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Estrogen and progesterone receptor isoforms expression in the stomach of Mongolian gerbils

World Journal of Gastroenterology 2008年第37期14卷 5701-5706页

作者： milena saqui-salces Teresa Neri-Gómez Armando Gamboa-Dominguez Guillermo Ruiz-Palacios Ignacio Camacho-Arroyo Facultad de Química Departamento de Biología Universidad Nacional Autónoma de MéxicoMéxico DF 04510 México Departamento de Patología INCMNSZMéxico DF14000 México Departamento de Infectología INCMNSZMéxico DF 14000 México

AIM: We studied the estrogen receptor (ER) and progesterone receptor (PR) isoforms expression in gastric antrum and corpus of female gerbils and their regulation by estradiol (E2) and progesterone (P4). METHODS: Ovariectomized adult female gerbils were subcutaneously treated with E2, and E2 + P4. Uteri and stomachs were removed, the latter were cut along the greater curvature, and antrum and corpus were excised. Proteins were immunoblotted using antibodies that recognize ER-alpha, ER-beta, and PR-A and PR-B receptor isoforms. Tissues from rats treated in the same way were used as controls. RESULTS: Specific bands were detected for ER-alpha (68 KDa), and PR isoforms (85 and 120 KDa for PR-A and PR-B isoforms, respectively) in uteri, gastric antrum and corpus. We could not detect ER-beta isoform. PR isoforms were not regulated by E2 or P4 in uterus and gastric tissues of gerbils. ER-alpha isoform content was significantly down-regulated by E2 in the corpus, but not affected by hormones in uterus and gastric antrum. CONCLUSION: The presence of ER-alpha and PR isoforms in gerbils stomach suggests that E2 and P4 actions in this organ are in part mediated by their nuclear receptors.

关键词：胃雌激素黄体酮蒙古沙鼠动物实验性激素

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