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INTERIM ANALYSIS OF ACUPUNCTURE PROVES BLINDING IN A RANDOMIZED CONTROLLED TRIAL IS FEASIBLE IN THE INTENSIVE CARE UNIT

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Journal of Integrative Medicine 2014年第3期 300-301页

作者： Alexis Moren Jennifer Watters Brian Diggs Kate Watson Erika Simeon David Shapiro Robert Kaneko miko enomoto David Hampton Oregon Health & Science University University of Connecticut School of Medicine

Objective: The use of alternative therapies in the intensive care unit(ICU) is infrequent in the United *** has been proven to reduce pain, swelling, nausea, and sedative use for *** hypothesized that acupuncture would reduce sedative and analgesic requirements during mechanical ventilation(MV) with fewer side effects, and decrease length of MV and length of ICU ***, we hypothesized that acupuncture can be effectively blinded in the ***: A randomized controlled trial was conducted randomly assigning patients in the ICU to verum or sham *** were compared between the two groups using descriptive *** analysis using Mann-Whitney-U tests was used on all continuous ***: Fourteen enrolled patients were included in the interim analysis, 8 males(57%) and 6 females(43%).Verum and sham groups had similar vital signs when compared over all sessions: heart rate(97.2 vs.93.8; P=0.78), systolic blood pressure(110.2 vs.116.4; P=0.47), respiratory rate(16.8 vs.14.2; P=0.36) and RASS score(-1.3 vs.-2.7; P=0.52).No significance was found when assessing age(51 vs.50; P=0.79), APACHE score(15 vs.10.5; P=0.1), number of completed sessions(3 vs.2.5; P=0.37), or time to first acupuncture session(20 h vs.18.2 h; P=0.89).Although without statistically significant(P=0.69), large variation was demonstrated in time to extubation(65.3 h vs.138.3 h).Blinding proved successful as there was no significant difference between groups(P=0.77).Conclusion: Blinding in a randomized controlled trial of acupuncture in the ICU is feasible.

关键词： ICU INTERIM ANALYSIS OF ACUPUNCTURE PROVES BLINDING IN A RANDOMIZED CONTROLLED TRIAL IS FEASIBLE IN THE INTENSIVE CARE UNIT

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