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Chinese Journal of Cancer Research 2014年第4期26卷 486-492页

作者： min Yan Hui-min lv Meng-Wei Zhang Shu-De Cui Henan Breast Cancer Center Affiliated Cancer Hospital of Zhengzhou University

Molecular subtyping of breast cancer may provide additional prognostic information regarding patient outcome. The epidermal growth factor receptor （HER2） overexpressing breast cancers are designated as HER2-postive （HER2＋） breast cancer and carry a particularly unfavorable prognosis. We present two cases of HER2-postive metastatic breast cancer （MBC） who are found to be a challenge to treat, especially due to the occurrence of brain metastasis. Trastuzumab-based therapy improves clinical outcomes, even if the patient has undergone multi-line treatment. These case reports also emphasize the importance of retesting HER2 status because it can be discordance in receptor status between primary and recurrent breast cancer.

关键词： Breast cancer trastuzumab brain metastasis

Graphene-based nanomaterials in biosystems

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Nano Research 2019年第2期12卷 247-264页

作者： Na Lu Liqian Wang min lv Zisheng Tang Chunhai Fan School of Materials Engineering Shanghai University of Engineering Science Shanghai 201620 China Division of Physical Biology and Bioimaging Center Shanghai Synchrotron Radiation Facility CAS Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China Department of Endodontics Shanghai Ninth Peoples Hospital College of Stomatology Shanghai Jiao Tong University School of Medicine Shanghai 200011 China National Clinical Research Center of Oral Diseases Shanghai 200011 China Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology Shanghai 200011 China School of Chemistry and Chemical Engineering and Institute of Molecular Medicine Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200240 China

Graphene-based nanomaterials have emerged as a novel type of materials with exceptional physicochemical properties and numerous applications in various areas. In this review, we summarize recent advances in studying interactions between graphene and biosystems. We first provide a brief introduction on graphene and its derivatives, and then discuss on the toxicology and biocompatibility of graphene, including the extracellular interactions between graphene and biomacromolecules, cellular studies of graphene, and in vivo toxicological effects. Next, we focus on various graphene-based practical applications in antibacterial materials, wound addressing, drug delivery, and water *** finally present perspectives on challenges and future developments in these exciting fields.

关键词： graphene-based nanomaterials toxicology and biocompatibility biomacromolecules cells living entitles applications

Favorable response of primary pulmonary lymphoepithelioma-like carcinoma to sintilimab combined with chemotherapy: A case report

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World Journal of Clinical Cases 2022年第31期10卷 11617-11624页

作者： Shu-Ying Zeng Jin Yuan min lv Department of Oncology The First People's Hospital of Longquanyi District ChengduChengdu 652532Sichuan ProvinceChina

BACKGROUND There is no established treatment for primary pulmonary lymphoepithelioma-like carcinoma(LELC)until *** SUMMARY In this study,the patient responded well to sintilimab combined with paclitaxel and carboplatin,showing no obvious side ***,the values of carbohydrate antigen 15-3(CA15-3)and carbohydrate antigen 72-4(CA72-4)gradually returned to *** Immunotherapy combined with chemotherapy in advanced-stage LELC may be more effective than immunotherapy or chemotherapy ***15-3 and CA72-4 are biomarkers for evaluating therapeutic effects for LELC.

关键词： Lymphoepithelioma-like carcinoma Non-small cell lung cancer Immunotherapy Sintilimab Programmed death-1 Case report

Oligomeric donor with appropriate crystallinity for organic solar cells

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Chinese Chemical Letters 2024年第2期35卷 289-294页

作者： Kaiming Yang min lv Yanhong Chang Kun Lu Zhixiang Wei CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Department of Environmental Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Resource Treatment of Typical Industrial Pollutants Beijing 100083China

Improving the performance of all-small-molecule organic solar cells(ASM-OSCs)largely depends on the design and application of novel donors with appropriate *** molecular conjugation is an effective method for regulating molecular stacking and *** this work,we successfully designed and synthesized two novel acceptor-donor-donor-donor-acceptor(A-D-D-D-A)type oligomeric donors with three dithieno[2,3-d:2′,3′-d′]benzo[1,2-b:4,5-b']dithiophene(DTBDT)as the central unit,named as 3DTBDT-Cl and 3DTBDT,depending on with and without chlorine substitution on the thiophene side *** found that the introduction of chlorine atoms makes the blend films display stronger crystallinity but with large-scale phase separation morphology and more defects,which eventually leads to a power conversion efficiency(PCE)of only 10.83%,whereas the blend films based 3DTBDT with appropriate crystallinity achieved 13.74%*** with 3DTBDT-Cl/L8-BO,the 3DTBDT/L8-BO films exhibited a nanoscale bi-continuous interpenetrating network morphology with a smaller domain size and more suitable crystallinity,which guarantees the corresponding devices obtained more efficient exciton dissociation,efficient charge transport,reduced bimolecular recombination,and performed more balanced carrier *** results demonstrated that regulating the crystallinity of oligomeric donors to obtain the desired phase separation morphology in the blend films could facilitate further improving the performance of ASM-OSCs.

关键词： Linked donor unit Oligomeric donors Crystallinity regulation Organic solar cells

Combining chlorination and sulfuration strategies for high-performance all-small-molecule organic solar cells

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Journal of Energy Chemistry 2021年第1期30卷 228-233,I0008页

作者： Ruimin Zhou Chen Yang Wenjun Zou Muhammad Abdullah Adil Huan Li min lv Ziyun Huang Menglan lv Jianqi Zhang Kun Lu Zhixiang Wei CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Sino-Danish Center for Education and Research Sino-Danish CollegeUniversity of Chinese Academy of SciencesBeijing 100190China Nano-Science Center&Department of Chemistry University of CopenhagenCopenhagen DK-2100Denmark School of Chemical Engineering Guizhou Institute of TechnologyGuiyang 550003GuizhouChina

Three small-molecule donors based on dithieno [2,3-d:2’,3 ’-d’]-benzo[1,2-b:4,5-b’] dithiophene(DTBDT)unit were designed and synthesized by side chain regulation with chlorinated or/and sulfurated substitutions(namely ZR1,ZR1-Cl,and ZR1-S-Cl respectively),along with a crystalline non-fullerene acceptor IDIC-4 Cl with a chlorinated 1,1-dicyanomethylene-3-indanone(IC) end *** levels,molar extinction coefficients and crystallinities of three donor molecules can be effectively altered by combining chlorination and sulfuration ***,the ZR1-S-Cl exhibited the best absorption ability,lowest higher occupied molecular orbital(HOMO) energy level and highest crystallinity among three donors,resulting in the corresponding all-small-molecule organic solar cells to produce a high power conversion efficiency(PCE) of 12.05% with IDIC-4 Cl as an acceptor.

关键词： All-small-molecule Chlorination and sulfuration Fibrous morphology Crystallinity

A virtual test of screening technology based on the AGEIA PhysX

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Journal of China University of mining and Technology 2008年第2期18卷 300-304页

作者： LI Ai-min lv Rui-ling LIU Chu-sheng School of Mechanical and Electrical Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221116 China

The authors have created a virtual test of vibration particle-screening using Autodesk's 3ds Max software,the MAXScript scripting language and the AGEIA PhysX physics processing unit(PPU).The affect of various parameters on screening efficiency were *** parameters included vibration amplitude,frequency and *** length and inclination of the vibrating surface were also *** virtual experiment is in basic agreement with results predicted from screening *** shows that the virtual screener can be used for preliminary investigations and the results used to evaluate screen *** addition it can help with theoretical research.

关键词： screening AGEIA PhysX virtual test

Research on Cloud Manufacturing Resource-Aware and Access Technology Using RFID

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Journal of Harbin Institute of Technology(New Series) 2014年第3期21卷 101-110页

作者： min lv Chuan-Xia Zhou Ji-Shuai Shi Lei Liu Dept. of Industrial Engineering Harbin Institute of Technology

With the continuous development of cloud manufacturing technology,in order to solve more complex manufacturing problem and conduct large-scale networked manufacturing,combining with the characteristic of discrete manufacturing enterprise's demands and RFID( Radio Frequency Identification),a kind of RFIDbased cloud manufacturing resource-aware and access technology is proposed. Firstly,the architecture of the cloud manufacturing system and RFID system is briefly introduced. Then,the key technologies of manufacturing resource-aware and access technology are analyzed,including anti-collision technology,reader management technology and so on. Finally,taking the manufacturing of the key components in discrete manufacturing enterprise as an example,the practicality and feasibility of the technology is verified. The results show that the application of this technology provides a strong guarantee for the sharing and collaboration of manufacturing resources and capacity in the discrete manufacturing industry.

关键词： cloud manufacturing RFID resource-aware

Synthesis of Mg-Al-carbonate layered double hydroxide by an atom-economic reaction

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Particuology 2010年第3期8卷 198-201页

作者： Xiangyu Xu Dianqing Li Jiaqing Song Yanjun Lin Zhi lv min Wei Xue Duan State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 China

A clean method for preparing layered double hydroxides （LDHs） has been developed, featured by using the hydroxides of two different metals as starting materials by atom-economic reactions. The reactions were carried out under hydrothermal conditions in either a high pressure autoclave or a microwave digester. The compositions, structural parameters and thermal behavior of the resulting LDHs are very similar to those of materials produced by using the separate nucleation and aging steps （SNAS） method. The major advantage of the new method is that no by-product is produced, so that filtration and washing processes are unnecessary. The consequent reduction in water consumption is beneficial to the environment.

关键词： Layered double hydroxides Atom-economic reaction Clean method Mg(OH)2Al(OH)3

Solidification behaviour and hot cracking susceptibility of a novel Ni-based superalloy

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Journal of Iron and Steel Research International 2024年第4期31卷 956-966页

作者： Yue Chen Shao-min lv Xing-fei Xie Xiao-can Wen Jng-long Qu Jin-hui Du High-Temperature Materials Institute China Iron and Steel Research Institute Group Co.Ltd.Beijing 100081China Beijing GAONA Materials and Technology Co. Ltd.Beijing 100081China Sichuan CISRI-GAONA Forging Co. Ltd.Deyang 610000SichuanChina

A novel Ni-based superalloy GH4151,with a γ′ volume fraction of about 55%and a service temperature capability up to 8oo oC,was *** to the different cooling conditions of various regions during the solidification of ingots,significant cooling rate variations may lead to the occurrence of hot *** scanning laser microscope was utilised to investigate the solidification process and phase precipitation behaviour of the GH4151 under wide range cooling *** characteristics of L→γ transformation were analysed,and the growth rates of at each stage were *** segregation behaviour was predicted using the Scheil equation,and the predicted results match well with the experimental *** sensitivity coefficient for hot cracking was modified,and cracking sensitivity coefficient values for the alloy under different cooling rates were computed,revealing that the alloy is most susceptible to hot cracking at 10℃/min cooling ***,controlling the cooling rate can reduce the possibility of hot cracking in ingot.

关键词： Ni-based superalloy Solidification behaviour In-situ observation Clyne and Davies's criterion:Hot cracking susceptibility

Construction and agrochemical efficacy of novel indolo[2,3-b]andrographolide derivatives

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Advanced Agrochem

Advanced Agrochem 2023年第4期2卷 349-355页

作者： Meng Hao min lv Tianze Li Hui Xu College of Plant Protection Northwest A&F UniversityYangling712100China

To find new pesticide candidates,by using of a natural product andrographolide as the precursor,a series of novel indolo[2,3-b]andrographolide derivatives were semisynthesized by Fischer-indole rearrangement *** structures were identified by 1H NMR,IR,mp,and HRMS,and the steric configuration of compound Ic was further determined on single-crystal *** If and IIb showed 5.9 and 7.0 times potent acaricidal activity compared to andrographolide against Tetranychus *** Ib displayed 4.2 folds higher aphicidal activity compared to andrographolide against Eriosoma *** addition,the pronounced insecticidal activity of compound IIc against Aphis citricola was 4.2 folds of that of *** electron microscopy revealed that compound IIb can destroy the epidermis of *** results can provide a basis for future research on botanical agrochemicals.

关键词： Andrographolide Indole Structural modifications Insecticidal activities SEM