwon Lee Department of Energy and Resources Engineering Chonnam National UniversityGwangju 61186Republic of Korea Department of Earth Resources and Environmental Engineering Hanyang UniversitySeoul 04763Republic of Korea

The long and large diameter uncharged hole boring(LLB)method is a cut blasting method that minimizes blast-induced vibrations by creating long and large diameter uncharged holes at the excavation face of tunnels prior to tunnel *** in this method typically uses a 50 m long with a 382 mm diameter hammer bit in the horizontal direction at the tunnel ***,the significant weight and uni-directional rotation of the rod head,as well as variables such as geological characteristics,machine conditions,and inexperienced operators result in significant deviation from the target borehole alignment that hinders the vibration-dampening effect of the uncharged ***,since there is no method to verify the alignment of the boreholes until main tunnel construction,borehole misalignment is often not discovered until weeks after construction,which requires tunnel construction to cease until the equipment can be remobilized and an additional borehole be created,causing significant delays and increased costs for the entire tunnel *** this study,the borehole alignment tracking and ground exploration system(BGS)is developed to predict and monitor the quality and alignment of boreholes for cut blasting methods such as the LLB methods immediately after *** BGS was subsequently tested at a subway construction site to evaluate its performance in the *** measurements yielded by the BGS were compared with manually measured boring positions at every 5 m along the *** the BGS showed a maximum deviation of approximately 12%at a local point where the hole surface was relatively rough,the accuracy for the final boring position was approximately 97%,demonstrating excellent precision of the alignment tracking *** BGS demonstrates excellent performance in predicting ground conditions and the boring quality of a cut hole immediately after drilling,and shows promise in various other applications for monitoring borehole alignment.

关键词： Tunnel blasting LLB method Drilling deviation Vertical sagging Horizontal alignment tracking BGS

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Anomaly Detection in Imbalanced Encrypted Traffic with Few Packet Metadata-Based Feature Extraction

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 585-607页

作者： min-Gyu kim Hwankuk kim Department of Financial Information Security Kookmin UniversitySeoul02707Republic of Korea Department of Information Security Cryptography Mathematics Kookmin UniversitySeoul02707Republic of Korea

In the IoT(Internet of Things)domain,the increased use of encryption protocols such as SSL/TLS,VPN(Virtual Private Network),and Tor has led to a rise in attacks leveraging encrypted *** research on anomaly detection using AI(Artificial Intelligence)is actively progressing,the encrypted nature of the data poses challenges for labeling,resulting in data imbalance and biased feature extraction toward specific *** study proposes a reconstruction error-based anomaly detection method using an autoencoder(AE)that utilizes packet metadata excluding specific node *** proposed method omits biased packet metadata such as IP and Port and trains the detection model using only normal data,leveraging a small amount of packet *** makes it well-suited for direct application in IoT environments due to its low resource *** experiments comparing feature extraction methods for AE-based anomaly detection,we found that using flowbased features significantly improves accuracy,precision,F1 score,and AUC(Area Under the Receiver Operating Characteristic Curve)score compared to packet-based ***,for flow-based features,the proposed method showed a 30.17%increase in F1 score and improved false positive rates compared to Isolation Forest and ***,the proposedmethod demonstrated a 32.43%higherAUCwhen using packet features and a 111.39%higher AUC when using flow features,compared to previously proposed oversampling *** study highlights the impact of feature extraction methods on attack detection in imbalanced,encrypted traffic environments and emphasizes that the one-class method using AE is more effective for attack detection and reducing false positives compared to traditional oversampling methods.

关键词： One-class anomaly detection feature extraction auto-encoder encrypted traffic CICIoT2023

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Efficacy of chemotherapy containing bevacizumab in patients with metastatic colorectal cancer according to programmed cell death ligand 1

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3521-3528页

作者： Shin Woo Kang Sung Hee Lim min-Ji kim Jeeyun Lee Young suk Park Ho Yeong Lim Won Ki Kang Seung Tae kim Division of Hematology Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Samsung Biomedical Research Institute Samsung Medical CenterSeoul 06351South Korea

BACKGROUND Bevacizumab,an anti-vascular endothelial growth factor(VEGF)monoclonal antibody,inhibits angiogenesis and reduces tumor *** VEGF-C,lactate dehydrogenase,and inflammatory markers have been reported as predictive markers related to bevacizumab *** cell death ligand 1(PD-L1)could act upon VEGF receptor 2 to induce cancer cell angiogenesis and *** To investigate the efficacy of bevacizumab-containing chemotherapy in patients with metastatic colorectal cancer(CRC)according to the expression of *** This analysis included CRC patients who received bevacizumab plus FOLFOX or FOLFIRI as first-line therapy between June 24,2014 and February 28,2022,at Samsung Medical Center(Seoul,South Korea).Analysis of patient data included evaluation of PD-L1 expression by the combined positive score(CPS).We analyzed the efficacy of bevacizumab according to PD-L1 expression status in patients with *** A total of 124 patients was included in this *** all patients were treated with bevacizumab plus FOLFIRI or FOLFOX as the first-line *** 77%of patients received FOLFOX,23%received FOLFIRI as backbone first-line *** numbers of patients with a PD-L1 CPS of 1 or more,5 or more,or 10 or more were 105(85%),64(52%),and 32(26%),*** results showed no significant difference in progression-free survival(PFS)and overall survival(OS)with bevacizumab treatment between patients with PDL1 CPS less than 1 and those with PD-L1 CPS of 1 or more(PD-L1<1%vs PD-L1≥1%;PFS:P=0.93,OS:P=0.33),between patients with PD-L1 CPS less than 5 and of 5 or more(PD-L1<5%vs PD-L1≥5%;PFS:P=0.409,OS:P=0.746),and between patients with PD-L1 CPS less than 10 and of 10 or more(PD-L1<10%vs PD-L1≥10%;PFS:P=0.529,OS:P=0.568).CONCLUSION Chemotherapy containing bevacizumab can be considered as first-line therapy in metastatic CRC irrespective of PD-L1 expression.

关键词： Bevacizumab Colorectal cancer Programmed cell death ligand 1 expression First-line chemotherapy Metastatic colorectal cancer

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Weighted Forwarding in Graph Convolution Networks for Recommendation Information Systems

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Computers, Materials & Continua 2024年第2期78卷 1897-1914页

作者： Sang-min Lee Namgi kim Department of Computer Science Kyonggi UniversitySuwonKorea

Recommendation Information Systems(RIS)are pivotal in helping users in swiftly locating desired content from the vast amount of information available on the *** Convolution Network(GCN)algorithms have been employed to implement the RIS ***,the GCN algorithm faces limitations in terms of performance enhancement owing to the due to the embedding value-vanishing problem that occurs during the learning *** address this issue,we propose a Weighted Forwarding method using the GCN(WF-GCN)*** proposed method involves multiplying the embedding results with different weights for each hop layer during graph *** applying the WF-GCN algorithm,which adjusts weights for each hop layer before forwarding to the next,nodes with many neighbors achieve higher embedding *** approach facilitates the learning of more hop layers within the GCN *** efficacy of the WF-GCN was demonstrated through its application to various *** the MovieLens dataset,the implementation of WF-GCN in LightGCN resulted in significant performance improvements,with recall and NDCG increasing by up to+163.64%and+132.04%,***,in the *** dataset,LightGCN using WF-GCN enhanced with WF-GCN showed substantial improvements,with the recall and NDCG metrics rising by up to+174.40%and+169.95%,***,the application of WF-GCN to Self-supervised Graph Learning(SGL)and Simple Graph Contrastive Learning(SimGCL)also demonstrated notable enhancements in both recall and NDCG across these datasets.

关键词： Deep learning graph neural network graph convolution network graph convolution network model learning method recommender information systems

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Intelligent structured nanocomposite adhesive for bioelectronics and soft robots

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Nano Research 2024年第2期17卷 534-549页

作者： Yeon Soo Lee min-Seok kim Da Wan kim Changhyun Pang School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Mechanical Metrology Group Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Department of Electronic Engineering Korea National University of TransportationChungbuk 27469Republic of Korea Samsung Advanced Institute for Health Sciences and Technology Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea

The remarkable functionality of biological systems in detecting and adapting to various environmental conditions has inspired the design of the latest electronics and robots with advanced *** review focuses on intelligent bio-inspired strategies for developing soft bioelectronics and robotics that can accommodate nanocomposite adhesives and integrate them into biological *** underlying principles of the material and structural design of nanocomposite adhesives were investigated for practical applications with excellent functionalities,such as soft skin-attachable health care sensors,highly stretchable adhesive electrodes,switchable adhesion,and untethered soft *** addition,we have discussed recent progress in the development of effective fabrication methods for micro/nanostructures for integration into devices,presenting the current challenges and prospects.

关键词： biomimetics bio-adhesive switchable adhesion bioelectronics nanocomposite soft robotics

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Highly Elastic,Bioresorbable Polymeric Materials for Stretchable,Transient Electronic Systems

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Nano-Micro Letters 2024年第6期16卷 1-13页

作者： Jeong‑Woong Shin Dong‑Je kim Tae‑min Jang Won Bae Han Joong Hoon Lee Gwan‑Jin Ko Seung min Yang Kaveti Rajaram Sungkeun Han Heeseok Kang Jun Hyeon Lim Chan‑Hwi Eom Amay J.Bandodkar Hanul min suk‑Won Hwang KU‑KIST Graduate School of Converging Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea SK Hynix 2091Gyeongchung‑daeroBubal‑eupIcheon‑siGyeonggi‑do 17336Republic of Korea Hanwha Systems Co. Ltd.188Pangyoyeok‑roBundang‑guSeongnam‑siGyeonggi‑do 13524Republic of Korea Department of Electrical and Computer Engineering North Carolina State UniversityRaleighNC 27606USA Center for Advanced Self‑Powered Systems of Integrated Sensors and Technologies(ASSIST) North Carolina State UniversityRaleighNC 27606USA Department of Integrative Energy Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea Biomaterials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang‑ro 14‑gilSeongbuk‑guSeoul 02792Republic of Korea Semiconductor R&D Center Samsung Electronics Co.Ltd.Hwaseong‑siGyeonggi‑do 18448Republic of Korea Center for Advanced Biomolecular Recognition Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Substrates or encapsulants in soft and stretchable formats are key components for transient,bioresorbable electronic systems;however,elastomeric polymers with desired mechanical and biochemical properties are very limited compared to nontransient ***,we introduce a bioresorbable elastomer,poly(glycolide-co-ε-caprolactone)(PGCL),that contains excellent material properties including high elongation-at-break(<1300%),resilience and toughness,and tunable dissolution *** of PGCLs as polymer matrices,in combination with conducing polymers,yields stretchable,conductive composites for degradable interconnects,sensors,and actuators,which can reliably function under external *** of device components with wireless modules demonstrates elastic,transient electronic suture system with on-demand drug delivery for rapid recovery of postsurgical wounds in soft,time-dynamic tissues.

关键词： Biodegradable elastomer Conductive polymer composites Biomedical device Transient electronics

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Soleus arthrogenic muscle inhibition following acute lateral ankle sprain correlates with symptoms and ankle disability but not with postural control

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Journal of Sport and Health Science 2024年第4期13卷 559-568,F0003页

作者： Kyung-min kim Joo-Sung kim Alan R.Needle Department of Sport Science Sungkyunkwan UniversitySuwon-si 16419Republic of Korea Department of Health and Human Performance Texas State UniversitySan MarcosTX 78666USA Department of Public Health&Exercise Science Appalachian State UniversityBooneNC 28608USA Department of Rehabilitation Science Appalachian State UniversityBooneNC 28608USA

Background:Acute lateral ankle sprains(ALAS)are associated with long-term impairments and instability tied to altered neural *** muscle inhibition(AMI)has been observed in this population;however,relationships with injury-related impairments are unclear,potentially due to the resting,prone position in which AMI is typically *** AMI during bipedal stance may provide a better understanding of this ***:AMI was assessed in 38 young adults(19 ALAS within 72 h of injury:10 males,21.4±2.7 years;19 healthy controls:10 males,21.9±2.2 years;mean±SD)using the Hoffmann reflex(H-reflex)during bipedal *** stimulation was administered to identify the _(max)imal H-reflex(H_(max))and _(max)imal motor response(M_(max))from the soleus,fibularis longus,and tibialis anterior *** primary outcome measure was the H_(max)/M_(max) *** outcomes included acute symptoms(pain and swelling),postural control during bipedal stance,and self-reported ***:No significant group-by-limb interactions were observed for any ***,a significant group main effect was observed in the soleus muscle(F(1,35)=6.82,p=0.013),indicating significantly lower H_(max)/M_(max) ratios following ALAS(0.38±0.20)compared to healthy controls(0.53±0.16).Furthermore,lower H_(max)/M_(max) ratios in the soleus significantly correlated with acute symptoms and self-reported function but not with postural ***:This study supports previous evidence of AMI in patients with ALAS,providing insight into neurophysiologic impacts of musculoskeletal *** results suggest that assessing AMI in a standing position following acute injury may provide valuable insight into how AMI develops and guide potential therapeutic options to curb and offset the formation of joint instability.

关键词： Acute injuries Balance Hoffmann reflex Neural excitability Patient-reported outcomes

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