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Deep Learning Model Ensemble for the Accuracy of Classification Degenerative Arthritis

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Computers, Materials & Continua 2023年第4期75卷 1981-1994页

作者： Sang-min Lee Namgi kim Department of Computer Science Kyonggi UniversitySuwonKorea

Artificial intelligence technologies are being studied to provide scientific evidence in the medical field and developed for use as diagnostic *** study focused on deep learning models to classify degenerative arthritis into Kellgren–Lawrence ***,degenerative arthritis was assessed by X-ray radiographic images and classified into five ***,the use of various deep learning models was investigated for automating the degenerative arthritis classification *** research on the classification of osteoarthritis using deep learning has been conducted in previous studies,only local models have been used,and an ensemble of deep learning models has never been applied to obtain more accurate *** address this issue,this study compared the classification performance of deep learning models,includingVGGNet,DenseNet,ResNet,TinyNet,EfficientNet,MobileNet,Xception,and ViT,on a dataset commonly used for osteoarthritis classification *** experimental results verified that even without applying a separate methodology,the performance of the ensemble was comparable to that of existing studies that only used the latest deep learning model and changed the learning *** the trained models,two ensembles were created and evaluated:weight and *** weight ensemble showed an improvement in accuracy of 1%,and the proposed specialist ensemble improved accuracy,precision,recall,and F1 score by 5%,6%,6%,and 6%,respectively,compared with the results of prior studies.

关键词： Knee osteoarthritis deep learning convolutional neural network Kellgren–Lawrence grade classification knee X-ray

Switching-on of serotonergic calcium signaling in activated hepatic stellate cells

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World Journal of Gastroenterology 2011年第2期17卷 164-173页

作者： kyu-Sang Park Pyo-Jin Sin Dong Hyeon Lee Seung-Kuy Cha min-Jeong kim Na-Hyun kim Soon-Koo Baik Seong-Woo Jeong In Deok Kong Department of Physiology and Institute of Lifelong Health Yonsei University Wonju College of Medicine Department of Physiology College of MedicinePochon CHA University Department of Basic Nursing Science Keimyung University College of Nursing Department of Internal Medicine Yonsei University Wonju College of Medicine

AIM:To investigate serotonergic Ca 2+ signaling and the expression of 5-hydroxytryptamine(5-HT) receptors,as well as Ca 2+ transporting proteins,in hepatic stellate cells(HSCs) . METHODS:The intracellular Ca 2+ concentration([Ca 2+ ]i) of isolated rat HSCs was measured with a fluorescence microscopic imaging *** PCR was per-formed to determine the transcriptional levels of 5-HT receptors and endoplasmic reticulum(ER) proteins involved in Ca 2+ storage and release in cultured rat HSCs. RESULTS:Distinct from quiescent cells,activated HSCs exhibited[Ca 2+ ]i transients following treatment with 5-HT,which was abolished by U-73122,a phospholipase C *** of 5-HT2A and 5-HT2B receptors,but not 5-HT3,was prominent during trans-differentiation of *** with ritanserin,a 5-HT2 antagonist,inhibited[Ca 2+ ]i changes upon application of *** of type 1 inositol-5'-triphosphate receptor and type 2 sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase were also increased during activation of HSCs and serve as the major isotypes for ER Ca 2+ storage and release in activated *** 2+ binding chaperone proteins of the ER,including calreticulin,calnexin and calsequestrin,were up-regulated following activation of HSCs. CONCLUSION:The appearance of 5-HT-induced[Ca 2+ ]i response accompanied by upregulation of metabotropic 5-HT2 receptors and Ca 2+ transporting/chaperone ER proteins may participate in the activating process of HSCs.

关键词： Hepatic stellate cells 5-hydroxytryptamine Intracellular Ca 2+ transient Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase Inositol-5’-triphosphate receptor Endoplasmic reticulum chaperone

Changes of tear film lipid layer thickness by 3% diquafosol ophthalmic solutions in patients with dry eye syndrome

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1555-1560页

作者： Dong-Hyun Kang Yong-Woo Lee kyu-Yeon Hwang kyung-min Koh Young-A Kwon Byung-Yeop kim Sang-Wroul Song Kook-Young kim Myung-Gok Eye Research Institute Department of Ophthalmology Kim’s Eye Hospital Konyang University College of Medicine

AIM: To evaluate the quantitatively changes in lipid layer thickness(LLT) when 3% diquafosol eye drop is used for dry eye patients using the tear film interferometer. METHODS: A total 124 participants(32 males, 92 females;mean age, 28.9 y) diagnosed with dry eye disease(DED) received topical instillation of 4 ophthalmic solutions in one eye: diquafosol, normal saline, 0.1% sodium hyaluronate and 0.3% gatifloxacin, in a masked manner. LLT was measured using an interferometer at baseline and 20 min after the instillation of each ophthalmic ***: Changes of LLT after instillation(nm, mean± standard error) were as follows: 12.6±2.0 for diquafosol(P<0.001), 1.2±2.2 for normal saline(P=0.301), 1.5±2.0 for hyaluronate(P=0.495), and 0.5±3.2 for gatifloxacin(P=0.884).CONCLUSION: Topical instillation of diquafosol increases tear film LLT in DED patients. Diquafosol 3% eye drop might be effective treatment option of evaporative DED with meibomian gland dysfunction.

关键词： diquafosol ophthalmic solutions dry eye syndrome tear film lipid layer thickness

Effects of Scutellaria baicalensis on neurogenesis in the hippocampal dentate gyrus and on spatial memory of adult rats

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Neural Regeneration Research 2011年第27期6卷 2085-2093页

作者： Sun-Hwa Lee Byung-soo Ahn Bong-soo Lim Seong-kyu kim Sam-Ki kim Dae-Il Lee Sung-Rae Cho Deok-Gon kim Jae-Bok Han Byung-Il min Department of East-West Medicine Graduate SchoolKyunghee University Department & Research Institute of Rehabilitation Medicine Yonsei University Department of Oriental Pediatrics Kyunghee Medical CenterKyunghee University Department of Physiology College of MedicineKyunghee University

We investigated the effects of ethanol extracted Scutellaria baicalensis（EESB） on spatial memory function and neurogenesis in the hippocampal dentate *** Sprague-Dawley rats were orally administered 50,100,or 200 mg/kg of EESB for 6 successive *** radial-arm maze test showed that 200 mg/kg of EESB improved the spatial memory of adult *** microscopy results showed that 100 mg/kg of EESB increased the number of bromodeoxyuridine（BrdU）-and neuron-specific nuclear protein-positive cells in the granular cell layer,and that 100 and 200 mg/kg of EESB increased the number of BrdU-/neuron-specific nuclear protein-positive cells in the sub-granular zone.200 mg/kg of EESB increased the number of BrdU-/glial fibrillary acid protein-positive cells in the subgranular *** findings indicate that EESB can effectively promote neurogenesis in the hippocampal dentate gyrus and improve spatial memory function.

关键词： Scutellaria baicalensis neurogenesis dentate gyrus hippocampus bromodeoxyuridine neuron-specific nuclear protein glial fibrillary acidic protein neural regeneration

Construction of tantalum/poly(ether imide)coatings on magnesium implants with both corrosion protection and osseointegration properties

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Bioactive Materials 2021年第4期6卷 1189-1200页

作者： Kwang-Hee Cheon Cheonil Park min-Ho Kang In-Gu Kang min-kyu Lee Hyun Lee Hyoun-Ee kim Hyun-Do Jung Tae-Sik Jang Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea Department of Biomedical-Chemical Engineering Catholic University of KoreaBucheonGyeonggi-doRepublic of Korea Institute of Health Science Research Korea UniversitySeoul02841Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangjuRepublic of Korea

Poly(ether imide)(PEI)has shown satisfactory corrosion protection capability with good adhesion strength as a coating for magnesium(Mg),a potential candidate of biodegradable orthopedic implant ***,its innate hydrophobic property causes insufficient osteoblast affinity and a lack of ***,we modify the physical and chemical properties of a PEI-coated Mg implant.A plasma immersion ion implantation technique is combined with direct current(DC)magnetron sputtering to introduce biologically compatible tantalum(Ta)onto the surface of the PEI *** PEI-coating layer is not damaged during this process owing to the extremely short processing time(30 s),retaining its high corrosion protection property and adhesion *** Ta-implanted layer(roughly 10-nm-thick)on the topmost PEI surface generates long-term surface hydrophilicity and favorable surface conditions for pre-osteoblasts to adhere,proliferate,and ***,in a rabbit femur study,the Ta/PEI-coated Mg implant demonstrates significantly enhanced bone tissue affinity and osseointegration *** results indicate that Ta/PEI-coated Mg is promising for achieving early mechanical fixation and long-term success in biodegradable orthopedic implant applications.

关键词： Magnesium Tantalum Poly(ether imide) Bio-functionalized coating Biodegradable orthopedic implants

Analysis of prognostic factors and outcomes of gastric cancer in younger patients:A case control study using propensity score methods

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World Journal of Gastroenterology 2014年第12期20卷 3369-3375页

作者： Ki-Han kim Yoo-min kim min-Chan kim Ghap-Joong Jung Department of Surgery Dong-A University College of Medicine

AIM:To understand the clinicopathological and prognostic features of gastric cancer in younger and older ***:Between January 2002 and December2008,1667 patients underwent curative gastric *** comparative purposes,the patients were divided into two groups:younger patients who were less than 40 years old(112 patients),and older patients who were 40 years old and older(1555 patients).In both groups,propensity scoring methods were used to select patients with similar disease statuses.A total of224 matched cases,with 112 patients in each group,were included in the final ***:Compared to the older group,the younger group with gastric cancer had a significantly higher percentage of females(P=0.007),poorly differentiated or signet ring cell carcinoma(P<0.001),advanced T stage gastric cancer(P=0.045),and advanced tumornode-metastasis stage cancer(P=0.036).The older group with gastric cancer had more comorbidities(P<0.001).With the exception of the number of lymph node dissection(P<0.001)and retrieved lymph node(P=0.010),there were no statistically significant differences between the postoperative outcomes of the two *** the follow-up period,there were19 recurrences in the younger group and 11 recurrences in the older *** overall five-year survival rates in the younger and older groups were 84.3%and89.6%,respectively(P=0.172).There were no significant differences(P=0.238)in the overall survival of patients with advanced T stage gastric cancer in the two groups,with five-year survival rates of 70.8%in the younger group and 79.5%in the older *** regard to the age-adjusted survival rate,there was significant difference between the two groups(P=0.225).CONCLUSION:In spite of aggressive cancer patterns in the younger group with gastric cancer,the younger group did not have a worse prognosis than the older group in our study.

关键词： Gastric cancer Younger patients Prognosis

Intelligent structured nanocomposite adhesive for bioelectronics and soft robots

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Nano Research 2024年第2期17卷 534-549页

作者： Yeon Soo Lee min-Seok kim Da Wan kim Changhyun Pang School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Mechanical Metrology Group Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Department of Electronic Engineering Korea National University of TransportationChungbuk 27469Republic of Korea Samsung Advanced Institute for Health Sciences and Technology Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea

The remarkable functionality of biological systems in detecting and adapting to various environmental conditions has inspired the design of the latest electronics and robots with advanced *** review focuses on intelligent bio-inspired strategies for developing soft bioelectronics and robotics that can accommodate nanocomposite adhesives and integrate them into biological *** underlying principles of the material and structural design of nanocomposite adhesives were investigated for practical applications with excellent functionalities,such as soft skin-attachable health care sensors,highly stretchable adhesive electrodes,switchable adhesion,and untethered soft *** addition,we have discussed recent progress in the development of effective fabrication methods for micro/nanostructures for integration into devices,presenting the current challenges and prospects.

关键词： biomimetics bio-adhesive switchable adhesion bioelectronics nanocomposite soft robotics

Closed-loop Control Using High Power Hexapole Magnetic Tweezers for 3D Micromanipulation

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Journal of Bionic Engineering 2020年第1期17卷 113-122页

作者： Xiao Zhang Louis WRogowski min Jun kim Department of Mechanical Engineering Southern Methodist UniversityDallasTX 75275USA

This paper presents the design,modeling,integration,and application of 3D printed high power hexapole magnetic tweezers for 3D micromanipulation *** sharp-tipped magnetic poles were configured with electromagnetic coils and mounted on 3D printed magnetic yokes to form a tilted Cartesian coordinate system for actuation.A closed loop control algorithm was developed to automatically manipulate external power supplies connected to the magnetic tweezers,by using 3D positional information obtained from real-time image processing *** compared against other designs of magnetic tweezers,our system has a larger working space and can generate higher magnetic field *** allows for more diverse applications regarding small scale manipulation,including cell manipulation and cell *** and analytics explained in this paper demonstrate the closed-loop manipulation of microswimmers can provide a magnetic force as high as 800 pN while maintaining a positional error below 4μm in 3D and 1.6μm in *** the desired location as the control input,the microswimmers investigated were able to achieve arbitrary 2D and 3D *** also show that the implemented hexapole magnetic tweezers have adequate power to control microswimmers in Newtonian fluid *** system will later be optimized and deployed to control microswimmers in non-Newtonian fluid environments.

关键词： magnetic tweezers micromanipulation magnetic gradient control 3D motion control microswimmers

The Southern Annular Mode(SAM) in PMIP2 Simulations of the Last Glacial Maximum

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Advances in Atmospheric Sciences 2014年第4期31卷 863-878页

作者： Seong-Joong kim L Junmei Baek-min kim Korea Polar Research Institute KORDI Chinese Academy of Meteorological Sciences

The increasing trend of the Southern Annular Mode （SAM） in recent decades has influenced climate change in the Southem Hemisphere （SH）.How the SAM will respond increased greenhouse gas concentrations in the future remains *** the variability of the SAM in the past under a colder climate such as during the Last Glacial Maximum （LGM） might provide some understanding of the response of the SAM under a future warmer *** analyzed the changes in the SAM during the LGM in comparison to pre-industrial （PI） simulations using five coupled ocean-atmosphere models （CCSM,FGOALS,IPSL,MIROC,HadCM） from the second phase of the Paleoclimate Modelling Intercomparison Project （PMIP2）.In CCSM,MIROC,IPSL,and FGOALS,the variability of the simulated SAM appears to be reduced in the LGM compared to the PI simulations,with a decrease in the standard deviation of the SAM ***,four out of the five models suggest a weaker SAM amplitude in the LGM consistent with a weaker SH polar vortex and westerly winds found in some proxy records and model *** weakening of the SAM in the LGM was associated with an increase in the vertical propagation of Rossby waves in southern high latitudes.

关键词： Southern Annular Mode Last Glacial Maximum PMIP2 Southern Hemisphere westerly winds