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Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 87-89页

作者： milica mitrovic jovanovic Dusan Saponjski Aleksandra Djuric Stefanovic Aleksandra Jankovic Stefan Milosevic Katarina Stosic Djordje Knezevic Jelena Kovac Department of Abdominal Radiology Center for Radiology and MRIClinical Center of SerbiaBelgradeSerbia Faculty of Medicine University of BelgradeBelgradeSerbia Clinic for Digestive Surgery–First Surgical Clinic Clinical Center of SerbiaBelgradeSerbia

Chronic pancreatitis is a long-standing inflammation of the pancreas,characterized by progressive inflammatory and fibrotic changes,resulting in permanent structural damage of pancreatic parenchyma[1].Pancreatitis(chronic or acute)is the primary risk factor for pseudo-splenic artery aneurysms,along with pancreatic pseudocysts and *** the disease progresses,patients with chronic pancreatitis may develop complications due to exocrine and endocrine pancreatic functional loss,such as fat malabsorption with steatorrhea,glucose intolerance,and ultimately diabetes mellitus[1,2].Furthermore,severe pancreatic inflammation can cause weakening of vessel walls,with subsequent formation of arterial *** artery is the most commonly affected visceral artery[2,3].Liver cirrhosis,portal hypertension,liver transplantation,atherosclerosis,hypertension,pregnancy and multiparity are main risk factors for true splenic artery aneurysms[2].Rupture and intraperitoneal bleeding is the cause of death in 30%−50%of ***,prompt diagnosis and appropriate treatment are of great clinical importance[4,5].Herein,we present a case of a giant splenic artery pseudoaneurysm within a walled of necrosis involving pancreatic parenchyma,as a complication of long standing chronic pancreatitis.

关键词： pancreatitis aneurysm inflammation

Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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Neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： milica Zeljkovic jovanovic Jelena Stanojevic Ivana Stevanovic milica Ninkovic Tihomir V.Ilic Nadezda Nedeljkovic Milorad Dragic Laboratory for Neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling

Galectin-3 possible involvement in antipsychotic-induced metabolic changes of schizophrenia:A minireview

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World Journal of Diabetes 2021年第10期12卷 1731-1739页

作者： milica M Borovcanin Katarina Vesic Milena jovanovic Natasa R Mijailovic Department of Psychiatry University of KragujevacFaculty of Medical SciencesKragujevac 34000SumadijaSerbia Department of Neurology University of KragujevacFaculty of Medical SciencesKragujevac 34000SumadijaSerbia PhD Studies University of KragujevacFaculty of Medical SciencesKragujevac 34000SumadijaSerbia Clinic for Nephrology and Dialysis University Clinical Center KragujevacKragujevac 34000SumadijaSerbia Department of Pharmacy University of KragujevacFaculty of Medical SciencesKragujevac 34000SumadijaSerbia

Recently,specific immunometabolic profiles have been postulated in patients with schizophrenia,even before full-blown disease and independent of antipsychotic *** profiling studies offer a promising potential for elucidating the cellular and molecular pathways that may be involved in the onset and progression of schizophrenia symptoms,and co-occurrent metabolic *** view of all this,we were intrigued to explore galectin-3(Gal-3)as a glycan,and in our previous study,we measured its elevated levels in remission of *** finding may be a consequence of antipsychotic treatment and may have an impact on the onset of inflammation,the development of obesity,and the presumed cognitive changes in *** the animal study,it was shown that downregulation of Gal-3 was beneficial in insulin regulation of obesity and cognitive *** involving plasma exchange are discussed in this review,particularly in the context of Gal-3 elimination.

关键词： Galectin-3 Schizophrenia Metabolic syndrome Insulin resistance Cognition Antipsychotics

Diabetes mellitus type 2 as an underlying,comorbid or consequent state of mental disorders

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World Journal of Diabetes 2023年第5期14卷 481-493页

作者： milica M Borovcanin Katarina Vesic Ivica Petrovic Ivan P jovanovic Natasa R Mijailovic Department of Psychiatry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Neurology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pathophysiology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Center for Molecular Medicine and Stem Cell Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pharmacy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

Somatic disturbances that occur in parallel with psychiatric diseases are a major challenge in clinical *** factors contribute to the development of mental and somatic *** 2 diabetes mellitus(T2DM)is a significant health burden worldwide,and the prevalence of diabetes in adults is *** comorbidity of diabetes and mental disorders is very *** sharing a bidirectional link,both T2DM and mental disorders influence each other in various manners,but the exact mechanisms underlying this link are not yet *** potential mechanisms of both mental disorders and T2DM are related to immune and inflammatory system dysfunction,oxidative stress,endothelial dysfunction,and metabolic ***,diabetes is also a risk factor for cognitive dysfunction that can range from subtle diabetesassociated cognitive decline to pre-dementia and dementia.A complex relationship between the gut and the brain also represents a new therapeutic approach since gut-brain signalling pathways regulate food intake and hepatic glucose *** aim of this minireview is to summarize and present the latest data on mutual pathogenic pathways in these disorders,emphasizing their complexity and *** also focused on the cognitive performances and changes in neurodegenerative *** importance of implementing integrated approaches in treating both of these states is highlighted,along with the need for individual therapeutic strategies.

关键词： Diabetes mellitus type 2 Mental disorders Neuroinflammation Neurodegeneration Cognition

High dose chemotherapy with stem cell support in the treatment of testicular cancer

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World Journal of Stem Cells 2015年第11期7卷 1222-1232页

作者： Lazar Popovic Gorana Matovina-Brko milica Popovic Dragana Petrovic Ana Cvetanovic Jelena Vukojevic Darjana jovanovic Medical School University of Novi Sad Department for Medical Oncology Oncology Institute of Vojvodina Department for Internal Medicine Clinical Center of Vojvodina Department for Oncology Clinical Center Nis

Testicular germ cell cancer(TGCC) is rare form of malignant disease that occurs mostly in young man between age 15 and 40. The worldwide incidence of TGCC is 1.5 per 100000 man with the highest rates in North Europe. After discovery of cisplatin cure rates of TGCC are very favorable between 90%-95% and unlike most solid tumors, cure rate for metastatic TGCC is around 80%. Metastatic TGCC is usually treated with 3-4 cycles of bleomycin, etoposide, cisplatinum chemotherapy with or without retroperitoneal surgery and cure rates with this approach are between 41% in poor risk group and 92% in good risk group of patients. Cure rates are lower in relapsed and refractory patients and many of them will die from the disease if not cured with first line chemotherapy. High dose chemotherapy(HDCT) approach was used for the first time during the 1980 s. Progress in hematology allowed the possibility to keep autologous haematopoietic stem cells alive ex-vivo at very low temperatures and use them to repopulate the bone marrow after sub-lethal dose of intesive myeloablative chemotherapy. Despite the fact that there is no positive randomized study to prove HDCT concept, cure rates in relapsed TGCC are higher after high dose therapy then in historical controls in studies with conventional treatment. Here we review clinical studies in HDCT for TGCC, possibilities of mobilising sufficient number of stem cells and future directions in the treatment of this disease.

关键词： High dose chemotherapy Germ-cell cancer Stem cell transplantation Plerixafor

Primary colorectal lymphoma:An overview

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World Journal of Gastrointestinal Oncology 2011年第1期3卷 14-18页

作者： Goran Z Stanojevic milica D Nestorovic Branko R Brankovic Miroslav P Stojanovic Milan M jovanovic Milan D Radojkovic Clinic for General Surgery Clinical Center NisBul Zorana Djindjica 4818000 NisSerbia

Lymphomas represent common hematological malignancies with increasing incidence in recent *** major site of extranodal non-Hodgkin lymphoma is the gastrointestinal *** of the large intestine is rare in comparison to the stomach or small *** disease appears later in life,predominantly in the male *** are nonspecific,requiring a high index of suspicion in order to establish the *** treatment varies from chemotherapy alone to multimodal therapies combining surgery,chemotherapy and *** small number of patients with various histological subtypes and different stage at presentation results in unclear protocol for the treatment of primary colorectal *** purpose of this paper is to review current data on primary lymphoma of the colon and rectum while analyzing reported case series and published material on the subject.

关键词： Lymphoma non-Hodgkin Extranodal lympho-ma Large intestine Colorectal surgery Chemotherapy

Galectin-3 mediated risk of inflammation in stable schizophrenia,with only possible secondary consequences for cognition

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World Journal of Psychiatry 2022年第9期12卷 1183-1193页

作者： Slavica Minic Janicijevic Ivan P jovanovic Nevena M Gajovic Milena M Jurisevic Monojit Debnath Nebojsa N Arsenijevic milica M Borovcanin University of Kragujevac Faculty of Medical SciencesKragujevac 34000Serbia Center for Molecular Medicine and Stem Cell Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pharmacy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Human Genetics National Institute of Mental Health and NeurosciencesBangalore 560029India Department of Psychiatry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

BACKGROUND Evidence suggests that cytokines cause immune disturbances,shape immunological sequelae later in life,and modulate the risk of schizophrenia(SC).Galectin-3(Gal-3),a multifaceted molecule of the glycan family,is involved in the formation of the immunological synapse and modulates the signalling pathway and effector functions of T lymphocytes,which are major producers of *** have previously reported elevated serum Gal-3 levels in stable SC ***,Gal-3 as a link between cognitive functioning and inflammation has not yet been investigated in *** To investigate the relationship between serum Gal-3 levels and cognitive performance,serum cytokines,and white blood cell count in three-month stably treated SC *** Twenty-seven patients with SC in remission and 18 healthy volunteers participated in this casecontrol and correlational *** assessment was performed using the Positive and Negative Syndrome Scale and the Montreal-Cognitive *** results of previously measured serum levels of Gal-3,interleukin(IL)-33,soluble suppression of tumorigenicity 2(sST2),tumor necrosis factor-alpha(TNF-α),IL-6 and IL-17 were used for further statistical analyses,and IL-4,IL-23,IL-1βand transforming growth factor-beta(TGF-β)were now additionally measured with a sensitive enzyme-linked immunosorbent *** number of leukocytes in the blood and the percentage of neutrophils,lymphocytes,and monocytes were determined with a standardized routine measurement procedure(Sysmex Technology).Statistical analyses were performed using SPSS 20.0 *** We found no correlation between serum Gal-3 levels and cognitive functioning in SC patients.A positive correlation was found between the levels of Gal-3 and TNF-α(r=0.476;P=0.012),Gal-3and IL-23(r=0.417;P=0.031),and Gal-3 and sST2(r=0.402;P=0.038).The binary logistic model,which included all nine cytokines measured in this patient sample,indicated the particular role of Gal-3 and T

关键词： Schizophrenia Galectin-3 Cytokines Leukocytes Antipsychotics

循环肿瘤细胞在非小细胞肺癌中的临床应用:我们达到目标了吗?

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国际病理科学与临床杂志 2013年第5期33卷 376-378页

作者： milica Kontic Miodrag Ognjanovic Dragana jovanovic Simona Ognjanovic 朱珉 Clinic for Pulmonology Clinical Center of SerbiaBelgrade Serbia Department of Environmental Health and Safety University of MinnesotaMinneapolis Minnesota USA Medical Faculty University in BelgradeSerbia Mayo Graduate School Mayo ClinicRochesterMinnesota USA 华中科技大学同济医学院附属同济医院胸外科武汉430030

早在140年前，人们就在患者循环系统中发现了与患者原发肿瘤细胞形态学相似的肿瘤细胞[1]。循环系统中的这些细胞很可能是患者原发肿瘤中脱落的，这个观点随着细胞遗传学技术的进步而得到了证实，表明这些循环细胞同样携带了原发肿瘤中... 详细信息

早在140年前，人们就在患者循环系统中发现了与患者原发肿瘤细胞形态学相似的肿瘤细胞[1]。循环系统中的这些细胞很可能是患者原发肿瘤中脱落的，这个观点随着细胞遗传学技术的进步而得到了证实，表明这些循环细胞同样携带了原发肿瘤中检出的基因突变[2]。

关键词：非小细胞肺癌循环肿瘤细胞临床应用肿瘤细胞形态学细胞遗传学技术循环系统原发肿瘤基因突变

Primary pancreatic lymphoma:A case report and review of literature

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World Journal of Clinical Oncology 2024年第11期15卷 1444-1453页

作者： Marko M Stojanovic Vesna Brzacki Goran Marjanovic milica Nestorovic Jelena Zivadinovic Miljan Krstic Marko Gmijovic Ilija Golubovic Svetlana jovanovic Miroslav P Stojanovic Katarina Terzic Department of Gastroenterology and Hepatology Clinic University Clinical Center NisMedical Faculty University of NisNis 18000Serbia Immunology Medical Faculty University of NisNis 18000Serbia Clinic for Digestive Surgery University Clinical CenterMedical Faculty University of NisNis 18000Serbia Clinic of Aneasthesiology and Intensive Therapy University Clinical Center NisUniversity of NisNis 18000Serbia Department of Pathology Medical Faculty University of NisNis 18000Serbia

BACKGROUND Primary pancreatic lymphoma(PPL)is a rare tumor that mimics pancreatic adenocarcinoma,leading to diagnostic and therapeutic *** accounts for 0.2%of all pancreatic tumors and is typically treated with ***,the long-term survival rates for PPL with chemotherapy and radiotherapy alone are *** to the improvements in pancreatic surgery,there is a need to reevaluate the treatment strategies for *** SUMMARY A 62-year-old male presented to our clinic.A biopsy was unsuccessful,and the imaging was suggestive of pancreatic ***,subtotal splenopancreatectomy was performed and histopathology was *** was then diagnosed with primary pancreatic diffuse large B-cell *** received adjuvant chemotherapy and ***,the patient is alive with no evidence of disease 36 months after *** The potential role of surgery in the treatment of PPL should be emphasized and added in the management protocol of early stage lymphoma.

关键词： Lymphoma Primary Pancreas Treatment Strategy Surgery Case report