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In vivo study of conductive 3D printed PCL/MWCNTs scaffolds with electrical stimulation for bone tissue engineering

Bio-Design and Manufacturing 2021年第2期4卷 190-202页

作者： Edney P.e Silva Boyang Huang Júlia V.Helaehil Paulo R.L.Nalesso Leonardo Bagne Maraiara A.de Oliveira Gabriela C.C.Albiazetti Ali Aldalbahi Mohamed El-Newehy milton santamaria-jr Fernanda A.S.Mendonça Paulo Bártolo Guilherme F.Caetano Postgraduate Program in Biomedical Sciences University Center of Hermínio Ometto Foundation-FHOArarasSao PauloBrazil Department of Mechanical Aerospace and Civil EngineeringSchool of EngineeringUniversity of ManchesterManchester M139PLUK King Abdullah Institute for Nanotechnology King Saud UniversityRiyadh 11451Saudi Arabia

Critical bone defects are considered one of the major clinical challenges in reconstructive bone *** combination of 3D printed conductive scaffolds and exogenous electrical stimulation(ES)is a potential favorable approach for bone tissue *** this study,3D conductive scaffolds made with biocompatible and biodegradable polycaprolactone(PCL)and multi-walled carbon nanotubes(MWCNTs)were produced using the extrusion-based additive manufacturing to treat large calvary bone defects in *** results show that the use of PCL/MWCNTs scaffolds and ES contributes to thicker and increased bone tissue formation within the bone *** and mineralization are also significantly promoted using high concentration of MWCNTs(3 wt%)and ***,scaffolds favor the tartrate-resistant acid phosphatase(TRAP)positive cell formation,while the addition of MWCNTs seems to inhibit the osteoclastogenesis but present limited effects on the osteoclast functionalities(receptor activator of nuclear factor κβ ligand(RANKL)and osteoprotegerin(OPG)expressions).The use of ES promotes the osteoclastogenesis and RANKL expressions,showing a dominant effect in the bone remodeling *** results indicate that the combination of 3D printed conductive PCL/MWCNTs scaffold and ES is a promising strategy to treat critical bone defects and provide a cue to establish an optimal protocol to use conductive scaffolds and ES for bone tissue engineering.

关键词： Additive manufacturing Bone regeneration Bone remodeling Carbon nanotube Conductive scaffolds Electrical stimulation

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The effect of chlorhexidine on plaque index and mutans streptococci in orthodontic patients:A pilot study

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Open Journal of Stomatology 2013年第6期3卷 323-328页

作者： Gisele Faria milton santamaria jr. Bianca Mota dos Santos Izabel Yoko Ito Janete Cinira Bregagnolo Maria Bernadete Sasso Stuani Department of Restorative Dentistry School of Dentistry of AraraquaraUniversity of the State of Sao Paulo(UNESP)AraraquaraBrazil Department of Pediatric Clinics Preventive and Social DentistrySchool of Dentistry of Ribeirao PretoUniversity of Sao Paulo(USP)Ribeirao PretoBrazil Private Practice AracajuBrazil Department of Clinical Analysis Toxicology and BromatologySchool of Pharmaceutical Sciences of Ribeirao PretoUniversity of Sao Paulo(USP)Ribeirao PretoBrazil

Aim: The purpose of this study was to assess chlorhexidine effects on plaque index and salivary levels of mutans streptococci (MS) when used as the immersion solution for removable orthodontic appliances and added to their acrylic resin composition. Methods: Forty-five patients (6 to 12 years old) were randomly assigned into three groups with 15 patients each. Group I (control)—without orthodontic appliances disinfection;Group II—removable orthodontic appliances which had been immersed in 0.12% chlorhexidine digluconate overnight (8 hours), and Group III—orthodontic appliances in which 0.12% chlorhexidine digluconate solution had been incorporated into their resin composition. Saliva was collected for quantification of MS and evaluation of plaque index was performed before and after installation of orthodontic appliance at 0, 2, 4, 6, 8, and 10 weeks. Data were analyzed by using analysis of variance. Results: Number of MS colonies in saliva and plaque index showed no statistically differences among groups at the different periods (p > 0.05). Conclusions: It could be concluded that chlorhexidine incorporation into the acrylic resin of removable orthodontic appliances at 0.12% concentration and immersion of the appliance into 0.12% chlorhexidine solution were not effective in reducing plaque index and the number of MS in saliva.

关键词： Chlorhexidine Self-Polymerising Acrylic Removable Orthodontic Appliances Mutans Streptococci Plaque Index

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