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Mucosal healing effect of mesalazine granules in naproxen-induced small bowel enteropathy

World Journal of Gastroenterology 2013年第6期19卷 889-896页

作者： István Rácz milán szalai Valéria Kovács Henriett Regczi Gyngyi Kiss Zoltán Horváth Department of Gastroenterology Petz Aladár County and Teaching Hospital Department of Mathematics and Computational Sciences Széchenyi István University

AIM:To investigate the effect of mesalazine granules on small intestinal injury induced by naproxen using capsule endoscopy (CE).METHODS:This was a single center,non-randomized,open-label,uncontrolled pilot study,using the PillCam SB CE system with RAPID 5 *** Lewis Index Score (LIS) for small bowel injury was investigated to evaluate the severity of mucosal *** patients with at least one month history of daily naproxen use of 1000 mg and proton pump inhibitor co-therapy were *** with a minimum LIS of 135 were eligible to enter the 4-wk treatment phase of the *** this treatment period,3 × 1000 mg/d mesalazine granules were added to ongoing therapies of 1000 mg/d naproxen and 20 mg/d *** the end of the 4-wk combined treatment period,a second small bowel CE was performed to re-evaluate the enteropathy according to the LIS *** primary objective of this study was to assess the mucosal changes after 4 wk of mesalazine ***:A total of 18 patients (16 females),ranging in age from 46 to 78 years (mean age 60.3 years) were screened,all had been taking 1000 mg/d naproxen for at least one *** patients were excluded from the mesalazine therapeutic phase of the study for the following reasons:the screening CE showed normal small bowel mucosa or only insignificant damages (LIS n five patients,the screening esophagogastroduodenoscopy revealed gastric ulcer in one patient,capsule technical failure and incomplete CE due to poor small bowel cleanliness in two *** patients (9 female,mean age 56.2 years) whose initial LIS reached mild and moderate-to-severe enteropathy grades (between 135 and 790 and ≥ 790) entered the 4-wk therapeutic phase and a repeat CE was *** comparing the change in LIS from baseline to end of treatment in all patients,a marked decrease was seen (mean LIS:1236.4 ± 821.9 vs 925.2 ± 543.4,P=0.271).Moreover,a significant difference between pre-and post-t

关键词： nonsteroidal anti-inflammatory drug Small bowel enteropathy Mesalazine granules Mucosal healing Capsule endoscopy

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First prospective European study for the feasibility and safety of magnetically controlled capsule endoscopy in gastric mucosal abnormalities

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World Journal of Gastroenterology 2022年第20期28卷 2227-2242页

作者： milán szalai Krisztina Helle Barbara Dorottya Lovász Ádám Finta András Rosztóczy László Oczella László Madácsy Department of Gastroenterology Endo-Kapszula Health Centre and Endoscopy UnitSzékesfehérvár 8000Hungary Department of Internal Medicine University of SzegedSzeged 6725Hungar

BACKGROUnD While capsule endoscopy(CE)is the gold standard diagnostic method of detecting small bowel(SB)diseases and disorders,a novel magnetically controlled capsule endoscopy(MCCE)system provides non-invasive evaluation of the gastric mucosal surface,which can be performed without sedation or *** standard SBCE,passive movement of the CE may cause areas of the complex anatomy of the gastric mucosa to remain unexplored,whereas the precision of MCCE capsule movements inside the stomach promises better visualization of the entire *** To evaluate the Ankon MCCE system’s feasibility,safety,and diagnostic yield in patients with gastric or SB *** Of outpatients who were referred for SBCE,284(male/female:149/135)were prospectively enrolled and evaluated by *** stomach was examined in the supine,left,and right lateral decubitus positions without ***,all patients underwent a complete SBCE study *** gastric mucosa was explored with the Ankon MCCE system with active magnetic control of the capsule endoscope in the stomach,applying three standardized pre-programmed computerized algorithms in combination with manual control of the magnetic *** The urea breath test revealed Helicobacter pylori positivity in 32.7%of *** mean gastric and SB transit times with MCCE were 0 h 47 min 40 s and 3 h 46 min 22 s,*** average total time of upper gastrointestinal MCCE examination was 5 h 48 min 35 *** magnetic movement of the Ankon capsule through the pylorus was successful in 41.9%of *** diagnostic yield for detecting abnormalities in the stomach and SB was 81.9%(68.6%minor;13.3%major pathologies);25.8%of abnormalities were in the SB;74.2%were in the *** diagnostic yield for stomach/SB was 55.9%/12.7%for minor and 4.9%/8.4%for major *** MCCE is a feasible,safe diagnostic method for evaluating gastric mucosal lesions and is a promising non-invasive scree

关键词： Bowel diseases Capsule endoscopy Diagnostic techniques Gastrointestinal diseases Gastric mucosa Helicobacter pylori

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Scanning-slit topography in patients with keratoconus

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International Journal of Ophthalmology(English edition) 2017年第11期10卷 1686-1692页

作者： László Módis Jr. Gábor németh Eszter szalai Zsuzsa Flaskó Berthold Seitz Department of Ophthalmology University of Debrecen Medical and Health Science Center Debrecen 4032 Hungary Borsod-Abau-Zemplen County Hospital and University Teaching Hospital Miskolc 3526 Hungary Department of Ophthalmology Homburg Kemtoconus Center University of Saarland Homburg/Saar 66424 Germany

AIM： To evaluate the anterior and posterior corneal surfaces using scanning-slit topography and to determine the diagnostic ability of the measured corneal parameters in ***： Orbscan II measurements were taken in 39 keratoconic corneas previously diagnosed by corneal topography and in 39 healthy eyes. The central minimum, maximum, and astigmatic simulated keratometry（K） and anterior axial power values were determined. Spherical and cylindrical mean power diopters were obtained at the central and at the steepest point of the cornea both on anterior and on posterior mean power maps. Pachymetry evaluations were taken at the center and paracentrally in the 3 mm zone from the center at a location of every 45 degrees. Receiver operating characteristic（ROC） analysis was used to determine the best cut-off values and to evaluate the utility of the measured parameters in identifying patients with ***： The minimum, maximum and astigmatic simulated K readings were 44.80±3.06 D, 47.17±3.67 D and 2.42±1.84 D respectively in keratoconus patients and these values differed significantly（P〈0.0001 for all comparisons） from healthy subjects. For all pachymetry measurements and for anterior and posterior mean power values significant differences were found between the two groups. Moreover, anterior central cylindrical power had the best discrimination ability（area under the ROC curve=0.948）.COnCLUSIOn： The results suggest that scanning-slit topography and pachymetry are accurate methods both for keratoconus screening and for confirmation of the diagnosis.

关键词： keratoconus Orbscan topography pachymetry

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Scheimpflug imaged corneal changes on anterior and posterior surfaces after collagen cross-linking

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 313-316页

作者： Ziad Hassan Laszlo Modis Eszter szalai Andras Berta Gabor nemeth Orbident Refractive Surgery and Medical Center Department of Ophthalmology Medical and Health Science Center University of Debrecen

AIM:To compare the anterior and posterior corneal parameters before and after collagen cross-linking therapy for ***:Collagen cross-linking was performed in31 eyes of 31 keratoconus patients(mean age 30.6±8.9y).Prior to treatment and an average 7mo after therapy,Scheimpflug analysis was performed using Pentacam *** addition to corneal thickness assessments,corneal radius,elevation,and aberrometric measurements were performed both on anterior and posterior corneal *** obtained before and after surgery were statistically ***:In terms of horizontal and vertical corneal radius,and central corneal thickness no deviations were observed an average 7mo after *** higher order aberration showed no difference neither on anterior nor on posterior corneal *** follow-up period,no significant deviation was detected regarding elevation values obtained by measurement in mm units between the 3.0-8.0 ***:Corneal stabilization could be observed in terms of anterior and posterior corneal surfaces,elevation and higher order aberration values 7mo after collagen cross-linking therapy for keratoconus.

关键词： corneal back surface higher order aberration elevation collagen cross-linking high resolution Pentacam

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Groundwater uptake of different surface cover and its consequences in great Hungarian plain

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Ecological Processes 2017年第1期6卷 408-416页

作者： Zoltán Gribovszki Péter Kalicz Kitti Balog András Szabó Tibor Tóth Péter Csáfordi Mohamed Metwaly Sándor szalai Institute of Geomatics and Civil Engineering University of SopronSopronHungary Institute for Soil Sciences and Agricultural Chemistry Centre for Agricultural ResearchHungarian Academy of SciencesBudapestHungary Forest Research Institute National Agricultural Research and Innovation CentreBudapestHungary Archaeology Department College of Tourism and ArchaeologyKing Saud UniversityRiyadhSaudi Arabia national Research Institute of Astronomy and Geophysics(nRIAG) CairoEgypt MTA CSFK GGI SopronHungary

Introduction:Forest cover in Hungary has increased from 1.1 to 2.0 million hectares during the last *** EU(European Union)promotes further afforestation;thus,15,000–18,000 ha are being forested each year,mainly in the Hungarian Great *** terms of species used for afforestation,poplar plantations are preferred over native oak *** groundwater uptake of trees can be a significant water balance element of forested areas in shallow groundwater environments within the Hungarian Great *** can cause water table depressions and subsurface salt accumulation in areas with negative water *** study examined the hydrological impact of forest cover in the Hungarian Great *** the framework of this research,climatic water balance,water table depth and salinity,subsoil layering,tree species and stand age were analysed as influencing *** paper compares the effect which an oak forest,a poplar plantation and a pasture have on groundwater uptake and salt ***:The water table level was roughly 0.4–0.5 m lower beneath the oak forest and the poplar plantation than it was beneath the *** groundwater use was 1.5–2 times higher than that of *** uptake of oak forest was greater than that of poplar plantation during the monitoring *** accumulation,which shows water use in the longer run,was slightly higher for poplar in deeper ***:The greater amount of groundwater used by trees does not lead to a higher salt uptake as only a slight accumulation of salt was measured beneath the ***,hybrid poplar was slightly less favourable than native oak when considering salinization ***,even greater groundwater uptake by trees over longer timescales could cause more significant salt accumulation under pronounced drought conditions due to climate change.

关键词： Groundwater recharge/water budget Evapotranspiration Diurnal fluctuation Forest cover Salinization

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Region-dependent effects of diabetes and insulin-replacement on neuronal nitric oxide synthase-and heme oxygenase-immunoreactive submucous neurons

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World Journal of Gastroenterology 2017年第41期23卷 7359-7368页

作者： nikolett Bódi Zita szalai Lalitha Chandrakumar Mária Bagyánszki Department of Physiology Anatomy and Neuro-science Faculty of Science and Informatics University of Szeged

AIM To investigate the intestinal segment-specific effects of diabetes and insulin replacement on the density of different subpopulations of submucous neurons. METHODS Ten weeks after the onset of type 1 diabetes samples were taken from the duodenum, ileum and colon of streptozotocin-induce diabetic, insulin-treated diabetic and sex-and age-matched control rats. Whole-mount preparations of submucous plexus were prepared from the different gut segments for quantitative fluorescent immunohistochemistry. The following double-immunostainings were performed: neuronal nitric oxide synthase(n nOS) and Hu C/D, heme oxygenase(HO) 1 and peripherin, as well as HO2 and peripherin. The density of n nOS-, HO1-and HO2-immunoreactive(IR) neurons was determined as a percentage of the total number of submucous neurons. RESULTS The total number of submucous neurons and the proportion of n nOS-, HO1-and HO2-IR subpopulations were not affected in the duodenal ganglia of control, diabetic and insulin-treated rats. While the total neuronal number did not change in either the ileum or the colon, the density of nitrergic neurons exhibited a 2-and 3-fold increase in the diabetic ileum and colon, respectively, which was further enhanced after insulin replacement. The presence of HO1-and HO2-IR submucous neurons was robust in the colon of controls(38.4%-50.8%), whereas it was significantly lower in the small intestinal segments(0.0%-4.2%, P nder pathophysiological conditions the only alteration detected was an increase in the ileum and a decrease in the colon of the proportion of HO-IR neurons in insulin-treated diabetic animals. COnCLUSIOn Diabetes and immediate insulin replacement induce the most pronounced region-specific alterations of n nOS-, HO1-and HO2-IR submucous neuronal density in the distal parts of the gut.

关键词： nitrergic neurons Heme oxygenase 1 Heme oxygenase 2 Submucous neurons Gut regionspecificity Diabetes Insulin

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Corneal biomechanical data and biometric parameters measured with Scheimpflug-based devices on normal corneas

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 217-222页

作者： Gabor nemeth Eszter szalai Ziad Hassan Agnes Lipecz Zsuzsa Flasko Laszlo Modis Department of Ophthalmology Borsod-Abauj-Zemplen County Hospital and University Teaching HospitalMiskolc 3526Hungary Department of Ophthalmology University of DebrecenDebrecen 4032Hungary Orbi-Dent Refractive Surgery and Medical Centre Debrecen 4032Hungary

AIM： To analyze the correlations between ocular biomechanical and biometric data of the eye,measured by Scheimpflug-based devices on healthy ***： Three consecutive measurements were carried out using the corneal visualization Scheimpflug technology（Cor Vis ST） device on healthy eyes and the 10 device-specific parameters were *** HR-derived parameters（corneal curvature radii on the anterior and posterior surfaces;apical pachymetry;corneal volume;corneal aberration data;depth,volume and angle of the anterior chamber） and axial length（AL） from IOLMaster were correlated with the 10 specific CorV is ST ***： Measurements were conducted in 43 eyes of 43 volunteers（age 61.24±15.72y）.The 10 specific Cor Vis ST data showed significant relationships with corneal curvature radii both on the anterior and posterior surface,pachymetric data,root mean square（RMS） data of lower-order aberrations,and posterior RMS of higher-order aberrations and spherical aberration of the posterior *** chamber depth showed a significant relationship,but there were no significant correlations between corneal volume,anterior chamber volume,mean chamber angle or AL and the 10 specific CorV is ST ***： Cor Vis ST-generated parameters are influenced by corneal curvature radii,some corneal RMS data,but corneal volume,anterior chamber volume,chamber angle and AL have no correlation with the biomechan-ical *** parameters measured by CorV is ST seem to refer mostly to corneal properties of the eye.

关键词： anterior segment parameters biomechan-ics corneal visualization Scheimpflug technology OcularResponse Analyzer

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Ocular biomechanical measurements on post- keratoplasty corneas using a Scheimpflug-based noncontact device

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International Journal of Ophthalmology(English edition) 2016年第2期9卷 235-238页

作者： Laszlo Modis Jr. Ziad Hassan Eszter szalai Zsuzsanna Flasko Andras Berta Gabor nemeth Department of Ophthalmology University of DebrecenDebrecen H-4032 Hungary Orbi-Dent Health and Laser Center Debrecen H-4032Hungary

AIM： To analyse ocular biomechanical properties, central corneal thickness （CCT） and intraocular pressure （lOP） in post-keratoplasty eyes, as compared to normal subjects, with a new Scheimpflug-based technology. Moreover, biomechanical data were correlated with the size and age of the donor and recipient corneas. METHODS： Measurements were conducted on 46 eyes of 46 healthy patients without any corneal pathology （age： 53.83 ±20.8y） and 30 eyes of 28 patients after penetrating keratoplasty （age： 49.43 ±21.34y）. Ten biomechanical parameters, the CCT and lOP were recorded by corneal visualization Scheimpflug technology （CorVis ST） using high-speed Scheimpflug imaging. Keratometry values were also recorded using Pentacam HR system. Scheimpflug measurements were performed after 43.41± 40.17mo （range： 11-128mo） after the keratoplasty and after 7.64±2.34mo （range： 5-14mo） of suture removal. RESULTS： Regarding the device-specific biomechanical parameters, the highest concavity time and radius values showed a significant decrease between these two groups （P=0.01 and P 〈0.001）. none of other biomechanical parameters disclosed a significant difference. The CCT showed a significant difference between post keratoplasty eyes as compared to normal subjects （P= 0.003） using the CorVis ST device. The lOP was within the normal range in both groups （P=0.84）. There were no significant relationships between the keratometric data, the size of the donor and recipient, age of the donor and recipient and biomechanical properties obtained by CorVis ST. COnCLUSIOn： The ocular biomechanics remain stable after penetrating keratoplasty according to the CorVis ST measurements. Only two from the ten device-specific parameters have importance in the follow-up period after penetrating keratoplasty.

关键词： corneal visualization Scheimpflugtechnology ocular biomechanics penetrating keratoplasty

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An alternative to MInFLUX that enables nanometer resolution in a confocal microscope

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Light(Science & Applications) 2022年第9期11卷 2077-2085页

作者： LUCIAnO A.MASULLO ALAn M.szalai LUCIA F.LOPEZ MAURICIO PILO-PAIS GUILLERMO P.ACUnA Fernando D.Stefani Centro de Investigaciones en Bionanociencias(CIBIOn) Consejo Nacionallde Investigaciones Cientificas y Técnicas(CONICET)Godoy Cruz 2390C1425FQD Ciudad Autónoma de Buenos AiresBuenos AiresArgentina Departamento de Fisica Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresGuiraldes 2620C1428EHA Ciudad Autónoma de Buenos AiresBuenos AiresArgentina Department of Physics University of FribourgChemin du Musee 3Fribourg CH-1700Switzerland

Localization of single fluorescent emitters is key for physicochemical and biophysical measurements at the nanoscale and beyond ensemble *** include single-molecule tracking and super-resolution imaging by single-molecule localization *** the numerous localization methods available,MInFLUX outstands for achieving a~10-fold improvement in resolution over wide-field camera-based approaches,reaching the molecular scale at moderate photon *** application of MInFLUX and related methods has been hindered by the technical complexity of the ***,we present RASTMIn,a single-molecule localization method based on raster scanning a light pattern comprising a minimum of *** delivers~1-2nm localization precision with usual fluorophores and is easily implementable on a standard confocal microscope with few *** demonstrate the performance of RASTMIn in localization of single molecules and super-resolution imaging of DnA origami structures.

关键词： resolution pattern enable

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Redistribution of Soil Organic Carbon Triggered by Erosion at Field Scale Under Subhumid Climate,Hungary

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Pedosphere 2016年第5期26卷 652-665页

作者： Zoltan szalai Judit SZABO Jozsef KOVACS Erzsebet MESZAROS Gaspar ALBERT Csaba CEnTERI Boglarka SZABO Balazs MADARASZ Dora ZACHARY Gergely JAKAB Geographical Institute Research Centre for Astronomy and Earth Sciences Hungarian Academy of SciencesBudapest 1112(Hungary) Department of Environmental and Landscape Geography Eotvos Lordnd UniversityBudapest 1117(Hungary) Department of Applied and Environmental Geology Eotvos Lordnd UniversityBudapest 1117(Hungary) Department of Cartography and Geoinformatics Eotvos Lordnd UniversityBudapest 1117(Hungary) Department of nature Conservation and Landscape Ecology Szent Istvdn UniversityGodollo 2100(Hungary)

Soil organic carbon(SOC) has primary importance in terms of soil physics, soil fertility and even of climate change control. One hundred soil samples were taken from an intensively cultivated Cambisol to quantify SOC redistribution triggered by soil erosion under a subhumid climate, by the simultaneous application of diffuse reflectance(240–1 900 nm) and traditional physico-chemical *** representative sample points were collected from the solum along the slopes at the depth of 20–300 cm with a mean SOC content of 12 g kg^(-1). Hierarchical cluster analyses were performed based on the determined SOC results. The spatial pattern of the groups created were similar, and even though the classifications were not the same, diffuse reflectance had proven to be a suitable method for soil/sediment classification even within a given arable field. Both organic and inorganic carbon distributions were found to be a proper tool for estimations of past soil erosion processes. The SOC enrichment was found on two sedimentary spots with different geomorphological positions. Soil organic matter composition also differed between the two spots due to selective deposition of the delivered organic matter. The components with low-molecular-weight reached the bottom of the slope where they could leach into the profile, while the more polymerised organic matter compositions were delivered and deposited even before on a higher segment of the slope in an aggregated form. This spatial difference appeared below the uppermost tilled soil layer as well, referring the lower efficiency of conventional ploughing tillage in soil spatial homogenisation.

关键词： Cambisol carbon sequestration diffuse reflectance selective erosion soil organic matter composition

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