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Anesthesia of a patient with congenital cataract,facial dysmorphism,and neuropathy syndrome for posterior scoliosis:A case report

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World Journal of Clinical Cases 2022年第13期10卷 4207-4213页

作者： Jan Hudec Martina Kosinova Tereza Prokopova milan filipovic Martin Repko Petr Stourac Department of Anesthesiology and Intensive Care Medicine University Hospital BrnoMedical Faculty of Masaryk UniversityBrno 62500Czech Republic Department of Simulation Medicine Medical Faculty of Masaryk UniversityBrno 62500Czech Republic Department of Pediatric Anesthesiology and Intensive Care Medicine University Hospital BrnoMedical Faculty of Masaryk UniversityBrno 62500Czech Republic Department of Orthopedic Surgery University Hospital BrnoMedical Faculty of Masaryk UniversityBrno 62500Czech Republic

BACKGROUND Congenital cataract,facial dysmorphism,and neuropathy(CCFDN)syndrome is an extremely rare multiorgan *** include congenital cataracts,facial deformation,extremity deformities,and demyelinating *** syndrome is associated with increased risk during anesthesia including rhabdomyolysis or epileptic *** is a lack of published information about difficult airways in these *** airways during intubation represent one of the most dreaded anesthesia complications:A"can not intubate,can not oxygenate"*** herein is the first described successful endotracheal intubation of a CCFDN syndrome *** SUMMARY We report the anesthetic management of a 13-year-old girl with CCFDN syndrome scheduled for posterior neuromuscular scoliosis correction *** patient suffered from extensive progressive neuromuscular scoliosis with a Cobb angle of 83°.Her limitations included neuropathy and a scoliotic *** condition negatively impacted her quality of *** case reflects the potential anesthetic complications for posterior scoliosis correction and CCFDN *** challenge for our anesthetic team was the limited amount of data about anesthetic management of this *** total,one case report without any data about endotracheal intubation of patients with this condition was *** intubation in our case was *** focus of our case was the prevention of possible complications associated with this syndrome,including rhabdomyolysis and *** can be triggered by some types of anesthetic agents like suxamethonium or volatile anesthetics,especially in patients with certain types of *** Adequate understanding of the anesthetic management of CCFDN syndrome can reduce perioperative complications and improve patient outcome after surgery.

关键词： CCFDN syndrome Neuromuscular scoliosis Anesthetic management Total intravenous anesthesia Endotracheal intubation Case report

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Primary leiomyosarcoma of the thyroid gland with prior malignancy and radiotherapy:A case report and review of literature

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World Journal of Clinical Cases 2019年第4期7卷 473-481页

作者： Snezana Vujosevic Djordjije Krnjevic milan Bogojevic Ljiljana Vuckovic Aleksandar filipovic Du?ko Dun?erovi? Jelena Sopta Endocrinology Clinical Center of Montenegro Internal Medicine Clinic Clinical Center of Montenegro Institute of Pathology Clinical Center of Montenegro Surgery Clinical Center of Montenegro Institute of Pathology University of Belgrade

BACKGROUND Leiomyosarcoma(LMS) of the thyroid gland is a rarely presented tumor that offers poor prognosis. To the best of the authors' knowledge, there currently exist only 28 known cases described in the literature(limited to English).CASE SUMMARY Herein a case is reported of a 60-year-old female patient who had an LMS of the thyroid, which was accompanied by periodic dysphonia and breathing disorder as well as the feeling of pressure in the chest and neck. At the time the disease was diagnosed, no metastases were detected. Prior to the diagnosis, the patient experienced a uterine adenocarcinoma that had been treated by surgical procedure and radiotherapy. For the LMS, a total thyroidectomy was performed,followed by radiotherapy. Since metastases were also discovered in the lungs,sternum, and femur, chemotherapy was administered as ***, the tumor cells in the thyroid indicated positively for alpha smooth muscle actin, calponin, and H-caldesmon, but were negative for CD34, p63, estrogen receptor, progesterone receptor, and Epstein-Barr *** Although the etiology of the LMS is as of yet unknown, prior malignancy and radiation should be considered as risk factors.

关键词： Thyroid Leiomyosarcoma Smooth muscle tumor Radiotherapy Thyroidectomy Case report

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Response of Chlorophyll a, SPAD Values and Chlorophyll Fluorescence Parameters in Leaves of Apricot Affected Some Abiotic Factors

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Journal of Food Science and Engineering 2013年第1期3卷 19-24页

作者： Adrijana filipovic milan Poljak and Dragan Skobic Faculty of Agriculture and Food Technology University of Mostar Biskupa Cule bb 88000 Mostar Faculty of Agriculture University of Mostar Svetogimunska cesta 25 10000 Zagreb Faculty of Mathematics and Science Education University of Mostar Matice Hrvatske b.b. 88000 Mostar

Experimental trail conducted in Jasenica, Bosnia and Herzegovina have showed apricot （Prunus persica L） leaf injures especially on the edges in the middle of the season. Leaf edges show chlorosis starting from the tip due to lack of Chlorophyll. Affected leaves start falling and renew leaves masse as respond to stress conditions which also delay fruits maturation. Technological development in detecting the stress of high plants trough the leaf fluorescence and Chlorophyll concentration have led to the introduction of instruments which utilize fluorescence as a basis for determining stress level. The paper was aimed to show whether the productivity values calculated from Chlorophyll fluorescence Fv/Fm were comparable to those produced by spectrophotometric method in detecting Chlorophyll a concentration and SPAD values detected by Chlorophyll meter （SPAD-502）. Measurements of nitrogen content were also provided in order to obtain accuracy of SPAD meter since Chlorophyll molecules contain nitrogen in their structure. To test the relationship between these three technique regression relationship was obtained. Regression coefficient between Fv/Fm values and Chlorophyll a concentration mg g-t was high. Also, strong regression coefficient was observed between Chlorophyll a and SPAD values indicating a good accuracy of this device which was also confirmed by good regression between nitrogen content and SPAD values. Fluorometer measurements on injured leaves samples of apricot have also reviled the Fv/Fm values below 0.83 which is in according with numerous authors who considered a line for indicating stress factors.

关键词： Plant stress apricot Fv/Fm values Chlorophyll fluorometer Chlorophyll a concentration SPAD values.

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Characterization of value-added chemicals derived from the thermal hydrolysis and wet oxidation of sewage sludge

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Frontiers of Environmental Science & Engineering 2021年第1期15卷 185-198页

作者： milan Malhotra Anurag Garg Environmental Science and Engineering Department Indian Institute of Technology BombayPowai Mumbai 400076India

We evaluated the effect of hydrothermal pretreatments,i.e.,thermal hydrolysis(TH)and wet oxidation(WO)on sewage sludge to promote resource *** hydrothermal processes were performed under mild temperature conditions(140°C–180°C)in a high pressure *** reaction in acidic environment(pH=3.3)suppressed the formation of the color imparting undesirable Maillard’s *** oxidative conditions resulted in higher volatile suspended solids(VSS)reduction(~90%)and chemical oxygen demand(COD)removal(~55%)whereas TH caused VSS and COD removals of~65%and~27%,respectively at a temperature of 180°*** TH,the concentrations of carbohydrates and proteins in treated sludge were 400–1000 mg/L and 1500–2500 mg/L,***,WO resulted in solids solubilization followed by oxidative degradation of organics into smaller molecular weight carboxylic acids such as acetic acid(~400–500 mg/L).Based on sludge transformation products generated during the hydrothermal pretreatments,simplified reaction pathways are ***,the application of macromolecules(such as proteins),VFAs and nutrients present in the treated sludge are also *** future study should focus on the development of economic recovery methods for various value-added compounds.

关键词： Hydrothermal pretreatment Reaction kinetics Reaction pathway Sewage sludge Thermal hydrolysis Wet oxidation

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Expansion of Small Terrestrial Mammals and Their Parasites into the Barun Valley (Makalu Mt. Region, Nepal Himalaya) Linked with Changes in Glaciation and Human Activities

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Journal of Mountain Science 2015年第1期12卷 14-29页

作者： milan DANIEL National Institute of Public Health ?robárova 48 100 42 Prague 10 Czech Republic

The article is based on collection of small terrestrial mammals(Soriculus nigrescens,Episoriculus caudatus, Neodon sikimensis,Alticola stoliczkanus, Niviventer eha and Ochotona roylei) collected in the Barun Valley, east Nepal in the pre-monsoon period of *** and ecological characteristics and altitudinal stratification of these species are analysed, depending both on abiotic(geomorphological and climatic) and biotic(vegetation, and human presence and activities)factors. All the captured mammals were examined for ecto- and endoparasities. Infestations of Trombiculid mites and Ixodid ticks were tightly linked to the local habitat where these ectoparasites must survive during their nonparasitic phase. Analysis of their occurrence completes the reconstruction of migration routes during the expansion of small mammals into the Barun Valley and the exacerbating influence of human activities(summer pasturing,mountaineering expeditions and trekking parties).An indicator of anthropogenic influence was the occurrence of synantropic flies. The potential medical importance of these findings is *** is assumed a possible occurrence of arboviruses transmitted by ticks and also rickettsioses(transmitted by ticks and chigger mites). As far bacteriological infections, plague cannot be excluded.

关键词： Himalaya Barun Makalu region Small mammal Parasite Ecology Medicalimportance

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Optimal velocity functions for car-following models

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第7期11卷 520-529页

作者： milan BATISTA Elen TWRDY Faculty of Maritime Studies and Transport University of Ljubljana

The integral part of the optimal velocity car-following models is the optimal velocity function (OVF), which can be derived from measured velocity-spacing data. This paper discusses several characteristics of the OVF and presents regression analysis on two classical datasets, the Lincoln and Holland tunnels, with different possible OVFs. The numerical simulation of the formation of traffic congestion is conducted with three different heuristic OVFs, demonstrating that these functions give results similar to those of the famous Bando OVF (Bando et al., 1995). Also an alternative method is present for determining the sensitivity and model parameters based on a single car driving to a fixed barrier.

关键词： Traffic flow Car following Optimal velocity function

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Synthesis of high-performance nickel hydroxide nanosheets/gadolinium doped-α-MnO_(2) composite nanorods as cathode and Fe_(3)O_(4)/GO nanospheres as anode for an all-solid-state asymmetric supercapacitor

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Journal of Energy Chemistry 2022年第1期31卷 475-484,I0013页

作者： milan Babu Poudel Han Joo Kim Department of Convergence Engineering Technology Jeonbuk National UniversityJeonju Jeollabuk-do 54896Republic of Korea

The wide use of manganese dioxide(MnO_(2))as an electrode in all-solid-state asymmetric supercapacitors(ASCs)remains challenging because of its low electrical *** complication can be circumvented by introducing trivalent gadolinium(Gd)ions into the MnO_(2).Herein,we describe the successful hydrothermal synthesis of crystalline Gd-doped MnO_(2) nanorods with Ni(OH)_(2) nanosheets as cathode,which we combined with Fe_(3)O_(4)/GO nanospheres as anode for all-solid-state *** tests dem on strate that Gd dopi ng sign ifica ntly affected the electrochemical activities of the MnO_(2),which was further enhanced by introducing Ni(OH)_(2).The GdMnO_(2)/Ni(OH)_(2) electrode offers sufficient surface electrochemical activity and exhibits excellent specific capacity of 121.8 mA h g^(-1),at 1A g^(-1),appealing rate performance,and ultralong lifetime stability(99.3%retention after 10,000 discharge tests).Furthermore,the GdMnO_(2)/Ni(OH)_(2)//PVA/KOH//Fe_(3)O_(4)/GO solid-state ASC device offers an impressive specific energy density(60.25 W h kg^(-1))at a high power density(2332 W kg^(-1)).This investigation thus shows its large potential in developing novel approaches to energy storage devices.

关键词： Solid-state supercapacitor Manganese dioxide Gadolinium doping Nickel hydroxide nanosheets

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The role of grain boundaries in solid-state Li-metal batteries

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Materials Futures 2023年第1期2卷 104-120页

作者： Emily milan Mauro Pasta Department of Materials University of OxfordOxford OX13PHUnited Kingdom The Faraday Institution Didcot OX110RAUnited Kingdom

Despite the potential advantages promised by solid-state batteries,the success of solid-state electrolytes has not yet been fully *** is due in part to the lower ionic conductivity of solid *** many solid superionic conductors,grain boundaries are found to be ionically resistive and hence contribute to this lower ionic ***,in spite of the hope that solid electrolytes would inhibit lithium filaments,in most scenarios their growth is still observed,and in some polycrystalline systems this is suggested to occur along grain *** is apparent that grain boundaries affect the performance of solid-state electrolytes,however a deeper understanding is *** this perspective,the current theories relating to grain boundaries in solid-state electrolytes are explored,as well as addressing some of the challenges which arise when trying to investigate their *** are presented as a possible solution to reduce the effect of grain boundaries in *** research directions are suggested which will aid in both understanding the role of grain boundaries,and diminishing their contribution in cases where they are detrimental.

关键词： solid electrolytes grain boundaries lithium growth glasses

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A new species of Atelopus(Amphibia:Bufonidae)from eastern Panama

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Zoological Research 2021年第3期42卷 272-279页

作者： milan Vesely Abel Batista Department of Zoology Faculty of Natural SciencesPalacky UniversityOlomouc 77146Czech Republic Universidad Autónoma de Chiriquí Ciudad Universitaria El Cabrero DavidChiriquí427Panama Asociacion ADOPTA el Bosque Panamá Gamboa 119xPanama Fundacion Los Naturalistas DavidChiriquí426-01459Panama

A new species of the genus Atelopus,Atelopus fronterizo ***.,from eastern Panama is described herein based on molecular,morphological,and bioacoustic *** new species can be distinguished from its congeners occurring in the region by a combination of the following characters:(1)phalangeal reduction in thumb;(2)SVL(females only)(35.1-50.1;n=13),HW/SVL(0.23-0.34;n=59),EYND/HW(0.27-0.39;n=60),TIBL/SVL(0.41-0.56;n=58),and HAL/SVL(0.22-0.28;n=49);(3)dorsal color pattern with green or yellow background and extensive dark olive blotches forming transversal bands or mottling;(4)advertisement call duration 176-235 ms with 19-34 pulses,average pulse rate 131.69 pulses/s,and dominant frequency 2422.50-2606.50 *** new species is nested within the Central American clade of *** minimum Kimura‐2‐parameter(K2P)genetic divergence between Atelopus fronterizo *** its most phylogenetically similar congeners(*** and ***)is>2.6%for 16S and>4.9%for COI(Table 1).The phylogenetic relationship is strongly supported by ultrafast bootstrap values for the maximum-likelihood trees of both genetic markers(16S,96;COI,100,Figure 1A).Bayesian analysis of the concatenated sequences resulted in a tree with similar topology and high posterior probability support(0.99;Supplementary Figure S1).In addition,haplotype networks inferred from COI and 16S(Supplementary Figure S2)showed a well-separated clade containing the new species(two for COI,four for 16S).

关键词： 16S Figure eastern

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New insights in bilirubin metabolism and their clinical implications

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World Journal of Gastroenterology 2013年第38期19卷 6398-6407页

作者： Eva Sticova milan Jirsa Centre for Experimental Medicine Institute for Clinical and Experimental Medicine14021 Prague 4Czech Republic Third Faculty of Medicine Charles University10000 Prague 10Czech Republic

Bilirubin,a major end product of heme breakdown,is an important constituent of bile,responsible for its characteristic *** recent decades,our understanding of bilirubin metabolism has expanded along with the processes of elimination of other endogenous and exogenous anionic substrates,mediated by the action of multiple transport systems at the sinusoidal and canalicular membrane of *** inherited disorders characterised by impaired bilirubin conjugation(Crigler-Najjar syndrome typeⅠand typeⅡ,Gilbert syndrome)or transport(Dubin-Johnson and Rotor syndrome)result in various degrees of hyperbilirubinemia of either the predominantly unconjugated or predominantly conjugated ***,disrupted regulation of hepatobiliary transport systems can explain jaundice in many acquired liver *** this review,we discuss the recent data on liver bilirubin handling based on the discovery of the molecular basis of Rotor *** data show that a substantial fraction of bilirubin conjugates is primarily secreted by MRP3 at the sinusoidal membrane into the blood,from where they are subsequently reuptaken by sinusoidal membrane-bound organic anion transporting polypeptides OATP1B1 and ***1B proteins are also responsible for liver clearance of bilirubin conjugated in splanchnic organs,such as the intestine and kidney,and for a number of endogenous compounds,xenobiotics and *** of one or both OATP1B proteins thus may have serious impact on toxicity of commonly used drugs cleared by this system such as statins,sartans,methotrexate or *** liverblood cycling of conjugated bilirubin is impaired in cholestatic and parenchymal liver diseases and this impairment most likely contributes to jaundice accompanying these disorders.

关键词： Hyperbilirubinemia Hereditary jaundice UGT1A1 ABCC2 Organic anion transporting polypeptide 1B1 Organic anion transporting polypeptide 1B3

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