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Modeling mitochondria,where are the numbers?

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Neural Regeneration Research 2024年第7期19卷 1435-1436页

作者： Adrian M.Davies Alan G.holt University Center Shrewsbury ShrewsburyShropshireUK

Models and simulations are particularly useful for exploring ideas and concepts in the biological sciences that are expe rimentally *** silico methods are also gaining acceptance with regulatory authorities as an alte... 详细信息

关键词： eliminate authorities acceptance

Oral fluoroquinolones and the risk of Achilles tendon rupture

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Journal of Sport and Health Science 2024年第6期13卷 749-750页

作者： Peter Vibe Rasmussen Jarl Emanuel Strange Anders holt Department of Cardiology Herlev-Gentofte University HospitalCopenhagen 2730Denmark Department of Cardiology Bispebjerg-Frederiksberg University HospitalCopenhagen 2400Denmark Department of Cardiology Rigshospitalet University HospitalCopenhagen 2100Denmark

Dear editor,Fluoroquinolones(FQs)are a class of antibiotics used to treat bacterial infections,such as lower respiratory,gastrointestinal,and urinary tract *** to its broad-spectrum action and wide availability,it is ... 详细信息

关键词： prescribed spectrum action

Social relationship satisfaction and accumulation of chronic conditions and multimorbidity:a national cohort of Australian women

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General Psychiatry 2023年第1期36卷 9-18页

作者： Xiaolin Xu Gita D Mishra Julianne holt-Lunstad Mark Jones School of Public Health The University of QueenslandBrisbaneQueenslandAustralia Departments of Psychology and Neuroscience Brigham Young UniversityProvoUtahUSA

Background Social relationships are associated with mortality and chronic ***,little is known about the effects of social relationship satisfaction on multiple chronic conditions(multimorbidity).Aims To examine whether social relationship satisfaction is associated with the accumulation of *** Data from 7694 Australian women who were free from 11 chronic conditions at 45–50 years of age in 1996 were *** types of social relationship satisfaction(partner,family members,friends,work and social activities)were measured approximately every 3 years and scored from 0(very dissatisfied)to 3(very satisfied).Scores from each relationship type were summed to provide an overall satisfaction score(range:≤5–15).The outcome of interest was the accumulation of multimorbidity in 11 chronic *** Over a 20-year period,4484(58.3%)women reported ***,the level of social relationship satisfaction had a dose–response relationship with the accumulation of *** with women reporting the highest satisfaction(score 15),women with the lowest satisfaction(score≤5)had the highest odds of accumulating multimorbidity(odds ratio(OR)=2.35,95%confidence interval(CI):1.94 to 2.83)in the adjusted *** results were observed for each social relationship *** risk factors,such as socioeconomic,behavioural and menopausal status,together explained 22.72%of the *** Social relationship satisfaction is associated with the accumulation of multimorbidity,and the relationship is only partly explained by socioeconomic,behavioural and reproductive *** connections(eg,satisfaction with social relationships)should be considered a public health priority in chronic disease prevention and intervention.

关键词： morbidity prevention behaviour

Design and guidance of a multi-active debris removal mission

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Astrodynamics 2023年第4期7卷 383-399页

作者： Minduli C.Wijayatunga(B) Roberto Armellin Harry holt Laura Pirovano Aleksander A.Lidtke Te Pūnaha Atea–Space Institute The University of AucklandAuckland 1010New Zealand Astroscale Japan Inc. 1-16-4-16 KinshiSumida-kuTokyoJapan

Space debris have become exceedingly dangerous over the years as the number of objects in orbit continues to *** debris removal(ADR)missions have gained significant interest as effective means of mitigating the risk of collision between objects in *** study focuses on developing a multi-ADR mission that utilizes controlled reentry and *** mission comprises two spacecraft:a Servicer that brings debris to a low altitude and a Shepherd that rendezvous with the debris to later perform a controlled reentry.A preliminary mission design tool(PMDT)was developed to obtain time and fuel optimal trajectories for the proposed mission while considering the effect of J2,drag,eclipses,and duty *** PMDT can perform such trajectory optimizations for multi-debris missions with computational time under a *** guidance schemes are also studied,taking the PMDT solution as a reference to validate the design methodology and provide guidance solutions to this complex mission profile.

关键词： active debris removal(ADR) trajectory design optimization autonomous guidance low-thrust electric propulsion △u-law guidance Q-law guidance

In vivo degradability and biocompatibility of a rheo-formed Mg–Zn–Sr alloy for ureteral implantation

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Journal of Magnesium and Alloys 2022年第6期10卷 1631-1639页

作者： Di Tie Renguo Guan Huinan Liu Minfang Chen Sviatlana A.Ulasevich Ekaterina V.Skorb Patricia holt-Torres Xiaopeng Lu Norbert Hort Engineering Research Center of Continuous Extrusion Ministry of EducationDalian Jiaotong UniversityDalian 116028China School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Department of Bioengineering University of CaliforniaRiversideCA 92521USA School of Materials Science and Engineering Tianjin University of TechnologyTianjin 300384China Infochemistry Scientific Center ITMO UniversitySt.Petersburg 192007Russia Magnesium Innovation Center-MAGIC Helmholtz Zentrum GeesthachtGeesthacht D-21502Germany

The introduction of biodegradable implant materials has significantly improved the postoperative subjective feelings of patients within the past few decades,among which magnesium alloy is widely considered a favorable choice as its appropriate biodegradability and evident antibacterial ***,we reveal a semisolid rheo-formed Mg–Zn–Sr alloy ureteral implant that displayed suitable degradability and biocompatibility in a pig *** non-dendritic microstructure was observed in the rheo-formed alloy,which led to ca.47%increase in ultimate tensile strength(from 195.0 MPa to 288.1 MPa)and more homogeneous degradation process compared with the untreated *** post-interventional inflammation or pathological changes of the test animals were observed during the implantation period,and the corrosion rate(0.22±0.04 mm·y^(-1))perfectly fitted the clinical ureteral stent indwelling *** urine bacteria numbers decreased from 88±13 CFU·mL^(-1)at 7 weeks post operation to 59±8 CFU·mL^(-1)at 14 weeks post operation,which confirmed the evident antibacterial activity of the *** study demonstrates that the Mg–Zn–Sr alloy is clinically safe for urinary system,enabling its efficacious use as ureteral implant materials.

关键词： In vivo Biodegradability Biocompatibility Mg–Zn–Sr alloy Ureteral implant

Ionospheric longitudinal variations at midlatitudes: Incoherent scatter radar observation at Millstone Hill

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Science China(Technological Sciences) 2012年第5期55卷 1153-1160页

作者： COSTER Anthea holt John FOSTER John ERICKSON Phil MIT Haystack Observatory Off Route 40 Westford MA 01866 USA

Incoherent scatter radar (ISR) extra-wide coverage experiments during the period of 1978-2011 at Millstone Hill are used to investigate longitudinal differences in electron density. This work is motivated by a recent finding of the US east-west coast difference in TEC suggesting a combined effect of changing geomagnetic declination and zonal winds. The current study provides strong supporting evidence of the longitudinal change and the plausible mechanism by examining the climatology of electron density Ne on both east and west sides of the radar with a longitude separation of up to 40o for different heights within 300-450 km. Main findings include: 1) The east-west difference can be up to 60% and varies over the course of the day, being positive (East side Ne > West side Ne) in the late evening, and negative (West side Ne > East side Ne) in the pre-noon. 2) The east-west difference exists throughout the year. The positive (relative) difference is most pronounced in winter; the negative (relative) difference is most pronounced in early spring and later summer. 3) The east-west difference tends to enhance toward decreasing solar activity, however, with some seasonal dependence; the enhancements in the positive and negative differences do not take place simultaneously. 4) Both times of largest positive and largest negative east-west differences in Ne are earlier in summer and later in winter. The two times differ by 12-13 h, which remains constant throughout the year. 5) Variations at different heights from 300-450 km are similar. Zonal wind climatology above Millstone Hill is found to be perfectly consistent with what is expected based on the electron density difference between the east and west sides of the site. The magnetic declination-zonal wind mechanism is true for other longitude sectors as well, and may be used to understand longitudinal variations elsewhere. It may also be used to derive thermospheric zonal winds.

关键词：非相干散射雷达观测中纬度地区石山电离层电子密度一年四季纬向风

In vivo urinary compatibility of Mg-Sr-Ag alloy in swine model

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Bioactive Materials 2022年第1期7卷 254-262页

作者： Di Tie Norbert Hort Minfang Chen Renguo Guan Sviatlana Ulasevich Ekaterina V.Skorb Dapeng Zhao Yili Liu Patricia holt-Torres Huinan Liu Engineering Research Center of Continuous Extrusion Ministry of EducationDalian Jiaotong UniversityDalian116028China Magnesium Innovation Center Helmholtz-Zentrum GeesthachtD-21502GeesthachtGermany School of Materials Science and Engineering Tianjin University of TechnologyTianjin300384China Infochemistry Scientific Center ITMO UniversitySt.Petersburg192007Russia College of Biology Hunan University410082ChangshaChina Department of Urology China Medical UniversityShenyang110084China Department of Bioengineering Bourns College of EngineeringUniversity of California at RiversideCA92521USA

A biodegradable metallic ureteral stent with suitable mechanical properties and antibacterial activity remains a *** we reveal the scientific significance of a biodegradable Mg-Sr-Ag alloy with a favorable combination of balanced mechanical properties,adjustable indwelling time in urinary tract and evident antibacterial activity via in vivo experiments in a swine *** to the rheo-solidification process,equiaxial microstructure and significantly refined grains(average grain size:27.1μm)were ***17Sr2 and Mg4Ag were found as the primary precipitates in the matrix,due to which the alloy obtained ca.111%increase in ultimate tensile strength in comparison to pure *** the in vitro and in vivo results demonstrated the satisfactory biocompatibility of the *** evaluation and bioindicators analysis suggested that there was no tissue damage,inflammation and lesions in the urinary system caused by the degradation *** stent also improved the post-operative bladder functions viewed from the urodynamic *** findings highlight the potential of this alloy as antibacterial biodegradable urinary implant material.

关键词： In vivo Magnesium alloy Biodegradable metals Mechanical properties Urinary compatibility

Noninvasive ventilation for pediatric interfacility transports:a retrospective study

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World Journal of Pediatrics 2020年第4期16卷 422-425页

作者： Samantha Holbird Tanya holt Adam Shaw Gregory Hansen College of Medicine University of SaskatchewanSaskatoonSKCanada Division of Pediatric Critical Care Jim Pattison Children’s Hospital103 Hospital DriveSaskatoonSKS7N 0W8Canada

Background To characterize pediatric patients supported with continuous positive airway pressure and bilevel positive airway pressure(CPAP/BiPAP)or high-flow nasal cannula(HFNC)during interfacility transport(IFT).Methods A retrospective study with a provincial pediatric transport team from a tertiary hospital pediatric intensive care *** patients aged 28 days to<17 years,who required IFT between January 2017 and December 2018,were identified through a transport registry and were included in the *** A total of 118(26.7%)patients received CPAP/BIPAP or HFNC support for *** most common respiratory diagnosis was bronchiolitis(46%).These patients were placed on respiratory support,31.4 minutes after the transport team’s *** required intubation during their IFT,despite mean transport times of 163 *** This study may provide important information for programs with large catchment areas,in which large distances and transport times should not be barriers to NIV implementation.

关键词： Children Critical illness Intubation Noninvasive ventilation Transportation of patients

Investigation into a practical approach and application of cotton fiber elongation

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Journal of Cotton Research 2023年第1期6卷 13-24页

作者： DELHOM Christopher D. WANJURA John D. PELLETIER Mathew G. holt Gregory A. HEQUET Eric F. USDA-ARS New OrleansLA 70124USA USDA-ARS LubbockTX 79403USA Texas Tech University LubbockTX 79409USA

Background The strength of cotton fiber has been extensively studied and significantly improved through selec-tive breeding,but fiber elongation has largely been ignored,even though elongation contributes to determining the energy needed to break *** developments to calibrate the high volume instrument(HVI)for elongation has renewed interest in ***,it is not understood how best to utilize yet another fiber property which has the potential to add to the complexity of fiber *** explore a practical approach to applying elongation,cot-ton samples were tested using single fiber methods,the Stelometer,and the *** of strength,elongation,and combined properties such as modulus were *** HVI testing was shown to be sensitive enough to characterize elongation differences but unlike single fiber testing it was unable to capture within-sample *** bundle testing,like Stelometer and HVI was shown to reduce bias due to fiber *** The use of secant modulus,an intrinsic material property,allowed for one value to represent both strength and *** modulus was shown to contain more useful information than either elongation or ***-to-break was shown to be more influenced by a specific value of breaking force or elongation rather than the intrinsic behavior of the sample being *** the influence of genetics and environment on elongation,and its interaction with other fiber properties,requires additional *** modulus,by combining strength and elongation into one value,shows the potential to incorporate elongation values into fiber characteriza-tion without increasing the complexity of current fiber selection processes.

关键词： Cotton Elongation Tenacity Work-to-break ModulusBackground