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NKX2-3 and IRGM variants are associated with diseasesu sceptibility to IBD in Eastern European patients

World Journal of Gastroenterology 2010年第41期16卷 5233-5240页

作者： Nora Meggyesi Lajos S Kiss Magdalena Koszarska Martin Bortlik Dana Duricova Laszlo Lakatos Tamas Molnar Martin Lenicek Libor Vítek Istvan Altorjay Maria Papp Zsolt Tulassay Pal Miheller Janos Papp Attila Tordai Hajnalka Andrikovics milan lukas Peter Laszlo Lakatos Department of Molecular Diagnostics Hun-garian National Blood Transfusion Service H-1113 BudapestHungary 1st Depart-ment of Medicine Semmelweis University H-1083 BudapestHungary IBD Clinicaland Research Centre ISCARE IVF and 1st Medical FacultyCharles University 170 04 Prague Czech Republic 1st Department of Medicine Csolnoky F.County Hospital H8200 Veszprem Hungary 1st Department of Medicine University ofSzeged H6720 Szeged Hungary Department of Biochemistry andLaboratory Diagnostics 1st Medical Faculty Charles Univer-sity 170 04 Prague Czech Republic 2nd Department of Medicine University of Debrecen H4032 Debrecen Hungary 2nd Department of Medicine Semmelweis University H1085 Budapest Hungary

AIM: To investigate variants of immunity-related GT-Pase family M (IRGM) and NKX2-3 genes and genotype-phenotype in Eastern European patients with inflammatory bowel disease (IBD).METHODS: We analyzed 1707 Hungarian and Czech subjects with Crohn’s disease (CD) (n = 810, age: 37.1 ± 12.6 years, duration: 10.7 ± 8.4 years) and ulcerative colitis (UC) (n = 428, age: 43.7 ± 15.0 years, duration: 12.6 ± 9.9 years), as well as 469 healthy controls. IRGM rs13361189, NKX2-3 rs10883365 and ECM1 rs13294 polymorphisms were tested by LightCy-cler allele discrimination. Detailed clinical phenotypes were determined by reviewing the medical charts. RESULTS: NKX2-3 rs10883365 variant allele was as-sociated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79). In contrast, ECM1 rs13294 was not associat-ed with either CD or UC. In CD, the variant IRGM allele was associated with a colon-only location (P = 0.02, OR = 1.62, 95% CI = 1.07-2.44), whereas in UC, the ECM1 variant was associated with cutaneous manifestations (P = 0.002, OR = 3.36, 95% CI = 1.48-7.63). Variant alleles did not predict resistance to steroids or azathio-prine, efficacy of infliximab, or need for surgery. CONCLUSION: NKX2-3 and IRGM are susceptibility locifor IBD in Eastern European patients. Further studies are needed to confirm the reported phenotype-genotype associations.

关键词： Crohn’s disease Ulcerative colitis NKX2-3 Immunity-related GTPase family M ECM1 Genotype Phenotype Pharmacogenetics

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Boron isotopic variations in tourmaline from metacarbonates and associated calc-silicate rocks from the Bohemian Massif: Constraints on boron recycling in the Variscan orogen

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Geoscience Frontiers 2021年第1期12卷 219-230页

作者： lukas Krmcek milan Novak Robert B.Trumbull Jan Cempirek Stanislav Houzar Department of Geological Sciences Faculty of ScienceMasaryk UniversityKotlarska 2CZ-61137BrnoCzech Republic Institute of Geology of the Czech Academy of Sciences Rozvojova 269CZ-16502Prague 6Czech Republic Brno University of Technology Faculty of Civil EngineeringAdMaS CentreVeve■rí95CZ-60200BrnoCzech Republic GFZ German Research Centre for Geosciences TelegrafenbergD-14473PotsdamGermany Department of Mineralogy and Petrography Moravian MuseumZelnyTrh 6CZ-67401BrnoCzech Republic

Various metacarbonate and associated calc-silicate rocks form minor but genetically significant components of the lithological units in the Bohemian Massif of the Variscan orogen in Central *** rocks vary in terms of their lithostratigraphy,chemical composition and mineral assemblage(dolomite/calcite ratio,silicate abundance).Tourmaline is present in five paragenetic settings within the metacarbonate and calc-silicate ***Ⅰcomprises individual,euhedral,prismatic grains and grain aggregates in a carbonate-dominant(calcite±dolomite)matrix poor in ***Ⅱis characterized by euhedral to subhedral grains and coarse-to fine-grained aggregates in silicate-rich layers/nests within metacarbonate bodies whereas typeⅢoccurs as prismatic grains and aggregates at the contact zones between carbonate and associated silicate host ***Ⅳis in veins crosscutting metacarbonate bodies,and typeⅣtourmaline occurs at the exocontacts of elbaite-subtype granitic *** from the different settings shows distinctive compositional *** for typeⅠare Mg-rich compositions,with fluor-uvite>dravite>>*** from typeⅡsilicate-rich layers/nests are highly variable,corresponding to oxy-schorl,magnesio-foitite,Al-rich dravite and *** for typeⅢtourmalines are Ca,Ti-bearing oxy-dravite *** typeⅣveins feature dravite and fluor-uvite tourmaline compositions whereas typeⅤtourmaline is Li,F-rich *** is the only Bbearing phase in paragenetic typesⅠ-Ⅳ,where it is characterised by two principal ranges of B-isotope composition(δ^11B=-13‰to-9‰and-18‰to-14‰).These ranges correspond to regionally different units of the Moldanubian ***,the Svratka Unit(Moldanubian Zone s.l.)contains only isotopically lighter tourmaline(δ^11B=-18‰to-14‰),whereas metacarbonates in the Poli?ka unit(Teplá-Barrandian Zone)and Olesnice unit(Moravicum of the Moravo-Silesian Zone)has exclusively isotopically heav

关键词： Boron isotopes Tourmaline Metacarbonates Moldanubicum Variscan orogeny

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Population distribution modelling at fine spatio-temporal scale based on mobile phone data

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International Journal of Digital Earth 2019年第11期12卷 1319-1340页

作者： Petr Kubicek milan Konecny Zdenek Stachon Jie Shen lukas Herman Tomas Reznik Karel Stanek Radim Stampach Simon Leitgeb Department of Geography Faculty of ScienceMasaryk UniversityBrnoCzech Republic Key Laboratory of Virtual Geographic Environment of Ministry of Education Nanjing Normal UniversityNanjingChina Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application NanjingChina School of Geography Nanjing Normal UniversityNanjingChina

Population distribution modelling can benefit many different domains,for example,transportation,urban planning,ecology or emergency *** about the location and number of people in an affected area is crucial for decision-makers during emergencies and *** phone data represents relatively reliable and time accurate information on real-time population distribution,movement and *** this study,we evaluate the spatio-temporal distribution of population derived from phone data of the selected pilot area(City of Brno,Czech Republic).Analysis is based on the dataset describing the estimated human presence(EHP)with two values-visitors and transiting *** temporal change of data is first analysed and further processed using two methodological ***,the dasymetric method is used where the building geometry and technical attributes served as a target ***,the results of building level analysis are transformed into a regular grid zone of both visitors and the general *** spatio-temporal patterns are compared to the census *** demonstrate how the proposed building level dasymetric approach can improve the spatial granularity of *** use of proposed methodology within selected emergency situations is further discussed.

关键词： Population distribution modelling mobile phone data estimated human presence emergency management

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The effect of fitness level on cardiac autonomic regulation, IL-6,total antioxidant capacity, and muscle damage responses to a single bout of high-intensity interval training

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Journal of Sport and Health Science 2018年第3期7卷 363-371页

作者： lukas Cipryan Human Motion Diagnostic Centre and Department of Human Movement Studies Ostrava University

Purpose:The aim of this study was to investigate the influence of the cardiorespiratory fitness level on the response to high-intensity interval training(HIIT)with an individually adjusted running speed of the same relative *** evaluation focused on acute cardiorespiratory response,postexercise cardiac autonomic modulation(heart rate variability(HRV))and biochemical markers of inflammation,oxidative stress,and muscle ***:Thirty participants were divided into 3 subgroups:well trained,moderately trained,and *** the participants performed30 min HIIT composed of 6×2 min interval exercise with work-to-relief ratio=1 and work intensity 100%of individual velocity at maximal oxygen consumption(VO2max).Acute cardiorespiratory variables,postexercise HRV,lactate,interleukin-6(IL-6),total antioxidant capacity(TAC),creatine kinase,and myoglobin up to 4h after HIIT were ***:The differences in relatively expressed cardiorespiratory variables(heart rate,VO2)during HIIT were at most moderate,with the most pronounced between-group differences in absolute VO2 *** disruption of the postexercise HRV was the most pronounced in untrained individuals,and this difference persisted 1 h after *** highest postexercise IL-6 and TAC concentrations and the lowest changes in creatine kinase and myoglobin were revealed in well-trained ***:The higher fitness level was associated with the less pronounced postexercise cardiac autonomic changes and their faster restoration,even when there were similar acute cardiorespiratory *** findings were simultaneously accompanied by the higher postexercise IL-6 and TAC concentrations and less significant changes in muscle damage biochemical markers in well-trained individuals.

关键词： Creatine kinase Heart rate variability Inflammation Myoglobin Total antioxidant capacity Training status

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The tip of the iceberg?The underestimated potential of non-canonical beta-amyloids for Alzheimer's disease

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Neural Regeneration Research 2023年第12期18卷 2689-2690页

作者： lukas Busch Bernd Bufe Department of Informatics and Microsystems Technology University of Applied Sciences KaiserslauternZweibrückenGermany

Formation and deposition of amyloid-beta(Aβ) are considered one of the main drivers of Alzheimer's disease(AD). For more than 30 years, Aβ has challenged researchers through its complex physicochemical properties an... 详细信息

关键词： amyloid Alzheimer Aβ

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Frost Damage Index:The Antipode of Growing Degree Days

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Plant Phenomics 2023年第4期5卷 757-766页

作者： Flavian Tschurr Norbert Kirchgessner Andreas Hund lukas Kronenberg Jonas Anderegg Achim Walter lukas Roth Department of Environmental System Sciences Institute of Agricultural SciencesETH ZürichZürichSwitzerland Crop Genetics John Innes CentreNorwichUK Department of Environmental System Sciences Institute of Integrative BiologyETH ZürichZürichSwitzerland

Abiotic stresses such as heat and frost limit plant growth and ***-based field phenotyping methods allow quantifying not only plant growth but also plant *** crops show senescence caused by cold spells,visible as declines in leaf *** accurately quantified such declines by monitoring changes in canopy cover based on time-resolved high-resolution imagery in the ***-six winter wheat genotypes were measured in multiple years.A concept termed"frost damage index"(FDI)was developed that,in analogy to growing degree days,summarizes frost events in a cumulative *** measured sensitivity of genotypes to the FDI correlated with visual scorings commonly used in breeding to assess winter *** FDI concept could be adapted to other factors such as drought or heat *** commonly not considered in plant growth modeling,integrating such degradation processes may be key to improving the prediction of plant performance for future climate scenarios.

关键词： winter analogy integrating

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Corrosion Behavior of AZ31 Magnesium Alloy in Highly Alkaline Environment

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Acta Metallurgica Sinica(English Letters) 2017年第4期30卷 367-375页

作者： Somi Doja lukas Bichler Simon Fan School of Engineering University of British ColumbiaOkanagan 3333 University Way Kelowna BC V1V 1VTCanada ZincNyx Energy Solutions Vancouver BC V6P 6T3 Canada

Industrial components made with a magnesium-aluminum alloy AZ31 are often used in diverse engineering applications where component weight, strength, and durability are critical. Similarly as other Mg alloys, however, the AZ31 is susceptible to corrosion in alkaline environments. In this work, corrosion of commercial grade AZ31 alloy plate was examined in potassium hydroxide （KOH） using immersion and potentiodynamic studies. The results suggest that the concentration of A1 and Mn in the alloy may govern the kinetics of micro-galvanic corrosion and the initiation of corrosion pits. Further, trace amounts of Ni in the AZ31 alloy were seen to enable formation of Ni（OH）2 surface layer, which may have further accelerated alloy corrosion due to its cracking and void coalescence. The effect of pH on the corrosion behavior of AZ31 was studied with reference to Pourbaix diagrams.

关键词： Magnesium alloy AZ31 KOH

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From Neglecting to Including Cultivar-Specific Per Se Temperature Responses:Extending the Concept of Thermal Time in Field Crops

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Plant Phenomics 2024年第3期6卷 547-562页

作者： lukas Roth Martina Binder Norbert Kirchgessner Flavian Tschurr Steven Yates Andreas Hund lukas Kronenberg Achim Walter ETH Zurich Institute of Agricultural SciencesUniversitätstrasse 28092 ZürichSwitzerland John Innes Centre Crop GeneticsNorwich NR47UHUnited Kingdom

Predicting plant development,a longstanding goal in plant physiology,involves 2 interwoven components:continuous growth and the progression of growth stages(phenology).Current models for winter wheat and soybean assume species-level growth responses to *** challenge this assumption,suggesting that cultivar-specific temperature responses substantially affect *** investigate,we collected field-based growth and phenology data in winter wheat and soybean over multiple *** used diverse models,from linear to neural networks,to assess growth responses to temperature at various trait and covariate ***-specific nonlinear models best explained phenology-related cultivar-environment *** cultivar-specific models,additional relations to other stressors than temperature were *** availability of the presented field phenotyping tools allows incorporating cultivar-specific temperature response functions in future plant physiology studies,which will deepen our understanding of key factors that influence plant ***,this work has implications for crop breeding and cultivation under adverse climatic conditions.

关键词： temperature specific concept crops field time from cultivar extending including

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Balancing development and conservation needs of stakeholders in the Tusheti Protected Landscape

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Journal of Mountain Science 2020年第3期17卷 709-723页

作者： SVAJDA Juraj MALAC lukas KHARTISVILI Lela Matej Bel University Faculty of Natural Sciences97401 Banska BystricaSlovakia HaskoningDHV 18600 PrahaCzech Republic BOKU University of Natural Resources and Life Sciences 1190 WienAustria

Public governance and civil society play an important role in the preservation of the environmental and cultural values of the specific region of Tusheti. This area is an interesting study object also due to its unique governing model and different management issues including the historical background of the region and the current growth of tourism. In the region, where there is a significant number of initiatives supported by donors, a management plan for the protected landscape was prepared and put into practice and selected measures were implemented. Our evaluation of the activities was focused on relevance, efficiency, effectiveness,impacts and sustainability of outcomes. On the basis of the formulated conclusions, a few recommendations related to process and system nature, implementation and replicability of approaches are suggested. The results show an increase in tourism in the region,which leads to an improvement in the quality of life of the local population. On the other hand, it represents a threat to natural and cultural values, historical identity and uniqueness. The Management Plan is an excellent platform for stakeholder cooperation and implementation of specific measures to protect this exceptional territory.

关键词： Protected landscape Management plan Governance Biodiversity Tourism

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Carbon nanotube and graphene reinforced magnesium matrix composites:A state-of-the-art review

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Journal of Magnesium and Alloys 2023年第6期11卷 1825-1905页

作者： Lava Kumar Pillari Kyle Lessoway lukas Bichler School of Engineering The University of British Columbia-OkanaganKelownaBC V1V 1V7Canada

Magnesium(Mg)composites reinforced with carbon-based nanomaterial(CBN)often exhibit low density,enhanced strength,good conductivity,improved wear resistance,and excellent biocompatibility when compared to current industry Mg *** review aims to critically evaluate recent developments in Mg-CBN composites and is divided into five sections:First,a brief introduction to Mg-CBN composites is provided,followed by a discussion of different fabrication techniques for these composites,including powder metallurgy,casting,friction stir processing,and selective laser melting.A particular focus is on the current processing challenges,including dispersion strategies to create homogeneous Mg-CBN *** effect of processing on the quantifying disorder in CBNs and distinguishing different sp2carbon materials is also ***,the effect of CBN on various properties of Mg-CBN composites is thoroughly analyzed,and the strengthening efficiency of CNTs and graphene in the Mg matrix is ***,the potential applications of Mg-CBN composites in various industries are proposed,followed by a summary and suggestions for future research directions in the field of Mg-CBN composites.

关键词： Magnesium Carbon nanotubes(CNTs) Graphene Nanocomposites Processing Mechanical properties

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