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World Journal of Gastroenterology 2006年第12期12卷 1975-1977页

作者： Srdjan P Djuranovic Milan M Spuran Nada V Kovacevic milenko b uqliesic Dragutin M Kecmanovic Marian T Micev Institute for Digestive Diseases Clinical Center of SerbiaK.Todorovica St No 611000 BelgradeSerbia and Montenegro

Mucinous cystadenoma of the appendix is a rare condition and represents one of the three entities with the common name mucocele of the appendix. It is characterized by a cystic dilatation of the lumen with stasis of mucus inside it. Histopathologically mucocele is divided into three groups： focal or diffuse mucosal hyperplasia, mucinous cystadenoma and mucinous cystadenocarcinoma. This condition is often associated with other neoplasia, especially adenocarcinoma of the colon and ovaries. We here describe a 57 year old male patient who presented with abdominal discomfort, constipation, fresh blood in stool and frequent urination. He had a big cystadenoma of the appendix associated with adenocarcinoma of the colon and hepatocellular carcinoma of the liver. The patient underwent right haemicolectomy, sigmoid colon resection and segmental resection of the liven Now 3 years later he has no evidence of disease relapse. According to this, we stress the need of accurate preoperative diagnosis and intraoperative exploration of the whole abdomen in these patients.

关键词： Hucocele Appendiceal cystadenoma Colon carcinoma Hepatocellular carcinoma

Double common bile duct: A case report

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World Journal of Gastroenterology 2007年第27期13卷 3770-3772页

作者： Srdjan P Djuranovic milenko b Ugljesic Nenad S Mijalkovic Viktorija A Korneti Nada V Kovacevic Tamara M Alempijevic Slaven V Radulovic Dragan V Tomic Milan M Spuran Clinic for Gastroenterology and Hepatology Clinical Center of Serbia Belgrade Serbia 1st Surgical Clinic Clinical Center of Serbia Belgrade Serbia

Double common bile duct （DCbD） is a rare congenital anomaly in which two common bile ducts exist. One usually has normal drainage into the papilla duodeni major and the other usually named accessory common bile duct （ACbD） opens in different parts of upper gastrointestinal tract （stomach, duodenum, ductus pancreaticus or septum）. This anomaly is of great importance since it is often associated with biliary lithiasis, choledochal cyst, anomalous pancreaticobiliary junction （APbJ） and upper gastrointestinal tract malignancies. We recently recognized a rare case of DCbD associated with APb3 with lithiasis in better developed common bile duct. The opening site of ACbD was in the pancreatic duct. The anomaly was suspected by transabdominal ultrasonography and finally confirmed by endoscopic retrograde cholangiopancreatography （ERCP） followed by endoscopic sphincterotomy and stone extraction. According to the literature, the existence of DCbD with the opening of ACbD in the pancreatic duct is most frequently associated with APb3 and gallbladder carcinoma. In case of DCbD, the opening site of ACbD is of greatest clinical importance because of its close implications with concomitant pathology. The adequate diagnosis of this rare anomaly is significant since the operative complications may occur in cases with DCbD which is not recognized prior to surgical treatment.

关键词： Double common bile duct Accessory common bile duct Anomalous pancreaticobiliary junction

Mathematical Modeling of Hemoglobin Release under Hypotonic Conditions

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Engineering（科研） 2012年第10期4卷 176-179页

作者： Ivana Pajic-Lijakovic branko bugarski milenko Plavsic Dept. of Chem. Eng. University of belgrade Faculty of Technology and Metallurgy Belgrade Serbia Dept. of Polymer Eng. University of Belgrade Faculty of Technology and Metallurgy Belgrade Serbia

Mathematical model is developed to estimate hemoglobin release under hypotonic conditions at microscopic level. The phenomenon of hemoglobin (Hb) release depends on: 1) the dynamics of repeated opening of hemolytic holes and 2) the radial fluctuations of lipid membrane. both processes are sensitive to the rate of ionic strength decrease within the surrounding medium. Influence of the rate of ionic strength decrease on hemoglobin release is quantified by the model parameters: 1) the specific decrease of erythrocyte radius and 2) the specific decrease of hole radius during single opening time period of hemolytic hole. The prediction of released amount of Hb influenced by the conductive mechanism is equal to 2.9 %. The prediction of total released amount of Hb influenced by the conductive and convective mechanisms is approximately equal to 4 % of the initial amount of Hb within erythrocyte.

关键词： Hemoglobin Transport Hemolytic Hole Thermodynamics Cellular biology and Engineering Mathematical Modeling

Micro-environmentally Restricted Yeast Cell Growth within Ca-alginate Microbeads

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Engineering（科研） 2012年第10期4卷 180-183页

作者： Ivana Pajic-Lijakovic branko bugarski branko bugarski milenko Plavsic Steva Levic Ana Kalusevic Viktor Nedovic Dept. of Chem. and Polymer Eng. University of Belgrade Faculty of Technology and Metallurgy Belgrade Serbia Dept. of Food Technol. University of Belgrade Faculty of Agriculture Belgrade Serbia

Micro-environmental restriction effects to yeast cell growth obtained within Ca-alginate microbeads are considered. It is complex phenomenon influenced by: (1) relaxation of expanded polymer network around the cellular clusters, (2) forces generated by cell growth inside the beads and (3) interactions between solvent, network parts and cells. The resulting effects are measured experimentally by estimating volume of microbeads and yeast cell concentration as function of time of cultivation. Comparative analysis of dynamics of cell growth and increase of microbead volume through four regimes indicates that reversible and irreversible local structural changes of Ca-alginate hydrogel induces micro-environmental restrictions to cell growth. The mechanism of restrictions includes both mechanical and electrostatic effects.

关键词： Yeast Cells Micro-environmental Restrictions Ca-alginate Hydrogel Matrix Structural Changes Pattern of Volumetric Yeast Growth