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^(11)C-PK11195 plasma metabolization has the same rate in multiple sclerosis patients and healthy controls:a cross-sectional study

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Neural Regeneration Research 2021年第12期16卷 2494-2498页

作者： Aline Morais de Souza milena sales pitombeira Larissa Estessi de Souza Fabio Luiz Navarro Marques Carlos Alberto Buchpiguel Caroline Cristiano Real Daniele de Paula Faria Laboratory of Nuclear Medicine(LIM43) Department of Radiology and OncologyFaculdade de Medicina FMUSPUniversidade de Sao PauloSao PauloSPBrazil Department of Neurology Faculdade de Medicina FMUSPUniversidade de Sao PauloSao PauloSPBrazil

^(11)C-PK11195 is a positron emitter tracer used for Positron Emission Tomography(PET)imaging of innate immune cell activation in studies of neuroinflammatory *** the image quantitative analysis,it is necessary to quantify the intact fraction of this tracer in the arterial plasma during imaging acquisition(plasma intact fraction).Due to the complexity and costs involved in this analysis it is important to evaluate the real necessity of individual analysis in each 11C-PK11195 PET imaging *** purpose of this study is to compare 11CPK11195 plasma metabolization rate between healthy controls and multiple sclerosis(MS)patients and evaluate the interference of sex,age,treatment,and disease phenotype in the tracer intact fraction measured in arterial plasma samples.11C-PK11195 metabolization rate in arterial plasma was quantified by high performance liquid chromatography in samples from MS patients(n=50)and healthy controls(n=23)at 20,45,and 60 minutes after 11C-PK11195 *** were also stratified by sex,age,treatment type,and MS *** results showed no significant differences in the metabolization rate of healthy controls and MS patients,or in the stratified *** conclusion,11C-PK11195 metabolization has the same rate in patients with MS and healthy controls,which is not affected by sex,age,treatment,and disease ***,these findings could contribute to exempting the necessity for tracer metabolization determination in all 11C-PK11195 PET imaging acquisition,by using a population metabolization rate *** study procedures were approved by the Ethics Committee for Research Projects Analysis of the Hospital das Clinicas of the University of Sao Paulo Medical School(approval No.624.065)on April 23,2014.

关键词： ^(11)C-PK11195 HPLC kinetic modeling metabolization multiple sclerosis neuroinflammation PET imaging PET tracer radiometabolites

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