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Electroacupuncture for abdominal pain relief in patients with acute pancreatitis:A three-arm randomized controlled trial

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Journal of Integrative Medicine 2023年第6期21卷 537-542页

作者： Dong Kee Jang Jun kyu Lee Chan Yung Jung kyung Ho Kim Ha Ra Kang Yeon Sun Lee Jong Hwa Yoon Kwang Ro Joo min kyu chae Yong Hyeon Baek Byung-Kwan Seo Sang Hyub Lee Chiyeon Lim Department of Internal Medicine Seoul Metropolitan Government Boramae Medical CenterSeoul National University College of MedicineSeoul 07061Republic of Korea Department of Internal Medicine Dongguk University Ilsan HospitalDongguk University College of MedicineGoyang 10326Republic of Korea Department of Acupuncture and Moxibustion Dongguk University Ilsan Oriental HospitalCollege of Korean MedicineDongguk UniversityGoyang 10326Republic of Korea Department of Korean Medicine Dongguk UniversityGoyang 10326Republic of Korea Department of Acupuncture and Moxibustion College of Korean MedicineDongguk UniversityGyeongju 38067Republic of Korea Department of Gastroenterology Kyung Hee University Hospital at GangdongSeoul 05278Republic of Korea Department of Acupuncture and Moxibustion Kyung Hee University Korean Medicine Hospital at GangdongSeoul 05278Republic of Korea Department of Internal Medicine and Liver Research Institute Seoul National University HospitalSeoul National University College of MedicineSeoul 03080Republic of Korea Department of Biostatistics College of MedicineDongguk UniversityGoyang 10326Republic of Korea

Background: Electroacupuncture(EA) may reduce the severity of acute pancreatitis(AP) and provide additional pain relief in patients with chronic pancreatitis. However, the ability of EA to relieve pain in patients with AP has not been well ***: This study was undertaken to compare the pain-relieving effects of EA and conventional treatment in patients with ***, setting, participants and interventions: This study was conducted using a randomized, controlled,three-arm, parallel-group and multi-center design. Patients diagnosed with AP were randomly and equally assigned to EA1, EA2 or control groups. All participants received conventional standard-of-care therapy for AP. Local EA alone was administered in EA1, and local plus distal EA was given in *** EA included two abdominal acupoints, while distal EA included twelve peripheral acupoints. EA groups underwent one session of EA daily for 4 days(days 1–4), or until pain was resolved or *** outcome measures: The primary outcome measure was the change in the visual analogue scale(VAS;0–100) pain score between baseline and day ***: Eighty-nine participants were randomized into EA1, EA2 and control groups, and 88(EA1, 30;EA2, 29;control, 29) were included in the full-analysis set. VAS score change(median [interquartile range]) on day 5 was(12.3 ± 22.5) in the EA1 group,(10.3 ± 21.5) in the EA2 group, and(8.9 ± 15.2) in the control group. There were not significant differences in the change in VAS score among treatments(P = 0.983). However, time to food intake was significantly shorter in the EA group(EA1 + EA2) than in the control group(median 2.0 days vs 3.0 days), with a hazard ratio of 0.581(P = 0.022;95% CI,0.366–0.924). No significant adverse events ***: EA treatment did not significantly reduce pain after 4 days of treatment in patients with AP-associated abdominal pain but significantly reduced time to first food intake.

关键词： Acute pancreatitis Electroacupuncture Pain management Abdominal pain Randomized controlled trial

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Enhanced Li storage of pure crystalline-C60 and TiNb2O7-nanostructure composite for Li-ion battery anodes

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Journal of Energy Chemistry 2024年第10期97卷 478-485页

作者： Injun Jeon Linghong Yin Dingcheng Yang Hong Chen Seong Won Go min Seung Kang Hyung Soo Ahn chae-Ryong Cho Department of Nano Fusion Technology Pusan National University Division of Energy & Environmental Technology Daegu Gyeongbuk Institute of Science & Technology (DGIST) College of Life Sciences Qingdao Agricultural University Department of Electronics Material Engineering Korea Maritime and Ocean University Department of Nanoenergy Engineering Pusan National University

We propose a method for producing composite materials(hTNO@C60) comprising crystalline C60particles and hollow-structu red TiNb2O7（hTNO） nanofibers via facile liquid-liquid interface precipitation followed by low-temperature *** allows the systematic design of crystalline C60as an active material for Li-ion battery *** hTNO@C60composite demonstrates outstanding cyclic stability,retaining a capacity of 465 mA h g-1after 1,000 cycles at 1 A g-1It maintains a capacity of 98 mA h g-1even after16,000 ultralong cycles at 8 A g-1The enhancement in electrochemical properties is attributed to the successful growth and uniform doping of crystalline C60,resulting in improved electrical *** excellent electrochemical stability and properties of these composites make them promising anode materials.

关键词： Anode material Electrochemical performance Fullerene Li-ion battery TiNb2O7 nanofiber

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Synthesis of a Rod-rod Diblock Copolymer, Poly (3-hexylthiophene)-block-poly(furfuryl isocyanate), through the Anionic Polymerization with an Oxyanionic Macroinitiator

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Chinese Journal of Polymer Science 2019年第9期37卷 866-874页

作者： Chang-Geun chae Joonkeun min In-Gyu Bak Jae-Suk Lee School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST)

A rod-rod diblock copolymer (diBCP), poly(3-hexylthiophene)-block-poly(furfuryl isocyanate)(P3HT-b-PFIC), was synthesized through the anionic polymerization with an oxyanionic macroinitiator of P3HT. The properties of the diBCP (molecular weight, dispersity, composition, thermal stability, UV-visible absorption, and thin film morphology) were determined by various analytical methods. P3HT-b-PFIC was blended with C60 in a toluene solution to prepare a thin film of binary electron donor/acceptor system. Such blending enabled partial conjugation of the two components by the Diels-Alder reaction between furan and C60 at 60℃ for 3 h;the mixture was then spin-cast as a thin film, and annealed at 250℃ for 24 h. Tapping-mode atomic force microscopy (AFM) revealed that P3HT and C60 domains had nanoscale interfaces without a large phase segregation. This result indicated that the microphase separation of C60-functionalized P3HT-b-PFIC preserved even at high temperature provided free C60 molecules with channels to diffuse on the sides of P3HT domain, thus preventing the macroscopic crystallization of free C60 through the interfacial stabilization.

关键词： Rod-rod diblock copolymer Poly(3-hexylthiophene)-block-poly(furfuryl isocyanate) C60 Diels-Alder reaction Nanoscale interfaces

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Effects of Momentum Ratio and Weber Number on Spray Half Angles of Liquid Controlled Pintle Injector

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Journal of Thermal Science 2015年第1期24卷 37-43页

作者： min Son Kijeong Yu Jaye Koo Oh chae Kwon Jeong Soo Kim Korea Aerospace University School of Aerospace and Mechanical Engineering Korea Aerospace University School of Mechanical Engineering Sungkyunkwan University Department of Mechanical Engineering Pukyong National University

A pintle injector is advantageous for throttling a liquid rocket engine and reducing engine weight. This study ex- plores the effects of momentum ratio and Weber number at various injection conditions on spray characteristics of the pintle injector for liquid-gas propellants. A liquid sheet is injected from a center pintle nozzle and it is broken by a gas jet from an annular gap. The pressure drops of propellants, and the pintle opening distance were consi- dered as control variables; using 0.1 -1.0 as a bar for the pressure drop of the liquid injection, a 0.01-4）.2 bar for the pressure drop of gas jet and a 0.2 - 1.0 mm for the pintle opening distance. The discharge coefficient was de- creased linearly before the pintle opening distance of 0.75 mm and then, the coefficient was slightly increased. Spray images were captured by a CMOS camera with high resolution. Then, the shadow and reflected images were analyzed. Spray distributions were measured by a pattemator with an axial distance of 50 mm from a pintle tip. Finally, the spray half angles had an exponentially decreasing correlation as a momentum ratio divided by the Weber number. Also, the spray half angles from the spray distribution were underestimated compared to those measured from the captured images.

关键词： Pintle Injector Spray Half Angle Spray Distribution Visualization

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Helicobacter pylori eradication with moxifloxacin-containing therapy following failed first-line therapies in South korea

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World Journal of Gastroenterology 2014年第22期20卷 6932-6938页

作者： kyu Keun Kang Dong Ho Lee Dong Hyun Oh Hyuk Yoon Cheol min Shin Young Soo Park Nayoung Kim Hyun chae Jung Department of Internal Medicine Seoul National University Bundang HospitalSeongnamGyeongi-do 463-707South Korea Department of Internal Medicine Seoul National University College of MedicineSeoul 100-744South Korea

AIM: To investigate moxifloxacin-containing triple therapy as second-line treatment for Helicobacter pylori (H. pylori) infection following failed first-line treatment.

关键词： Fluoroquinolones Helicobacter pylori Disease eradication Drug resistance Second-line

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A Study of the Gas Flow through Air Jet Loom

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Journal of Thermal Science 2007年第2期16卷 159-163页

作者： Heuy-Dong Kim chae-min Lim Ho-Joon Lee Doo-Hwan Chun School of Mechanical Engineering Andong National University388Songcheon-dongAndong 760-749KoreaE-mail:kimhd Korea Textile Machinery Research Institute 300Sampoong-dongKyeongsan 712-210Korea

Air jet loom, as one of the shuttleless looms, transports a yam into warps using viscosity and kinetic energy of an air jet. Performance of this picking system depends on the ability of instantaneous inhalation/exhaust, configuration of nozzle, operation characteristics of a check valve, etc. In the recent past, many studies have been reported on the air jet discharged from a nozzle exit, but studies for understanding the flow field characteristics associated with shear layer and shock wave/boundary layer interaction in the nozzle were not conducted enough. In this paper, a computational study was performed to explain the flow field in the air jet nozzle with an acceleration tube and validated with previous experimental data available. The results obtained from the computational study show that, in the supersonic flow regime, the flow field depends significantly on the length of acceleration tube. As nozzle pressure ratio increases, drag force acting on the string also increases. For a longer acceleration tube, the total pressure loss is large, owing to the frictional loss.

关键词： compressible flow nozzle shear layer shock wave air jet loom shuttleless loom

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Bibliometric and visual analysis of post-stroke hemiplegia in the past 20 years

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Clinical Research Communications 2024年第3期7卷 29-37页

作者： Jie Li Xue-min Yin Yong-Fang Yang Xin-Ju Li Acupuncture department Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin 300120China. School of Acupuncture Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjin 301617China. College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China.

Objective:The purpose of this study is to use CiteSpace software to examine the development patterns and hotspots in post-stroke hemiplegia research during the last 20 ***:Articles about post-stroke hemiplegia from January 2005 to December 2024 were analyzed in the Web of Science *** software was used to conduct co-citation analysis of the articles about post-stroke hemiplegia as well as cooperative network analyses of authors,countries,and institutions,as well as keyword co-occurrence,clustering,emergence,and time line *** results were displayed in a visual ***:A total of 2625 papers were obtained,and there were more publications *** and the United States had the most number of articles,while chae,John was the author with the most number of *** Med University and Ohio State University had the most articles among their *** keywords"stroke"and"rehabilitation"were used the *** key word analysis indicates that the present study focus is on exercise rehabilitation measures and post-stroke ***:Using CiteSpace software to analyze the literature on post-stroke hemiplegia,it is discovered that the use of new technologies in the field of mechanical thrombectomy and the effectiveness of rehabilitation techniques like mirror treatment are the key areas of study *** study has positive significance for finding safer and more effective treatments for post-stroke hemiplegia.

关键词： CiteSpace stroke hemiplegia visual analysis

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Early treadmill exercise increases macrophage migration inhibitory factor expression after cerebral ischemia/reperfusion

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Neural Regeneration Research 2019年第7期14卷 1230-1236页

作者： min Cheol Chang chae Ri Park Seung Hwa Rhie Woo Hyun Shim Dae Yul Kim Department of Rehabilitation Medicine College of MedicineYeungnam University Asan Institute for Life Sciences Asan Medical CenterUniversity of Ulsan College of Medicine Department of Rehabilitation Medicine Asan Medical CenterUniversity of Ulsan College of Medicine Department of Radiology Asan Medical CenterUniversity of Ulsan College of Medicine

The neuroprotective function of macrophage migration inhibitory factor(MIF) in ischemic stroke was rarely *** study aimed to investigate the effects of early treadmill exercise on recovery from ischemic stroke and to determine whether these effects are associated with the expression levels of MIF and brain-derived neurotrophic factor(BDNF) in the ischemic area.A total of 40 male Sprague-Dawley rats were randomly assigned to the ischemia and exercise group [middle cerebral artery occlusion(MCAO)-Ex,n = 10),ischemia and sedentary group(MCAO-St,n = 10),sham-surgery and exercise group(Sham-Ex,n= 10),or sham-surgery and sedentary group(Sham-St,n = 10).The MCAO-Ex and MCAO-St groups were subjected to MCAO for 60 minutes,whereas the Sham-Ex and Sham-St groups were subjected to an identical operation without *** in the MCAO-Ex and Sham-Ex groups then ran on a treadmill for 30 minutes once a day for 5 consecutive *** reperfusion,the hanging time tested by the wire hang test was longer and the relative fractional anisotropy determined by MRI was higher in the peri-infarct region of the MCAO-Ex group compared with the MCAO-St *** expression levels of MIF and BDNF in the peri-infarct region were upregulated in the MCAO-Ex *** MIF and BDNF levels were positively correlated with relative fractional anisotropy changes in the peri-infarct *** was no significant difference in the levels of MIF and BDNF in the peri-infarct region between the Sham-Ex and Sham-St *** study demonstrated that early exercise(initiated 48 hours after the MCAO) could improve motor and neuronal recovery after ischemic ***,the increased levels of MIF and BDNF in the peri-infarct region(penumbra) may be one of the mechanisms of enhanced neurological function *** experiments were approved by the Institutional Animal Care and Use Committee in Asan Medical Center in South Korea(2016-12-126).

关键词： ischemic stroke early exercise macrophage migration inhibitory factor brain-derived neurotrophic factor motor recovery neural regeneration

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Stage-specific nutritional management and developmental programming to optimize meat production

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Journal of Animal Science and Biotechnology 2023年第2期14卷 451-464页

作者： Liang Zhao Xiangdong Liu Noe A Gomez Yao Gao Jun Seok Son Song Ah chae Mei‑Jun Zhu min Du College of Animal Science and Technology Nanjing Agricultural University210095 NanjingPR China Nutrigenomics and Growth Biology Laboratory Department of Animal SciencesWashington State UniversityWA 99164 PullmanUSA Laboratory of Perinatal Kinesioepigenetics Department of ObstetricsGynecology and Reproductive SciencesUniversity of Maryland School of MedicineMD 21201 BaltimoreUSA School of Food Science Washington State UniversityWAPullmanUSA.

Over the past few decades,genetic selection and refined nutritional management have extensively been used to increase the growth rate and lean meat production of ***,the rapid growth rates of modern breeds are often accompanied by a reduction in intramuscular fat deposition and increased occurrences of muscle abnor‑malities,impairing meat quality and processing *** stages of animal development set the long‑term growth trajectory of ***,due to the seasonal reproductive cycles of ruminant livestock,gestational nutrient deficiencies caused by seasonal variations,frequent droughts,and unfavorable geological locations nega‑tively affect fetal development and their subsequent production efficiency and meat ***,enrolling live‑stock in nutritional intervention strategies during gestation is effective for improving the body composition and meat quality of the offspring at *** crucial early developmental stages include embryonic,fetal,and postnatal stages,which have stage‑specific effects on subsequent offspring development,body composition,and meat *** review summarizes contemporary research in the embryonic,fetal,and neonatal development,and the impacts of maternal nutrition on the early development and programming effects on the long‑term growth performance of *** the developmental and metabolic characteristics of skeletal muscle,adipose,and fibrotic tissues will facilitate the development of stage‑specific nutritional management strategies to optimize production efficiency and meat quality.

关键词： Adipose tissue Embryonic development Fetal programming Fibro/adipogenic progenitors Marbling Nutritional regulations Skeletal muscle

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Characterization of transgenic mice expressing EGFP under the control of the monkey 20α-hydroxysteroid dehydrogenase promoter

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Science China(Life Sciences) 2018年第8期61卷 966-974页

作者： chae-Won Park Seong-Keun Jeong Tsevelmaa Nanjidsuren Munkhzaya Byambaragchaa Myung-Hwa Kang Bo-Woong Sim Kwan-Sik min Animal Biotechnology Graduate School of Future Convergence Technology Department of Animal Life Science Institute of Genetic Engineering Hankyong National University Department of Food Science and Nutrition Hoseo University National Primate Research Center Korea Research Institute of Bioscience and Biotechnology

To directly assess the molecular function of the monkey 20α-hydroxysteroid dehydrogenase （20α-HSD） promoter, we generated transgenic mice （tg） expressing enhanced green fluorescent protein （EGFP） under control of this promoter. We demonstrated that prostaglandin F2α induced 20α-HSD promoter activity in CHO cells in a dose-dependent manner. Furthermore, forskolin treatment markedly reduced 20α-HSD promoter activity, and prolactin exhibited weak inhibitory activity. The transgenic mouse obtained one positive founder male. The transgene was propagated in 10 successive generations without any notable defects to the progeny. EGFP and 20α-HSD in the tg mice were colocalized in the luteal cells of the ovary during late pregnancy. Strong EGFP and 20et-HSD protein signals were also detected in the adult testis. Immtmohistochemical analysis revealed high EGFP levels in the seminiferous epithelium, whereas 20α-HSD was expressed in the seminiferous tubules. Our data suggest that the ovaries in monkey and mouse exhibit similar expression patterns of 20α-HSD during pregnancy. However, the expression pattern of EGFP in tg mice testis slightly differed from that of the endogenous 20α-HSD. Further investigation is required to elucidate the functional mechanisms underlying regulation of the monkey 20α-HSD promoter in the tg mice.

关键词： transgenic mice EGFP monkey 20α-HSD promoter

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