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Deficiency of Adenomatous Polyposis Coli protein in sporadic colorectal adenomas and its associations with clinical phenotype and histology

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World Journal of Gastroenterology 2006年第24期12卷 3901-3905页

作者： Martin Bortlík Ivana Vítková Martina Pape(z|ˇ)ová Milada Kohoutová Ale(s|ˇ) Novotn(y|') Stanislav Adamec Petra Chalupná milan luká(s|ˇ) Gastroenterology Center 4th Internal Department General Faculty Hospital1st School of MedicineCharles UniversityPragueCzech Republic Department of Pathology General Faculty Hospital 1st School of MedicineCharles UniversityPragueCzech Republic Institute for Biology and Medical Genetics General Faculty Hospital 1st School of MedicineCharles UniversityPragueCzech Republic

AIM： To evaluate the frequency of the loss of the Adenomatous Polyposis Coil （APC） protein and to compare the APC status with the characteristics of colorectal adenomas. METHODS： Immunohistochemical analysis of the APC protein was performed on 118 adenomas and the results were compared with parameters of malignant potential, location of adenomas, macroscopic appearance and age of the patients. RESULTS： A complete loss of the APC protein was found in 28 （24%） adenomas, while 90 （76%） were APC positive. The mean size of adenomas was 13.5± 14.2 mm （95% CI 10.5-16.5） in APC-positive, and 13.8 ±15.5 mm （95% CI 7.8-19.8） in APC-negative adenomas （P = 0.364）. Statistical analysis revealed no difference between APC-positive and negative adenomas as to the histological type （P = 0.327） and grade of dysplasia （P =0.494）. We found that even advanced adenomas did not differ in their APC status from the non-advanced tumors （P = 0.414）. Finally, no difference was found when the location （P = 0.157）, macroscopic appearance （P = 0.571） and age of patients （P = 0.438） were analysed and compared between both APC positive and negative adenomas. CONCLUSION： Most adenomas expressed full-length APC protein, suggesting that protein expression is not a reliable marker for assessment of APC gene mutation. Complete loss of APC protein did not influence morphology, location, or appearance of adenomas, nor was it affected by the patient＇s age.

关键词： Adenomatous Polyposis Coli protein Adeno-ma Immunohistochemistry Histology

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Boron isotopic variations in tourmaline from metacarbonates and associated calc-silicate rocks from the Bohemian Massif: Constraints on boron recycling in the Variscan orogen

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Geoscience Frontiers 2021年第1期12卷 219-230页

作者： lukas Krmcek milan Novak Robert B.Trumbull Jan Cempirek Stanislav Houzar Department of Geological Sciences Faculty of ScienceMasaryk UniversityKotlarska 2CZ-61137BrnoCzech Republic Institute of Geology of the Czech Academy of Sciences Rozvojova 269CZ-16502Prague 6Czech Republic Brno University of Technology Faculty of Civil EngineeringAdMaS CentreVeve■rí95CZ-60200BrnoCzech Republic GFZ German Research Centre for Geosciences TelegrafenbergD-14473PotsdamGermany Department of Mineralogy and Petrography Moravian MuseumZelnyTrh 6CZ-67401BrnoCzech Republic

Various metacarbonate and associated calc-silicate rocks form minor but genetically significant components of the lithological units in the Bohemian Massif of the Variscan orogen in Central *** rocks vary in terms of their lithostratigraphy,chemical composition and mineral assemblage(dolomite/calcite ratio,silicate abundance).Tourmaline is present in five paragenetic settings within the metacarbonate and calc-silicate ***Ⅰcomprises individual,euhedral,prismatic grains and grain aggregates in a carbonate-dominant(calcite±dolomite)matrix poor in ***Ⅱis characterized by euhedral to subhedral grains and coarse-to fine-grained aggregates in silicate-rich layers/nests within metacarbonate bodies whereas typeⅢoccurs as prismatic grains and aggregates at the contact zones between carbonate and associated silicate host ***Ⅳis in veins crosscutting metacarbonate bodies,and typeⅣtourmaline occurs at the exocontacts of elbaite-subtype granitic *** from the different settings shows distinctive compositional *** for typeⅠare Mg-rich compositions,with fluor-uvite>dravite>>*** from typeⅡsilicate-rich layers/nests are highly variable,corresponding to oxy-schorl,magnesio-foitite,Al-rich dravite and *** for typeⅢtourmalines are Ca,Ti-bearing oxy-dravite *** typeⅣveins feature dravite and fluor-uvite tourmaline compositions whereas typeⅤtourmaline is Li,F-rich *** is the only Bbearing phase in paragenetic typesⅠ-Ⅳ,where it is characterised by two principal ranges of B-isotope composition(δ^11B=-13‰to-9‰and-18‰to-14‰).These ranges correspond to regionally different units of the Moldanubian ***,the Svratka Unit(Moldanubian Zone s.l.)contains only isotopically lighter tourmaline(δ^11B=-18‰to-14‰),whereas metacarbonates in the Poli?ka unit(Teplá-Barrandian Zone)and Olesnice unit(Moravicum of the Moravo-Silesian Zone)has exclusively isotopically heav

关键词： Boron isotopes Tourmaline Metacarbonates Moldanubicum Variscan orogeny

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