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Frontiers of Engineering Management 2024年第3期11卷 542-567页

作者： Hongyan DUI Xinmin WU Shaomin WU min xie School of Management Zhengzhou UniversityZhengzhou 450001China Kent Business School University of KentCanterburyKent CT27FSUK Department of Systems Engineering and Engineering Management City University of Hong KongHong Kong 999077China

Numerous maintenance strategies have been proposed in the literature related to *** paper focuses on the utilization of reliability importance measures to optimize maintenance *** analyze maintenance strategies based on importance measures and identify areas lacking sufficient *** paper presents principles and formulas for advanced importance measures within the context of optimizing maintenance ***,it classifies methods of maintenance strategy optimization according to importance measures and outlines the roles of these measures in various maintenance ***,it discusses potential challenges that optimization of maintenance strategies based on importance measures may encounter with future technologies.

关键词： maintenance strategy importance measure reliability maintenance cost

Experimental and numerical study on protective effect of RC blast wall against air shock wave

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Defence Technology（防务技术） 2024年第1期31卷 567-579页

作者： Xin-zhe Nian Quan-min xie Xin-li Kong Ying-kang Yao Kui Huang State Key Laboratory of Precision Blasting Jianghan UniversityWuhan430056China Hubei Key Laboratory of Blasting Engineering Jianghan UniversityWuhan430056China Hubei(Wuhan)Institute of Explosion and Blasting Technology Jianghan UniversityWuhan430056China College of Defense Engineering Army Engineering University of PLANanjing210007China Institute of Defense Engineering AMSPLALuoyang471023China

Prototype experiments were carried out on the explosion-proof performance of the RC blast *** mass of TNT detonated in the experiments is 5 kg and 20 kg *** shock wave overpressure was tested in different *** above experiments were numerically simulated,and the simulated shock wave overpressure waveforms were compared with that tested and given by CONWEP *** results show that the numerically simulated waveform is slightly different from the test waveform,but similar to CONWEP *** dimensional analysis and numerical simulation under different working conditions,the equation for the attenuation rate of the diffraction overpressure behind the blast wall was *** to the corresponding standards,the degree of casualties and the damage degree of the brick concrete building at a certain distance behind the wall can be determined when parameters are *** above results can provide a reference for the design and construction of the reinforced concrete blast wall.

关键词： Blast wall Shock wave Diffraction Overpressure Protection

Publication trends of Leber congenital amaurosis researches:a bibliometric study during 2002-2022

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1501-1509页

作者： Xiao-Xu Huang Yi-min Wang min-Yue xie Yi-Qing Sun Xiao-Huan Zhao Yu-Hong Chen Jie-Qiong Chen Si-Yang Han min-Wen Zhou Xiao-Dong Sun Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China National Clinical Research Center for Eye Disease Shanghai 200080China Shanghai Key Laboratory of Ocular Fundus Diseases Shanghai 200080China Shanghai Engineering Center for Visual Science and Photomedicine Shanghai 200080China Department of Ophthalmology Zhongshan HospitalFudan UniversityShanghai 200030China Beijing Tongren Hospital Capital Medical UniversityBeijing 100054China Eberly College of Science Penn State UniversityUniversity Park 16802-1503United States

AIM:To analyze the changes in scientific output relating to Leber congenital amaurosis(LCA)and forecast the study trends in this ***:All of the publications in the field of LCA from 2002 to 2022 were collected from Web of Science(WOS)*** analyzed the quantity(number of publications),quality(citation and H-index)and development trends(relative research interest,RRI)of published LCA research over the last two ***,VOSviewer software was applied to define the co-occurrence network of keywords in this ***:A total of 2158 publications were ultimately *** found that the focus on LCA kept rising and peaked in 2015 and 2018,which is consistent with the development trend of gene *** USA has contributed most to this field with 1162 publications,56674 citations and the highest H-index value(116).The keywords analysis was divided into five clusters to show the hotspots in the field of LCA,namely mechanism-related,genotype-related,local phenotype-related,system phenotype-related,and *** also identified gene therapy and antiretinal degeneration therapy as a major focus in recent ***:Our study illustrates historical research process and future development trends in LCA *** may help to guide the orientation for further clinical diagnosis,treatment and scientific research.

关键词： VOSviewer bibliometrics Leber congenital amaurosis gene therapy hotpots

Exploring the molecular mechanism of Solanum nigrum L in breast cancer treatment through network pharmacology and molecular docking validation

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Pharmacology Discovery 2024年第3期4卷 1-16页

作者： Mei Zheng Ju-min xie Hubei Key Laboratory of Renal Disease Occurrence and Intervention Hubei Polytechnic UniversityHuangshi 435003China

In 2020,breast cancer emerged as the leading type of cancer worldwide,surpassing lung cancer in the number of new *** high cost and frequent failure of current treatments due to drug resistance and other challenges underscore the urgent need for novel,affordable,efficient,and less toxic breast cancer therapies with fewer side *** study aims to investigate the molecular mechanisms by which Solanum Nigrum *** breast cancer,employing network pharmacology and molecular docking ***:The study identified the primary active compounds of Solanum Nigrum *** databases such as TCMSP,TCM-ID,NPASS,and *** of the compounds'targets was facilitated by the SwissADME website,while main breast cancer targets were sourced from the GeneCards,OMIM,and TTD *** identified drug-disease intersection targets were analyzed using the STRING platform to construct a protein interaction network,which was then visualized and refined to select hub targets using Cytoscape 3.9.0 *** Metascape database's MOCDE functional plugin was employed for identifying potential functional modules within the protein interaction ***,the DAVID database was utilized for GO and KEGG enrichment analyses of the intersection *** docking of key active compounds with core targets was performed using AutoDock Tools 1.5.7 ***,the GEPIA2.0 database was used for predicting overall survival curves of hub targets and conducting a pan-cancer ***:Eleven active compounds of Solanum Nigrum L.,including Diosgenin,Tigogenin,and Quercetin,were identified from traditional Chinese medicine *** discovered 113 targets common to both Solanum Nigrum *** breast *** Nigrum *** anti-breast cancer properties through interactions with 14 key targets,including SRC,PIK3R1,HSP90AA1,PIK3CA,AKT1,VEGFA,and *** interactions influence several critical signaling pathways,notably the cancer signaling pa

关键词： anti-cancer molecular docking network pharmacology Solanum Nigrum L

Secular trends of asthma mortality in China and the United States from 1990 to 2019

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Chinese Medical Journal 2024年第3期137卷 273-282页

作者： Xiaochen Li mingzhou Guo Yang Niu min xie Xiansheng Liu Department of Pulmonary and Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China NHC Key Laboratory of Respiratory Diseases WuhanHubei 430030China

Background:Asthma imposes a large healthcare burden in China and the United States(US).However,the trends of asthma mortality and the relative risk factors have not been comparatively analyzed between the *** aim of this study was to compare the mortality and risk factors between China and the ***:The deaths,and mortality rates of asthma in China and the US during 1990–2019 were obtained from the Global Burden of Disease Study *** age–period–cohort model was used to estimate these mortality rates based on a log-linear scale with additive age,period,and cohort *** population attributable fractions of risk factors for asthma were ***:In 1990–2019,the asthma mortality rate was higher in China than in the *** crude and age-standardized asthma mortality rates trended downward in both China and the US from 1990 to *** decline in mortality was more obvious in *** gap between the two countries was narrowing.A sex difference in asthma mortality was observed with higher mortality in males in China and females in the *** age effects showed that mortality increased with age in adults older than 20 years,particularly in the *** trends were generally observed in the period and cohort rate ratios in both countries,with China experiencing a more obvious *** and high body mass index(BMI)were the leading risk factors for asthma mortality in China and the US,*** attributable to occupational asthmagens and smoking decreased the most in China and the US,***:In 1990–2019,the asthma mortality rate was higher in China than in the US;however,the mortality gap has *** increased with age in *** improvements in asthma death risk with period and birth cohort were more obvious in China than in the ***,high BMI,and aging are major health problems associated with asthma *** role of occupational asthmagens in asthma mortality under

关键词： Asthma Mortality Global disease burden China the United States Age–period–cohort model

COVID-19 pandemic amplified mortality rates among adolescents with bipolar disorder through family-related factors

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World Journal of Clinical Cases 2024年第11期12卷 1929-1935页

作者： Zhuo-Fan Ye Yi-Han Hong Jian-Lin Yang Meng-Qing Tan Ju-min xie Zu-Cai Xu Department of Neurology The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Hubei Key Laboratory of Renal Disease Occurrence and Intervention Medical SchoolHubei Polytechnic UniversityHuangshi 435003Hubei ProvinceChina Psychological Children's Ward Mental Health Center of HuangshiHuangshi 435111Hubei ProvinceChina The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND Recently,a growing number of adolescents have been afflicted with mental disorders,with annual morbidity rates on the *** trend has been exacerbated by the global coronavirus disease 2019(COVID-19)pandemic,leading to a surge in suicide and self-harm rates among this *** To investigate the impact of the COVID-19 pandemic on adolescent bipolar disorder(BD),along with the underlying factors contributing to heightened rates of suicide and self-harm among *** A comprehensive statistical analysis was conducted utilizing clinical interviews and self-reports obtained from patients or their *** criteria for BDs were based on the Diagnostic and statistical manual of mental disorders,international classification of diseases-11,and the National institute of mental health research domain *** analyses were performed using SPSS 26.0 software,with significance set at P<*** A cohort of 171 adolescents diagnosed with BD between January 1,2018,and December 31,2022,was included in the *** gender distribution was 2.8:1(female to male),with ages ranging from 11 to 18 years *** factors contributing to adolescent BDs included familial influences,academic stress,genetic predisposition and exposure to school-related ***,a significant increase in suicide attempts and self-harm incidents was observed among adolescents with BD during the COVID-19 *** analysis indicated that the pandemic exacerbated familial discord and heightened academic stress,thereby amplifying the prevalence of suicidal behavior and self-harm among *** The COVID-19 pandemic has exacerbated familial tensions and intensified the incidence of suicide and self-harm among adolescents diagnosed with *** study underscores the urgent need for societal,familial and educational support systems to prioritize the well-being of adolescents and offers valuable insights and guidelines

关键词： Adolescents Bipolar disorder COVID-19 Suicide Self-harm

Investigating the molecular mechanism of Chelidonii Herba against liver cancer using network pharmacology and molecular docking validation

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Integrative Medicine Discovery 2024年第22期8卷 1-12页

作者： ming-Zhi Yang Zi-Xuan Yang Zhang Yu Ju-min xie Hubei Key Laboratory of Renal Disease Occurrence and Intervention Medical SchoolHubei Polytechnic UniversityHuangshi 435003China

Background:The molecular mechanism of Chelidonii Herba in treating hepatocellular carcinoma was investigated using network pharmacology and molecular docking ***:The main active components of Chelidonii Herba were screened using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform database,and the targets of these active ingredients were identified using the SwissTargetPrediction *** related to liver cancer were sourced from GeneCards,Therapeutic Targets Database,and Online Mendelian Inheritance in Man *** targets between the active components of Chelidonii Herba and liver cancer were determined using the jvenn online *** protein interaction network was analyzed via STRING database and visualized using Cytoscape *** targets were identified and further analyzed within the protein interaction *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted for the intersection targets using the DAVID database to correlate gene *** bubble diagrams for Gene Ontology enrichment analysis and circular diagrams for Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were generated using CNSknowall and SangerBox online *** docking and visualization were performed using AutoDockTools 1.5.7 and PyMOL 2.5.7 software,*** survival and pan-cancer analysis of core targets were conducted using the GEPIA2 online ***:Twelve active components of Chelidonii Herba were identified through screening.A total of 103 intersection targets and 12 core targets were found between these active constituents of Chelidonii Herba and liver *** Herba may exert its effects on liver cancer through these 12 core *** signaling pathways are implicated,including chemical carcinogen-receptor activation,endocrine resistance,HIF-1 signaling pathway,and proteoglycans in ***

关键词： Chelidonii Herba liver cancer network pharmacology molecular docking

Treatment of a patient with severe cerebral malaria during the COVID-19 pandemic in China:A case report

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World Journal of Clinical Cases 2024年第20期12卷 4419-4426页

作者： Yan-Fang Zhu Wen-Jing Xia Wei Liu Ju-min xie Department of Critical Care Medicine Huangshi Hospital of TCM(Infectious Disease Hospital)Huangshi 435000Hubei ProvinceChina Hubei Key Laboratory of Renal Disease Occurrence and Intervention Medical SchoolHubei Polytechnic UniversityHuangshi 435003Hubei ProvinceChina

BACKGROUND On June 30,2021,China received certification from the World Health Organization for malaria ***,this certification does not signify the absence of malaria within *** to the increasing frequency of international exchanges and collaborations,the threat of imported malaria persists in ***,the prevention and control of imported malaria have become a primary focus for our country to maintain its malaria elimination *** SUMMARY Herein,we present a case report of a 53-year-old Chinese man who worked in Africa for nearly two *** was diagnosed with malaria in the Democratic Republic of the Congo between November 19 and November 23,*** receiving effective treatment with oral antimalarial drugs,his condition improved,allowing him to return to *** was later admitted to our hospital on January 12,2023,during the coronavirus disease 2019 pandemic in Huangshi,*** a thorough evaluation of the patient's symptoms,clinical signs,imaging and laboratory test results,and epidemiological data,he was rapidly diagnosed with severe cerebral *** patient underwent successful treatment through a series of intensive care unit *** The successful treatment of this imported case of severe cerebral malaria provides a valuable reference for managing patients with similar malaria infections and has significant clinical implications.

关键词： Pernicious malaria Severe cerebral malaria Imported patients Traditional Chinese medicine Angong niuhuang Pill Case report

考虑发用电相似性的海上风电中长期双边协商交易优化决策模型

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电力系统自动化 2024年第14期48卷 42-51页

作者：谢敏李弋升董凯元谢宇星黄莹刘明波华南理工大学电力学院广东省广州市510640 广东省绿色能源技术重点实验室(华南理工大学) 广东省广州市510640

海上风电是未来最有潜力的可再生能源之一,但其出力具有随机性和波动性。为了更好地促进海上风电的市场化消纳,文中基于海上风电商与负荷聚合商间的中长期双边协商交易构建了优化决策模型。首先,通过时间序列相似性评估方法,为目标海上... 详细信息

海上风电是未来最有潜力的可再生能源之一,但其出力具有随机性和波动性。为了更好地促进海上风电的市场化消纳,文中基于海上风电商与负荷聚合商间的中长期双边协商交易构建了优化决策模型。首先,通过时间序列相似性评估方法,为目标海上风电寻找最优的用电负荷组合。其次,考虑需求响应备用容量配置和发用电曲线预测误差,构建了基于两阶段分布鲁棒优化的中长期交易优化决策模型,为海上风电配置适应其未来一段时间内出力特性的需求响应资源,并合理调整中长期交易曲线。最后,通过仿真算例验证了所提模型的有效性和实用性。

关键词：海上风电中长期交易双边协商时序曲线匹配分布鲁棒优化

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县域城乡融合的“晋江经验”

福州党校学报 2024年第1期 54-62页

作者：谢敏闽南理工学院福建泉州325000

2021年的中央一号文件中首次提出建立健全县域城乡融合的体制机制。2022年和2023年的中央一号文件中均提到了“县域城乡融合”的相关内容。由此可见“县域城乡融合”已成为新时代城镇化建设的重要突破口。福建晋江作为城乡融合较为典范... 详细信息

2021年的中央一号文件中首次提出建立健全县域城乡融合的体制机制。2022年和2023年的中央一号文件中均提到了“县域城乡融合”的相关内容。由此可见“县域城乡融合”已成为新时代城镇化建设的重要突破口。福建晋江作为城乡融合较为典范的县域城市,自改革开放以来就“始终坚持党和政府的正确引导,始终坚持做大做强民营经济推动地方发展、始终秉持包容性增长理念、致力于打造多元社会治理的格局”,走出了县域城乡融合的晋江之路。在国家提出“推动县域城乡融合”的大背景下,晋江县域城乡融合的经验不仅能丰富理论探索,也能从实践上对其他城市产生一定的借鉴作用,助力更多的县域城市实现融合发展。

关键词：县域城乡融合晋江经验新型城镇化包容性增长多元治理