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Hypothyroidism affects astrocyte and microglial morphology in type 2 diabetes

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Neural Regeneration Research 2013年第26期8卷 2458-2467页

作者： Sung min Nam Yo Na kim dae Young Yoo Sun Shin Yi Jung Hoon Choi In Koo Hwang Je Kyung Seong Yeo Sung Yoon Department of Anatomy and Cell Biology College of Veterinary Medicine Research Institute for Veterinary Science Seoul National University Department of Biomedical Laboratory Science College of Biomedical Sciences Soonchunhyang University Department of Anatomy College of Veterinary Medicine Kangwon National University

In the present study, we investigated the effects of hypothyroidism on the morphology of astrocytes and microglia in the hippocampus of Zucker diabetic fatty rats and Zucker lean control rats. To induce hypothyroidism, Zucker lean control and Zucker diabetic fatty rats at 7 weeks of age orally received the vehicle or methimazole, an anti-thyroid drug, treatment for 5 weeks and were sacrificed at 12 weeks of age in all groups for blood chemistry and immunohistochemical staining. In the me- thimazole-treated Zucker lean control and Zucker diabetic fatty rats, the serum circulating triiodo- thyronine （T3） and thyroxine （＇I＂4） levels were significantly decreased compared to levels observed in the vehicle-treated Zucker lean control or Zucker diabetic fatty rats. This reduction was more prominent in the methimazole-treated Zucker diabetic fatty group. Glial fibrillary acidic protein im- munoreactive astrocytes and ionized calcium-binding adapter molecule 1 （Iba-1）-immunoreactive microglia in the Zucker lean control and Zucker diabetic fatty group were diffusely detected in the hippocampal CA1 region and dentate gyrus. There were no significant differences in the glial fibril- lary acidic protein and Iba-1 immunoreactivity in the CA1 region and dentate gyrus between Zucker lean control and Zucker diabetic fatty groups. However, in the methimazole-treated Zucker lean control and Zucker diabetic fatty groups, the processes of glial fibrillary acidic protein immunoreac- tive astrocytes and Iba-1 immunoreactive microglia, were significantly decreased in both the CA1 region and dentate gyrus compared to that in the vehicle-treated Zucker lean control and Zucker diabetic fatty groups. These results suggest that diabetes has no effect on the morphology of as- trocytes and microglia and that hypothyroidism during the onset of diabetes prominently reduces the processes of astrocytes and microglia.

关键词： neural regeneration astrocytes microglia diabetes hypothyroidism complications thyroid hormone obesity methimazole Zucker diabetic fatty rat grants-supported paper neuroregeneration

Activation of less affected corticospinal tract and poor motor outcome in hemiplegic pediatric patients:a diffusion tensor tractography imaging study

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Neural Regeneration Research 2015年第12期10卷 2054-2059页

作者： Jin Hyun kim Su min Son Department of Physical Medicine and Rehabilitation College of MedicineYeungnam University

The less affected hemisphere is important in motor recovery in mature ***,in terms of motor outcome in immature brains,no study has been reported on the less affected corticospinal tract in hemiplegic pediatric ***,we examined the relationship between the condition of the less affected corticospinal tract and motor function in hemiplegic pediatric *** patients with hemiplegia due to perinatal or prenatal injury（13.7±3.0 months）and 40 age-matched typically developing controls were *** patients were divided into two age-matched groups,the high functioning group（20 patients）and the low functioning group（20 patients）using functional level of hemiplegia *** tensor tractography images showed that compared with the control group,the patient group of the less affected corticospinal tract showed significantly increased fiber number and significantly decreased fractional anisotropy *** increased fiber number and significantly decreased fractional anisotropy value in the low functioning group were observed than in the high functioning *** findings suggest that activation of the less affected hemisphere presenting as increased fiber number and decreased fractional anisotropy value is related to poor motor function in pediatric hemiplegic patients.

关键词： nerve regeneration unaffected hemisphere hemiplegia corticospinal tract diffusiontensor imaging motor function neural regeneration

A Delayed Stochastic Volatility Correction to the Constant Elasticity of Variance Model

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Acta Mathematicae Applicatae Sinica 2016年第3期32卷 611-622页

作者： min-Ku LEE Jeong-Hoon kim Department of Mathematics Kunsan National University Department of Mathematics Yonsei University

The Black-Scholes model does not account non-Markovian property and volatility smile or skew although asset price might depend on the past movement of the asset price and real market data can find a non-flat structure of the implied volatility surface. So, in this paper, we formulate an underlying asset model by adding a delayed structure to the constant elasticity of variance （CEV） model that is one of renowned alternative models resolving the geometric issue. However, it is still one factor volatility model which usually does not capture full dynamics of the volatility showing discrepancy between its predicted price and market price for certain range of options. Based on this observation we combine a stochastic volatility factor with the delayed CEV structure and develop a delayed hybrid model of stochastic and local volatilities. Using both a martingale approach and a singular perturbation method, we demonstrate the delayed CEV correction effects on the European vanilla option price under this hybrid volatility model as a direct extension of our previous work [12].

关键词： constant elasticity variance , delay stochastic volatility martingale option pricing

A mass and energy estimation for the hydrogen utilization in the iron-making process

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Science China(Technological Sciences) 2011年第7期54卷 1655-1660页

作者： Wan Ho kim Dong Joon min Department of Materials Science and Engineering YONSEI University

The possibility of using hydrogen to lower CO 2 emissions in the iron-making process was confirmed by the heat and mass balances in the blast furnace operation. The mass and heat balances for hydrogen utilization in the blast furnace were estimated by using the basic concept of RIST operating diagram. In this study, the RIST operating diagram was modified to be suitable for representing the operation with respect to hydrogen, where the RIST operating diagram is a graphical representation of heat and mass balance in blast furnace operation. RIST operating diagram was applied here to some individual parameters of interest such as H 2 injection in blast furnace process to reduce coke (carbon consumption). It was observed that the point W moved to the right in the RIST operating diagram under the condition of increasing hydrogen injection at tuyere, which originates from the contribution of gas composition (O/H 2 ) equilibrated with Fe/FeO at a certain temperature. Point P also moved downward due to heat requirement with respect to hydrogen utilization, by which the new RIST operating diagram for hydrogen utilization was able to be constructed. Under the condition of hydrogen injection, the expected overall carbon consumption in the blast furnace decreased due to the contribution of hydrogen.

关键词： hydrogen carbon consumption (CO2 emission) mass and heat balances RIST operating diagram blast furnace

User Profile System Based on Sentiment Analysis for Mobile Edge Computing

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Computers, Materials & Continua 2020年第2期62卷 569-590页

作者： Sang-min Park Young-Gab kim Korea University 145 Anam-roSeongbuk-guSeoul02841Korea Sejong University 209Neungdong-roGwangjin-guSeoul05006Korea

Emotions of users do not converge in a single application but are scattered across diverse *** devices are the closest media for handling user data and these devices have the advantage of integrating private user information and emotions spread over different *** this paper,we first analyze user profile on a mobile device by describing the problem of the user sentiment profile system in terms of data granularity,media diversity,and server-side ***-grained data requires additional data and structural analysis in mobile *** diversity requires standard parameters to integrate user data from various applications.A server-side solution presents a potential risk when handling individual privacy ***,in order to overcome these problems,we propose a general-purposed user profile system based on sentiment analysis that extracts individual emotional preferences by comparing the difference between public and individual data based on particular *** proposed system is built based on a sentiment hierarchy,which is created by using unstructured data on mobile *** can compensate for the concentration of single media,and analyze individual private data without the invasion of privacy on mobile devices.

关键词： User profile sentiment analysis mobile edge computing social network

Remarkably slow corrosion rate of high-purity Mg microalloyed with 0.05wt% Sc

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Journal of Magnesium and Alloys 2023年第3期11卷 991-997页

作者： Soo-min Baek Jeong-Ki kim Du-Won min Sung Soo Park Department of Materials Science and Engineering Ulsan National Institute of Science and TechnologyUlsan 44919Republic of Korea

We report that the corrosion resistance of Mg is significantly improved by adding 0.05wt%*** rates evaluated from weight loss values after room-temperature immersion in 0.6 M NaCl solution for two weeks were 0.27 and 4.0 mm y^(-1)for the high-purity Mg samples with and without microalloyed 0.05wt%Sc,*** beneficial effect of Sc microalloying on the corrosion resistance of Mg is discussed in connection with Sc-induced microstructural modifications.

关键词： Magnesium Microalloying Intermetallic phase Microgalvanic corrosion

Deformation prediction of porcelain-enameled steels with strain history by press forming and high-temperature behavior of coating layer

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中国有色金属学会会刊：英文版 2012年第S3期22卷 838-844页

作者： Young-Ki SON Chan-Joo LEE Jung-min LEE Byung-min kim School of Mechanical Engineering Pusan National University Dongnam Regional Division Korea Institute of Industrial Technology

Porcelain enamel coatings were widely applied for the protection of steel products because they offered high corrosion protection,resistance to heat and abrasion,high hardness,hygiene and ease of *** typical process to produce enameled steels is roughly divided into two stages:the first stage consists of a forming process to give the desired shape to a steel substrate,and the second stage consists of a firing process to bond enamel frits on the *** firing process requires a high temperature above 800 °C,which may lead to austenitic transformation and severe thermal deformation of the steel *** aim of this study is to develop a finite element analysis (FE analysis) technique to predict the mechanical and thermal deformations of the enameled steels during forming and any further enameling process,including *** FE analysis involves analyzing the strain history of the steel substrate,which comprises the stress and thickness distributions of the substrate and its deformed shape,and the high-temperature behavior of the enamel coating *** validity of the FE analysis is verified through the U-bending test and firing test with various numbers and positions of enamel coating layers on the *** results reveal that the FE analysis results agree well with the experimental results with 8% error.

关键词： porcelain enamel firing process finite element analysis enameled steel thermal deformation

Microstructural evolution and grain growth mechanism of pre-twinned magnesium alloy during annealing

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Journal of Magnesium and Alloys 2021年第4期9卷 1238-1251页

作者： Ye Jin kim Jong Un Lee Young min kim Sung Hyuk Par School of Materials Science and Engineering Kyungpook National JJniversityDaegu 41566Republic of Korea Implementation Research Division Korea Institute of Materials ScienceChanson 51508Republic of Korea

The microstructural evolution and underlying grain growth mechanism of a{1012}-twin-containing Mg alloy during annealing are investigated through quasi in situ electron backscatter diffraction measurements of a rolled AZ31 alloy subjected to precompression along the rolling direction(RD).The precompressed material shows a partially twinned structure consisting of a twinned region and a residual matrix region,and this structure changes to an almost twin-free structure consisting of grown grains with serrated grain boundaries in twinand matrix-originated regions after annealing at 250℃ for 1 *** addition,the average grain size almost doubles and the internal strain energy decreases significantly after *** microstructural variations are induced mainly by grain growth through the strain-induced migration of high-angle grain boundaries without the movement of twin *** twinned region of the precompressed material has higher stored strain energy than the residual matrix region because the crystallographic orientation of the former region is favorable for basal slip and because of the occurrence of the dislocation transmutation reaction in the *** reducing the total strain energy accumulated in the precompressed material,the residual matrix region—having lower stored strain energy—preferentially grows while consuming the twinned regions formed in the surrounding grains during *** a result,the area fraction of grains with a matrix texture increases whereas that of grains with a twin texture decreases after *** twin texture intensity increases significantly and this texture becomes more concentrated along the RD because the highly RD oriented twins tend to grow during annealing on account of their fairly low stored strain energy.

关键词： Magnesium Twin Annealing Grain growth Strain energy

Effects of elastic-plastic properties of materials on residual indentation impressions in nano-indentation using sharp indenter

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中国有色金属学会会刊：英文版 2012年第S3期22卷 585-595页

作者： Jung-min LEE Chan-Joo LEE Kyung-Hun LEE Byung-min kim Dongnam Regional Division Korea Institute of Industrial Technology Precision Manufacturing Systems Division Pusan National University School of Mechanical Engineering Pusan National University

One of the primary features of nano-indentation technique is that the contact area induced by an indenter is indirectly measured by a relationship between the penetration depth and the known geometry of the ***,this indirect measurement occasionally leads to inaccurate properties of the indented *** objective of this study is to investigate the effects of E/σr and the strain hardening exponents n of materials on the behaviors of pile-up and sink-in in nano-indentation and to predict n values of materials from the residual indentation *** relations between the residual indentation profile and n value of the indented material were identified by dimensional ***,they were numerically formulated using FE analysis of nano-indentation for 140 different combinations of elastic-plastic parameters such as E,σy and *** parameters of hrp/hm,herp/hm,Rr/hm and HO&P/Hreal were introduced as various dimensionless parameters to represent and quantify the residual indentation profile after *** were subsequently characterized as dimensionless functions using n and E/σr ***,the validity of these functions was verified through 3D FE analysis of nano-indentation for Al 6061-T6 and AISI 1010 materials.

关键词： nano-indentation pile-up sink-in strain hardening exponent FE simulation