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The Melastoma dodecandrum genome and the evolution of Myrtales

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Journal of Genetics and Genomics 2022年第2期49卷 120-131页

作者： yang Hao Yu-zhen Zhou Bin Chen Gui-zhen Chen zhen-Ying wen Diyang Zhang Wei-Hong Sun Ding-Kun liu Jie Huang Jin-liao Chen xiao-Qin Zhou Wan-lin Fan wen-Chun Zhang lin Luo wen-Chao Han yan zheng Long li peng-Cheng Lu Yue Xing Shu-Ya liu Jia-Ting Sun Ying-hui Cao yan-Ping Zhang xiao-ling Shi Sha-Sha Wu Ye Ai Jun-wen Zhai Si-ren Lan Zhong-jian liu Dong-hui peng Key Laboratory of National Forestry and Grassland Administration for Orchid Conservation and Utilization at College of Landscape Architecture Fujian Agriculture and Forestry UniversityFuzhou 350002China Innovation and Application Engineering Technology Research Center of Ornamental Plant Germplasm Resources in Fujian Province Fuzhou 350002China

Melastomataceae has abundant morphological diversity with high economic and ornamental merit in Myrtales. The phylogenetic position of Myrtales is still contested. Here, we report the chromosome-level genome assembly of Melastoma dodecandrum in Melastomataceae. The assembled genome size is299.81 Mb with a contig N50 value of 3.00 Mb. Genome evolution analysis indicated that M. dodecandrum,Eucalyptus grandis, and Punica granatum were clustered into a clade of Myrtales and formed a sister group with the ancestor of fabids and malvids. We found that M. dodecandrum experienced four whole-genome polyploidization events: the ancient event was shared with most eudicots, one event was shared with Myrtales, and the other two events were unique to M. dodecandrum. Moreover, we identified MADS-box genes and found that the AP1-like genes expanded, and AP3-like genes might have undergone subfunctionalization. The SUAR63-like genes and AG-like genes showed different expression patterns in stamens, which may be associated with heteranthery. In addition, we found that LAZY1-like genes were involved in the negative regulation of stem branching development, which may be related to its creeping features. Our study sheds new light on the evolution of Melastomataceae and Myrtales, which provides a comprehensive genetic resource for future research.

关键词： Melastoma Genome evolution Flower development Heteranthery Flower color Creeping stem

新型维A酸CD437对表皮样癌A431细胞的致凋亡作用

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南方医科大学学报 2008年第3期28卷 305-308页

作者：潘敏彭振辉肖生祥李晓莉刘艳李政霄任建文西安交通大学医学院第二附属医院皮肤科陕西西安710004

目的研究一种新合成的维A酸CD437及全反式维A酸(ATRA)对体外培养的人表皮样癌细胞系(A431)及正常人类表皮角质形成细胞的增殖抑制及诱导凋亡作用。方法MTT法测定CD437及ATRA对A431细胞系及正常人类表皮角质形成细胞的增殖抑制作用,光镜... 详细信息

目的研究一种新合成的维A酸CD437及全反式维A酸(ATRA)对体外培养的人表皮样癌细胞系(A431)及正常人类表皮角质形成细胞的增殖抑制及诱导凋亡作用。方法MTT法测定CD437及ATRA对A431细胞系及正常人类表皮角质形成细胞的增殖抑制作用,光镜观察两种药物对细胞形态的影响,用流式细胞术研究两种药物对细胞凋亡及细胞周期的影响。结果维A酸CD437较传统ATRA更显著抑制A431细胞系的生长,并具有时间、浓度依赖性;显微镜观察可见细胞有细胞毒性、凋亡特征性改变;CD437可促进A431细胞的快速凋亡及正常人类表皮角质形成细胞G1期抑制;与CD437相比,ATRA对A431细胞的促凋亡作用相对无效;CD437不能诱导正常人类表皮角质形成细胞发生显著凋亡。结论与传统维A酸ATRA相比较,CD437更有效抑制表皮样癌细胞的增殖并显著诱导其凋亡;相对于正常表皮角质形成细胞,CD437对A431细胞具有选择性诱导凋亡作用,从而为临床治疗或预防皮肤癌提供实验依据。

关键词： CD437 全反式维A酸 A431细胞系增殖抑制细胞凋亡

A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)

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Military Medical Research 2020年第1期7卷 1-22页

作者： Ying-hui Jin lin Cai zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-hui li Yi-Rong li Ke liang li-Kai lin li-Sha Luo Jing Ma lin-Lu Ma Zhi-Yong peng Yun-Bao pan zhen-Yu pan Xue-Qun ren hui-min Sun Ying Wang Yun-Yun Wang Hong weng Chao-Jie Wei Dong-Fang Wu jian Xia Yong Xiong Hai-Bo Xu xiao-Mei Yao Yu-Feng Yuan Tai-sheng Ye xiao-Chun Zhang Ying-wen Zhang Yin-Gao Zhang Hua-min Zhang yan Zhao ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-yan Wang Xing-Huan Wang 无 Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Hospital Management Wuhan UniversityWuhan 430071China Department of Respiratory Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Pharmacy Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Evidence-Based Medicine and Knowledge Translation Henan UniversityKaifeng 475000China China Academy of Chinese Medical Sciences Beijing 100700China China Center for Evidence Based Traditional Chinese Medicine(CCEBTCM) Beijing 100700China Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Clinical Laboratory Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Infectious Diseases Zhongnan Hospital of Wuhan UniversityWuhan 430071China Division of Medical Affairs Zhongnan Hospital of Wuhan UniversityWuhan 430071China Division of Nursing Affairs Zhongnan Hospital of Wuhan UniversityWuhan 430071China Office of Nosocomial Infection Control Zhongnan Hospital of Wuhan UniversityWuhan 430071China Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Health Research Methods Evidenceand ImpactMcMaster UniversityHamiltonON L8S 4L8Canada Department of Traditional Chinese Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Global Health Institute Wuhan UniversityWuhan 430072China the Zhongnan Hospital of Wuhan University Novel Coronavirus Management and Research Team Evidence-Based Medicine Chapter of China International Exchange and Promotive Association for Medical and Health Care(CPAM)

In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named "2019 novel coronavirus(2019-nCoV)" by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV.

关键词： 2019 novel coronavirus 2019-nCoV Respiratory disease Pneumonia Infectious diseases Rapid advice guideline Clinical practice guideline Evidence-based medicine

Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： wen-Tao Zhang Xue-Qian Wang Feng-Qi Zhang xiao-Ya Cui Bing-Bing Fan Jia-ming Guo Zhi-min Guo Rui Huang wen Huang Xu-Bo li Meng-Ru li yan Ma Zhi-Hua Shen Yong-Gang Sun De-Zhuang Wang Fei-yang Wang li-Qiang Wang Nan Wang Tian-li Wang Wei Wang xiao-yang Wang Yi-Han Wang Fu-Jie Yu Yu-zhen Yin ling-Kun Zhang Yi Zhang jian-yang Zhang Qi Zhao Yu-Ping Zhao Xin-Dong Zhu Yasir Sohail Ya-Nan Chen Tao Feng Qi-Long Gao Hai-yan He Yong-jiang Huang Zeng-Bao Jiao Hua Ji Yao jiang Qiang li xiao-ming li Wei-Bing liao Huai-Jun lin hui liu Qi liu Qing-Feng liu Wei-Di liu Xiong-Jun liu yang Lu Yi-Ping Lu wen Ma Xue-Fei Miao Jie pan Qing Wang Hong-hui Wu Yuan Wu Tao yang Wei-ming yang Qian Yu Jin-Yu Zhang Zhi-Gang Chen liang Mao yang ren Bao-Long Shen Xun-li Wang Zhe Jia He Zhu zhen-Duo Wu Si Lan School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189China Department of Physics City University of Hong KongHongKong 999077China School of Materials Science and Engineering Tianjin UniversityTianjin 300072China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Department of Mechanical Engineering Research Institute for Advanced ManufacturingThe Hong Kong Polytechnic UniversityHong Kong 100872China Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Solidification Control and Digital Preparation Technology(liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China Institute of Advanced Wear&Corrosion Resistance and Functional Materials Jinan UniversityGuangzhou 510632China School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 221116China School of Physical Sciences Great Bay UniversityDongguan 523000China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon NeutralityUniversity of Science and Technology BeijingBeijing 100083China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China School of Computing Macquarie UniversitySydney 2113Australia Key Laboratory of Optoelectronic Devices and Systems of ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China State Key Laborato

Owing to their exceptional properties,high-entropy alloys(HEAs)and high-entropy materials have emerged as promising research areas and shown diverse ***,the recent advances in the field are comprehensively reviewed,organized into five *** first section introduces the background of HEAs,covering their definition,significance,application prospects,basic properties,design principles,and *** subsequent section focuses on cutting-edge high-entropy structural materials,highlighting developments such as nanostructured alloys,grain boundary engineering,eutectic systems,cryogenic alloys,thin films,micro-nano-lattice structures,additive manufacturing,high entropy metallic glasses,nano-precipitate strengthened alloys,composition modulation,alloy fibers,and refractory *** the following section,the emphasis shifts to functional materials,exploring HEAs as catalysts,magneto-caloric materials,corrosion-resistant alloys,radiation-resistant alloys,hydrogen storage systems,and materials for ***,the review encompasses functional high-entropy materials outside the realm of alloys,including thermoelectric,quantum dots,nanooxide catalysts,energy storage materials,negative thermal expansion ceramics,and high-entropy wave absorption *** paper concludes with an outlook,discussing future directions and potential growth areas in the *** this comprehensive review,researchers,engineers,and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： High entropy alloys Cutting-edge structural materials Cutting-edgefunctional materials

Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)

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Military Medical Research 2020年第3期7卷 249-282页

作者： Ying-hui Jin Qing-Yuan Zhan Zhi-Yong peng Xue-Qun ren Xun-Tao Yin lin Cai Yu-Feng Yuan Ji-Rong Yue xiao-Chun Zhang Qi-wen yang jianguang Ji jian Xia Yi-Rong li Fu-xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu ming-li Tu li-ming Tan min yang Fang Chen xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can liu jian yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei li wen Chen Yue-Xian Shi Xiu-Zhi yang Xue-Jun Wang yan-Jun Zhong ming-Juan Zhao Bing-hui li lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao li Qiao Huang Hong weng xiang-Ying ren li-Sha Luo Man-Ru Fan Di Huang Hong-yang Xue lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun li zhen-Shun Cheng xiao-Mei Yao Xing-Huan Wang Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Clinical Research Center for Respiratory Diseases China-Japan Friendship HospitalBeijing 100029China Department of Pulmonary and Critical Care Medicine China-Japan Friendship HospitalBeijing 10029China Leishenshan Hospital in Wuhan Wuhan 430200China Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institutes of Evidence-based Medicine and Knowledge Translation Henan UniversityKaifeng 475000HenanChina Department of Medical Imaging Guizhou Provincial People’s HospitalGuiyang 550002China Departments of Orthopedics Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Clinical Research Center for Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China Department of Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Clinical Laboratory Peking Union Medical College Hospital(PUMCH)Peking Union Medical CollegeChinese Academy of Medical Sciences(CAMS)Beijing 100730China Center for Primary Health Care Research Lund University and Region Skåne25002 MalmöSweden Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 403371China Department of Allergology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 43071China Department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Emergency Medicine and Chest Pain Center Qilu Hospital of Shandong UniversityJinan 250002China Department of Respiratory and Critical Care Medicine Suizhou Central HospitalHubei University of MedicineSuizhou 441300HubeiChina Department of Clinic Pharmacy Second People’s Hospital of Huaihua Ci

The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the *** and treatment guidelines for clinicians caring for patients are *** the early stage,we have issued"A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)";now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based *** formed a working group of clinical experts and *** steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge *** searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)*** were either strong or weak,or in the form of ungraded consensus-based ***,we issued 34 *** them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based *** covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung

关键词： COVID-19 SARS-CoV-2 Recommendation Chemoprophylaxis Diagnosis Treatment Discharge management Traditional Chinese medicine guideline

遗传性对称性色素异常症家系的DSRAD基因突变

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中国皮肤性病学杂志 2009年第5期23卷 271-272,281页

作者：刘艳彭振辉肖生祥李晓莉任建文吴佳纹西安交通大学第二医院皮肤科陕西西安710004

目的研究遗传性对称性色素异常症(DSH)家系中的DSRAD基因突变情况。方法收集了2个遗传性对称性色素异常症家系的外周血标本,用聚合酶链反应(PCR)扩增DSRAD基因的全部外显子并测序,检测2个家系中的患者及正常人和50例无关正常人的DSRAD... 详细信息

目的研究遗传性对称性色素异常症(DSH)家系中的DSRAD基因突变情况。方法收集了2个遗传性对称性色素异常症家系的外周血标本,用聚合酶链反应(PCR)扩增DSRAD基因的全部外显子并测序,检测2个家系中的患者及正常人和50例无关正常人的DSRAD基因。结果家系1中所有患者的DSRAD基因第2 565位至2 568位缺失GACT。家系2中所有患者的DSRAD基因第2 433位至2 434位均缺失AG。2家系中的正常人及50例无关正常人未发现突变。结论2个DSH家系患者均有DSRAD基因突变,可能由此引起编码蛋白的结构和功能改变,致皮肤色素异常。

关键词：遗传性对称性色素异常症基因突变 DSRAD基因

遗传性对称性色素异常症一家系DSRAD基因的突变

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中国皮肤性病学杂志 2010年第12期24卷 1103-1104页

作者：刘艳刘峰王晓鹏许庆强霍佳李晓莉任建文肖生祥彭振辉西安交通大学医学院附属第二医院皮肤科陕西西安710004 陕西省疾病预防控制中心陕西西安710054

目的检测一个遗传性对称性色素异常症家系中的DSRAD基因突变情况。方法收集了一个遗传性对称性色素异常症家系的外周血标本,用聚合酶链反应(PCR)扩增DSRAD基因的全部15个外显子并测序,检测家系中的患者及正常人和100例无关正常人的DSRA... 详细信息

目的检测一个遗传性对称性色素异常症家系中的DSRAD基因突变情况。方法收集了一个遗传性对称性色素异常症家系的外周血标本,用聚合酶链反应(PCR)扩增DSRAD基因的全部15个外显子并测序,检测家系中的患者及正常人和100例无关正常人的DSRAD基因。结果家系中所有患者的DSRAD基因存在外显子3的杂合缺失突变:c.1615delG。家系中的正常人及100例无关正常人未发现此突变。结论发现DSH家系患者DSRAD基因的一个新的突变。

关键词：遗传性对称性色素异常症基因突变 DSRAD基因

Searching for ^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao Zhang Jun-zheng Wang li-Tao yang Qian Yue Ke-Jun Kang Yuan-Jing li Hai-peng An C.Greeshma jian-Ping Chang Yun-Huan Chen jian-Ping Cheng wen-Han Dai Zhi Deng Chang-Hao Fang Xin-Ping Geng hui Gong Qiu-Ju Guo Xu-Yuan Guo li He sheng-ming He Jin-Wei Hu Han-Xiong Huang Tu-Chen Huang Hai-Tao Jia Xi jiang S.Karmakar Hao-Bin li jian-min li Jin li Qian-Yun li ren-ming-Jie li Xue-Qian li Yu-Lan li Yi-Fan liang Bin liao Fong-Kay lin Shin-Ted lin Jia-Xuan liu Shu-Kui liu yan-Dong liu Yu liu Yuan-Yuan liu Zhong-Zhi liu Hao Ma Yu-Cai Mao Qi-Yuan Nie Jin-Hua Ning hui pan Ning-Chun Qi Jie ren Xi-Chao Ruan Ze She Manoj Kumar Singh Tian-Xi Sun Chang-jian Tang Wei-You Tang yang Tian Guang-Fu Wang li Wang Qing Wang Yu-Feng Wang Yun-xiang Wang Henry-Tsz-King Wong Shi-Yong Wu Yu-Cheng Wu Hao-yang Xing Rui Xu Yin Xu Tao Xue Yu-Lu yan Nan Yi Chun-Xu Yu Hai-Jun Yu jian-Feng Yue ming Zeng Zhi Zeng Feng-Shou Zhang Lei Zhang zhen-Hua Zhang zhen-Yu Zhang Kang-Kang Zhao ming-Gang Zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou Key Laboratory of Particle and Radiation Imaging(ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the China Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of ^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:<3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

Consensus statement on layout and delivery of automatic external defibrillator in China

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Journal of Hainan Medical University 2020年第15期26卷 18-23页

作者： Yu Cao Song Chen yan-Fen Chai xiao-hui Chen Yu-Guo Chen Shao-wen Cheng wen-Wei Cheng Bang-Han Ding yang Deng Jie Fu Bang-jiang Fang Mai-Ying Fan li Gui Ping Gong Wei Guo Shu-Bin Guo liang Huang Ji-Yuan Han Zhong Ji Xian-Fei Ji Xin-Cai Ji Hong-Xu Jin Xin-Jun jiang Wang-xiang jiang Jia-liang liu xiao-Ran liu Zhi liu Chuan-Zhu Lv Feng Lu Tan-Shi li Xin li Yong li Shang-Lun li Shuang-ming li xiao-Gang li Bao-Jun li Pei-Wu li Chun-sheng li Zhi-Jun li Chang-Luo li xiang-min li Yin-Ping li Zong-Jun Lu Zu-Xun Lu Zhong-Qiu Lu Zhi-Qian Luo xiao-Xing liao jian-Bo Lei Tao Ma Yu Ma Yue-Feng Ma Qing-Bian Ma lin-Hao Ma Jun-Qi Ma Shi-Nan Nie Jie-Miao Ou-yang peng peng Qiao Pei Shu-ming pan Guo-Zhong Qing li-Jie Qin Wu-Ying Qiao Fei Shao Wei Song Xing-Yue Song zhen-Ju Song Rong-Ju Sun De-Ya Shang Du-Juan Sha Gui-Lan Tao Guo-Gang Tian Ying-Ping Tian jian-Guang Tian Chao-yang Tong Zi-ren Tang Meng-Xiong Tang Guo-Ping Wu Zhi Wan Tao Wang Xin Wang peng Wang Zhong Wang Tong Wang Ri-Xing Wang Yi-Xin Wang xiao-Dan Wang ling Wu Wei Wei Hua xiang Feng Xu Jun Xu Jie Xu Miao-Rong Xie Shuo-Gui Xu Tie Xu Feng Yu wen Yi li-Shan yang Shi-Jiao yan Jin-jian Yao Shou-Chun yan Xue-Zhong Yu Xian-Zhi Ye Xian-liang yan Fu-Bing Zhou Rong-Bin Zhou ming Zhou Qiang Zhou Jin Zhou Ping Zhou Chang-Ju Zhu Hua-Dong Zhu Ji-Hong Zhu Hong Zhang Mao Zhang Hua Zhang Na Zhang Guo-Qiang Zhang Guo-Xiu Zhang Jin-Song Zhang wen-Wu Zhang wen-Zhong Zhang jian-Feng Zhang Yi-min Zhu Jun Zeng Yuan zheng Zhi-Jie zheng Shen Zhao yan Zhao min Zhao Bin Zhao xiao-Dong Zhao xiao-Jing Zhao Hong-Ke Zeng sheng-Qiang Zou The Chinese Society of Emergency Medicine Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical University Key Laboratory of Emergency and Trauma of ministry of Education Hainan Medical UniversityHaikouHainanChina Emergency and Trauma College Hainan Medical UniversityHaikouHainanChina Department of Emergency Hainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikouHainanChina Key Laboratory of Hainan Trauma and Disaster Rescue Key Laboratory of Trauma of Hainan Medical University

*** Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac *** is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in China[2].

关键词： cardiac death respiratory