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中华高血压杂志 2016年第1期24卷 43-43页

作者：刘莉叶鹏 Weissgerber TL milic nm MilinLazovic JS Garovic VD

内皮功能障碍被认为在先兆子痫中发挥关键作用,然而,目前还不清楚内皮功能障碍先于妊娠或是继发于妊娠早期的病理生理变化,也不明确血管功能障碍在产后可持续多长时间、是否是先兆子痫与未来的心血管病发生关联的机制。

关键词：血流介导先兆子痫内皮功能障碍血管舒张心血管病血管功能障碍舒张功能受损妊娠早期病理生理荟萃分析

Non-alcoholic fatty liver disease and obesity: Biochemical, metabolic and clinical presentations

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World Journal of Gastroenterology 2014年第28期20卷 9330-9337页

作者： Sandra milic Davorka Lulic Davor Stimac Division of Gastroenterology Department of Internal MedicineUniversity Hospital Rijeka

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. Presentation of the disease ranges from simple steatosis to non-alcoholic steatohepatitis (NASH). NAFLD is a hepatic manifestation of metabolic syndrome that includes central abdominal obesity along with other components. Up to 80% of patients with NAFLD are obese, defined as a body mass index (BMI) > 30 kg/m2. However, the distribution of fat tissue plays a greater role in insulin resistance than the BMI. The large amount of visceral adipose tissue (VAT) in morbidly obese (BMI > 40 kg/m2) individuals contributes to a high prevalence of NAFLD. Free fatty acids derived from VAT tissue, as well as from dietary sources and de novo lipogenesis, are released to the portal venous system. Excess free fatty acids and chronic low-grade inflammation from VAT are considered to be two of the most important factors contributing to liver injury progression in NAFLD. In addition, secretion of adipokines from VAT as well as lipid accumulation in the liver further promotes inflammation through nuclear factor kappa B signaling pathways, which are also activated by free fatty acids, and contribute to insulin resistance. Most NAFLD patients are asymptomatic on clinical presentation, even though some may present with fatigue, dyspepsia, dull pain in the liver and hepatosplenomegaly. Treatment for NAFLD and NASH involves weight reduction through lifestyle modifications, anti-obesity medication and bariatric surgery. This article reviews the available information on the biochemical and metabolic phenotypes associated with obesity and fatty liver disease. The relative contribution of visceral and liver fat to insulin resistance is discussed, and recommendations for clinical evaluation of affected individuals is provided.

关键词： Fatty liver Insulin resistance Intra-abdominal fat Metabolism Non-alcoholic fatty liver disease Obesity

A model for the chain-to-plane charge transfer in YBa2Cu3O6+x

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Chinese Physics B 2012年第11期21卷 450-454页

作者： V.M.Matic N.Dj.Lazarov M.milic Laboratory of Theoretical Physics Institute of Nuclear Sciences “Vinca”Belgrade University

A model for the chain-to-plane charge transfer is proposed to account for the two plateaus,at 60 K and at 90 K,of the Tc(x) characteristics of the YBa2Cu3O6+x high-Tc *** is assumed that the number of holes transferred from a CuO chain of length l to two nearby CuO2 sheets is proportional to l(that is,to the number of oxygen atoms in the chain),if the chain length is greater than,or equal to,a certain critical chain length,lcr,that is required to trigger the charge transfer *** holes are assumed to have been transferred from chains of length l更多还原AbstractFilter('ChDivSummary', 'ChDivSummaryMore', 'ChDivSummaryReset');

关键词： YBCO oxygen ordering critical temperature doping

Pharmacotherapy of acute alcoholic hepatitis in clinical practice

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World Journal of Gastroenterology 2014年第9期20卷 2159-2167页

作者： Ludovico Abenavoli Natasa milic Samir Rouabhia Giovanni Addolorato Department of Health Sciences University Magna Graecia Campus Germaneto 88100 CatanzaroItaly Department of Pharmacy University of Novi Sad 21000 Novi Sad Serbia Department of Internal Medicine University Hospital Center Touhami Benfis Batna 05000 Algeria Department of Internal Medicine Catholic University of Rome 00168 Rome Italy

Severe alcoholic hepatitis(AH)is an acute form of alcohol induced liver disease with a poor prognosis that is seen in the patients who consume large quantities of *** diagnosis of AH is based on the appropriate alcohol intake history and is supported with clinical and histological features,and several scoring *** are the mainstay for treating severe AH with pentoxifylline used as an alternative to steroids in addition to total alcohol *** transplantation is a possible therapeutic option for severe *** the anti-craving medications able to improve abstinence rate,baclofen seems to be effective and safe in the alcoholic patients affected by severe liver damage.

关键词： Severe alcoholic hepatitis, Maddrey’ s discriminant function, Glucocorticoids, Baclofen, Orthotopic liver transplantation, Alcoholic liver disease

Advances in diagnosis of chronic liver diseases in pediatric patients

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World Journal of Pediatrics 2018年第6期14卷 541-547页

作者： Lucija Ruzman Ivana Mikolasevic Kristina Baraba Dekanic Sandra milic Goran Palcevski Pediatric Clinic UHC RijekaIstarska 4351000 RijekaCroatia Department of Gastroenterology UHC RijekaRijekaCroatia Pediatric Clinic Department of GastroenterologyUHC RijekaRijekaCroatia

Background Chronic liver diseases (CLD) present important clinical problem in children with various age-dependent causes. Nonalcoholic fatty liver disease (NAFLD) with its increasing prevalence is a major problem with regard to its timely recog-nition and the need for long-term disease monitoring. At present, a perfect non-invasive method for the evaluation of liver fibrosis is not available. Methods A non-systematic literature search was performed to summarize the current knowledge about transient elastog-raphy (TE) with controlled attenuation parameter (CAP) in children with CLD. Ovid MEDLINE, Ovid EMBASE, Google scholar, and The Cochrane Library databases were searched for relevant articles evaluating TE in the pediatric population. Results Normal values of liver stiffness measurements (LSM) according to the age are given, as well as the advantages and disadvantages of the method. The utility of TE in specific liver disease in pediatric population is summarized. Conclusions TE with CAP is a valuable non-invasive method for the liver-damage assessment. Clinical interpretation of TE results should be made in parallel with the assessment of the patient's demographics, disease etiology, and essential laboratory parameters.

关键词： Child Liver disease Liver stiffness Pediatric Transient elastography

Fundamentals about onset and progressive disease character of type 2 diabetes mellitus

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World Journal of Diabetes 2020年第5期11卷 165-181页

作者： Rob nm Weijers Teaching Hospital Onze Lieve Vrouwe GasthuisAmsterdam 1090Netherlands

ResearchGate is a world wide web for scientists and researchers to share papers,ask and answer questions,and find *** one of the more than 15 million members,the author uploads research output and reads and responds to some of the questions raised,which are related to type 2 *** that way,he noticed a serious gap of knowledge of this disease among medical professionals over recent *** main aim of the current study is to remedy this situation through providing a comprehensive review on recent developments in biochemistry and molecular biology,which can be helpful for the scientific understanding of the molecular nature of type 2 *** fill up the shortcomings in the curricula of medical education,and to familiarize the medical community with a new concept of the onset of type 2 diabetes,items are discussed like:Insulin resistance,glucose effectiveness,insulin sensitivity,cell membranes,membrane flexibility,unsaturation index(UI;number of carboncarbon double bonds per 100 acyl chains of membrane phospholipids),slowdown principle,effects of temperature acclimation on phospholipid membrane composition,free fatty acids,energy transport,onset of type 2 diabetes,metformin,and *** on the reviewed data,a new model is presented with proposed steps in the development of type 2 diabetes,a disease arising as a result of a hypothetical hereditary anomaly,which causes hyperthermia in and around the *** is counterbalanced by the slow-down principle,which lowers the amount of carbon-carbon double bonds of membrane phospholipid acyl *** accompanying reduction in the UI lowers membrane flexibility,promotes a redistribution of the lateral pressure in cell membranes,and thereby reduces the glucose transporter protein pore diameter of the transmembrane glucose transport channel of all Class I GLUT *** events will set up a reduction in transmembrane glucose ***,a new blood glucose regulation syst

关键词： ATP Free fatty acid Glucose transporter Membrane flexibility Metformin Slow-down principle Type 2 diabetes Unsaturation index

Free fatty acids, glucose, and insulin in type 2 diabetes mellitus

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World Journal of Diabetes 2022年第3期13卷 275-277页

作者： Rob nm Weijers Teaching Hospital OLVGAmsterdam 95500Netherlands

Xu et al used the HOMA2 model to estimate theβ-cell function and insulin resistance levels in an individual from simultaneously measured fasting plasma glucose and fasting plasma insulin *** method is based on the assumption that the glucose-insulin axis is central for the metabolic activities,which led to type 2 ***,significant downregulation of both the NKX2-1 gene and the TPD52L3 gene force an increase in the release of free fatty acids(FFAs)into the blood circulation,which leads to a marked reduction in membrane *** data favor a FFA-glucose-insulin *** authors are invited to extend their study with the introduction of the saturation index(number of carbon-carbon double bonds per 100 fatty-acyl chains),as observed in erythrocytes.

关键词： Free fatty acids Membrane flexibility NKX2-1 gene RNA sequencing Type 2 diabetes TPD52L-3 gene Unsaturation index

Transient elastography(Fibro Scan~?) with controlled attenuation parameter in the assessment of liver steatosis and fibrosis in patients with nonalcoholic fatty liver disease- Where do we stand?

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World Journal of Gastroenterology 2016年第32期22卷 7236-7251页

作者： Ivana Mikolasevic Lidija Orlic Neven Franjic Goran Hauser Davor Stimac Sandra milic Department of Gastroenterology UHC Rijeka Department of Nephrology Dialysis and Kidney Transplantation UHC Rijeka

Non-alcoholic fatty liver disease(NAFLD) is the most common cause of chronic liver disease worldwide. Currently, the routinely used modalities are unable to adequately determine the levels of steatosis and fibrosis(laboratory tests and ultrasonography) or cannot be applied as a screening procedure(liver biopsy). Among the non-invasive tests, transient elastography(Fibro Scan?, TE) with controlled attenuation parameter(CAP) has demonstrated good accuracy in quantifying the levels of liver steatosis and fibrosis in patients with NAFLD, the factors associated with the diagnosis and NAFLD progression. The method is fast, reliable and reproducible, with good intra- and interobserver levels of agreement, thus allowing for population-wide screening and disease follow-up. The initial inability of the procedure to accurately determine fibrosis and steatosis in obese patients has been addressed with the development of the obese-specific XL probe. TE with CAP is a viable alternative to ultrasonography, both as an initial assessment and during follow-up of patients with NAFLD. Its ability to exclude patients with advanced fibrosis may be used to identify low-risk NAFLD patients in whom liver biopsy is not needed, therefore reducing the risk of complications and the financial costs.

关键词： Non-alcoholic fatty liver disease Transient elastography Controlled attenuation parameter

Insulin resistance and liver steatosis in chronic hepatitis C infection genotype 3

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World Journal of Gastroenterology 2014年第41期20卷 15233-15240页

作者： Ludovico Abenavoli Mario Masarone Valentina Peta Natasa milic Nazarii Kobyliak Samir Rouabhia Marcello Persico Department of Health Sciences University Magna Gr?cia Internal Medicine and Hepatology Unit University of Salerno Department of Pharmacy University of Novi Sad Bogomolets National Medical University Department of Internal Medicine University Hospital Center Touhami Benfis

Hepatitis C virus(HCV) infection is a common chronic liver disease ***-alcoholic fatty liver disease and insulin resistance(IR) are the major determinants of fibrosis progression and response to antiviral *** pathogenetic link between IR and chronic HCV infection is complex,and is associated with HCV *** steatosis is the most common in the patients infected with genotype 3 virus,possibly due to direct effects of genotype 3 viral *** the contrary,hepatic steatosis in the patients infected with other genotypes is thought to be mostly due to the changes in host metabolism,involving *** HCV genotype 3,liver steatosis correlates with viral load,reverts after reaching the sustained virologic response and reoccurs in the relapsers.A therapeutic strategy to improve IR and liver steatosis and subsequently the response to antiviral treatment in these patients is warranted.

关键词： Insulin resistance Non-alcoholic fatty liver disease Hepatitis C virus Genotype 3 Sustained virological response

Alimentary regimen in non-alcoholic fatty liver disease:Mediterranean diet

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World Journal of Gastroenterology 2014年第45期20卷 16831-16840页

作者： Ludovico Abenavoli Natasa milic Valentina Peta Francesco Alfieri Antonino De Lorenzo Stefano Bellentani Department of Health Sciences University Magna Graecia Campus Germaneto 88100 Catanzaro Italy Department of Pharmacy University of Novi Sad University MEIER 20124 Baranzate (MI) Italy Division of Clinical Nutrition and Nutrigenomic Department of Biomedicine and Prevention University of Tor Vergata Azienda USL di Modena Consultant for Primary Care Gastroenterology "Ramazzini" Hospital

Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease *** mechanisms of the underlying disease development and progression are awaiting *** resistance and obesity-related inflammation status,among other possible genetic,dietary,and lifestyle factors,are thought to play the key *** is no consensus concerning the pharmacological ***,the dietary nutritional management to achieve weight loss is an essential component of any treatment *** the basis of its components,the literature reports on the effectiveness of the Mediterranean diet in reducing cardiovascular risk and in preventing major chronic diseases,including obesity and *** evidence supports the idea that the Mediterranean diet,associated with physical activity and cognitive behaviour therapy,may have an important role in the prevention and the treatment of NAFLD.

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Insulin resistance Nutrition Mediterranean diet