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Application of artificial synapse based on all-inorganic perovskite memristor in neuromorphic computing

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Nano Materials Science 2024年第1期6卷 68-76页

作者： Fang Luo Wen-min Zhong Xin-Gui Tang Jia-Ying chen Yan-ping jiang Qiu-Xiang Liu school of Physics&Optoelectric Engineering Guangdong University of TechnologyGuangzhou Higher Education Mega CenterGuangzhou510006China

Artificial synapse inspired by the biological brain has great potential in the field of neuromorphic computing and artificial *** memristor is an ideal artificial synaptic device with fast operation and good ***,we have prepared a memristor device with Au/CsPbBr_(3)/ITO *** memristor device exhibits resistance switching behavior,the high and low resistance states no obvious decline after 400 switching *** memristor device is stimulated by voltage pulses to simulate biological synaptic plasticity,such as long-term potentiation,long-term depression,pair-pulse facilitation,short-term depression,and short-term *** transformation from short-term memory to long-term memory is achieved by changing the stimulation *** addition,a convolutional neural network was constructed to train/recognize MNIST handwritten data sets;a distinguished recognition accuracy of~96.7%on the digital image was obtained in 100 epochs,which is more accurate than other memristor-based neural *** results show that the memristor device based on CsPbBr3 has immense potential in the neuromorphic computing system.

关键词： Memristor CsPbBr_(3) Resistive switching Artificial synapse Neuromorphic computing

Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1199-1208页

作者： Xinyi Yang Xu Zheng Yuqi Zhu Xiaying Zhao Jun Liu jiangna Xun Songhua Yuan Jun chen Hanyu Pan Jinlong Yang Jing Wang Zhimin Liang Xiaoting Shen Yue Liang Qinru Lin Huitong Liang min Li Fei Peng Daru Lu Jianqing Xu Hongzhou Lu Shibo jiang ping Zhao Huanzhang Zhu State Key Laboratory of Genetic Engineering and Engineering research center of Gene Technology Ministry of EducationInstitute of GeneticsSchool of Life SciencesYiwu Research InstituteFudan UniversityShanghaiChina Department of Microbiology Faculty of Naval MedicineNaval Medical UniversityShanghai 200433China Scientific research center Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Department of Infectious Diseases and Immunology Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Changzheng Hospital Naval Medical UniversityShanghaiChina Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) Shanghai Institute of Infectious Disease and BiosecuritySchool of Basic Medical SciencesFudan UniversityShanghaiChina Department of Infectious Diseases and Nursing research Institution National Clinical Research Center for Infectious DiseasesThe Third People’s Hospital of ShenzhenShenzhenGuangdongChina

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes multi-organ damage,which includes hepatic dysfunction,as observed in over 50%of COVID-19 *** I converting enzyme(peptidyl-dipeptidase A)2(ACE2)is the primary receptor for SARS-CoV-2 entry into host cells,and studies have shown the presence of intracellular virus particles in human hepatocytes that express ACE2,but at extremely low ***,we asked if hepatocytes might express receptors other than ACE2 capable of promoting the entry of SARS-CoV-2 into *** address this question,we performed a genome-wide CRISPR-Cas9 activation library screening and found that Asialoglycoprotein receptor 1(ASGR1)promoted SARS-CoV-2 pseudovirus infection of HeLa *** Huh-7 cells,simultaneous knockout of ACE2 and ASGR1 prevented SARS-CoV-2 pseudovirus *** the immortalized THLE-2 hepatocyte cell line and primary hepatic parenchymal cells,both of which barely expressed ACE2,SARSCoV-2 pseudovirus could successfully establish an ***,after treatment with ASGR1 antibody or siRNA targeting ASGR1,the infection rate significantly dropped,suggesting that SARS-CoV-2 pseudovirus infects hepatic parenchymal cells mainly through an ASGR1-dependent *** confirmed that ASGR1 could interact with Spike protein,which depends on receptor binding domain(RBD)and N-terminal domain(NTD).Finally,we also used Immunohistochemistry and electron microscopy to verify that SARS-CoV-2 could infect primary hepatic parenchymal *** inhibiting ASGR1 in primary hepatic parenchymal cells by siRNA,the infection efficiency of the live virus decreased ***,these findings indicate that ASGR1 is a candidate receptor for SARS-CoV-2 that promotes infection of hepatic parenchymal cells.

关键词： ACE2 infection glycoprotein

Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao chen Jing-Yu Tang Rui-Rui Fan Qiang Li Gong Li Dong Liu Zheng-Yao Jin Xing-Zhu Cui Tian-Xiang chen Yi-Wei Yang Rong Liu Han Yi Yang Li Zhen Yang Qi An Hao-Fan Bai jiang-Bo Bai Jie Bao ping Cao Qi-ping chen Zhen chen Zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Wei-Hua Jia Hao-yu jiang Wei jiang Zhi-jie jiang Ling Kang Bo Li Chao Li Jia-Wen Li Xiao Li Jie Liu Shu-Bin Liu Guang-Yuan Luan Chang-Jun Ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Xin Tan Li-Jiao Wang Peng-cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Mo-Han Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Yue Zhang Zhi-Yong Zhang Mao-Yuan Zhao Lu-ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science center Dongguan 523803China school of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China university of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the china Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

Corrigendum to"Crystal structure of RNA helicase from Saint Louis encephalitis virus and discovery of its inhibitors"[Genes Dis 10(2023)389-392]

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Genes & Diseases 2024年第3期11卷 484-484页

作者： De-ping Wang Fang-Ying jiang Xian-Yan Zeng Yu-Jie Liu Rong Zhao Mei-Yue Wang Jing Luo chen chen Yong Zhu Ji-min Cao Key Laboratory of Cellular Physiology at Shanxi Medical university Ministry of Educationand the Department of PhysiologyShanxi Medical UniversityTaiyuanShanxi 030001China College of Life Sciences Chongqing Medical UniversityChongqing 400016China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesTianjin Medical UniversityTianjin300070China Department of Rheumatology The Second Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China

We're very sorry for missing a funding program in funding ***,we would like to add this program:The Natural Science Foundation of Tianjin(china)(No.21JCQNJCO1890)from Tianjin Science and Technology in the first *** au... 详细信息

关键词： section. Tianjin funding

累积移动量表在住院老年患者中的汉化及信效度检验

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中国实用护理杂志 2024年第18期40卷 1418-1423页

作者：梁宇琪邹敏田冰洁刘奕艳陈华王萍姜丽萍上海交通大学护理学院上海200025 上海交通大学医学院附属新华医院护理部上海200092 上海市杨浦区控江医院护理部上海200093

目的检验累积移动量表(CAS)中文版的信效度及对住院老年患者移动能力评估的效果,为评估患者住院期间基础移动能力提供依据。方法采用横断面研究方法,经作者授权、遵循WHO的量表跨文化翻译流程,形成中文版累积移动量表。采用便利抽样法,... 详细信息

目的检验累积移动量表(CAS)中文版的信效度及对住院老年患者移动能力评估的效果,为评估患者住院期间基础移动能力提供依据。方法采用横断面研究方法,经作者授权、遵循WHO的量表跨文化翻译流程,形成中文版累积移动量表。采用便利抽样法,于2021年3—9月选取上海交通大学医学院附属新华医院和上海市杨浦区控江医院414例住院老年患者为研究对象,采用Cronbachα系数检验量表内部一致性,线性加权Kappa评价评分者间信度,以Barthel指数中移动能力相关条目总分为校标进行校标效度检验。结果414例患者中,男221例,女193例,年龄(76.67±9.98)岁。122例(29.5%)CAS得分为满分6分,基础移动能力正常,89例(21.5%)为0分,能力完全丧失,其余203例患者为1~5分,基本移动能力不同程度下降。中文版CAS的Cronbachα系数为0.952,各条目及总分评分者间加权Kappa均>0.85;以Barthel指数为校标,其校标效度r=0.935(P23~0.944,均P<0.01)。结论中文版CAS信效度较好,条目表达简明清晰,易操作,适合作为医护人员快速评估住院老年患者的基本移动能力初步筛查工具。

关键词：住院病人老年患者累积移动量表基本移动能力信度效度

Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in china:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan Liu Rui-Xia Ma Xian-Bao Cao Hua Zhang Shui-Hong Zhou Wei-Hong jiang Yan jiang Jing-Wu Sun Qin-Tai Yang Xue-Zhong Li Ya-Nan Sun Li Shi min Wang Xi-cheng Song Fu-Quan chen Xiao-Shu Zhang Hong-Quan Wei Shao-Qing Yu Dong-Dong Zhu Luo Ba Zhi-Wei Cao Xu-ping Xiao Xin Wei Zhi-Hong Lin Feng-Hong chen Chun-Guang Shan Guang-Ke Wang Jing Ye Shen-Hong Qu Chang-Qing Zhao Zhen-Lin Wang Hua-Bin Li Feng Liu Xiao-Bo Cui Sheng-Nan Ye Zheng Liu Yu Xu Xiao Cai Wei Huang Ru-Xin Zhang Yu-Lin Zhao Guo-Dong Yu Guang-Gang Shi Mei-ping Lu Yang Shen Yu-Tong Zhao Jia-Hong Pei Shao-Bing Xie Long-Gang Yu Ye-Hai Liu Shao-Wei Gu Yu-cheng Yang Lei cheng Jian-Feng liu Graduate school of Beijing university of Chinese medicine BeijingChina Department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina Department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina Department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina Department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina Department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial center for Disease Control and Prevention LanzhouChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina Department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

Chinese clinical practice guidelines for ultrasound-guided irreversible electroporation of liver cancer(version 2022)

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 462-471页

作者： min Xu Li-Ting Xie Yue-Yong Xiao ping Liang Qi-Yu Zhao Zhong-min Wang Wei-Lu Chai Ying-Tian Wei Lin-Feng Xu Xiao-Kun Hu ming Kuang Li-Zhi Niu chen-Guo Yao Hai-Ying Kong Guo Tian Xiao-Yan Xie Xin-Wu Cui Dong Xu Jun Zhao Tian-An jiang The Interventional Diagnosis and Treatment Group of the Ultrasonic medicine Branch of Chinese Medical Association,The Nanoknife Tumor Ablation Society of the Interventional minimally Invasive Therapy Special Committee of china medicine Education Association Department of Ultrasound medicine First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory of Pulsed Power Translational medicine of Zhejiang Province HangzhouZhejiang 310003China Department of Radiology The First Medical CenterChinese PLA General HospitalBeijing 100000China Department of Radiology The Fifth Medical CenterChinese PLA General HospitalBeijing 100853China Department of Interventional Radiology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Interventional Radiology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Department of the Interventional Medical center the Affiliated Hospital of Qingdao UniversityQingdao 266000China Division of Interventional Ultrasound The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Department of Oncology Affiliated Fuda Cancer HospitalJinan UniversityGuangzhou 510665China school of Electrical Engineering Chongqing UniversityChongqing 400033China Department of Anesthesiology First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Medical Ultrasonics Institute of Diagnostic and Interventional UltrasoundThe First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Department of Medical Ultrasound Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Interventional Ultrasound The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Department of Anatomy School of Basic MedicineHuazhong University of Science and TechnologyWuhan 430030China 不详

Introduction Liver cancer remains a global health challenge,and its incidence is increasing *** is estimated that by 2025,more than one million individuals will be affected by liver cancer annually[1,2].In recent years,ablation has become a widely accepted treatment option for patients with primary and secondary liver malignancies[3].The commonly used ablation method for liver cancer is thermal ablation,including radiofrequency ablation.

关键词： cancer liver Liver

Design,synthesis and antitumor evaluation of a new series of N-substi-tuted-thiourea derivatives

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Acta Pharmacologica Sinica 2006年第9期27卷 1259-1271页

作者： Jian LI~2 Jin-zhi TAN~2 Li-li chen~2 Jian ZHANG~2 Xu SHEN~(2,3)Chang-lin MEI~(4,6)Li-li FU~4 Li-ping LIN~5 Jian DING~5 Bing XIONG~2 Xi-shan XIONG~4 Hong LIU~(2,6)Xiao-min LUO~(2,6)Hua-liang jiang~(2,3)2 Drug Discovery and Design Centre,State Key Laboratory of Drug research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 201203.china 3 school of Pharmacy.East china university of Science and Technology,Shanghai 200237,china 4 Division of Nephrology,Department of Internal medicine,Changzheng Hospital,Second Military Medical university,Shanghai 200003,china 5 Division of Antitumor Pharmacology,Shanghai Institute of Materia Medica,Shanghai 201203.china Drug Discovery and Design Centre State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China school of Pharmacy East China University of Science and Technology Shanghai China Division of Nephrology Department of Internal Medicine Changzheng Hospital Second Military Medical University Shanghai China Division of Antitumor Pharmacology Shanghai Institute of Materia Medica Shanghai China

Aim:To design and synthesize a novel class of protein tyrosine kinase inhibitors,featuring the N-(2-oxo-1,2-dihydroquinolin-3-yl-methyl)-thiourea ***:First,compounds 1 and 2 were identified using the virtual screeningapproach in conjunction with binding assay based on surface plasmon ***,3 regions of compounds 1 and 2 were selected for chemical *** compounds were characterized potent inhibitory activities toward thehuman lung adenocarcinoma cell line SPAC ***:Forty new compounds(1-2,3a-g,4a-w,and 5a-l)were designed,synthesized and *** com-pounds(1,3e,41,4w,5a,and 5b)were found to show promising inhibitory activityagainst the SPAC1 tumor cell *** inhibitory activity of compound 5aincreases approximately 10 times more than that of the original compound ***:This study provides a promising new template with potential antitu-mot activity.

关键词： N-substituted-thiourea derivatives antitumor SPAC1 tyrosine kinase inhibitor virtual screening

电针预处理对异丙肾上腺素诱发小鼠急性心肌缺血的保护作用研究

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时珍国医国药 2024年第1期35卷 228-232页

作者：蒋薪吉李美平陈卓彬黄丽尤行宏湖北中医药大学基础医学院湖北武汉430065

目的探讨电针预处理“额旁1线”对异丙肾上腺素(ISO)诱发小鼠急性心肌缺血的保护效应及可能机制。方法 30只雄性昆明小鼠随机分为对照组、模型组和电针预处理组,每组10只。模型组和电针预处理组通过背部皮下多点位注射ISO诱发小鼠急性... 详细信息

目的探讨电针预处理“额旁1线”对异丙肾上腺素(ISO)诱发小鼠急性心肌缺血的保护效应及可能机制。方法 30只雄性昆明小鼠随机分为对照组、模型组和电针预处理组,每组10只。模型组和电针预处理组通过背部皮下多点位注射ISO诱发小鼠急性心肌缺血模型,对照组皮下注射生理盐水。电针预处理组电针小鼠头穴双侧“额旁1线”区域,疏密波,频率2 Hz/100 Hz,强度2mA,每次电针30min,每天1次,连续7天,第6天和第7天电针后注射ISO造模。末次给药造模2h后,对小鼠进行心电图检测;取心肌组织经苏木素-伊红(HE)和masson染色观察小鼠心肌形态学变化,透射电镜观察心肌细胞超微结构变化;采用酶联免疫吸附试验(ELISA)测定小鼠心肌组织白细胞介素-6(IL-6),肿瘤坏死因子-α(TNF-α)及血清肌酸激酶同工酶MB(CK-MB)、肌钙蛋白cTnI含量。结果模型组小鼠造模后心电图T波高度降低、J点位移明显(P<0.01),电针预处理组小鼠造模后心电图T波高度、J点电压减小不显著,与对照组相比,模型组小鼠心肌TNF-α、IL-6以及血清CK-MB、cTnI均显著增高(P<0.01),形态学观察显示缺血心肌组织出现明显损伤。与模型组相比,电针预处理组小鼠血清,CK-MB、cTnI及血清心肌TNF-α、IL-6水平明显降低(P<0.01),形态学观察缺血心肌损伤程度显著减轻。结论电针预处理“额旁1线”能明显改善急性心肌缺血小鼠心电图T波及J点偏移,减轻心肌病理损伤程度,降低心肌CK-MB、cTnI及血清IL-6、TNF-α含量等发挥心肌保护作用。

关键词：心肌缺血电针预处理异丙肾上腺素额旁1线