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World Journal of Clinical Cases 2018年第16期6卷 1094-1100页

作者： Masatoshi Nakagawa Kazuyuki Kojima mikito inokuchi Kenta Kobayashi Toshiro Tanioka Keisuke Okuno Kentaro Gokita Department of Gastric Surgery Tokyo Medical and Dental University Center for Minimally Invasive Surgery Tokyo Medical and Dental University

AIM To investigate safety and oncological feasibility of laparoscopic total gastrectomy(LTG) in overweight(OW) *** Patients who underwent total gastrectomy(110 laparoscopic, 211 open) for gastric cancer between January 1999 and July 2016 were included. Propensity score matching selected 152 patients(76 laparoscopic, 76 open), which were subsequently divided into the OW(≥ 25) or non-OW(< 25) group by body mass index. Postoperative outcomes of laparoscopic versus open approaches were compared between OW and non-OW groups. RESULTS In the propensity-matched population, baseline characteristics were comparable between the OW and nonOW groups for the laparoscopy and open groups. In the laparoscopy group, operative time was longer(P = 0.01) in the OW group, however, other perioperative results including complication rates were comparable between the non-OW and OW groups. In the open group, number of retrieved lymph nodes were less(P = 0.03) and local complication rate was more frequent(P = 0.03) in the OW group. CONCLUSION LTG in OW patients remains technically challenging but can be performed safely. Our findings imply that OW has a lesser effect on the laparoscopic versus open approach to total gastrectomy.

关键词： Gastric cancer Laparoscopy Overweight Total gastrectomy

Systematic review of anastomotic complications of esophagojejunostomy after laparoscopic total gastrectomy

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World Journal of Gastroenterology 2015年第32期21卷 9656-9665页

作者： mikito inokuchi Sho Otsuki Yoshitaka Fujimori Yuya Sato Masatoshi Nakagawa Kazuyuki Kojima Department of Surgical Oncology Tokyo Medical and Dental University Department of Minimally Invasive Surgery Tokyo Medical and Dental University

AIM: To investigate the anastomotic complications ofesophagojejunostomy(EJS) after laparoscopic total gastrectomy(LTG), we reviewed retrospective ***: A literature search was conducted in Pub Med for studies published from January 1, 1994 through January 31, 2015. The search terms included "laparoscopic," "total gastrectomy," and "gastric cancer." First, we selected 16 non-randomized controlled trials(RCTs) comparing LTG with open total gastrectomy(OTG) and conducted an updated meta-analysis of anastomotic complications after total gastrectomy. The Newcastle-Ottawa scoring system(NOS) was used to assess the quality of the non-RCTs included in this study. Next, we reviewed anastomotic complications in 46 case studies of LTG to compare the various procedures for EJS. RESULTS: The overall incidence of anastomotic leakage associated with EJS was 3.0%(30 of 984 patients) among LTG procedures and 2.1%(31 of 1500 patients) among OTG procedures in the 16 non-RCTs. The incidence of anastomotic leakage did not differ significantly between LTG and OTG(odds OR = 1.42, 95%CI: 0.86-2.33, P = 0.17, I2 = 0%). Anastomotic stenosis related to EJS was reported in 72(2.9%) of 2484 patients, and the incidence was 3.2% among LTG procedures and 2.7% among OTG procedures. The incidence of anastomotic stenosis related to EJS was slightly, but not significantly, higher in LTG than in OTG(OR = 1.55, 95%CI: 0.94-2.54, P = 0.08, I2 = 0%). The various procedures for LTG were classified into six categories in the review of case studies of LTG. The incidence of EJS leakage was similar(1.1% to 3.2%), although the incidence of EJS stenosis was relatively high when the Or VilTM device was used(8.8%) compared with other procedures(1.0% to 3.6%).CONCLUSION:The incidence of anastomotic complications associated with EJS was not different between LTG and OTG. Anastomotic stenosis was relatively common when the Or VilTM device was used.

关键词： Gastric cancer Laparoscopic Gastrectomy Anastomosi

Clinical significance of MET in gastric cancer

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World Journal of Gastrointestinal Oncology 2015年第11期7卷 317-327页

作者： mikito inokuchi Sho Otsuki Yoshitaka Fujimori Yuya Sato Masatoshi Nakagawa Kazuyuki Kojima Department of Gastrointestinal Surgery Tokyo Medical and Dental University Department of Minimally Invasive Surgery Tokyo Medical and Dental University

Chemotherapy has become the global standard treatment for patients with metastatic or unresectable gastric cancer(GC),although outcomes remain *** molecular-targeted therapies inhibiting signaling pathways of various tyrosine kinase receptors have been developed,and monoclonal antibodies targeting human epidermal growth factor receptor 2 or vascular endothelial growth factor receptor 2 have become standard therapy for *** growth factor and its receptor,c-MET(MET),play key roles in tumor growth through activated signaling pathways from receptor in GC *** amplification of MET leads to the aberrant activation found in GC tumors and is related to survival in patients with *** review discusses the clinical significance of MET in GC and examines MET as a potential therapeutic target in patients with *** studies in animal models have shown that MET antibodies or smallmolecule MET inhibitors suppress tumor-cell proliferation and tumor progression in MET-amplified GC *** drugs are now being evaluated in clinical trials as treatments for metastatic or unresectable GC.

关键词： MET Gastric cancer Genomic amplification Immunohis

Combinations of Transportation Policies to Promote BRT Usage Using Artificial Society Model

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Journal of Traffic and Transportation Engineering 2024年第1期12卷 1-10页

作者： Hiroaki inokuchi Faculty of Environmental and Urban Engineering Kansai University3-3-35 Yamate-choSuitaOsaka 564-8680Japan

Various transportation systems have been developed in recent *** this study,an artificial society model is developed to examine the combination of transportation policies in urban *** this model,each trip maker selects the primary and terminal transportation *** artificial society model is applied to the southeastern region of Osaka City,*** effects of introducing BRT(bus rapid transit,primary transportation)and on-demand buses(terminal transportation)are *** results confirm that BRT is used by a certain number of *** increase in the use of BRT will increase the amount of walking,thus resulting in a healthy ***,on-demand buses are rarely used as terminal ***,the development of bicycle parking stations near BRT stops is shown to be effective in the northern section of the BRT route.

关键词： Artificial society model bus rapid transit on-demand bus transportation policy.

Large Eddy Simulation of Swirling Jet in a Bluff-Body Burner

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Journal of Thermal Science 2005年第1期14卷 28-33页

作者： Yohei FUJIMOTO Yuzo inokuchi Nobuhiko YAMASAKI Department of Aeronautics and Astronautics Kyushu-University 6-10-1HakozakiHigashikuFukuoka812-8581JapanDepartment of Aeronautics and Astronautics Kyushu-University 6-10-1HakozakiHigashikuFukuoka812-8581JapanDepartment of Aeronautics and Astronautics Kyushu-University 6-10-1HakozakiHigashikuFukuoka812-8581Japan

The large eddy simulation (LES) is applied to an unconfined swirling flow of an air surrounding a bluff-body having a central jet of air, and the complicated flowfield that involves the recirculation and vortex breakdown is investigated. The Smagorinsky model is used as the sub-grid scale model. The results of the present numerical simulation are compared with the experimental data of the mean and stochastic root mean square (RMS) variations of two velocity components. Although the inflow conditions are specified in a simple manner, the obtained numerical results are in reasonable agreement with the experiments, except for a part of RMS variation values near downstream of the bluff body. The present numerical calculations can successfully reproduce the two characteristics of the flow, i.e., an upstream recirculation zone established just downstream of the burner plane and the additional recirculation zone established at the more downstream location.

关键词： large eddy simulation swirl bluff-body recirculation.

Measurement and Numerical Simulation of a Small Centrifugal Compressor Characteristics at Small or Negative Flow Rate

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Journal of Thermal Science 2017年第2期26卷 107-112页

作者： Kaname Tsukamoto Mizuki Okada Yuzo inokuchi Nobuhiko Yamasaki Akihiro Yamagata Kyushu University Motooka 744819-0395FukuokaJapan IHI Corporation Shin-Nakahara 1235-8501YokohamaJapan

For centrifugal compressors used in automotive turbochargers, the extension of the surge margin is demanded because of lower engine speed. In order to estimate the surge line exactly, it is required to acquire the compressor characteristics at small or negative flow rate. In this paper, measurement and numerical simulation of the characteristics at small or negative flow rate are carried out. In the measurement, an experimental facility with a valve immediately downstream of the compressor is used to suppress the surge. In the numerical work, a new boundary condition that specifies mass flow rate at the outlet boundary is used to simulate the characteristics around the zero flow rate region. Furthermore, flow field analyses at small or negative flow rate are performed with the numerical results. The separated and re-circulated flow fields are investigated by visualization to identify the origin of losses.

关键词： centrifugal compressor turbocharger measurement CFD RANS surge small flow negative flow

CFD Simulation of Pulsation Noise in a Small Centrifugal Compressor with Volute and Resonance Tube

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Journal of Thermal Science 2015年第1期24卷 24-29页

作者： Daich Wakaki Yuta Sakuka Yuzo inokuchi Kosuke Ueda Nobuhiko Yamasaki Akihiro Yamagata Kyushu University IHI Corporation

The rotational frequency tone noise emitted from the automobile turbocharger is called the pulsation noise. The cause of the pulsation noise is not fully understood, but is considered to be due to some manufacturing errors, which is called the mistuning. The effects of the mistuning of the impeller blade on the noise field inside the flow passage of the compressor are numerically investigated. Here, the flow passage includes the volute and duct located downstream of the compressor impeller. Our numerical approach is found to successfully capture the wavelength of the pulsation noise at given rotational speeds by the comparison with the experiments. One of the significant findings is that the noise field of the pulsation noise in the duct is highly one-dimensional although the flow fields are highly three-dimensional.

关键词： Pulsation Tone Noise CFD URANS Centrifugal Compressor Turbocharger Volute

以[M(DETA)_2)](n＋)(M=Cu(2＋),Ni(2＋),Co(3＋))为客体的MnPS_3夹层化合物的合成、结构表征与磁性研究(英文)

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无机化学学报 2010年第12期26卷 2237-2242页

作者：颜小兵陈兴国秦金贵 inokuchi Makoto 有机高分子光电功能材料(湖北省)重点实验室武汉大学化学与分子科学学院武汉430072 Department of Materials Science and Engineering Science University of Tokyo in Yamaguchi Onoda Yamaguchi 756-0884 Japan

将过渡金属配合物阳离子([M(DETA)2]n+(M=Cu2+,Ni2+,Co3+;DETA=Diethylenetriamine,二乙烯三胺)作为客体插入层状MnPS3层间得到了相应的3个夹层化合物。通过X-射线粉末衍射、元素分析和红外光谱对夹层化合物的结构进行了表征。结果表明... 详细信息

将过渡金属配合物阳离子([M(DETA)2]n+(M=Cu2+,Ni2+,Co3+;DETA=Diethylenetriamine,二乙烯三胺)作为客体插入层状MnPS3层间得到了相应的3个夹层化合物。通过X-射线粉末衍射、元素分析和红外光谱对夹层化合物的结构进行了表征。结果表明,与主体MnPS3 0.65 nm的层间距相比较,夹层化合物(Mn0.88PS3[Cu(DETA)2]0.12)的层间距扩大了0.32 nm,由此推测客体[Cu(DETA)2]2+在层间以平面四方的配位形式存在,而另2个夹层化合物(Mn0.79PS3[Ni(DETA)2]0.21和Mn0.74PS3[Co(DETA)2]0.17)的层间距扩大了0.48nm,说明客体[(M(DETA)2]n+,M=Co3+,Ni2+)在主体层间以八面体配位形式存在。磁性测试结果表明过渡金属离子[(M(DETA)2]n+(M=Cu2+,Co3+)的插入能引起主体MnPS3的磁性在35～40 K发生由顺磁向亚铁磁性的转变并表现自发磁化,而客体[Ni(DETA)2]2+却使夹层化合物的反铁磁相互作用增强,抑制了自发磁化的发生。

关键词：夹层作用层状MnPS3 二乙烯三胺配合物磁性

VACUUM-UV PHOTOELECTRON SPECTRA FOR SEVERAL POLYMERS

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Chinese Science Bulletin 1989年第8期34卷 636-639页

作者：陈尚贤陈柳生 K.SEKI N.SATO H.inokuchi Institute oF Chemistry Academia Sinica Beijing Institute for Molecular Science Okazaki Japan

Vacuum-UV Photoelectron Spectroscopy (UPS) has attracted increasing attention since it was demonstrated to be a useful method for obtaining detailed information on electron structure of molecules, and valence-band and conduction-band of solid and crystal. A lot of investigations on both gas and solid by UPS have been reported, but only few of them on polymers. We have reported the characterization of vinyl polymers using UPS. The object of the present report is

关键词： photoelectron spectroscopy threshold of ionization energy photochemicsl reaction polymer.

Ulcerative colitis patients in clinical remission demonstrate correlations between fecal immunochemical test results, mucosal healing, and risk of relapse

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World Journal of Gastroenterology 2016年第21期22卷 5079-5087页

作者： Asuka Nakarai Jun Kato Sakiko Hiraoka Shiho Takashima Daisuke Takei Toshihiro inokuchi Yuusaku Sugihara Masahiro Takahara Keita Harada Hiroyuki Okada Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Second Department of Internal Medicine Wakayama Medical University Department of Endoscopy Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences

AIM: To assess the risk of relapse in ulcerative colitis (UC) patients in clinical remission using mucosal status and fecal immunochemical test (FIT) ***: The clinical outcomes of 194 UC patients in clinical remission who underwent colonoscopy were based on evaluations of Mayo endoscopic subscores (MESs) and FIT ***: Patients with an MES of 0 (n = 94, 48%) showed a ten-fold lower risk of relapse than those with an MES of 1-3 (n = 100, 52%) (HR = 0.10, 95%CI: 0.05-0.19). A negative FIT result (fecal hemoglobin concentrations ≤ 100 ng/mL) was predictive of patients with an MES of 0, with a sensitivity of 0.94 and a specific of 0.76. Moreover, patients with a negative FIT score had a six-fold lower risk of clinical relapse than those with a positive score (HR = 0.17, 95%CI: 0.10-0.28). Inclusion of the distinguishing parameter, sustaining clinical remission > 12 mo, resulted in an even stronger correlation between negative FIT results and an MES of 0 with respect to the risk of clinical relapse (HR = 0.11, 95%CI: 0.04-0.23).CONCLUSION: Negative FIT results one year or more after remission induction correlate with complete mucosal healing (MES 0) and better prognosis. Performing FIT one year after remission induction may be useful for evaluating relapse risk.

关键词： Ulcerative colitis Clinical remission Mucosal healing Mayo endoscopic subscore Quantitative fecal immunochemical test