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PDA功能模块的设计

电子产品世界 2001年第17期8卷 49-51页

作者： miles brown 栋

Mitochondrial therapeutics and mitochondrial transfer for neurodegenerative diseases and aging

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Neural Regeneration Research 2025年第3期20卷 794-796页

作者： Neville Ng Michelle Newbery Nicole miles Lezanne Ooi Molecular Horizons and School of Chemistry and Molecular Bioscience University of WollongongWollongongNSWAustralia

Mitochondrial dysfunction and neurodegeneration:Progressive neurodegenerative diseases affect a significant proportion of the population;in a single year,there are as many as 276 million disabilities and 9 million dea... 详细信息

关键词： degenerative diseases Mitochondrial

Biomarker bust:meta-analyses reveal unreliability of neuronal extracellular vesicles for diagnosing parkinsonian disorders

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Neural Regeneration Research 2025年第1期20卷 201-202页

作者： Hash brown Taha Leonard Davis School of Gerontology University of Southern CaliforniaLos AngelesCAUSA

A range of neurodegenerative disorders,collectively termed parkinsonian disorders,present with a complex array of both motor and non-motor *** in this group are Parkinson’s disease(PD),dementia with Lewy bodies(DLB),multiple system atrophy(MSA),corticobasal syndrome(CBS),and progressive supranuclear palsy(PSP).These disorders are differentiated neuropathologically by their dominant protein pathologies involvingα-synuclein(α-syn)and/or tau,the types of brain cells affected,such as neurons,oligodendroglia,and astrocytes,and the specific brain regions involved(Tolosa et al.,2021).

关键词： disorders parkin

Immunoassay development guidelines for neurodegenerative disorders:lessons from a failed pS129-α-synuclein electrochemiluminescence immunoassay

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Neural Regeneration Research 2025年第10期20卷 2906-2908页

作者： Hash brown Taha Alanna Morris Leonard Davis School of Gerontology University of Southern CaliforniaLos AngelesCAUSA Deparmtent of Neurobiology David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCAUSA

An aging population is a double-edged *** one hand,advancements in biotechnology and healthcare allow more people to enjoy longer *** the other hand,increases in the aging population accompany a surge in age-associated diseases,particularly neurodegenerative *** aging is the primary risk factor for many neurodegenerative disorders,living longer does not necessarily equate to maintaining a reasonable quality of life(Feigin et al.,2020).

关键词： aging degenerative necessarily

Projective Hilbert modules and sequential approximations

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Science China Mathematics 2025年第1期 137-168页

作者： Lawrence G.brown Huaxin Lin Department of Mathematics Purdue University Department of Mathematics East China Normal University Department of Mathematics University of Oregon Shanghai Institute for Mathematics and Interdisciplinary Sciences

We show that when A is a separable C*-algebra,every countably generated Hilbert A-module is projective（with bounded module maps as morphisms）.We also study the approximate extensions of bounded module *** the case where A is a σ-unital simple C*-algebra with strict comparison,and every strictly positive lower semicontinuous affine function on quasitraces can be realized as the rank of an element in the Cuntz semigroup,we show that the Cuntz semigroup is equivalent to unitarily equivalent classes of countably generated Hilbert A-modules if and only if A has stable rank one.

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.brown Rafael J.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Control Scheme for Distributed Generator Providing Network Voltage Support

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电力系统自动化 2012年第8期36卷 198-202页

作者： miles A.REDFERN Department of Electronic and Electrical Engineering University of Bath

The distributed generator over the last 30years has posed several challenges when they are connected to a distributed *** most immediate problem is to change the voltage at the connection point depending on the power supplied to the network and may cause it to exceed statutory *** paper describes a new control scheme for a distributed generator for supporting the voltage control in the network,thus ensuring the distributed generator to contribute to network voltage *** scheme performance is demonstrated by a model for a distributed generator connected to a distribution *** result shows that using the new control scheme,the distribution network voltage constraints are maintained while maximizing the active power delivered by distributed generators.

关键词：分布式网络电压控制控制计划发电机电压管理网络连接分销网络有功功率

Targeting collective behaviors of transplanted retinal cells as a strategy to improve cellular integration

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Neural Regeneration Research 2022年第6期17卷 1271-1272页

作者： miles Markey Maribel Vazquez Department of Biomedical Engineering RutgersThe State University of New JerseyPiscatawayNJUSA

Introduction:The rapidly growing field of regenerative medicine incorporates fundamental principles of stem cell biology and biomedical engineering to repair tissues damaged by genetic disorder,degeneration,or traumatic *** global market for stem cell therapies is expanding at an accelerating rate and projected to triple to over 100 Billion USD by the end of the decade(No author listed,2019),as per Figure 1A.

关键词： degeneration collective traumatic

Participatory Disaster Recovery Simulation Modeling for Community Resilience Planning

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International Journal of Disaster Risk Science 2018年第4期9卷 519-529页

作者： Scott B.miles Department of Human Centered Design and Engineering University of Washington

A major challenge in enhancing the resilience of communities stems from current approaches used to identify needs and strategies that build the capacity of jurisdictions to mitigate loss and improve recovery. A new generation of resilience-based planning processes has emerged in the last several years that integrate goals of community well-being and identity into recovery-based performance measurement frameworks. Specific tools and refined guidance are needed to facilitate evidence-based development of recovery estimates. This article presents the participatory modeling process, a planning system designed to develop recovery-based resilience measurement frameworks for community resilience planning initiatives. Stakeholder engagement is infused throughout the participatory modeling process by integrating disaster recovery simulation modeling into community resilience planning. Within the process, participants get a unique opportunity to work together to deliberate on community concerns through facilitated participatory modeling. The participatory modeling platform combines the DESaster recovery simulation model and visual analytics *** is an open source Python Library for creating discrete event simulations of disaster recovery. The simulation model was developed using a human-centered design approach whose goal is to be open, modular, and extensible. The process presented in this article is the first participatory modeling approach for analyzing recovery to aid creation of community resilience measurement frameworks.

关键词： Community resilience planning Disasters Disaster recovery Participatory modeling Recovery-based performance targets Simulation modeling