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Plastic and Aesthetic research 2023年第1期10卷 322-338页

作者： Priscila C.Cevallos Daniel Najafali Thomas M.Johnstone mimi r.borrelli Oscar J.Manrique Gordon K.Lee rahim S.Nazerali Division of Plastic&reconstructive Surgery Department of SurgeryStanford University School of MedicinePalo AltoCA 94304USA Division of Plastic&reconstructive Surgery Department of SurgeryThe Warren Alpert Medical School of Brown UniversityProvidenceRI 02903USA Carle Illinois College of Medicine University of Illinois Urbana-ChampaignUrbanaIL 61801USA Geisel School of Medicine Dartmouth UniversityHanoverNH 03755USA Division of Plastic&reconstructive Surgery Department of SurgeryStrong Memorial HospitalUniversity of Rochester Medical CenterRochesterNY 14642USA

Breast reconstructive surgery utilizing free tissue transfer has revolutionized the restoration of aesthetic and functional outcomes for *** for the most routine free flap procedures,substantial hospital resources and costs are *** effectiveness of free flap surgery,along with any reconstructive procedure,hinges upon meticulous patient selection,thorough pre-operative planning,well-informed peri-operative decision-making,and diligent post-operative monitoring and care for the *** article presents a review of standard clinical care monitoring techniques during the post-operative period,as well as the diverse strategies currently employed for post-operative flap monitoring.

关键词： Flap monitoring flap salvage peri-operative monitoring post-operative monitoring

Numerical simulation of microwave-induced cracking and melting of granite based on mineral microscopic models

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1512-1524页

作者： Xiaoli Su Diyuan Li Junjie Zhao mimi Wang Xing Su Aohui Zhou School of resources and Safety Engineering Central South UniversityChangsha 410083China

This study introduces a coupled electromagnetic–thermal–mechanical model to reveal the mechanisms of microcracking and mineral melting of polymineralic rocks under microwave *** tests validate the rationality of the proposed *** microscopic mineral sections into the granite model for simulation shows that uneven temperature gradients create distinct molten,porous,and nonmolten zones on the fracture ***,the varying thermal expansion coefficients and Young's moduli among the minerals induce significant thermal stress at the mineral *** and biotite with higher thermal expansion coefficients are subjected to compression,whereas plagioclase with smaller coefficients experiences tensile *** the molten zone,quartz undergoes transgranular cracking due to theα–βphase *** local high temperatures also induce melting phase transitions in biotite and *** numerical study provides new insights into the distribution of thermal stress and mineral phase changes in rocks under microwave irradiation.

关键词： microwave numerical modeling microcracking phase change granite

GCArDTI:Drug–target interaction prediction based on a hybrid mechanism in drug SELFIES

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Quantitative Biology 2024年第2期12卷 141-154页

作者： Yinfei Feng Yuanyuan Zhang Zengqian Deng mimi Xiong School of Information and Control Engineering Qingdao University of TechnologyQingdaoChina Qingdao Municipal Hospital QingdaoChina

The prediction of the interaction between a drug and a target is the most critical issue in the fields of drug development and ***,there are still two challenges in current deep learning research:(i)the structural information of drug molecules is not fully explored in most drug target studies,and the previous drug SMILES does not correspond well to effective drug molecules and(ii)exploration of the potential relationship between drugs and targets is in need of *** this work,we use a new and better representation of the effective molecular graph structure,*** propose a hybrid mechanism framework based on convolutional neural network and graph attention network to capture multi-view feature information of drug and target molecular structures,and we aim to enhance the ability to capture interaction sites between a drug and a *** this study,our experiments using two different datasets show that the GCArDTI model outperforms a variety of different model algorithms on different *** also demonstrate the accuracy of our model through two case studies.

关键词： drug–target interaction drug SELFIES hybrid mechanism random forest

Enhancing the electrocatalytic performance of nitrate reduction to ammonia by in-situ nitrogen leaching

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Chinese Chemical Letters 2024年第2期35卷 564-569页

作者： mimi Fu Yini Mao Hua Wang Wei Luo Yimin Jiang Wei Shen Ming Li rongxing He College of Chemistry and Chemical Engineering Southwest UniversityChongqing 400715China

Electrochemical nitrate reduction reaction (NITrr) is regarded as a “two birds-one stone” method for the treatment of nitrate contaminant in polluted water and the synthesis of valuable ammonia, which is retarded by the lack of highly reactive and selective electrocatalysts .Herein, for the first time, nickel foam supported Co_(4) N was designed as a high-performance NITrr catalyst by an in-situ nonmetal leaching-induced *** the optimal potential, the Co_(4) N/NF catalyst achieves ultra-high Faraday efficiency and NH_(3) selectivity of 95.4% and 99.4%, *** situ X-ray absorption spectroscopy (XAS), together with other experiments powerfully reveal that the nitrogen vacancies produced by nitrogen leaching are stable and play a key role in boosting nitrate reduction to *** calculations confirm that Co_(4) N with abundant nitrogen vacancies can optimize the adsorption energies of NO_(3)^(-) and intermediates, lower the free energy (Δ G ) of the potential-determining step (*NH_(3) to NH_(3) ) and inhibit the formation of N-containing *** addition, we also conclude that the nitrogen vacancies can stabilize the adsorbed hydrogen, making H_(2) quite difficult to produce, and lowering ΔG from *NO to *NOH, which facilitates the selective reduction of *** study reveals significant insights about the in-situ nonmetal leaching to enhance the NITrr activity.

关键词： Co4N Nitrate reduction In-situ nonmetal leaching Nitrogen vacancy Mechanism

Chemotactic nanomotor for multimodal combined therapy of glioblastoma

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Science China Chemistry 2024年第4期67卷 1277-1288页

作者： Ting Li Lin Chen Yunxin Xue Xiangyu Xiao Wenjun Dai Kaiyuan Tan Tiantian Chen Yingfang Tao Chun Mao Jian Shen mimi Wan National and Local Joint Engineering research Center of Biomedical Functional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China

Glioblastoma(GBM) is the most aggressive malignant brain tumor. Due to the infiltration and heterogeneity of GBM, the obstruction of the blood-brain barrier(BBB) and the unique immunosuppressive mechanism, it is hard to achieve significant effects of GBM treatment. Here, a kind of chemotactic nanomotor that loaded with glucose oxidase(GOx) and carboxylated cisplatin(Pt(IV)) prodrug on the L-arginine-derived polymer is proposed. The nanomotors are driven by catalysis of glucose decomposition and the positive chemotaxis towards the GBM microenvironment where inducible nitric oxide synthase and reactive oxygen species are highly expressed. This facilitates the BBB crossing and GBM targeting of the nanomotors. In addition, the released nitric oxide(NO) during propulsion as well as the loaded GOx and Pt(IV) can exert combined NO/starvation/chemotherapy. Meanwhile, it is able to induce and enhance the immune response through multiple pathways, thus better coping with the complexities of GBM treatment.

关键词： chemotaxis combined therapy glioblastoma nanomotors

HPLC combined with chemometrics for quality control of Huamoyan Granules or Capsules

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Chinese Herbal Medicines 2024年第3期16卷 449-456页

作者： Minhang Dou Jiayi Huang mimi Yu Huahua Li Yang Song Ziwei Peng Shouying Du Jie Bai School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China Beijing Institute for Drug Control NMPA Key Laboratory for Quality Evaluation of Traditional Chinese Medicine(Traditional Chinese Patent Medicine)Beijing Key Laboratory of Analysis and Evaluation on Chinese MedicineBeijing 102206China

Objective:Huamaoyan Granules(HMYG)and Huamaoyan Capsules(HMYC)are Chinese patent medicines with different dosage forms of the same *** to the different preparation process,the chemical composition of these Chinese patent medicines varies greatly among different forms,but there were few studies on the difference comparison and quality control of *** order to improve the effectiveness and safety in its clinical application,an idea combining high performance liquid chromatography(HPLC)and chemometrics was put forward to study the quality control of Chinese patent medicines in different dosage forms of the same ***:The differential markers of HMYG and HMYC were explored based on HPLC fingerprint and chemometrics including orthogonal projections to latent structures-discriminant analysis(OPLS-DA),principal component analysis(PCA),and hierarchical cluster analysis(HCA).Finally,the quantitative analysis method of related components was established by ***:A quality control method for HMYG and HMYC was ***,the chemical components of HMYG and HMYC were systematically analyzed by HPLC *** exploration showed that there were 20 characteristic peaks and 57 common ***,the potential differential markers between HMYG and HMYC were explored by chemometrics,and the differential markers were screened after intersection with the 20 characteristic ***,HPLC quantitative analysis methods for nine components were established,including seven differential markers(neochlorogenic acid,protocatechualdehyde,chlorogenic acid,cryptochlorogenic acid,caffeic acid,rosmarinic acid and salvianolic acid A).The results of HPLC quantitative analysis showed that the contents of eight components in HMYG and HMYC samples were significantly *** to the above results,the differential markers between HMYG and HMYC screened based on HPLC fingerprint and chemometrics can effectively characterize the differ

关键词： chemometrics Chinese patent medicine high performance liquid chromatography fingerprint Huamoyan Granules/Capsules quality control synovitis

从《教学通义》白的内在困境看康有为的经学转向

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哲学动态 2024年第4期 34-41页

作者：皮迷迷首都师范大学哲学系

康有为从以《教学通义》为代表的古文经学立场转向以“两考”为标志的今文经学立场,前人多将之归因于廖平的影响和康有为上书清帝失败等外部因素。然而,以《教学通义》中的内在困境为线索,可以看到,此种转变自有其内在动因,即康有为对... 详细信息

康有为从以《教学通义》为代表的古文经学立场转向以“两考”为标志的今文经学立场,前人多将之归因于廖平的影响和康有为上书清帝失败等外部因素。然而,以《教学通义》中的内在困境为线索,可以看到,此种转变自有其内在动因,即康有为对建立一个完整、统一经学体系的诉求。由于廖平的“二变”处理了经学中周公、孔子的矛盾,帮助康有为克服了他在《教学通义》中的理论困境,实现了经学体系的一统。因此,康有为果断接受了廖平“二变”中以古学为刘歆所伪的结论,实现了他的经学转向。

关键词：康有为廖平《教学通义》经学转向

蜀山城市森林公园主要林分的土壤细菌群落特征及其影响因素

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西北林学院学报 2024年第5期39卷 176-186页

作者：王敉敉崔珺滕臻浙江万里学院设计艺术与建筑学院浙江宁波315100 安徽农业大学林学与园林学院安徽合肥230036 黄山学院生命与环境科学学院安徽黄山245021 徐州工程学院环境工程学院江苏徐州221018

基于暖温带-亚热带过渡带且人为活动频繁的城市森林生态系统,从数量生态学角度出发,系统分析蜀山城市森林公园“植被-土壤-细菌”之间的相互作用机制。采用高通量测序技术,全面分析近郊城市森林绿地土壤细菌群落多样性,明确城市森林土... 详细信息

基于暖温带-亚热带过渡带且人为活动频繁的城市森林生态系统,从数量生态学角度出发,系统分析蜀山城市森林公园“植被-土壤-细菌”之间的相互作用机制。采用高通量测序技术,全面分析近郊城市森林绿地土壤细菌群落多样性,明确城市森林土壤细菌群落结构的主导影响因素。结果显示,与次生林相比,人工林普遍表现出较低的土壤pH值、含水量、有机碳和营养物质含量,表明人工造林和人类活动会加速土壤酸化。次生林土壤铵态氮(AN)、可溶性有机碳(DOC)含量与人工林差异性显著。人工林土壤细菌OTUs总数较低,马尾松林、麻栎林土壤细菌α多样性指数(S_1指数、H′指数)和次生林差异显著。酸杆菌门、变形杆菌门和放线菌门是主要菌群;次生林土壤酸杆菌门、变形杆菌门相对丰度高于人工林,放线菌门相对丰度低于马尾松林和麻栎林,绿弯菌门相对丰度低于人工林,麻栎林土壤芽单胞菌门相对丰度高于其他林分。土壤pH、AN和DOC是影响细菌群落分布模式的主要理化因子。本研究揭示了地上植被指标与地下土壤理化特性、细菌多样性指标的相关性。

关键词：城市森林人工林次生林土壤理化性质细菌群落特征

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点云滤波算法构建矿山开采沉陷模型的对比研究

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测绘通报 2024年第S1期 252-255页

作者：张咪咪柴成富西安航天宏图信息技术有限公司陕西西安710199 中煤航测遥感集团有限公司陕西西安710199 中煤航测遥感集团有限公司企业技术中心陕西西安710199

针对现有机载LiDAr点云滤波算法缺乏详细对比的问题,本文以西部矿区某工作面地表沉陷区为试验区,选择渐进形态学滤波、三角网渐进加密滤波和基于坡度阈值滤波3种经典的算法去噪,并分析了算法的适用性。试验结果表明,在地表起伏明显、植... 详细信息

针对现有机载LiDAr点云滤波算法缺乏详细对比的问题,本文以西部矿区某工作面地表沉陷区为试验区,选择渐进形态学滤波、三角网渐进加密滤波和基于坡度阈值滤波3种经典的算法去噪,并分析了算法的适用性。试验结果表明,在地表起伏明显、植被稀疏的陕北矿区,采集的点云数据利用三角网渐进加密滤波得到去噪后的点云建模效果最优。试验结果可为矿区开采沉陷精细化建模提供重要的技术手段。

关键词：机载LIDAr 点云滤波矿山开采沉陷 DEM叠加分析

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颠覆性技术多元投入机制研究

中国科学院院刊 2024年第5期39卷 917-932页

作者：展咪咪彭现科曹晓阳胡晓棉中国工程科技创新战略研究院北京100088 北京应用物理与计算数学研究所北京100094

颠覆性技术是推动人类发展和产业变革的关键力量,世界各国都高度重视,纷纷进行相关战略规划和部署,期望占领技术创新的制高点。作为资源集聚的有效方式,颠覆性技术多元投入机制的构建逐渐上升为国家的战略需求,相关研究也日益得到国家... 详细信息

颠覆性技术是推动人类发展和产业变革的关键力量,世界各国都高度重视,纷纷进行相关战略规划和部署,期望占领技术创新的制高点。作为资源集聚的有效方式,颠覆性技术多元投入机制的构建逐渐上升为国家的战略需求,相关研究也日益得到国家的重视。文章首次以创新过程视角开展颠覆性技术多元投入机制研究。从创新理论出发,深入创新过程,系统分析了技术成长特性,明确了颠覆性技术多元投入机制内涵,并以案例研究为支撑,解析投入实践,总结投入模式,链接创新机理,实现了从创新机理到创新实践的颠覆性技术多元投入机制的系统构建。

关键词：颠覆性技术颠覆性创新多元投入机制