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Stari Slankamen--potential Destination of Nautical Tourism in Serbia

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Journal of Tourism and Hospitality Management 2020年第3期8卷 93-99页

作者： milošMiljković University of Novi Sad Novi SadSerbia

Nautical tourism has a high trend of growth,and the highest growth trend is expected in eastern and south-eastern *** is type of tourism that takes place on water or on the *** tourism in Serbia could include 3,500 km of waterways and 50 km of water surface on various types of lakes,using at least 6,000 km of *** tourism represents a great potential for Ap Vojvodina and Serbia,and it is necessary that local governments,private sector,and the state government work together on further *** international rivers,the Tisa and the Danube,flow through several European countries and merge at place where Stari Slankamen is *** Slankamen,as a settlement created at the mouth of two rivers,has great potential for the development of nautical tourism,both on the water and on the *** this work,it will be presented all potentials factors for the development of Stari Slankamen as a future destination of nautical tourism in Serbia,as well as all kind of events and hospitality ***,the attitudes of local residents towards tourism development were examined due to the great importance of support of local population for tourism development at the ***,weaknesses,opportunities,and threats(SWOT)analysis presented all strengths and opportunities for developing nautical tourism and weakness and threats as ***,based on examination of observed potentials and residents’attitudes,it will be proposed guidelines and conclusions for the further development of nautical tourism in this part of Serbia.

关键词： nautical tourism Danube Vojvodina Stari Slankamen local residents

Multi-species habitat models highlight the key importance of flooded reedbeds for inland wetland birds: implications for management and conservation

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Avian Research 2019年第2期10卷 186-198页

作者： Michelangelo Morganti milo Manica Giuseppe Bogliani Marco Gustin Federica Luoni paolo Trotti Vincenzo perin Mattia Brambilla Department of Earth and Environmental Sciences University of Pavia Department of Environmental Science and policy University of Milan Conservation Department Lipu/BirdLife Italy Riserva Naturale ‘Torbiere del Sebino’ Riserva Naturale Regionale ‘Lago di piano’ Casa della Riserva Fondazione Lombardia per l’Ambiente Settore Biodiversità ed Aree Protette MUSE Museo delle ScienzeSezione di Zoologia dei VertebratiCorso del Lavoro e della Scienza

Background: Inland wetlands are crucial for biodiversity conservation, especially in highly-urbanized landscapes. In the European Union, many wetlands are included in the EU ‘Natura 2000’ network, the main tool for biodiversity conservation over the continent, which requires the development of site-specific management plans. Clear and feasible recommendations are necessary to provide site managers with effective tools for the maintenance of biodiversity in these unstable environments. Birds are excellent umbrella species, therefore a management targeted at increasing habitat suitability for focal bird species would likely benefit broader wetland biological communities. Methods: During spring–summer 2017, we collected presence/absence data for 10 bird species of conservation interest at a site scale for 21 Natura 2000 sites. We also carried out a point count survey to detect presence/absence of four reedbed-dwelling species at 75 points. At the site level, we estimated landscape characteristics from regional GISlayers, whereas fine-scaled habitat composition was recorded on the field within a 100 m-buffer around the 75 points. We analysed the effect of the extent of different habitats on species’ occurrence probability by means of multi-species binomial multivariate adaptive regression splines (MARS) at both scales. We also run species-specific MARS models to compare their performance with those of multi-species models. Results: At the site scale, the extent of the reedbeds/mires was positively associated with the occurrence of all species of conservation concern. At the point-count scale, reedbed extent positively predicted species’ occurrence, but only in presence of patches of clear shallow water. Species-specific MARS models showed qualitatively similar results for some species, but generally were outperformed by multi-species ones. Conclusions: Multi-species MARS models confirmed to be an efficient tool in disclosing species-habitat relationships even for set of

关键词： Multivariate adaptive regression spline Natura 2000 pre-Alpine belt Species-habitat relationship Umbrella species Urbanized landscape

pediatric nasolacrimal duct obstruction-benefit of a combined therapeutic approach

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World Journal of pediatrics 2017年第5期13卷 427-432页

作者： milo(s)Fischer Iris-Susanne Horn Mathias Otto Mandy pirlich Andreas Dietz Christian Mozet Clinic of Otolaryngology Head and Neck Surgery and Department of Head Medicine and Oral Health.University Hospital LeipzigGermany Depamnent ofENT Head&Neck SurgerySchwarzwald-Baar KIinikum Villingen—SchwenningenGermany Clinic of Ophthalmology and Department of Head Medicine and Oral Health University Hospital LeipzigGermany Deparmaent ofNeurology University Hospital LeipzigGermany.

Background:pediatric nasolacrimal duct obstruction (pNDO) requires therapeutic intervention after conservative procedures *** resilient treatment guidelines for the treatment are missing,the aim of this study was to evaluate the advantages of two different intervention techniques in children with ***:Between January,2006 and June,2014,233 children (0-208 months) were treated either with conventional probing by ophthalmologists only (Group I) or with endonasal endoscopic interdisciplinary approach (Group Ⅱ).The clinical outcome was ***:The overall success rate of Group Ⅰ was 93.4% compared to 98.4% of Group Ⅱ (pp Ⅱ required further surgical procedures in addition to probing/irrigation,particularly with regard to children 24 ***:Endoscopic control in treatment of pNDO allows exact identification of the stenosis and appropriate surgical intervention with an improved clinical *** endoscopic surgical techniques should be the standard pNDO treatment.

关键词： dacryocystocele Hasner valve nasal endoscopy nasolacrimal duct probing pediatric nasolacrimal duct obstruction

Estimation of Chronic Subdural Hematoma Size Using CT Imaging;a Comparison of In-plane Thickness to 3D Volumetry

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Open Journal of Modern Neurosurgery 2014年第1期4卷 1-6页

作者： milo Stanisic Department of Neurosurgery Oslo University HospitalOsloNorway Department of psychology Oslo UniversityOsloNorway Department of Radiology Oslo University HospitalOsloNorway Unit of Biostatistics and Epidemiology Oslo University HospitalOsloNorway

Backgrounds: pre- and postoperative chronic subdural hematoma (CSDH) sizes have been used in clinical trials to predict the risk of postoperative recurrence. Commonly, dimensions of the pre- and postoperative lesions have been assessed by computerized tomography (CT) scans using maximum thickness as a linear measurement. Our goal was to characterize this common method for quantification of pre- and postoperative lesion sizes and to assess its estimation validity compared to estimation by hematoma volumetry. Methods: We prospectively investigated pre- and 1st postoperative day CT scans of 107 adult surgical patients with uni- or bilateral CSDH. pre- and postoperative thickness of CSDH was determined and then compared to pre- and postoperative lesion volume measured with 3D hematoma volumetry. Results: pearson correlation coefficients between mean pre- and postoperative lesion thickness and mean pre- and postoperative lesion volume in the unilateral subgroup were 0.491 and 0.498, respectively;in the bilateral subgroup 0.505 and 0.579, respectively;and in the whole series 0.653 and 0.472, respectively. Conclusions: pre- and postoperative thickness of CSDH does not offer reasonable approximations of the pre- and postoperative lesion size when compared with results from 3D volumetry in the unilateral subgroup, bilateral subgroup or overall.

关键词： Chronic Subdural Hematoma Computerized Tomography Thickness Volume

prevalence and Factors Associated with Depression, Anxiety and Stress in IBD patients Undergoing Intravenous Biological Therapy during the COVID-19 pandemic-Montenegro Experience

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International Journal of Mental Health promotion 2022年第4期24卷 551-564页

作者： Brigita Smolović MarijaĐurović milošLukić Marija Abramović Damir Muhović Department of Gastroenterohepatology Clinic for Internal MedicineClinical Center of MontenegroPodgorica81000Montenegro Faculty of Medicine University of MontenegroPodgorica81000Montenegro Clinic of Radiology Clinical Center of MontenegroPodgorica81000Montenegro

Throughout its duration,the coronavirus disease 2019(COVID-19)pandemic has been affecting lives worldwide and has had a sizeable impact on mental health,particularly for those who already suffer from a chronic ***,Anxiety and Stress(DAS)are common psychiatric comorbidities in inﬂammatory bowel disease(IBD)*** study aims to determine the prevalence and risk factors for moderate and severe symptoms of DAS in IBD patients have been undergoing intravenous biological therapy(IvBTh)during the COVID-19 *** study was conducted between September 1st and November 30th,2020 at the Clinical Center of Mon-tenegro-IBD unit,where all patients from Montenegro received the registered *** case control study consists of 94 IBD patients that completed a validated questionnaire Depression,Anxiety and Stress Score-21(DASS-21).A total of 59 patients received tumor necrosis factor alpha inhibitors(anti-TNF therapy),while 35 received anti-integrin *** we calculated the DASS-21 score,we divided the patients into two groups:those who had moderate and severe symptoms(if they had any of the mentioned DASS-21 subscale score above limit for moderate or more severe symptoms:DASS-21 Depression,higher than 14;DASS-21 Anxiety,higher than 10 and DASS-21 Stress,higher than 19)and those who did not have signiﬁcant symptoms(DASS-21 subscale score did not exceed the limit).We also examined demographic data,data on IBD characteristics and COVID-19 data and their impact on mental *** statistical processing tests were used to identify risk factors for examined mental *** the DASS-21 criteria,we diagnosed the least moderate depression in 19.1%,anxiety in 14.9%and stress in 20.2%*** multivariate analysis indicated there to be a statistically signiﬁcant relation of being higher at risk of developing depression,anxiety and stress when suffering from an active form of IBD(OR 6.487;95%Cl 1.220–34.500,p=0.028).Almost one t

关键词： Inflammatory bowel disease depression anxiety stress COVID-19

Genetic diversity,phylogenetic position and morphometric analysis of Astacus colchicus(Decapoda,Astacidae):a new insight into Eastern European crayfish fauna

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Integrative Zoology 2021年第3期16卷 368-378页

作者： Martin BLÁHA JirípATOKA Bella JApOSHVILI Marek LET milošBURˇICˇ Antonín KOUBA Levan MUMLADZE Faculty of Fisheries and protection of Waters South Bohemian Research Center of Aquaculture and Biodiversity of HydrocenosesUniversity of South Bohemia in CˇeskéBudeˇjoviceVodnˇanyCzech Republic Department of Zoology and Fisheries Faculty of AgrobiologyFood and Natural ResourcesCzech University of Life Sciences PraguePrahaCzech Republic Institute of Zoology of Ilia State University TbilisiGeorgia

The phylogeny of European crayfish fauna,especially with respect to Eastern European species,is still far from being completely *** fill this gap,we analyzed most of the European crayfish species focusing on the phylogenetic position of the endemic crayfish Astacus colchicus,inhabiting *** mitochondrial and one nuclear marker were used to study evolutionary relationships among European crayfish species,resulting in the unique phylogenetic position of *** indicating independent species status to *** analyses revealed a deep molecular divergence of *** in comparison to ***(6.5–10.9%in mtDNA and 1.1%in nDNA)as well as to pontastacus leptodactylus and ***(5.5–10.0%in mtDNA and 1.4–2.4%in nDNA).Absent ventral process on second male pleopod and abdominal somites II and III with pleura rounded lacking prominent spines clearly indicate taxonomic assignment to the genus Astacus;however,the species is distributed almost in the middle of ponto-Caspian area typical by occurrence of the genus *** morphological indices linked to head length,carapace,and total body length and width were found to demonstrate apparent differences between *** and *** this study provides a novel insight into European crayfish phylogeography,we also point out the gaps in comprehensive study of the *** species complex,which could reveal details about the potential species status of particular species and subspecies within this genus.

关键词： 12S rRNA 16S rRNA cytochrome c oxidase histone H3 ponto-Caspian crayfish

Research progress on KRAS mutations in colorectal cancer

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 364-380页

作者： Marco Cefalì Samantha Epistolio Maria Celeste palmarocchi milo Frattini Sara De Dosso Department of Medical Oncology Oncology Institute of Southern SwitzerlandBellinzona 6500Switzerland Institute of pathology Laboratory of Molecular PathologyLocarno 6600Switzerland Universitàdella Svizzera Italiana Lugano 6900Switzerland

The RAS gene family,responsible for signal transduction within the mitogen activated protein kinase(MApK)and phosphatidylinositol 3 kinase(pI3K)pathways,is frequently involved in carcinogenesis,and alterations in its member genes can be detected,with variable frequency,in a wide variety of solid and hematological *** alterations may behave as prognostic-predictive biomarkers and driver mutations,making them an interesting therapeutic *** their discovery,many strategies have been pursued to act on their signaling ***,in clinical practice,KRAS,the most prominent member of the RAS gene family,represents an especially elusive target in most malignancies;pathway inhibition is carried out upstream,on the EGFR receptor,or downstream,most frequently on the BRAF/MEK/ERK ***,clinically relevant direct RAS inhibition has been successfully achieved with the development of potent and selective covalent inhibitors of KRAS c.34G>T(p.G12C).These latest-generation drugs represent both a new and interesting tool in the therapeutic armamentarium and a symbolic end to the myth of KRAS ***,their clinical relevance and appropriate place in treatment strategies remain to be determined.

关键词： KRAS targeted therapies EGFR pathway MApK colorectal cancer

Changes in the Regulating Ecosystem Service on the Contaminated Site Used for Energy purposes

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Open Journal of Ecology 2020年第9期10卷 597-611页

作者： Jarmila Makovníková Beata Houšková pálka Boris Širáň miloš National Agricultural and Food Centre/Soil Science and Conservation Research Institute Bratislava Sovakia

Soil cleaning, the ability of the soil to immobilize the risk elements, belongs to important agroecosystem services in terms of protection of the hydrosphere and plant production from contamination. Dynamic monitoring of selected indicators of soil quality was realized in a special network of site on soil used for planting fast growing willow (Salix viminalis). Monitoring of the study site Kuchyňa (Mollic Fluvisol) is running since 2010 year. The fast-growing willow was planted on an area of about 43 hectares. Study site Kuchyňa belonged to the degraded contaminated sites, at the time of planting (the total contents of the risk elements were as follows: Cd 1.016 mg∙pan>kgp>−1p>, Zn 199.000 mg∙pan>kgp>−1p>, Ni 51.500 mg∙pan>kgp>−1p>) There were positive changes in the total content of cadmium, zinc and nickel (in 2018 year), the zinc content decreased by 27% compared to 2010, the nickel content was lower by 23% and the Cd content by 57% in comparison to 2010 year, these elements have a declining trend during the monitored period. The remediation ability of the willow in relation to the risk elements was manifested by the accumulation of these elements in the wood mass and by their decrease in the soil below the limit value. The regulatory ecosystem service, the potential for the immobilisation of the risk elements, was evaluated based on the sum of the assessment of the contamination potential and the sorption potential of soil. The decrease of the total content of risk elements in the soil below the limit value was manifested in the increase of the potential o

关键词： Soil Cleaning Willow Crops for Bioenergy Risk Elements Soil Quality Indicators

Regulating Ecosystem Service (Filtering/ Immobilization of Inorganic pollutants) Supplied by Soil in Model Regions of Slovakia

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Journal of Geoscience and Environment protection 2021年第11期9卷 61-72页

作者： Jarmila Makovníková Boris pálka miloš Širáň Stanislav Kološta National Agricultural and Food Centre/Soil Science and Conservation Research Institute Bratislava Regional Station Banská Bystica Slovakia Faculty of Economics Matej Bel University in Banská Bystrica Banská Bystrica Slovakia

The immobilization of soil contaminants (as one of the regulating ecosystem services) plays very important role in environment. This regulatory service prevents groundwater contamination and the entry of contaminants ... 详细信息

The immobilization of soil contaminants (as one of the regulating ecosystem services) playpan>s very important role in environment. This regulatory service prevents groundwater contamination and the entry of contaminants into the food chain. The evaluation as well as the spatial distribution of this regulatory service is important for optimal land management in a specific region. Mapping system combining input layers—slope topography, soil texture, climate region and land use (arable land, grassland)—were created for the analysis and the evaluation of potential of agroecosystem services. Filtering potential was calculated as accumulative function of soil sorption potential and potential of total content of inorganic pollutants evaluated according to The Slovak Soil Law. Calculated potential was categorised into five categories: very low, low, medium, high and very high. Four model areas were selected for the analysis of pollutant filtration, as one of the regulatory agroecosystem services, which are located in different climatic areas and different soil-ecological conditions of Slovakia. The greatest differences among model regions can be found in relation to climatic conditions, land use and diversity of soil types. The warm, dry, and lowland region has a higher potential for pollutant filtration than the moderately warm or cold region. These results are consistent with the location of the soil, its properties, processes and functions within the concept of agro-ecosystem services.pan> pan style="font-family:"">Based on the results, we can state that the high risk of inorganic contaminants is i

关键词： Filtering Ecosystem Service Inorganic Contaminants Soil Sorbents