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Neural stem cell therapy for brain disease

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World Journal of Stem Cells 2021年第9期13卷 1278-1292页

作者： Lan Zhao Jian-Wei Liu Hui-Yan Shi Ya-min ma First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300381China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China Tianjin University of Traditional Chinese Medicine Tianjin 301617China

Brain diseases, including brain tumors, neurodegenerative disorders, cerebrovasculardiseases, and traumatic brain injuries, are among the major disordersinfluencing human health, currently with no effective therapy. Due to the lowregeneration capacity of neurons, insufficient secretion of neurotrophic factors,and the aggravation of ischemia and hypoxia after nerve injury, irreversible lossof functional neurons and nerve tissue damage occurs. This damage is difficult torepair and regenerate the central nervous system after injury. Neural stem cells(NSCs) are pluripotent stem cells that only exist in the central nervous *** have good self-renewal potential and ability to differentiate into neurons,astrocytes, and oligodendrocytes and improve the cellular *** transplantation approaches have been made for various neurodegenerativedisorders based on their regenerative potential. This review summarizes anddiscusses the characteristics of NSCs, and the advantages and effects of NSCs inthe treatment of brain diseases and limitations of NSC transplantation that need tobe addressed for the treatment of brain diseases in the future.

关键词： Neural stem cell Brain disease Therapy Animal experiment Clinical trial Cellular therapy

Impacts of the COVID-19 pandemic on the energy sector

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2021年第12期22卷 941-956页

作者： Hong-fang LU Xin ma min-da ma China-Pakistan Belt and Road Joint Laboratory on Smart Disaster Prevention of major Infrastructures Southeast UniversityNanjing 210096China School of Civil Engineering Southeast UniversityNanjing 211189China School of Science Southwest University of Science and TechnologyMianyang 621010China Department of Earth System Science Tsinghua UniversityBeijing 100084China

The outbreak of coronavirus disease 2019(COVID-19)has had a considerable impact on every industrial *** a pillar of economic development,the energy sector is experiencing difficult times during the global *** paper reviews the impact of the pandemic on the global energy sector in terms of demand,price,employment,government policy,countermeasures,and academic research,and focuses on the two largest energy countries in the world:China and the United *** the virus has dramatically impacted the energy sector,action to address climate issues has not been suspended,but has become more urgent than *** have pointed out that it is time to promote the transition to clean energy ***,here we discuss progress towards clean energy transition,including bioenergy,mineral resources for clean energy techniques,batteries,and *** results indicate that supply chain stability,energy storage,and policymaking during the epidemic period and post-epidemic period are significant challenges for the transition to clean ***,the transition can also bring new opportunities for employment,economic recovery,and the human living environment.

关键词： Coronavirus disease 2019(COVID-19) Energy sector Energy policy Clean energy transition Bioenergy Battery Electrolyzer

Preparation and Superconducting Properties of F-doped SmO_(1-x)F_xFeAs

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Journal of materials Science & Technology 2011年第3期27卷 227-232页

作者： Zhiyong Liu Hongli Suo Lin ma min Liu Zhiping Wu Zhichao Guo Luping Han Meiling Zhou Key Laboratory of Advanced Functional materials Ministry of Education College of Materials Science and Engineering Beijing University of Technology Beijing 100022 China

Here we report the fabrication and superconductivity of the iron-based arsenic oxide SmO1-xFxFeAs compound. X-ray diffraction （XRD） results prove that the lattice parameters a and c decrease systematically with increasing x in between 0〈x≤0.35, but when x〉0.35 the a and c increase with the decrease of x in the SmO1-xFxFeAs. The critical temperature （To） increases with increasing x in between 0.15≤x≤0.3, while x〉0.3 the Tc decreases with the increase ofx. It is found that at x=0.3 SmO0.7F0.3FeAs has the highest onset resistivity transition temperature of 55.5 K. The critical current density （Jc） value at 10 K for the obtained ***0.3FeAs is 1.3×10^5 A/cm^2 （0 T）. Meanwhile one can estimates Hc2（0） from the slope of the Hc2（T） curve at T=-Tc （Hc2 is the upper critical field）, and for the 90% normal-state resistivity （Pn） criterion （Tc=55 K）, Hc2（0） is determined to be -253 T.

关键词： SmO1-xFxFeAs compound F-doped Superconductivity

Interaction of DNA with aromatic hydrocarbons fraction in atmospheric particulates of Xigu District of Lanzhou,China

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Journal of Environmental Sciences 2007年第8期19卷 948-954页

作者： GAO Hong ma min-quan ZHOU Lei JIA Run-ping CHEN Xing-guo HU Zhi-de Key Laboratory of Western China＇s Environmental Systems （ministry of Education） College of Earth and Environment Sciences Lanzhou University Lanzhou 730000 China. Lanzhou Environmental Monitoring Station Lanzhou 730000 China Department of Chemistry Lanzhou University. Lanzhou 730000 China

Voluminously epidemiological studies show that the relationships exist between the air pollution and human health and cancer. Aromatic hydrocarbons （AHs） in air form a large class of organic pollutants, which are widely in environment and many of them are known to be carcinogenic and/or mutagenic and contribute to ambient air pollution. In the past decades, bioassays mainly have been used to evaluate the toxicity of chemical mixtures in atmospheric particulates or aqueous environment. However, it is well known that the covalent complexes formed by carcinogens with DNA may be exert negative results in bioassay. So the main aim of this paper is to develop an evaluation method of toxicity effects of chemical mixtures in atmospheric particulates from chemical standpoint. In this study, the in vitro interaction of the AHs with DNA was investigated by absorption, fluorescence and resonance light scattering （RLS） spectroscopic techniques. The results showed that the AHs in the atmospheric particulates could combine with calf thymus DNA （ctDNA） and herring sperm DNA （hsDNA） without being activated or metabolized by organism, respectively. Intercalation may be present in the mechanism of interaction. The binding constants of the AHs with ctDNA and hsDNA were 2.5x102 and 2.0x103, respectively, which indicated that the interaction of the AHs with hsDNA is stronger than that with ctDNA. In addition, the relationships of dose-effect between the total mole concentration of chemical components and the ability of binding ctDNA and hsDNA were confirmed. This research made it possible to study the toxicity effects of chemical mixtures in atmospheric particulates by chemical method. It is believed that the composition and contents of unknown AHs and the interaction of DNA with AHs in atmospheric particulates of Xigu District of Lanzhou City, China are first reported in the past twenty years.

关键词： atmospheric particulates aromatic hydrocarbons fraction interaction with DNA

New Species of the Isolated Psaroniaceous Rachis from the Early Permian in China

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Journal of Integrative Plant Biology 2008年第1期50卷 119-127页

作者： Ning Xiang Shi-min ma Bao-Lin Tian Shi-Jun Wang ming-Shan Zhang State Key Laboratory of Systematic and Evolutionary Botany Institute of Botany the Chinese Academy of Sciences Beijing 100093 China Graduate University of the Chinese Academy of Sciences Beijing 100049 China China University of mining and Technology Beijing 100083 China 107th Team Northeast Coal Geology Bureau Fuxin 123000 China

A new kind of marattialean raches are reported from the coal balls in Coal Seam No.7 in the upper part of the Taiyuan Formation （early Early Permian） from Taiyuan, Shanxi, China and are assigned to the genus Stipitopteris Grand＇Eury （Psaroniaceae）. The present specimens are different from all six reported species of the genus, and are therefore proposed as a new species： Stipitopteris shanxiensis. The raches of the new species are generally dorsi-ventrally flattened. The main raches usually exhibit scales of different forms on their surface. Beneath the epidermis is a zone of parenchymatous cells, some of which contain tannin-like contents. Inside this is a zone of small sclerenchymatous cells. Inward are the ground tissue and vascular bundles. The vascular bundles are continuous and are in two circles： the outer circle assumes a transversely elliptical shape with the gap and pinna trace, and the inner circle assumes a shallow *** with inrolled ends. The ground tissue located at the inner side of the vascular bundle is composed of thicker-walled parenchymatous cells. The cells of the ground tissue are vertically elongated in longitudinal sections. Subordered raches are smaller and have simpler structures than the main raches. The parenchyma zone beneath the epidermis is thinner, usually one to two cells wide and the sclerenchyma zone is usually absent. The scales are poorly developed and there is only one C-shaped vascular bundle. The new species is comparable to the crosiers of Psaroniaceae of the Euramerican Flora in some aspects, for example, it has a dorsi-ventrally flattened rachis and scales on the surface of the rachis. However, the other features and the preservative conditions of the present specimens indicate that they are not crosiers, but fully developed or mature raches. The new species is the first well-studied anatomically-preserved rachis of Psaroniaceae from the Cathaysian Flora and bears significance not only in understanding the anatomy and ta

关键词： coal ball Early Permian new species Psaroniaceae rachis Stipitopteris.

Oxidative Degradation of 2,4,6-Trichlorophenolin the Presence of Air Ions

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Chinese Chemical Letters 2001年第3期12卷 211-214页

作者： Hui min ma Jens WOHLERS Uwe MEIERHENRICH Axel BERNECKER Vera SULING Wolfram THIEmaNN Center for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100080 Department of Chemistry University of BremenD-28334 BremenGermany

2,4,6-trichlorophenol (TCP) was firstly treated with air ions generated by electric discharge, and high dechlorination (53%) was observed after 60 min treatment, indicating that air ions are an efficient dechlorination means and might have a future in the oxidative removal of chlorinated phenols. In addition, a stepwise degradation of TCP, beginning with the formation of a major product 2,6-dichloro-1,4-benzenediol via substitution, is proposed through a detailed analysis of gas chromatography/mass spectrometry.

关键词： 2,4,6-trichlorophenol air ions electric discharge oxidative degradation pollutant treatment

Orbital liposarcoma: a retrospective, single-center study of thirteen patients

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1293-1298页

作者： Ning Gao Xin Ge Cheng Pei Jian-min ma Ya-Guang Hu Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

AIM:To explore the clinical and pathological characteristics of thirteen patients with orbital ***:The clinical history data of thirteen patients diagnosed as orbital liposarcoma at Beijing Tongren Hospital,from 2006 to 2021 were collected and *** data includes age,gender,affected orbital side,course of disease,status of disease(primary or recurrent),clinical manifestations,preoperative visual acuity,operative treatment,the relations between liposarcoma and surrounding tissue,longest diameter of liposarcoma,histological subtype,immunohistochemical indicators,follow-up treatment and ***:The initial symptoms are *** is the most frequent chief complaint and the others included vision loss,epiphora,diplopia,and eyelid palpable *** of imaging examination[computed tomography(CT)or magnetic resonance imaging(MRI)]showed orbital *** terms of treatment,10 patients received tumor resection,and the mean longest diameter of the tumor was 3.39±1.36 *** other 3 patients had optic nerve invaded,so they received orbital *** examination results confirmed the diagnose of liposarcoma for 13 *** patients displayed as myxoid type,and three patients in each type of dedifferentiated and welldifferentiated *** patient was verified as pleomorphic,which was a rare type of *** of the patients showed Vimentin positive,and most showed CD34 and S-100 ***,four patients showed smooth muscle actin *** thirteen patients were ***:Orbital liposarcoma is a rare disease and it has no specific clinical *** diagnosis of liposarcoma should be considered when proptosis and orbital mass occurred in *** is recommended to perform pathological examination to achieve early detection and early treatment.

关键词： liposarcoma orbital tumor orbital mass proptosis

Analysis of clinical and pathological features of ciliary body medulloepithelioma

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International Journal of Ophthalmology(English edition) 2023年第3期16卷 382-387页

作者： Jing He Cheng Pei Xin Ge Jian-min ma Ya-Guang Hu Department of Ophthalmology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

AIM:To analyze and summarize the clinical and pathological features of ciliary body ***:The clinical and pathological data of 11 patients(11 eyes) who were diagnosed with ciliary body medulloepithelioma at Beijing Tongren Hospital,Capital Medical University,from 2007 to 2021 were retrospectively ***:The initial symptoms of 11 patients included vision loss(6 eyes),atrophia bulbi(1 eye),proptosis(2 eyes),and leukocoria(2 eyes).Most patients suffered with corneal opacity,anterior chamber flare and *** neovascularization and synechia,complicated cataract,and secondar y glaucoma occurred in several *** patients even had lens subluxation and retinal detachment.B-scan ultrasonography showed vitreous opacity and a medium-high uneven echo mass in the *** biomicroscopy examination showed a spherical or hemispherical ciliary body mass with uneven internal echoes and irregular cystic *** of the 11 patients were diagnosed with malignant ciliary body medulloepithelioma by pathological *** this study,6 patients had enucleation(2 patients had systemic chemotherapy after surgery),and the other 5 patients had local tumor resection(1 patient had plaque radiotherapy after surgery).CONCLUSION:Ciliary body medulloepithelioma is a rare intraocular tumor and may be easily confused with *** the clinical and pathological features of ciliary body medulloepithelioma is useful to further understand ciliary body medulloepithelioma,and can make an accurate diagnosis and better treatment.

关键词： medulloepithelioma ciliary body intraocular tumor retrospective study

Innovation in metamaterials and beyond:an interview with *** Zhang

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Advanced Photonics 2022年第2期4卷 3-6页

作者： Ren-min ma Peking University School of PhysicsState Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronicsBeijingChina Collaborative Innovation Center of Quantum matter BeijingChina

Ren-min ma: Prof. Zhang, you have made a series of groundbreaking discoveries in metamaterials. How did you get started in this field?Xiang Zhang: The research in metamaterials started about two decades ago. We are ve... 详细信息

关键词： interview breaking Xiang