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Role of oxidative stress on growth responses of spring barley exposed to different environmental stressors

Journal of Plant Ecology 2015年第6期8卷 605-616页

作者： Giedrė Kacienė Jūratė Žaltauskaitė Eglė milčė Romualdas Juknys Department of Environmental Sciences Vytautas Magnus UniversityVileikos Street 8-223LT-44404 KaunasLithuania

Aims oxidative stress is one of the most important mechanisms in a plant’s reaction to the effects of different stressors;however,its role in plants’resistance is still poorly *** objective of this study is to evaluate an influence of oxidative stress induced by stress factors of different origin-ozone,ultraviolet(uV)-b radia-tion,drought,cadmium(Cd)and copper(Cu),to growth of spring barley and to check the hypothesis,that intensification of oxidative stress is the main factor of growth depression induced by strong treatments of different stressors;meanwhile,mitigation of oxidative stress determines eustress-induced growth *** a pot experiment was carried out in phytotron chambers with a controlled *** barley(Hordeum vulgare l.)plants were exposed to different doses of investigated environmental stress factors(O_(3),uV-b radiation,drought,Cd and Cu),and their effects on shoots growth,accumulation of superoxide(O_(2)^(˙−)),intensification of lipid peroxidation and antioxidative protection(superoxide dismutase,glutathione reductase and catalase activi-ties and concentration of carotenoids)were *** of variance(aNoVa)with classical eta-squared(η2)values was used to evaluate and to compare the contribution of non-specific oxi-dative stress and stressor-specific mechanisms on plants *** Findingslow doses of most stressors stimulated antioxidative protection and growth of barley shoots,reduced the concentration of o2˙−and/or intensity of lipid *** an impair-ment of growth and intensification of oxidative stress as well as a reduction in concentration of carotenoids and further increase in activity of antioxidative enzymes were noticed when the intensity of the stressors was *** the cases of ozone and uV-b stress,the effects of oxidative stress on plant growth was mitigated by strong antioxidative protection-highly increased catalase(CaT)and superoxide dismutase(SOD)activities,res

关键词： plant stress environmental stress factors superoxide lipid peroxidation eustress distress

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JAX-CNV:A Whole-genome Sequencing-based Algorithm for Copy Number Detection at Clinical Grade Level

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Genomics, Proteomics & Bioinformatics 2022年第6期20卷 1197-1206页

作者： Wan-Ping Lee Qihui Zhu Xiaofei Yang Silvia Liu Eliza Cerveira Mallory Ryan Adam mil-Homens Lauren Bellfy Kai Ye Charles Lee Chengsheng Zhang Precision Medicine Center The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China The Jackson Laboratory for Genomic Medicine FarmingtonCT 06032USA School of Cyber Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China Department of Pathology and Laboratory Medicine Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA School of Computer Science and Technology Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China MOE Key Lab for Intelligent Networks&Networks Security Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China Department of Life Sciences Ewha Womans UniversitySeoul 03760South Korea

We aimed to develop a whole-genome sequencing(WGS)-based copy number variant(CNV)calling algorithm with the potential of replacing chromosomal microarray assay(CMA)for clinical ***-CNV is thus developed for CNV detection from WGS *** performance of this CNV calling algorithm was evaluated in a blinded manner on 31 samples and compared to the 112 CNVs reported by clinically validated CMAs for these 31 *** result showed that JAX-CNV recalled 100%of these ***,JAX-CNV identified an average of 30 CNVs per individual,representing an approximately seven-fold increase compared to calls of clinically validated *** validation of 24 randomly selected CNVs showed one false positive,i.e.,a false discovery rate(FDR)of 4.17%.A robustness test on lowercoverage data revealed a 100%sensitivity for CNVs larger than 300 kb(the current threshold for College of American Pathologists)down to 10×*** CNVs larger than 50 kb,sensitivities were 100%for coverages deeper than 20×,97%for 15×,and 95%for 10×.We developed a WGS-based CNV pipeline,including this newly developed CNV caller JAX-CNV,and found it capable of detecting CMA-reported CNVs at a sensitivity of 100%with about a FDR of 4%.We propose that JAX-CNV could be further examined in a multi-institutional study to justify the transition of first-tier genetic testing from CMAs to ***-CNV is available at https://***/TheJacksonLaboratory/JAX-CNV.

关键词： Copy number variant Chromosomal microarray assay Whole-genome sequencing JAX-CNV Genetic testing

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Medical Costs by Disease Stage in Medicare Patients with Metastatic Melanoma

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Journal of Cancer Therapy 2017年第11期8卷 913-923页

作者： Amanda M. Farr Zhongyun Zhao Xue Song Beth Barber Boris Ivanov Marilyn novich Life Sciences Truven Health Analytics IBM Company Cambridge MA USA Global Health Economics Amgen Inc. Thousand Oaks CA USA

Background: Melanoma is a rare but serious skin cancer that is responsible for >90% of skin cancer-related deaths. This retrospective data analysis quantifies the direct cost of medical care by disease stage at diagnosis for patients with metastatic melanoma. Methods: The Surveillance, Epidemiology, and End Results (SEER)-Medicare database was queried for patients diagnosed between 2004-2009 with stage IIIB/C and stage IV (M1a, M1b, M1c) melanoma. The primary outcome was overall medical utilization and associated costs from diagnosis to death, the end of Medicare enrolment, or 12/31/2010. Results are stratified by disease stage at diagnosis and presented as per-patient per-month (PPPM) costs. Results: Of the 1263 patients meeting the study criteria (mean age: 75 years;64% male, 92% white, mean duration of follow up: 37.5 months), 66.6% were diagnosed at stage IIIB/C and 33.4% at stage IV. Cost of care increased with disease stage. Total PPPM costs ranged from $1966 for patients diagnosed with stage IIIB to $4585 among patients diagnosed with stage M1c. Outpatient costs accounted 48.9% of total medical costs among stage IIIB patients, and 38.7% of total medical costs for stage M1c patients. Inpatient costs accounted for 37.1% (stage M1b) - 40.9% (stage M1c) of total medical costs. Conclusions: Healthcare costs for treating patients with metastatic melanoma increase by disease stage. The cost of care was more than double among patients with late stage compared to those with early stage. Treatments demonstrating ability to prevent disease progression from early stage to late stage may confer an economic benefit among other clinical advantages.

关键词： Melanoma Healthcare Costs Disease Stage Medicare

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佛罗里达粘土质磷尾矿的流变学和矿物学与其工程性质间的关系

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化工矿山译丛 1990年第4期 34-41页

作者： novich,B 江辉

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First prospective European study for the feasibility and safety of magnetically controlled capsule endoscopy in gastric mucosal abnormalities

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World Journal of Gastroenterology 2022年第20期28卷 2227-2242页

作者： milán Szalai Krisztina Helle Barbara Dorottya Lovász Ádám Finta András Rosztóczy László Oczella László Madácsy Department of Gastroenterology Endo-Kapszula Health Centre and Endoscopy UnitSzékesfehérvár 8000Hungary Department of Internal Medicine University of SzegedSzeged 6725Hungar

BACKGROUND While capsule endoscopy(CE)is the gold standard diagnostic method of detecting small bowel(SB)diseases and disorders,a novel magnetically controlled capsule endoscopy(MCCE)system provides non-invasive evaluation of the gastric mucosal surface,which can be performed without sedation or *** standard SBCE,passive movement of the CE may cause areas of the complex anatomy of the gastric mucosa to remain unexplored,whereas the precision of MCCE capsule movements inside the stomach promises better visualization of the entire *** To evaluate the Ankon MCCE system’s feasibility,safety,and diagnostic yield in patients with gastric or SB *** Of outpatients who were referred for SBCE,284(male/female:149/135)were prospectively enrolled and evaluated by *** stomach was examined in the supine,left,and right lateral decubitus positions without ***,all patients underwent a complete SBCE study *** gastric mucosa was explored with the Ankon MCCE system with active magnetic control of the capsule endoscope in the stomach,applying three standardized pre-programmed computerized algorithms in combination with manual control of the magnetic *** The urea breath test revealed Helicobacter pylori positivity in 32.7%of *** mean gastric and SB transit times with MCCE were 0 h 47 min 40 s and 3 h 46 min 22 s,*** average total time of upper gastrointestinal MCCE examination was 5 h 48 min 35 *** magnetic movement of the Ankon capsule through the pylorus was successful in 41.9%of *** diagnostic yield for detecting abnormalities in the stomach and SB was 81.9%(68.6%minor;13.3%major pathologies);25.8%of abnormalities were in the SB;74.2%were in the *** diagnostic yield for stomach/SB was 55.9%/12.7%for minor and 4.9%/8.4%for major *** MCCE is a feasible,safe diagnostic method for evaluating gastric mucosal lesions and is a promising non-invasive scree

关键词： Bowel diseases Capsule endoscopy Diagnostic techniques Gastrointestinal diseases Gastric mucosa Helicobacter pylori

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A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity

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Acta Pharmaceutica Sinica B 2018年第2期8卷 188-199页

作者： Eneida Turiján-Espinoza Rául Alejandro Salazar-González Edith Elena Uresti-Rivera Gloria Estela Hernández-Hernández Montserrat Ortega-Juárez Rosa milán Diana Portales-Pérez Laboratory of Immunology and Cellular and Molecular Biology Faculty of Chemical Science UASLP Laboratory of Biopharmacy and Pharmacokinetics Faculty of Chemical Science UASLP

Arylamine N-acetyltransferase(NAT; E.C. 2.***.1.5) enzymes are responsible for the biotransformation of several arylamine and hydrazine drugs by acetylation. In this process, the acetyl group transferred to the acceptor substrate produces NAT deacetylation and, in consequence, it is susceptible of degradation. Sirtuins are protein deacetylases, dependent on nicotine adenine dinucleotide,which perform post-translational modifications on cytosolic proteins. To explore possible sirtuin participation in the enzymatic activity of arylamine NATs, the expression levels of NAT1, NAT2,SIRT1 and SIRT6 in peripheral blood mononuclear cells(PBMC) from healthy subjects were examined by flow cytometry and Western blot. The in situ activity of the sirtuins on NAT enzymatic activity was analyzed by HPLC, in the presence or absence of an agonist(resveratrol) and inhibitor(nicotinamide) of sirtuins. We detected a higher percentage of positive cells for NAT2 in comparison with NAT1, and higher numbers of SIRT1t cells compared to SIRT6 in lymphocytes. In situ NAT2 activity in the presence of NAM inhibitors was higher than in the presence of its substrate, but not in the presence ofresveratrol. In contrast, the activity of NAT1 was not affected by sirtuins. These results showed that NAT2 activity might be modified by sirtuins.

关键词： Arylamine N-acetyltransferase NAT Sirtuins Peripheral blood mononuclear cells Nicotinamide Resveratrol

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聚对苯二甲酸乙二醇酯(PET)和嵌段共聚酯—醚的混合纤维

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国外纺织技术 1984年第1期 17-18页

作者： novich Vlayko 曹惠椿

引言过去介绍的一些双组分混合纤维主要是(1)成份较少的组分以微纤形式连续分布在成份较多的基体中;(2)微纤相互缠绕并沿纤维轴向排列和伸展。双组分混合纤维的微观结构在许多地方与天然羊毛十分相似,直径约为70()的微纤被基体包裹成六... 详细信息

引言过去介绍的一些双组分混合纤维主要是(1)成份较少的组分以微纤形式连续分布在成份较多的基体中;(2)微纤相互缠绕并沿纤维轴向排列和伸展。双组分混合纤维的微观结构在许多地方与天然羊毛十分相似,直径约为70()的微纤被基体包裹成六角形,它们之间相距100(?);而羊毛的微纤是由高取向、结晶化

关键词：混合纤维双组分 PEE 弹性回复 PET

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Wireless Network Technologies Supporting M2M Applications

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ZTE Communications 2005年第1期3卷 6-9页

作者： Lei Zhenzhou (China Academy of Telecommunications Research of mil, Beijing 100083, China)

When computers and communication devices are available everywhere in the future, the categories of communication will expand to cover not only the man-man and the man-machine, but also the machine-machine (M2M) communication. Someday, the traffic generated by machines will greatly exceed those of man-machine and man-man applications. Large numbers of M2M applications will need various wireless networks to support them. This paper introduces the characteristics, advantages and disadvantages of the currently available various wireless network technologies, including WiFi, Bluetooth, ZigBee, passive RFID and the 802.15 standard networks.

关键词： ZigBee UWB Wireless Network Technologies Supporting M2M Applications RFID WiFi

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What 3G Terminals Mean for 3G Services

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ZTE Communications 2005年第2期3卷 57-59,62页

作者： Chen Kai (China Academy of Telecommunications Research of mil, Beijing 100083, China)

A better cost-performance of the terminals will lead to faster development of the 3G services. Poor R&D of the terminals may pose the bottleneck of the 3G development and the short supplies of terminals will have a negative effect on the service popularity. Diverse user groups will require personalized terminals. The terminal R&D should consider interoperability to guarantee smooth evolution from 2G to ***, 3G terminals will play a critical role in 3G deployment and deserve serious research and analysis.

关键词： What 3G Terminals Mean for 3G Services SCDMA Mean WCDMA ZTE

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水通道蛋白对人体皮肤重要性的研究

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中华皮肤科杂志 2009年第5期42卷 327-329页

作者： Frédéric Bonté Emmanuelle Noblesse miléne Juan Jean Marc Verbawatz Marc Dumas LVMH-Recherche 45804 Saint-Jean de Braye France CEA Saclay 91 Gif-sur-Yvette France

目的探讨水通道蛋白（AQPs）在人皮肤表皮上的功能和表达。方法免疫组化法检测30名30～40岁健康的白人女性大腿皮肤AQP3、Claudin-1和CD44表达。检测10名21～60岁亚洲健康妇女的前臂内侧AQP3表达与光暴露关系。结果在人表皮中，AQP3从... 详细信息

目的探讨水通道蛋白（AQPs）在人皮肤表皮上的功能和表达。方法免疫组化法检测30名30～40岁健康的白人女性大腿皮肤AQP3、Claudin-1和CD44表达。检测10名21～60岁亚洲健康妇女的前臂内侧AQP3表达与光暴露关系。结果在人表皮中，AQP3从基底层到粒层均有表达，但在角质层下方开始消失，AQP3和Claudin-1的表达与一种透明质酸盐受体CD44的表达呈负相关。对20～80岁之间的健康女性皮肤间接免疫荧光研究也发现，在衰老和长期慢性光暴露时皮肤AQP3表达会明显减少。结论人类皮肤供水系统缺陷可能与年龄有关，水通道蛋白在维持皮肤正常生理功能等方面具有重要意义。

关键词：水通道蛋白质衰老紫外线

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