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DAPK2 promotes autophagy to accelerate the progression of ossification of the posterior longitudinal ligament through the mTORC1.complex

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BIOCELL 2024年第9期48卷 1389-1400页

作者： LEI shi JIANshi YIN YU CHEN JIANGANG shi JINHAO MIAO Department of Spine Surgery Shanghai Changzheng HospitalShanghai200003China Department of Orthopedics The 967th Hospital of Chinese People’s Liberation ArmyDalian116000China

Background:Ossification of the posterior longitudinal ligament(OPLL)is a prevalent condition in *** death-associated protein kinase 2(DAPK2)is known to play roles in cellular apoptosis and autophagy,its specific contributions to the advancement of OPLL are not well ***:Ligament fibroblasts were harvested from patients diagnosed with *** such as real-time reverse transcriptasepolymerase chain reaction(RT-qPCR)and Western blot analysis were employed to assess DAPK2 levels in both ligament tissues and cultured *** extent of osteogenic differentiation in these cells was evaluated using an alizarin red S(ARS)***,the expression of ossification markers and autophagy markers was *** autophagic activity was further analyzed through LC3 immunofluorescence and transmission electron microscopy(TEM).An in vivo heterotopic bone formation assay was conducted in mice to assess the role of DAPK2 in ***:Elevated DAPK2 expression was confirmed in both OPLL patient tissues and derived fibroblasts,in contrast to non-OPLL *** of DAPK2 significantly curtailed osteogenic differentiation and autophagy in these fibroblasts,evidenced by decreased levels of LC3,and Beclin1.and reduced autophagosome ***,DAPK2 was found to inhibit the mechanistic target of the rapamycin complex 1.mTORC1.complex’s *** vivo studies demonstrated that DAPK2 facilitates ossification,and this effect could be counteracted by the mTORC1.inhibitor ***:DAPK2 enhances autophagy and osteogenic processes in OPLL through modulation of the mTORC1.pathway.

关键词： Ossification of the posterior longitudinal ligament DAPK2 Autophagy mTORC1

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Biophysical-driven piezoelectric and aligned nanofibrous scaffold promotes bone regeneration by re-establishing physiological electrical microenvironment

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Nano Research 2024年第8期17卷 7376-7393页

作者： Aoao Wang Xinbo Ma Yafeng Yang Guoliang shi Liwei Han Xiantong Hu Rui shi Jun Yan Quanyi Guo Yantao Zhao Senior Department of Orthopedics the Fourth Medical Center of PLA General HospitalBeijing 100048China Department of Chemistry Capital Normal UniversityBeijing 100048China National Center for Orthopaedics Beijing Research Institute of Traumatology and OrthopaedicsBeijing Jishuitan HospitalCapital Medical UniversityBeijing 100035China Xijing 986 Hospital Department The Fourth Military Medical UniversityXi'an 710032China Institute of Orthopedics Chinese PLA General HospitalBeijing Key Laboratory of Regenerative Medicine in OrthopedicsKey Laboratory of Musculoskeletal Trauma&War Injuries PLABeijing 100853China

The initial healing stages of bone fracture is a complex physiological process involving a series of spatially and temporally overlapping events,including pathogen clearance,immunological modulation,and *** this study,we have developed a piezoelectric and aligned nanofibrous scaffold composed of ZnO@PCL/PVDF with multiple antibacterial,immunomodulatory,and osteogenic effects using electrospinning *** scaffold’s piezoelectric signal output under ultrasound(US)control can be similar to the physiological electrical signals of healthy bone tissue,creating a truly biomimetic electrical microenvironment in the bone *** vitro studies have shown that ZnO@PCL/PVDF scaffold significantly enhances the proliferation,migration,and osteogenic differentiation of MC3T3-E1.cells under piezoelectric drive provided by ***,the scaffold exhibits inhibitory effects on the growth of *** and ***,as well as the ability to induce M2 macrophage polarization,indicating potent antibacterial and immunomodulatory *** vivo experiments demonstrated that the ZnO@PCL/PVDF scaffold can accelerate the repair of mandibular defects in rats,effectively inhibit bacterial colonization,and reduce inflammatory ***,this study confirms that the newly developed ZnO@PCL/PVDF scaffold effectively promotes bone repair by truly mimicking the endogenous electrical microenvironment and precisely regulating the temporospatial disorders of initial bone healing,thus providing a simple and effective solution for bone defects.

关键词： piezoelectricity bone defect bacterial infection ZnO nanoparticles immunomodulation osteogenesis

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Privacy-Preserving Frank-Wolfe on Shuffle Model

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Acta Mathematicae Applicatae Sinica 2024年第4期40卷 887-907页

作者： Ling-jie ZHANG shi-song WU Hai ZHANG School of Mathematics Northwest UniversityXi’an 710127China School of Mathematics and Information Science Baoji University of Arts and SciencesBaoji 721013China China Southern Power Grid Artificial Intelligence Technology Company Limited Guangzhou 510700China

In this paper,we design the differentially private variants of the classical Frank-Wolfe algorithm with shuffle model in the optimization of machine *** weak assumptions and the generalized linear loss(GLL)structure,we propose a noisy Frank-Wolfe with shuffle model algorithm(NoisyFWS)and a noisy variance-reduced Frank-Wolfe with the shuffle model algorithm(NoisyVRFWS)by adding calibrated laplace noise under shuffling scheme in thel_(p)(p∈[1.2])-case,and study their privacy as well as utility guarantees for the H?lder smoothness *** particular,the privacy guarantees are mainly achieved by using advanced composition and privacy amplification by *** utility bounds of the Noisy FWS and NoisyVRFWS are analyzed and obtained the optimal excess population risksO(n-(1.α/4α+log(d)√log(1.δ)/n∈and O(n-1.α/4α+log(d)√log1.+δ)/n^(2)∈with gradient complexity O(n(1.α)^(2)/4α^(2)forα∈[1.√3,1..It turns out that the risk rates under shuffling scheme are a nearly-dimension independent rate,which is consistent with the previous work in some *** addition,there is a vital tradeoff between(α,L)-Holder smoothness GLL and the gradient *** linear gradient complexity O(n)is showed by the parameterα=1.

关键词： differential privacy Frank-Wolfe algorithm privacy amplification shuffle model

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Highly efficient tunable photodetector with a bipolar response in van der Waals heterojunctions

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Science China(Technological Sciences) 2024年第2期67卷 639-646页

作者： shi ChaoFan ZHANG shi XIAO KeNing ZHANG LiBo HAN Li ZHU YuLin TANG WeiWei LIU ChangLong LI GuanHai CHEN XiaoShuang College of Physics and Optoelectronic Engineering Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences Hangzhou310024China State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China

The heterojunction integration of two-dimensional(2D)materials via van der Waals(vdW)forces,unencumbered by lattice and processing constraints,constitutes an efficacious approach to enhance the overall optoelectronic performance of photodetectors,due to an assortment of distinctive light-matter ***,vdW heterojunction photodetectors based on transition metal dichalcogenides(TMDs)face an inevitable trade-off between low dark currents and high responsivity,curtailing the application potential of myriad novel optoelectronic components in sensing,spectral,and communication *** this study,we present the successful actualization of a highly sensitive,self-powered,and gate-tunable bipolar response *** mechanisms underlying photocurrent generation were scrutinized via bias-,power-,and position-dependent mapping photoresponse measurements,identifying the photovoltaic effect,which is attributable to the Schottky junction’s built-in electric field,as the predominant *** prototype Au-WS2-graphene photodetector exhibits a remarkable light on/off ratio of 1.2×1.^(6),a specific detectivity of 6.1.×1.^(1.)cm H^(z1.2)W^(-1.with 20μs response time at 638 *** wide gate-tunable responsivity provides an adjustability scope,ranging from 0.9 to 3.1.A W^(-1..Notably,the device demonstrates an exceptional linear photocurrent response,with a linear dynamic range(LDR)value approximating 1.0 dB,which significantly surpasses that of other photodetectors based on TMDs.

关键词： WS2/graphene van der Waals heterojunction gate-tunable bipolar response

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Promotion effects of salt-alkali on ammonia volatilization in a coastal soil

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Pedosphere 2024年第1期34卷 191-199页

作者： Zhenqi shi Dongli SHE Yongchun PAN Yongqiu XIA College of Agricultural Science and Engineering Hohai UniversityNanjing 210098China Jiangsu Province Engineering Research Center for Agricultural Soil-Water Efficient Utilization Carbon Sequestration and Emission ReductionNanjing 210098China Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China

Coastal ecosystems are highly susceptible to salt-related problems due to their formation process and geographical location. As such ecosystems are the most accessible land resources on Earth, clarifying and quantifying the effects of salt-alkali conditions on N concentration and ammonia(NH_(3)) volatilization are pivotal for promoting coastal agricultural productivity. The challenge in establishing this effect is to deter{1.e how salt-alkali conditions impact NH_(3) volatilization through direct or indirect interactions. An incubation experiment using a coastal soil from a paddy farmland, combined with the structural equation modeling(SEM) method, was conducted to reveal the net effects of salt-alkali on NH_(3) volatilization and the role of environmental and microbial factors in mutual interaction networks. The specific experimental design consisted of four salt treatments(S1. S2, S3, and S4: 1., 3‰, 8‰, and 1.‰ NaCl by mass of soil, respectively), four alkaline treatments(A1. A2, A3, and A4: 0.5‰, 1., 3‰, and 8‰ NaHCO_(3)by mass of soil, respectively) and a control without NaCl or NaHCO_(3) addition(CK), and each treatment had three urea concentrations(N1. N2, and N3: 0.05, 0.1., and 0.1. g N kg^(-1. soil,respectively) and three replicates. At the N1. N2, and N3 levels, NH_(3)volatilization increased by 9.31.–34.98%, 3.07%–26.92%, and 2.99%–43.61. as the NaCl concentration increased from 1. to 1.‰, respectively, compared with CK. With an increase in the NaHCO_(3)concentration from 0.5‰ to 8‰, NH_(3) volatilization increased by 8.36%–56.46%, 5.49%–30.1.%, and 30.72%–73.1.% at the N1. N2, and N3 levels, respectively, compared with CK. According to the SEM method, salinity and alkalinity had positive direct effects on NH_(3)volatilization, with standardized path coefficients of 0.40 and 0.1., *** the total effects(net positive and negative effects) in the SEM results, alkalinity had a greater influence than salinity(total standardized coefficien

关键词： alkalinity coastal ecosystem NH_(3)emission N-transforming microbe salinity structural equation modeling

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General Method of Combining Grover and Simon for Attacking Block Ciphers

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China Communications 2024年第6期21卷 237-245页

作者： Fu Xiangqun Bao Wansu shi Jianhong Li Tan Henan Key Laboratory of Quantum Information and Cryptography PLA SSF IEUZhengzhou 450001China Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China

The compatibility of different quantum algorithms should be considered when these algorithms are *** this paper,the method of combining Grover and Simon is studied for the first time,under some preconditions or ***,we give two preconditions of applying Grover’s algorithm,which ensure that the success probability of finding the marked element is close to ***,based on these two preconditions,it is found out that the success probability of the quantum algorithm for FXconstruction is far less than ***,we give the design method of the Oracle function,and then present the general method of combining Grover and Simon algorithm for attacking block ciphers,with success probability close to 1.

关键词： block ciphers post-quantum crypto quantum algorithms

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Room-temperature hydrogen adsorption in Pd nanoparticle decorated UiO-66-NH2 via spillover

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Particuology 2024年第10期93卷 309-315页

作者： Jingchuan Wang Junhong Luo Yong Yao Jiangfeng Song Yan shi Institute of Materials China Academy of Engineering PhysicsJiangyou621908China

To improve room-temperature hydrogen storage, palladium (Pd) nanoparticles were innovatively decorated by carbon bridge onto the amino-group functioned Zr-terephthalate metal-organic framework (MOF) UiO-66 to reduce the diffusion energy barrier and then improve the hydrogen spillover effect. Powder X-ray diffraction shows broad Pd peak and retained UiO-66-NH_(2) integrity after Pd decoration. The hydrogen uptake capacity show that UiO-66-NH_(2)-Pd exhibits best hydrogen storage performance than UiO-66-NH_(2) and pristine UiO-66. The hydrogen up taken in Pd decorated UiO-66 (UiO-66-NH_(2)-1.d) was close to 4 wt% under 20 MPa at room temperature. Density functional theory (DFT) calculations show that hydrogen adsorption energy of UiO-66-NH_(2)-Pd was −0.5897 eV, which was much lower than that of UiO-66-NH_(2) (−0.371. eV) and UiO-66 (−0.2975 eV). Ultimately, Pd decorated NH_(2) group functioned UiO-66 enable improve storage capacities through hydrogen spillover under ambient conditions which could satisfy the demand for sustainable energy, especially for the long-term storage energy media.

关键词： Hydrogen storage UiO-66-NH_(2) Pd decorated Spillover

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Interplay between geometric and electronic structures of Pt entities over TiO_(2) for CO oxidation

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Science China Chemistry 2024年第2期67卷 705-714页

作者： Xixiong Zhang Wen shi Shaobo Han Yong Li Wenjie Shen School of Chemistry Dalian University of TechnologyDalian116024China State Key Laboratory of Catalysis Dalian Institution of Chemical PhysicsChinese Academy of SciencesDalian116023China

Monodispersed Pt colloids with a mean size of 2 nm were deposited uniformly on the {110} facets of a rod-shaped rutile TiO_(2),forming a well-defined Pt/TiO_(2) *** treatment of this precursor at elevated temperatures re-dispersed the Pt particles into clusters and ***-calcination at 673 K partially oxidized the Pt particle surface,while calcination at 773 K yielded Pt Oxclusters of 1.6 nm in 7–8 atomic *** calcination at 873 K formed a mixture of raft-like PtO_(x) clusters(1.6 nm,1–2 atomic layers) and cationic *** tested for CO oxidation at 373 K,the Pt particles showed a higher activity than the Pt Oxclusters,whereas the cationic single-atoms were much less *** H_(2)-reduction at 473 K converted the partially oxidized Pt particles into the metallic species,but they were encapsulated by TiO_(2)–xoverlayers because of the strong metal–support interactions,which decreased the activity dramatically.H_(2)-reduction of the PtO_(x) clusters at473 K enhanced the fraction of metallic Pt species without changing the size and geometry,and promoted the activity substantially.H_(2)-treatment of Pt single-atoms at 473 K increased the activity only moderately because most Pt species still kept at cationic *** results straightforwardly differentiated the catalytic behavior of Pt particles,clusters and single-atoms at the same metal loading and over the same TiO_(2) support,and further demonstrated that the electronic structures of Pt entities played a decisive role in the catalytic oxidation,in addition to the specified sizes.

关键词： Pt/TiO_(2)catalyst size effect Pt clusters active sites electronic structures CO oxidation

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Infrared radiation characteristics of dagger-type hypersonic missile

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Chinese Journal of Aeronautics 2024年第4期37卷 137-150页

作者： Xubo DU Qingzhen YANG Haoqi YANG Jin BAI Yongqiang shi School of Power and Energy Northwestern Polytechnical UniversityXi’an 710129China

Hypersonic vehicles emit strong infrared radiation from their high-temperature exhaust plume and body, which is critical for infrared early warning, tracking, and guidance. In this work, a comprehensive analysis is conducted on the factors involved in air dissociation reaction within the shock layer of hypersonic missile heads, as well as the multi-component afterburning effect of the exhaust plume. A novel Reverse Monte Carlo Method(RMCM) is proposed for infrared radiation calculation, which utilizes two-dimensional Low-Discrepancy Sequences(LDS) to improve computational accuracy. The numerical calculations for a dagger-type missile show that afterburning reactions increase the temperature on the centerline of the outlet exhaust plume by about 1.00 K. The total infrared radiation intensity of the missile is the highest in the 1.3 μm band, with the hightemperature wall of the nozzle being the primary source of solid radiation, and gas radiation primarily coming from H_(2)O. The radiation intensity of the missile exhaust plume in the 3–5 μm band is the highest, with radiation sources primarily coming from CO_(2), CO, and HCl. Afterburning reactions of the exhaust plume increase the total infrared radiation intensity of the missile by about 0.7times. These results can provide reference for the detection and guidance of hypersonic missiles.

关键词： Hypersonic vehicles Infrared radiation Monte Carlo methods Low-discrepancy sequences Exhaust plume Afterburning

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Role of oncogenic long noncoding RNA KCNQ1.T1.in colon cancer

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Oncology Research 2024年第3期32卷 585-596页

作者： GANG LIU LEI shi BIN WANG ZEHUI WU HAIYUAN ZHAO TIANYU ZHAO LIANGHUI shi Department of Gastrointestinal Surgery First ffiliated Hospital of Wannan Medical CollegeWuhu241001China Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences Stomatological Hospital of Chongqing Medical UniversityChongqing401147China

The role of lncRNA KCNQ1.opposite strand/antisense transcript 1.KCNQ1.T1.in colon cancer involves various tumorigenic processes and has been studed ***,the mechanism by which it promotes colon cancer remains *** vector pSEB61.was retroftted in established HCT1.6 siKCN and SW480-siKCN cells to silence KCNQ1.*** proliferation was measured using CCK8 assay,and flow cytometry(FCM)detected cell cydle *** sequencing(RNA Seq)analysis showed differentially expressed genes(DEGs).Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were carried out to analyze enriched functions and signaling ***-qPCR,immunofluorescence,and western blotting were carried out to validate downstream gene *** effects of tumorigenesis were evaluated in BALB/c nude mice by tumor *** data revealed that the silencing of KONQ1.T1.in HCT1.6 and SW480 cells slowed cell growth and decreased the number of cells in the G2/M ***-Seq analysis showed the data of DEGs enriched in various GO and KEGG pathways such as DNA replication and cell *** qPCR,immunofluorescence,and western blotting confirmed downstream CCNE2 and PCNA gene ***1.6 siKCN cells signifcantly suppressed tumorigenesis in BALB/c nude *** study suggests that lncRNA KCNQ1.T1.may provide a promising therapeutic strategy for colon cancer.

关键词： lncRNA KCNQ1.T1 Colon cancer HCT1.6 cells Tumorigenesis

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