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Science China Chemistry 2024年

作者： Bei Li Xiangxiang Zhang min lv Baibiao Huang Zhaoke Zheng State Key Laboratory of Crystal Materials Shandong University

Facet-dependent semiconductor photocatalysts exhibit immense potential in solar energy conversion and environmental purification. Variations in composition, morphology, atomic arrangement, and surface defects among different nanomaterials result in significant diversities in photocatalytic activities. Nevertheless, the structural diversity covered by integrity and uniformity is detrimental to highlighting the relationship between material and activity, compromising the logical design and optimization of photocatalysts. Fortunately, the “temporally-spatially” resolved single-particle fluorescence spectroscopy imaging technique paves the way for an in-depth exploration of facet-dependent carrier separation and transfer processes at different sites of single nanoparticle, thus providing a profound understanding of the photocatalytic reaction mechanism. In this review, we briefly introduce the imaging principle of single-particle fluorescence spectroscopy. Subsequently, we focus on the recent advancements in single-particle fluorescence spectroscopy technology to characterize the structural complexity and heterogeneity of facetdependent semiconductor photocatalysts, as well as its application in revealing the interfacial interactions between catalysts and reactants. Finally, we provide outlooks on the development prospects of single-particle fluorescence spectroscopy in the field of photocatalysis.

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Identification of novel bioactive proanthocyanidins with potent antioxidant and anti-proliferative activities from kiwifruit leaves

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Food Bioscience 2022年第2期46卷 539-549页

作者： Ji-min lv Mostafa Gouda Alaa El-Din Bekhit Ya-Ke He Xing-Qian Ye Jian-Chu Chen College of Biosystems Engineering and Food Science National-Local Joint Engineering Laboratory of Intelligent Food Technology and EquipmentZhejiang Key Laboratory for Agro-Food ProcessingZhejiang Engineering Laboratory of Food Technology and EquipmentZhejiang UniversityHangzhou310058China Department of Nutrition and Food Science National Research CentreDokki12622GizaEgypt Department of Food Science University of OtagoOtagoNew Zealand

Agro-wastes contribute major social,economic,and environmental challenges for food production and circular economy *** current increasing demand for clean label food production and use of natural bioactive compounds could turn these challenges into opportunities providing avenues for proper utilization of agro-wastes to produce valuable *** study aimed to investigate the potential use of kiwifruit(Actinidia chinensis)leaves as a source of proanthocyanidins(PAs)bioactive phenolic *** leaves PAs were extracted,purified,identified,and evaluated for their antioxidant and anti-proliferative *** structural composition of the purified PAs was characterized using HPLC-QTOF-MS/MS and *** results showed that purified kiwifruit leaves PAs(PKLPs)comprised mainly procyanidins,propelargonidins,and prodelphindins ranging from dimers to hexamers with(epi)catechin as terminal units and(epi)afzelechin or(epi)gallocatechin as dominant extension *** study reports the structure of novel PKLPs monomer fractions was unique compared to the PAs that extracted from the other plant *** PKLPs exhibited higher phenolic content than the skin and flesh of several kiwifruit ***,the PKLPs exhibited higher in vitro antioxidant activity in chemical-based(DPPH,ABTS,and FRAP)assays and H2O2-induced injury cell model than ascorbic,Trolox,and catechin(p<0.01).A remarkable dose-dependent anti-proliferation activity(IC_(50)=186.04±2.61μg/mL)against HepG2 cells was *** conclusion,this study demonstrated that kiwifruit leaves waste could serve as a sustainable and low-cost source of PAs,a group of multi-functional bioactive compounds that plays a key role in the food and pharmaceutical industries.

关键词： Proanthocyanidins Agro-waste valorisation HPLC-QTOF-MS/MS Antioxidant potential Anti-proliferative activity

Control of Iodine Deficiency Disorders Following 10-Year Universal Salt Iodization in Hebei Province of China

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Biomedical and Environmental Sciences 2009年第6期22卷 472-479页

作者： SHENG-min lv LI-JUN XIE RONG-HUA ZHOU ZHEN-SHUI CHONG LI-HUI JIA JING MA JUN ZHAO DONG XU Hebei Provincial Centre for Disease Control and Prevention Shijiazhuang 050021 Hebei China Hebei Provincial Bureau for Health Supervision Shijiazhuang 050071 Hebei China

Objective To evaluate the effectiveness of universal salt iodization （USI） for the control of IDD in Hebei province since it was implemented in 1995, identify the problems currently encountered in the implementation of USI and provide practical proposals for addressing these problems. Methods Probability proportionate to size sampling （PPS） was employed in the surveillance of IDD, for which a total of 1200 school children aged 8-10 years were randomly selected from 30 counties around the whole province during each IDD survey. The iodine content of salt was determined quantitatively with the titration method. The iodine content of urinary samples was measured by the method of ammonium persulfate oxidation. Results The coverage of iodized salt increased from 65.0% in 1995 to 98.0% in 1999, then decreased to 88.1% in 2005 which was below the national standard of 90%. The median urinary iodine of children aged 8-10 years varied between 160.1 μg/L and 307.4 μg/L, which was above the national standard. The proportion of urinary samples with iodine content above 300 lag/L was over 30% in 2005, implying exorbitant iodine nutrition among the children. The goiter rate （TGR） among children aged 8-10 years dropped from 11.8% in 1995 to 2.7% in 2005, indicating that the spread of endemic goiter was under control. Conclusion Preliminary elimination of IDD was achieved by USI in Hebei province. Nevertheless, some problems still existed in USI such as non-iodized salt competition, over iodization and un-standardized iodization. In order to address these problems, the management and supervision of salt market needs to be strengthened to prevent non-iodized salt from reaching households; updating equipment and modifying techniques are also necessary to ensure the quality of iodized salt; to clarify the causes of excessive urinary iodine content, the various sources of iodine from the diet need to be investigated in the future.

关键词： Iodine deficiency disorders (IDD) Universal salt iodization (USI) Assessment Effectiveness

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虫草菌粉中2种菌丝体的化学成分和药理活性研究进展

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中草药 2017年第22期48卷 4791-4796页

作者：吕敏吕圭源浙江中医药大学药物研究所浙江杭州310053

虫草菌粉是从新鲜冬虫夏草中分离得到菌丝体经发酵培养而得,近年来因其显著的药理活性而受到广泛关注。虫草菌粉中中国被毛孢和蝙蝠蛾拟青霉2种菌丝体的化学成分和药理活性具有明显差异,通过对二者的研究进展进行较为全面客观的文献整... 详细信息

虫草菌粉是从新鲜冬虫夏草中分离得到菌丝体经发酵培养而得,近年来因其显著的药理活性而受到广泛关注。虫草菌粉中中国被毛孢和蝙蝠蛾拟青霉2种菌丝体的化学成分和药理活性具有明显差异,通过对二者的研究进展进行较为全面客观的文献整理分析,以期为虫草菌粉的进一步研究和开发利用提供参考。

关键词：虫草菌粉中国被毛孢蝙蝠蛾拟青霉肺纤维化肝纤维化慢性肾衰竭

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Increased risk of colorectal neoplasia in inflammatory bowel disease patients with post-inflammatory polyps:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 348-361页

作者： De-Gao He Xi-Jie Chen Juan-Ni Huang Jun-Guo Chen min-Yi lv Tian-Ze Huang Ping Lan Xiao-Sheng He Department of Colorectal Surgery The Sixth Affiliated HospitalSun Yat-sen UniversityGuangdong Institute of GastroenterologyGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesGuangzhou 510655Guangdong ProvinceChina Department of Geriatrics the first Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510120Guangdong ProvinceChina

BACKGROUND Inflammatory bowel disease(IBD)patients with post-inflammatory polyps(PIPs)may carry an increased risk of colorectal neoplasia(CRN)including dysplasia and *** guidelines recommend active colonoscopy follow-up for these ***,the evidence for guidelines is still *** addition,some recent high-quality reports present a different view,which challenges the current *** hypothesize that IBD patients with PIPs are at increased risk of *** To evaluate the risk of CRN in IBD patients with and without *** A systematic search of PubMed,Embase,Cochrane Library,and Web of Science was performed to identify studies that compared the risk of CRN in IBD patients with and without *** addition,we screened the reference lists and citation indices of the included *** assessment was performed using the Newcastle–Ottawa *** odds ratio(OR)was calculated using the random-effects model to explore the final pooled effect size of the included studies and determine whether PIPs increase the risk of *** analysis,subgroup analysis,and assessment of publication bias were performed to examine the sources of *** Twelve studies with 5819 IBD patients,including 1281(22.01%)with PIPs,were considered eligible for this *** found that IBD patients with PIPs were at an increased risk of CRN as compared to those without PIPs[OR 2.01;95%confidence interval(CI):1.43–2.83].The results were similar when colorectal cancer was used as the study endpoint(OR 2.57;95%CI:1.69–3.91).Furthermore,the risk of CRN was still increased(OR 1.80;95%CI:1.12–2.91)when restricted to ulcerative colitis *** was high among the included studies(I^(2)=75%).Subgroup analysis revealed that the high heterogeneity was due to the study *** analysis showed that the main statistical outcomes did not essentially change after excluding any one of the included *** significant pu

关键词： Colorectal neoplasia Inflammatory bowel disease Ulcerative colitis Postinflammatory polyps Pseudopolyps Meta-analysis

Risk factors for recurrence of colorectal conventional adenoma and serrated polyp

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Gastroenterology Report 2022年第1期10卷 291-297页

作者： Zengjie Chi Yanyun Lin Juanni Huang min-Yi lv Junguo Chen Xijie Chen Bin Zhang Yufeng Chen Jiancong Hu Xiaosheng He Ping Lan Department of Colorectal Surgery Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesGuangdong Institute of Gastroenterologythe Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Geriatrics The First Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdongP.R.China

Background Removal of colorectal polyps during screening could reduce the incidence of colorectal cancer(CRC).However,there is a lack of data on risk factors associated with recurrence of polyps,including conventional adenomas and serrated polyps(SPs).This study aimed to determine risk factors for recurrence of colorectal polyps and their subtypes based on the characteristics of the patients and *** A total of 1,165 patients diagnosed with conventional adenoma or SP in the Sixth Affiliated Hospital of Sun Yat-sen University between January 2013 and December 2019 were enrolled in this study,including 668 cases with conventional adenomas,385 with SPs,and 112 with coexistence of adenomas and *** analysis and multivariate logistic regression were used to identify potential risk factors for polyp recurrence.A nomogram was established according to risk factors and the performance was evaluated using calibration *** During a median follow-up of 24 months,recurrent polyps were observed in 531(45.6%)***,age≥50 years,body mass index(BMI)≥24 kg/m^(2),at least three polyps,smoking,alcohol consumption,family history of polyps,and family history of CRC were independent risk factors for polyp *** Harrell’s C-index of the nomogram developed with these parameters was 0.69 and the calibration plots showed good agreement between actual polyp recurrence and nomogram-predicted recurrence *** the subtype analyses,conventional adenomas had the same risk factors for recurrence as all polyps,while smoking,alcohol consumption,family history of polyps,and family history of CRC were not risk factors for SP *** We identified several risk factors for recurrence of colorectal polyps and found that some of them could increase the risk of adenoma recurrence but not SP recurrence,including smoking,alcohol consumption,and family history of polyps/CRC,which might help us to understand different etiology and biology between

关键词： colorectal polyps recurrence conventional adenomas serrated polyps risk factors

Novel compound heterozygous mutation of SLC12A3 in Gitelman syndrome co-existent with hyperthyroidism:A case report and literature review

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World Journal of Clinical Cases 2022年第21期10卷 7483-7494页

作者： Yong-Zhang Qin Yan-ming Liu Yang Wang Cong You Long-Nian Li Xue-Yan Zhou Wei-min lv Shi-Hua Hong Li-Xia Xiao Department of Endocrinology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina Department of Endocrinology The First People’s Hospital of Nankang DistrictGanzhou 341400Jiangxi ProvinceChina Department of Dermatology and Venereology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina

BACKGROUND Gitelman syndrome(GS)is a rare inherited autosomal recessive tubulopathy,characterized clinically by hypokalemia,hypomagnesemia,hypocalciuria,and metabolic alkalosis,and is caused by an inactivating mutation in *** is prone to misdiagnosis when occurring simultaneously with *** is important to consider the possibility of other diseases when hyperthyroidism is combined with hypokalemia,which is difficult to *** SUMMARY A female patient with hyperthyroidism complicated with limb weakness was diagnosed with thyrotoxic hypokalemic periodic paralysis for 4 ***,the patient’s serum potassium level remained low despite sufficient potassium replacement and remission of *** was confirmed by whole exome and Sanger *** sequencing revealed compound heterozygous mutations of c.488C>T(***163Met),c.2612G>A(***871His),and c.1171_1178dupGCCACCAT(***393fs)in *** molecular modeling was performed to predict the effects of the identified missense *** three mutations cause changes in protein structure and may result in abnormal protein *** previously reported cases of GS coexisting with autoimmune thyroid disease are *** We have identified a novel compound heterozygous mutation in *** present study provides new genetic evidence for GS.

关键词： SLC12A3 Gitelman syndrome Hyperthyroidism Hypokalemia Gene sequencing Case report

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太湖常州水域水质的紫露草微核检测及防治

实验室研究与探索 2010年第9期29卷 30-32,85页

作者：吕敏常州工学院江苏常州213002

利用紫露草花粉母细胞减数分裂过程中,因染色体受到诱变物影响而损伤后出现的微核频率为指标,检测常州周边区域内的太湖水质,发现5#(周铁段)、1#(马山段)、3#(潘家段)的水质与对照组相比,经Duncan多重比较,在0.01水平上检测表现出的差... 详细信息

利用紫露草花粉母细胞减数分裂过程中,因染色体受到诱变物影响而损伤后出现的微核频率为指标,检测常州周边区域内的太湖水质,发现5#(周铁段)、1#(马山段)、3#(潘家段)的水质与对照组相比,经Duncan多重比较,在0.01水平上检测表现出的差异极为显著,具有较强的致变性,是污染严重的区段;4#(竺山湖段)的水质在0.05水平上检测表现出差异显著,具有较弱的致突变性;而2#(雪堰段)在0.01和0.05水平上检测均未显示差异性,水质良好。引起这种状况的原因主要与当地的工业、生活、种植业、养殖业、水土流失、航运旅游、降雨降尘等外源和长期积存于湖底的淤泥等内源的二次污染有关。

关键词：太湖水质紫露草微核检测

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