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Natural Science 2023年第4期15卷 179-189页

作者： Osamu Takagi Masamichi Sakamoto Kimiko Kawano mikio Yamamoto International Research Institute (IRI) Chiba Japan Aquavision Academy Chiba Japan

To date, numerous books have been published on so-called “pyramid power” but there have been few academic papers on this subject other than our own. Since 2007, to demonstrate the pyramid power, we have undertaken strictly scientific experiments using a pyramidal structure (PS) that we have carefully constructed. In previous reports, we used the edible cucumber, Cucumis sativus as an effective and practical biosensor. Through measurement and analysis of volatile components (gas concentrations) emitted from the biosensor, we were able to demonstrate the existence of the pyramid power and revealed some of its characteristics. In a paper published in 2022, we showed that gas concentration release from this biosensor displayed a circadian rhythm and that this rhythm changed with the season. Based on the result that the biosensor had a periodic diurnal oscillation called a circadian rhythm, we questioned whether or not pyramid power and Bio-Entanglement also had periodic diurnal oscillations. In this paper, we investigated that possibility. Our results have shown that pyramid power and Bio-Entanglement do not exhibit significant periodic diurnal oscillations. Thus we have revealed for the first time that the field associated with pyramid power is a type of static field that always exerts a constant influence. We expect that our research results will be widely accepted in the future and will become the foundation for a new research field in science, with a wide range of applications.

关键词： Pyramid Potential Power Bio-Entanglement Diurnal Oscillation Biosensor Cucumis sativus Gas Psi Index

Potential Power of the Pyramidal Structure IV: Discovery of Entanglement Due to Pyramid Effects

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Natural Science 2021年第7期13卷 258-272页

作者： Osamu Takagi Masamichi Sakamoto Kimiko Kawano mikio Yamamoto International Research Institute (IRI) Chiba Japan Aquavision Academy Chiba Japan

Since October 2007, we have been conducting rigorous scientific research on the unexplained “power” of a pyramidal structure (PS). From our research results so far, we could classify pyramid effects by the PS into the following two types: (i) the pyramid effects due to the potential power of the PS and (ii) the pyramid effects due to the influence of the test subject meditating inside the PS. We have been using edible cucumber sections as the biosensors. The pyramid effect existence was clarified by measuring and analyzing the concentration of volatile components released from the biosensors. The biosensors were arranged as a pair: one member of the pair was placed at the PS apex and the other was placed at the calibration control point 8.0 m away from the PS. In this paper, we report a new discovery regarding the type (i) pyramid effects. We discovered a phenomenon considered to be entanglement between the biosensor pairs detecting the pyramid effects. In other words, the biosensors at the PS apex, which were affected by the potential power of the PS, affected the biosensors at the calibration control point. We also confirmed that the effects on the biosensors placed at the calibration control point were not due to the potential power of the PS. Furthermore, we showed that the magnitude of the effect of entanglement changed with the seasons. We expect that our research results will be widely accepted in the future and will become the foundation for a new research field in science, with a wide range of applications.

关键词： Pyramid Potential Power Entanglement Meditation Non-Contact Effect Biosensor Cucumis sativus Gas Psi Index

Potential Power of the Pyramidal Structure VII: Effects of Pyramid Power and Bio-Entanglement on the Circadian Rhythm of Biosensors

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Natural Science 2023年第1期15卷 19-38页

作者： Osamu Takagi Masamichi Sakamoto Kimiko Kawano mikio Yamamoto International Research Institute (IRI) Chiba Japan Aquavision Academy Chiba Japan

We have demonstrated the existence of a pyramid power and have revealed its characteristics by strictly scientific experiments using biosensors. We also revealed the existence of a Bio-Entanglement, an entangled relationship between biosensors. A parallel study of biosensors (edible cucumber slices) had also been conducted, and we found that the circadian rhythm of gas concentrations emitted from biosensors changes seasonally. The pyramid power and Bio-Entanglement did not change the number of cycles in the periodic approximation curve representing circadian rhythm. Therefore, in this paper we analyzed the influence of the pyramid power and Bio-Entanglement, i.e., their influence on the phase, amplitude, and correlation coefficient of the periodic approximation curve representing the circadian rhythm of emitted gas concentrations. The main results are as follows. 1) The pyramid power shifted the phase of the periodic approximation curve representing the circadian rhythm by 43 minutes. 2) The amplitude of the periodic approximation curve changed with the pyramid power and the Bio-Entanglement. The effect on the lower and upper sections of the biosensors stacked in two layers was different, with a tendency to increase the amplitude of the lower layer and decrease the amplitude of the upper layer. 3) The pyramid power and the Bio-Entanglement affected the correlation coefficient between gas concentration and the periodic approximation curve representing the circadian rhythm of gas concentration. The effect on the lower and upper layers of the biosensors was different, with a tendency for the lower layer correlation coefficient to be larger and the upper layer correlation coefficient to be smaller. Previously we demonstrated that the pyramid power and the Bio-Entanglement affect the ratio of gas concentration, i.e., psi index Ψ. In this paper we demonstrate for the first time that the pyramid power and the Bio-Entanglement affect time, i.e., phase difference.

关键词： Pyramid Biosensor Cucumis sativus Circadian Rhythm Entanglement Gas Season

Potential Power of the Pyramidal Structure VI: Pyramid Effects due to Potential Power and Pyramid Effects due to Bio-Entanglement

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Natural Science 2022年第6期14卷 251-263页

作者： Osamu Takagi Masamichi Sakamoto Kimiko Kawano mikio Yamamoto International Research Institute (IRI) Chiba Japan Aquavision Academy Chiba Japan

Research on the so-called “pyramid power” began in the late 1930s. However, in general, pyramid power has been regarded as having no scientific basis, so there are very few systematic papers on pyramid power other than our academic research papers. Since October 2007, we have been conducting research to experimentally elucidate the unexplained phenomenon of a pyramid by using a pyramidal structure (PS). There have been two main types of experiments: (i) an experiment to detect the pyramid effects that appear due to the potential power (pyramid power) that the PS inherently has;and (ii) an experiment to detect the pyramid effects that appear when a test subject meditates inside the PS. To detect the pyramid effects, biosensors with evenly cut cucumber fruits, Cucumis sativus, were used. As a result of analyzing the concentration of volatile components emitted from the biosensors, we demonstrated the existence of pyramid power near the PS apex and discovered that the PS has the function of converting the unexplained energy of the meditator test subject. The research results so far have been reported as eleven original papers, three comprehensive reports, and one book chapter. We reported the phenomenon of the entanglement between biosensors in parts IV and V of the paper series, “Potential Power of the Pyramidal Structure”. Furthermore, we clarified that the influence of the entanglement is included in the psi index Ψ, which is an index of the magnitude of the pyramid effects. The purpose of the present paper was to separate and analyze the psi index Ψ into the effect of the potential power of the PS and the effect of the entanglement between biosensors (we have named this as the Bio-Entanglement). To do this, we placed biosensors at the PS apex in two layers. The value of the pyramid effect on the biosensors in the upper layer was always larger than that in the lower layer. We found that this was mainly due to the potential power of the PS. We also found that the fac

关键词： Pyramid Potential Power Entanglement Biosensor Cucumis sativus Gas Psi Index

Seasonal Changes in the Circadian Rhythm of Gas Released from Harvested Cucumbers

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Natural Science 2022年第11期14卷 503-516页

作者： Osamu Takagi Masamichi Sakamoto Kimiko Kawano mikio Yamamoto International Research Institute (IRI) Chiba Japan Aquavision Academy Chiba Japan

Vegetables and fruits are known to have long-lasting biological reactions even after harvesting. Volatile components may be released as a biological response to stimulation or injury. We measured the concentrations of volatiles released from the cut surfaces of cucumbers after their harvest and analyzed the relationship between the time the cucumbers were cut and gas concentrations. The results showed that gas concentrations indicate a circadian rhythm. We previously reported that the circadian rhythm of gas concentrations was 6 hours per cycle in the summer, i.e., from the vernal equinox to the autumnal equinox, and 24 hours per cycle in the winter, i.e., from the autumn equinox to the vernal equinox. We analyzed the gas concentrations emitted from cucumber sections in more detail in this paper and found that the circadian rhythms differ among winter, spring, summer, and autumn seasons. We found that one cycle of the circadian rhythm was 8 hours in winter, 6 hours in spring, 24 hours in summer, and a mixed cycle of 24 and 12 hours in autumn.

关键词： Cucumis sativus Biosensor Circadian Rhythm Season Gas Pyramid

Clinical usefulness of ursodeoxycholic acid for Japanese patients with autoimmune hepatitis

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World Journal of Hepatology 2017年第1期9卷 57-63页

作者： Yuichi Torisu Masanori Nakano Keiko Takano Ryo Nakagawa Chisato Saeki Atsushi Hokari Tomohisa Ishikawa Masayuki Saruta mikio Zeniya Division of Gastroenterology and Hepatology Department of Internal Medicine the Jikei University School of Medicine Department of Internal Medicine Fuji City General Hospital Department of Internal Medicine Sanno Medical Center

AIM To evaluate the therapeutic effects of ursodeoxycholic acid(UDCA) on autoimmune hepatitis(AIH).METHODS A total 136 patients who were diagnosed with AIH were included in our study. All of the patients underwent a liver biopsy, and had at least a probable diagnosis on the basis of either the revised scoring system or the simplified scores. Initial treatment included UDCA monotherapy(Group U, n = 48) and prednisolone(PSL) monotherapy(Group P, n = 88). Group U was further classified into two subgroups according to the effect of UDCA: Patients who had achieved remission induction with UDCA monotherapy and showed no sign of relapse(Subgroup U1, n = 34) and patients who additionally received PSL during follow-up(Subgroup U2, n = 14). We compared the clinical and histological findings between each groups, and investigated factorscontributing to the response to UDCA *** In Group U, 34 patients(71%) achieved and maintained remission over 49(range: 8-90) mo(Subgroup U1) and 14 patients(29%) additionally received PSL(Subgroup U2) during follow-up. Two patients in Subgroup U2 achieved remission induction once but additionally required PSL administration because of relapse(15 and 35 mo after the start of treatment). The remaining 12 patients in Subgroup U2 failed to achieve remission induction during follow-up, and PSL was added during 7(range: 2-18) mo. Compared with Subgroup U2, Subgroup U1 had significantly lower alanine aminotransferase(ALT) levels at onset(124 IU/L vs 262 IU/L, P = 0.023) and a significantly higher proportion of patients with mild inflammation(A1) on histological examination(70.6% vs 35.7%, P = 0.025). When multivariate analysis was performed to identify factors contributing to the response to UDCA monotherapy, only a serum ALT level of 200 IU/L or lower was found to be associated with a significant difference(P = 0.013).CONCLUSION To prevent adverse events related to corticosteroids, UDCA monotherapy for AIH needs to be considered in pat

关键词： Autoimmune hepatitis Japanese patients Adverse events Corticosteroids Ursodeoxycholic acid

Potential Power of the Pyramidal Structure V: Seasonal Changes in the Periodicity of Diurnal Variation of Biosensors Caused by Entanglement Due to Pyramid Effects

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Natural Science 2021年第12期13卷 523-536页

作者： Osamu Takagi Masamichi Sakamoto Kimiko Kawano mikio Yamamoto International Research Institute (IRI) Chiba Japan Aquavision Academy Chiba Japan

Since October 2007, we have been conducting rigorous scientific experiments to elucidate the so-called “pyramid power”. The experiments use a pyramidal structure (PS). In order to detect the PS effects, a biosensor is made from cucumber fruit sections and the released volatile components are analyzed as gas concentration. We reported the phenomenon of entanglement between biosensors in part IV of the paper series, Potential Power of the Pyramidal Structure. The entanglement affected the gas concentration of the biosensors 8 m away, but not the biosensors at the PS apex. In this paper, we report another characteristic of the entanglement. The results and our conclusion are as follows. Result 1: The periodicity of diurnal variation in gas concentration changed with entanglement. Result 2: As a result of analyzing the gas concentration data separately for the four seasons of winter, spring, summer, and autumn, the seasonal dependence of the periodicity of diurnal variation due to entanglement was clarified. Conclusion: We reaffirmed the existence of the entanglement between biosensors due to the pyramid effects by a phenomenon different from Part IV of the paper series, Potential Power of the Pyramidal Structure. We expect that our research results will be widely accepted in the future and will become the foundation for a new research field in science, with a wide range of applications.

关键词： Pyramid Potential Power Entanglement Meditation Biosensor Cucumis sativus Gas Psi Index

The Researches on Salary Fairness against the Background of Marketization: Evidence from Chinese Pharmaceutical Industry

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The Researches on Salary Fairness against the Background of ...

Feasibility of Outpatient Chemotherapy with S-1 and Cisplatin for Gastric Cancer

2016战略管理国际会议

作者： Wu Siqi mikio Kudo Business School Sichuan University International Graduate School of Accounting Policy Tohoku University

Salary fairness is the key to the reform of income distribution mechanisms in China. This research examines salary fairness under the background of marketization, using evidence from Chinese pharmaceutical listed companies. Based on the Rucker coefficient and related theories, a value added statement analysis is conducted. The research results indicate that salary inequity exists in China's pharmaceutical industry. It also suggests that non-state owned enterprises that located in regions with lower marketization level face a more serious problem of salary fairness. Most significantly, it reveals that the shareholders and government claim a larger portion of the value produced by the enterprises than other stakeholders. This is especially true concerning the shareholders who claim the largest share.

关键词： pharmaceutical industry marketization salary fairness Rucker coefficient value added statement analysis

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Journal of Cancer Therapy 2014年第8期5卷 759-765页

作者： Hironaga Satake Akihito Tsuji Takeshi Kotake mikio Fujita Department of Oncology Kobe City Medical Center General Hospital Kobe Japan

Objective: To evaluate the feasibility of S-1 and high-dose cisplatin short hydration regimens for outpatients with unresectable metastatic gastric cancer. Methods: Data for individual outpatients treated in our institution were retrospectively pooled to assess the feasibility of an S-1 and highdose cisplatin short hydration regimen (S-1: 80 to 120 mg on Days 1 to 21;cisplatin: 60 mg/m2?on Day 8, every 5 weeks), which included 2250 ml of intravenous fluids and 1000 ml oral hydration. Ten consecutive patients were treated with S-1 and high-dose cisplatin short hydration for unresectable metastatic gastric cancer from July 2011 to May 2012 and were included in the analysis. Results: With a median of 3.5 medication cycles, unscheduled admission occurred in two patients for 5 days each due to paralytic ileus and cerebral infarction. Four patients required dose reduction, in both S-1 and cisplatin in two patients, and in S-1 alone and cisplatin alone in one patient each. Renal function transiently declined after administration of cisplatin, but serum creatinine level and estimated glomerular filtration rate were both improved by the time of the next administration. Conclusion: This study suggests that an S-1 and high-dose cisplatin short hydration strategy for outpatients with unresectable metastatic gastric cancer might be feasible.

关键词： Gastric Cancer Cisplatin S-1 Short Hydration Outpatient Chemotherapy

An Experimental Investigation on the Quasi-Static Flotation Transport of a Glass Substrate Using Vortex Bearing Elements

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Journal of Flow Control, Measurement & Visualization 2013年第1期1卷 6-12页

作者： Xin Li Yoshihiro Nakamura mikio Horie Toshiharu Kagawa Department of Mechano-Micro Engineering Tokyo Institute of Technology Yokohama Japan Precision and Intelligence Laboratory Tokyo Institute of Technology Yokohama Japan

In this paper, we build an air conveyor with newly developed vortex bearing elements, and study the flotation precision of the front-end of the substrate in quasi-static flotation transport. We experimentally discuss the three influential factors: air supply pressure, thickness of the substrates and installing direction of the vortex bearing element. We find that during the process of transport the movement of the substrate leads to the variation of flotation height. The amplitude of variation (e.g. flotation precision) is dependent upon the bearing stiffness and the suction force of the vortex bearing elements. Increasing air supply pressure properly can improve the flotation precision, but an excess pressure can cause over-suction due to high negative pressure and result in a poor flotation precision. We also know that the flotation precision of thin and light substrates are easily affected by the suction force of vortex flow because they float with a high flotation height and are more susceptible to deformation. Finally, we investigate four installing directions of the vortex bearing element. Different installing direction can lead to different variation of flotation height.

关键词： Flotation Transport Air Conveyor Vortex Bearing Element Vortex Flow Suction Force