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Animal Models and Experimental Medicine 2021年第2期4卷 129-137页

作者： Kaela navarro Katechan Jampachaisri Monika Huss Cholawat Pacharinsak Department of Comparative Medicine Stanford UniversityStanfordCAUSA Department of Mathematics Naresuan UniversityPhitsanulokThailand

Background:Extended-release buprenorphine(XR)is indicated for pain management in rodents,but little is known about its use in *** study aimed to investigate whether high dose XR effectively attenuates post-operative hypersensitivity better than low dose XR in a mouse model of incisional ***:Mice(n 44)were randomly assigned to 1 of 4 treatment groups:(a)saline(1 ml/kg SC,once);(b)sustained release buprenorphine(Bup-SR,1 mg/kg SC,once);(c)low dose extended-release buprenorphine(XR-lo,3.25 mg/kg SC,once);(d)high dose extended-release buprenorphine(XR-hi,6.5 mg/kg SC,once).On days􀆴1,0(4 hours),1,2,and 3,mechanical and thermal hypersensitivities were evaluated,and plasma buprenorphine concentrations were ***:Mechanical(days 0-2)and thermal(days 0-1)hypersensitivities were ob-served in the saline ***-SR,XR-lo,and XR-hi attenuated mechanical hyper-sensitivity on days 0,1,and *** of the treatment groups,except XR-Lo on day 0,attenuated thermal hypersensitivity on days 0 or *** buprenorphine concen-tration peaked at 4 hours(day 0)in all treatment groups and remained greater than 1 ng/mL on days *** abnormal clinical observations or gross pathologic findings were seen in any ***:The results indicate XR-hi did not effectively attenuate post-operative hypersensitivity better than *** both 3.25 and 6.5 mg/kg XR are recom-mended for attenuating post-operative hypersensitivity for at least up to 48 hours in mice.

关键词： analgesia analgesics buprenorphine mouse pain management

Mating Disruption of Striped Rice Stem Borer: Importance of Early Deployment of Dispensers and Impact on Airborne Pheromone Concentration

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Rice science 2021年第6期28卷 525-528,I0027-I0029页

作者： Aitor GAVARA Sandra VACAS Jaime PRIMO Vicente navarro-LLOPIS Centre for Agricultural Chemical Ecology Mediterranean Agroforestry InstitutePolytechnic University of ValenciaBuilding 6CCamino de Vera s/n46022 ValenciaSpain

Mating disruption(MD)is an effective environmentally-friendly control method against the striped rice stem borer(RSB),Chilo suppressalis(Lepidoptera:Crambidae).In this study,the current MD dispensers release the pheromone exponentially,with higher initial release rates that decrease throughout the *** adjust the timing of dispensers'deployment and evaluate the importance of controlling the early first or the second male flight,field trials were carried out to test the efficacy of two strategies:the early dispenser deployment prior to the first male flight(May)and the late deployment prior to the second flight(June).The early dispenser deployment was more effective in reducing plant damage inflicted by RSB when assessed at ***,neither of these strategies was able to inhibit the male catches of the third flight due to the dispensers5 *** to the airborne pheromone concentrations obtained,around 1.60 ng/m3 were capable to inhib社*** male flight effectively.

关键词： release Impact adjust

Protective behaviors regarding coastal flooding risk in a context of climate change

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Advances in Climate Change Research 2020年第4期11卷 310-316页

作者： Colin LEMEE Oscar navarro Diego RESTREPO-OCHOA Denis MERCIER Ghozlane FLEURY-BAHI University of Brest Brest29200France Laboratoire de Psychologie des Pays de La Loire University of NantesNantes44312France CES University Medellin050022Colombia Laboratoire de Geographie Physique(UMR 8591-CNRS) Sorbonne UniversiteParis75000France

The physical vulnerability of coastal areas due to rising sea level and the flooding risk consequent,does not guarantee the implementation of protective behaviors by these risk zones’*** study aims to establish the link between the willingness to carry out protective behaviors and physical and perceived indicators of vulnerability.A typology of coastal flooding vulnerability,uses various physical indicators and their perceived counterparts which have been collected from 490 inhabitants of Cartagena(Colombia,declared world heritage of humanity by UNESCO in 1984),resident in areas of coastal flooding *** item-response theory(IRT)approach has been *** results reveal that the implementation of protective behaviors is more related to perceived indicators,such as distance to the sea,than to actual physical *** observe that physical vulnerability is linked to the intention to carry out protective *** presence of a defensive structure against coastal flooding could be considered as a visual cue and be a good predictor of the willingness to carry out protective *** the contrary,people in the most vulnerable situation(single-storey house)do not demonstrate a higher level of willingness to carry out protective behavior,as well of participants who lived in residential buildings which have demonstrated lower level of willingness to carry out such ***,vulnerability of the house is not seen as a criterion that encourages participants to better protect themselves.

关键词： Coastal flooding risk Protective behaviors Climate change Vulnerability Item response theory

Chemotherapy induces cell plasticity;controlling plasticity increases therapeutic response

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3563-3566页

作者： Francisco J.Iborra Cristina Martí Virtu Calabuig-navarro Petros Papadopoulos Salvador Meseguer Pedro M.Iborra Francisco García Antonio Martínez-Lorente Fernando Almazán Juana Calabuig Centro de Investigación Príncipe Felípe(Associated Unit to Instituto de Biomedicína de Valencia) ValenciaSpain Pathology and Molecular Therapy Department Instituto de Biomedicína de Valencia(IBV)CSICValenciaSpain Molecular and Cellular Biology Department Centro Nacional de Biotecnología(CNB)CSICMadridSpain Hematology Department Hospital Clínico San CarlosMadridSpain Medical Systems Biology Faculty of MedicineUniversity of HelsinkiHelsinkiFinland IC Biomed AlicanteSpain VinalopóHospitals Elcheand Biotechnology DepartmentUniversidad de AlicanteAlicanteSpain

Dear Editor,One of the most serious issues in modern oncology is the ineffectiveness of treatments in destroying tumours,which leads to tumour recurrence and,ultimately,patient *** phenomenon is caused by conventional therapies’fractional killing of tumour cells,which can also cause resistant cells to spread.1 We analysed chemotherapy-resistant cells and discovered that they are smaller than untreated cells(Fig.1a).The fact that this phenomenon occurs in all tested cell types(Hela,A549,Huh7,and MCF7)and regardless of the chemotherapy regimen(TRAIL,Camptothecin,Doxorubicin)suggests that it is a widespread phenomenon(Fig.1a,Supplementary Fig.S1).

关键词： chemotherapy tumour plasticity

Minimization of methabenzthiazuron residues in leaching water using amended soils and photocatalytic treatment with TiO_2 and ZnO

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Journal of Environmental Sciences 2014年第4期26卷 757-764页

作者： Jos Fenoll Pilar Flores Pilar Hellín Joaquín Hern'andez Simón navarro Department of Food Quality Murcia Institute of Agri-Food Research and Development Department of Agricultural Chemistry Geology and Pedology School of Chemistry University of Murcia Campus Universitario de Espinardo

In the present work, potential groundwater pollution by methabenzthiazuron （MTBU） and the effect of three different amendments （composted sheep manure, composted pine bark and spent coffee grounds） on its mobility were investigated under laboratory conditions. The efficiency of ZnO and TiO2 suspensions in the photocatalytic degradation of MTBU in leaching water was also investigated. The relative and cumulative breakthrough curves were obtained from disturbed soil columns. The presence and/or addition of organic matter drastically reduced the movement of the herbicide. On other hand, photocatalytic experiments showed that the addition of ZnO and TiO2 strongly enhances the degradation rate of this herbicide compared with the results of photolytic experiments under artificial light. ZnO appeared to be more effective in MTBU oxidation than TiO2. The results obtained point to the interest of using organic wastes and heterogeneous photocatalysis for reducing the pollution of groundwater by pesticide drainage.

关键词： groundwater pollution organic amendment pesticide movement photocatalytic oxidation semiconductor oxides

From contraction to gene expression:nanojunctions of the sarco/endoplasmic reticulum deliver site-and function-specific calcium signals

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Science China(Life Sciences) 2016年第8期59卷 749-763页

作者： A.Mark Evans Nicola Fameli Oluseye A.Ogunbayo Jingxian Duan Jorge navarro-Dorado Centre for Integrative Physiology College of Medicine and Veterinary MedicineHugh Robson BuildingUniversity of EdinburghEdinburgh EH8 9XDUK Institute of Biophysics Medical University of GrazGraz 8010Austria

Calcium signals determine, for example, smooth muscle contraction and changes in gene expression. How calcium signals select for these processes is enigmatic. We build on the "panjunctional sarcoplasmic reticulum" hypothesis, describing our view that different calcium pumps and release channels, with different kinetics and affinities for calcium, are strategically positioned within nanojunctions of the SR and help demarcate their respective cytoplasmic nanodomains. SERCA2 b and Ry R1 are preferentially targeted to the sarcoplasmic reticulum(SR) proximal to the plasma membrane(PM), i.e., to the superficial buffer barrier formed by PM-SR nanojunctions, and support vasodilation. In marked contrast, SERCA2 a may be entirely restricted to the deep, perinuclear SR and may supply calcium to this sub-compartment in support of vasoconstriction. Ry R3 is also preferentially targeted to the perinuclear SR, where its clusters associate with lysosome-SR nanojunctions. The distribution of Ry R2 is more widespread and extends from this region to the wider cell. Therefore, perinuclear Ry R3 s most likely support the initiation of global calcium waves at L-SR junctions, which subsequently propagate by calcium-induced calcium release via Ry R2 in order to elicit contraction. Data also suggest that unique SERCA and Ry R are preferentially targeted to invaginations of the nuclear membrane. Site- and function-specific calcium signals may thus arise to modulate stimulus-response coupling and transcriptional cascades.

关键词： calcium nanojunction ryanodine receptor sarco/endoplasmic reticulum calcium ATPase smooth muscle gene expression contraction

Single-stage laparoscopic management of acute gallstone pancreatitis:outcomes at different timings

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Hepatobiliary & Pancreatic Diseases International 2016年第3期15卷 297-301页

作者： Antonio navarro-Sanchez Hutan Ashrafian Aggelos Laliotis Kamran Qurashi Alberto Martinez-Isla Northwick Park and St Mark's Hospital North West London Hospitals NHS TrustWatford RoadHarrowMiddlesexLondonHA1 3UJUK Department of Surgery and Cancer Imperial College London10th Floor QEQM BuildingSt Mary's HospitalPraed StreetW2 1NYUK Guy's and St.Thomas'NHS Foundation Trust Great Maze PondLondonSE1 9RT and Westminster Bridge RoadLondonSE1 7EHUK Ealing Hospital NHS Trust Ux-bridge RdSouthallMiddlesexUB1 3HWUK

BACKGROUND： Definitive therapy for gallstone pancreatitis requires eradication of gallstones with cholecystectomy and common bile duct （CBD） clearance. Current guidelines rec- ommend this be done within the same admission and prefer- ably by laparoscopic cholecystectomy and CBD exploration. We report our experience of laparoscopic single-stage manage- ment with cholecystectomy and intraoperative cholangiogram followed by laparoscopic bile duct exploration （LBDE） when necessary performed at three different stages.

关键词： bile duct cholecystectomy pancreatitis

Validation of a preclinical dry eye model in New Zealand white rabbits during and following topical instillation of 1% ophthalmic atropine sulfate

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Animal Models and Experimental Medicine 2022年第3期5卷 266-273页

作者： Alejandra Sánchez-Ríos Elba Yadira Correa-Gallegos José Manuel Medina-Espinoza Andrea Anaid navarro-Sanchez Oscar Olvera-Montaño Leopoldo Baiza-Durán Patricia Muñoz-Villegas Medical Affairs Department Laboratorios SophiaSA de CVZapopanJaliscoMexico

Background : The objective of this study was to validate an animal model for dry eye during and after the administration of 1% ophthalmic atropine sulfate(OAS) in New Zealand white(NZW) *** : OAS(1%) was applied three times per day to 30 eyes of 15 healthy NZW rabbits. Sacrifice, enucleation, and lacrimal gland removal took place on days 15, 21,and 30(OAS group). A second group(n = 5) was used as control. Clinical evaluations took place on days 3, 10, 15, 18, 21, 24 and 30. The primary endpoints were:Schirmer I test, tear break-up time(TBUT), and corneal fluorescein staining. As secondary endpoints, clinical changes including intraocular pressure, and histopathology were *** : While OAS was administered, the Schirmer I test showed a statistically significant reduction for OAS group versus control( p < 0.001), and versus basal production( p < 0.001). TBUT showed statistically significant differences between groups(days 3 and 10;p = 0.001) and versus basal values(day 3;p < 0.001). Fluorescein staining showed a statistically significant difference(day 3;p = 0.001). The most frequent clinical finding was conjunctival hyperemia(76.9% OAS vs. 20% control). For histopathology, all OAS subjects presented some degree of inflammation(86.7% minimal;13.3% mild) whereas the control presented only 30% minimal inflammation. Goblet cell density showed no *** : The effectiveness of the OAS dry eye model in NZW rabbits as reported in previous studies was confirmed, provided that the application of the drug is maintained throughout the intervention;it is not a viable model after OAS administration is suspended.

关键词： atropine sulfate dry eye rabbit model safety Schirmer I test TBUT

Natural products:Perspectives in the pharmacological treatment of gastrointestinal anisakiasis

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Asian Pacific Journal of Tropical Medicine 2015年第8期8卷 604-609页

作者： Valero A Romero MC Gómez-Mateos M Hierro I navarro MC Department of Parasitology.Faculty of Pharmacy.University of Granada Department of Pharmacology.Faculty of Pharmacy.University of Granada

Objective: To evaluate the activity of different natural products against L3 larvae of Anisakis type I. Methods: Information on investigations into the activity of natural products against the L3 larvae of Anisakis simplex was collected from scientific journals, books, theses and reports via a library and electronic search(using Pubmed, Scopus, Medline, Web of Science and Science Direct). The search terms included: natural products, medicinal plants, essential oils, terpenic derivatives, Anisakis, antinematodal activity. Results: In the literature reviewed numerous papers were found concerning the in vitro and in vivo activity against Anisakis type I of various natural products(plant extracts, essential oils and their major components). Analysis of the results showed that in vitro tests the Melaleuca alternifolia essential oil and the ar-turmerone isolated from Curcuma longa displayed the greatest activity. In vivo, the most active compound was perillaldehyde, the main component of Perilla frutescens essential oil. Conclusions: This study shows that some natural products exhibited promising antianisakis properties.

关键词： Anisakis Anisakiasis Natural products Essential oils Terpenic derivatives

A"reappearance"of gallbladder in a liver transplant recipient

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Hepatobiliary Surgery and Nutrition 2018年第5期7卷 412-413页

作者： Al Warith Al Hashmi Fabrizio Panaro Francis navarro Department of General and Liver/Pancreas Transplant Surgery University of Montpellier-College of MedicineHopital Saint EloiMontpellierFrance

In liver transplantation graft cholecystectomy is performed *** leaks have an incidence of 2–25%following liver *** bile leaks are diagnosed within 30 days and rarely after 3 *** this article,we describe a case of bi... 详细信息

关键词： gallbladder routine liver