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Method to Identify the Material of a Single Grain Based on Its Magnetization and Anisotropy Measured in a Chamber Type μG Drop Shaft

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Journal of Iron and Steel Research International 2012年第S2期19卷 1081-1084页

作者： UYEDA Chiaki HISAYOSHI Keiji MAMIYA mikio NAGAI Yasuo Graduate School of Science.Osaka University AIST Tsukuba

Free translation caused by attractive field-gradient force was observed for Ni and ferrite(CuFe_2O_4) grains that were released in a diffuse *** order to exclude the effect of terrestrial gravity,translation was observed in micro-gravity(μG) condition produced by a compact drop-shaft installed in a ordinary laboratory *** Ms per unit mass of the grain is obtained by analyzing the above-mentioned translations in terms of a energy conservation rule;here conservation of the sum of field-induced potential mMsH and kinetic energy 1/2/mv^2 is considered for a particle with mass *** present method of obtaining Ms is free of measuring the mass of sample;this is because the field-gradient force is a volume force that is proportional to *** method is also free of an interfering signal emitted from the sample ***,Ms is detectable irrespective of sample size,provided that the field-induced translation is *** above-mentioned procedure to estimate Ms from filed-induced translation is a step to obtain a reliable magnetic data from a single nano-sized *** efficiency of material identification was recently confirmed on various solid grains,which was based on diamagnetic magnetization data obtained from its translations caused by field-gradient repulsive force.A diamagnetic material generally possesses an intrinsic value of magnetic susceptibility and its *** present results on nickel grains indicate that the principle of material identification based on its magnetization data is applicable for the three major category of magnetic materials,namely ferro-(or ferri-) magnetic, paramagnetic and diamagnetic material.

关键词： chamber type μG drop-shaft saturated magnetization field-gradient force magnetic ejection diamagnetic anisotropy magnetic orientation magnetic alignment

Direct Spectroscopic Determination of Europium（ Ⅱ ） Concentration During Europium（ Ⅲ ） Electro-Reduction in Hydrochloric Acid Medium

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Journal of Rare Earths 2007年第1期25卷 1-5页

作者： Ludek Jelinek Tsuyoshi Arai Wei Yuezhou mikio Kumagai Institute of Research and Innovation （IRI） 1201 Takada Kashiwa 277-0861 Japan

UV-Vis spectroscopy was used to directly determine the concentration of Eu（ Ⅱ） during electroreduction of Eu （ Ⅲ ） in hydrochloric acid medium. Electroreduction was carried out in a flow type electrolyzer with glassy carbon cathode at the constant potential of - 800 mV vs. Ag/AgCl. The effects of oxygen and concentration of hydrochloric acid on the system were investigated. For 0.01 mol· L^-1 hydrochloric acid, calibration curves for Eu （Ⅱ） absorption bands at 248 and 320 nm were constructed. Molar absorption coefficients were estimated to be 2016 and 648 L· mol^-1·cm^-1, respectively. The absorbance strongly decreased with decrease in pH of the solution, whereas concentration of chloride had only a negligible effect.

关键词： Eu( Ⅱ ) electroreduction hydrochloric acid UV spectroscopy rare earths

Recent Development of Dielectric Elastomer Transducers and Potential Applications

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Energy and Power Engineering 2023年第2期15卷 105-126页

作者： Seiki Chiba mikio Waki Chiba Science Institute Tokyo Japan Wits Inc. Tochigi Japan

Power generation using dielectric elastomer transducers is cheap, light, stackable, easy to install, and highly efficient. Also, since the dielectric elastomer transducer is an actuator developed into an artificial muscle, if the DE motor is further developed, it might be possibly be able to drive a vehicle. Efficient robot driving, various industrial machines and the use of dielectric elastomer sensors to optimize the driving may also help solve the above problems from the perspective of eco-driving. This paper describes the latest level of development of dielectric elastomers, their main problems and solutions to these problems, and their potential applications. The possibilities and concrete plans for building local global smart cities (including local generation power for local consumption), efficient transportation, and environmental monitoring systems utilizing dielectric elastomers are also discussed.

关键词： High-Efficiency Power Generation Lightweight and High-Output Actuator Sensor with Wide Measurement Range Flexible SWCNT Spray

Understanding prostate-specific antigen dynamics in monitoring metastatic castration-resistant prostate cancer： implications for clinical practice

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Asian Journal of Andrology 2017年第2期19卷 143-148页

作者： Atsushi Mizokami Kouji Izumi Hiroyuki Konaka Yasuhide Kitagawa Yoshifumi Kadono Kazutaka Narimoto Takahiro Nohara Amit K Bahl mikio Namiki Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science 13-1 Takaramachi Kanazawa 920-8640 Japan Bristol Haematology and Oncology Centre University Hospitals Bristol Bristol BS2 8ED UK

Availability of novel hormonal therapies as well as docetaxel and cabazitaxel treatment for metastatic castration-resistant prostate cancer （CRPC） has changed the outlook for this group of patients with improvements in progression-free survival and overall survival. Physicians often diagnose the progression of prostate cancer using serum prostate-specific antigen （PSA）. However, serum PSA is not always correlated with the clinical status in CRPC. To evaluate the PSA dynamics with greater precision, understanding of the control of PSA and of the mechanisms of development of CRPC is needed. Moreover, it is necessary to use new hormonal therapies with an appropriate timing to optimally improve the prognosis and the QOL of the patients. In the present review, we ascertain the PSA dynamics and the mechanisms of the development of CRPC to assist in optimal utilization of the new treatments for mCRPC.

关键词： castration-resistant prostate cancer new hormonal therapy prostate-specific antigen

Support from Healthcare Professionals for Couples/Partners Undergoing Assisted Reproductive Technology in Japan: A Literature Review

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Open Journal of Nursing 2023年第12期13卷 875-889页

作者： mikio Watanabe Naohiro Hohashi Division of Family Health Care Nursing Graduate School of Health Sciences Kobe University Kobe Japan

Background and Purpose: A growing number of couples/partners have been undergoing assisted reproductive technology (ART) in Japan. The purpose of this study was to clarify the support from healthcare professionals based on the support vectors in the Family Care/Caring Theory proposed by Hohashi (2015) through a literature review. Methods: Using Ichushi-Web, we searched for original articles using the keywords “assisted reproductive technology”, “infertility”, “family”, “couple”, “nursing”, “care”, and “support”. Thirteen articles suitable for the purpose of this study were subjected to content analysis. Family support was encoded and grouped into subcategories and categories, and classified according to support vectors. Results: A total of 21 categories of support from healthcare professionals was extracted. Intervention for family internal environment included seven categories, such as “Nursing professionals stay close to females”. Intervention for family system unit included five categories, such as “Nursing professionals adjust couple/partner relationships”. Intervention for micro system only included “Nursing professionals provide opportunities for peer support to the couples/partners” and intervention for macro system only included “Nursing professionals encourage medical doctors to relate to females”. Intervention for family chrono environment included seven categories, such as “Healthcare professionals resolve female’s anxieties”. Conclusion: The support from healthcare professionals could be organized by the support vectors of Family Care/Caring Theory, but intervention for supra system (culture, religion, etc.) was lacking. Moreover, because most support was directed toward females or couples/partners, male-focused direct and/or indirect support are also needed. .

关键词： Assisted Reproductive Technology Infertility Family Support Family Care/Caring Theory Literature Review

Agent-Based Simulation for Analyzing Network Formation with Learning Dynamics

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Journal of Mathematics and System Science 2012年第9期2卷 576-585页

作者： Michiharu Masui mikio Ogawa Department of Business Administration Ishinomaki Senshu University Miyagi 986-8580 Japan Oracle Corporation Japan Tokyo 107-0061 Japan

In game theoretic context, it is assumed that the decision maker has the extraordinary skills of reasoning and calculation. This assumption is called ＂perfect rationality＂. A player with perfect rationality can solve complex problems without making mistakes. However, recently, many studies have restricted this rationality or the structure of game. These restrictions are called ＂bounded rationality.＂ The authors also focus on bounded rationality, but with learning dynamics and complex networks. A complex network covers a wide area. Currently, a wide range of studies have not only investigated network formation and the characteristics of a formed network, but also analyzed situations where a network is already provided. In addition, in an analysis using game theory, a prisoners＇ dilemma type game was used to investigate how a change in the network structure would affect the players＇ relationships Therefore, our model employs decision makers with learning dynamics and describes the interaction of decision makers as a network. The purpose of this study is to examine the behavior of the decision maker with learning dynamics and the formation of networks by the interaction of decision makers through an agent-based simulation.

关键词： Game theory complex network simple dynamics best-response dynamics agent-based simulation.

Effects of long-term androgen replacement therapy on the physical and mental statuses of aging males with late-onset hypogonadism： a multicenter, randomized controlled trial in Japan （EARTH Study）

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Asian Journal of Andrology 2016年第1期18卷 25-34页

作者： Hiroyuki Konaka Kazuhiro Sugimoto Hideki Orikasa Teruaki Iwamoto Toshinari Takamura Yoshiyu Takeda Kazuyoshi Shigehara Masashi Iijima Eitetsu Koh mikio Namiki Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa Ishikawa Japan Division of Biostatistics and Clinical Epidemiology University of Toyama School of Medicine Toyama Toyama Japan Division of Male Infertility Center for Infertility and IVF International University of Health and Welfare Nasushiobara Tochigi Japan Department of Disease Control and Homeostasis Kanazawa University Graduate Schoofof Medical Science Kanazawa Ishikawa Japan Departrnent of Internal Medicine. Division of Endocrinology and Hypertension Kanazawa University Graduate School of Medical Science Kanazawa Ishikawa Japan.

Androgen replacement therapy （ART） efficacy on late-onset hypogonadism （LOH） has been widely investigated in Western countries; however, it remains controversial whether ART can improve health and prolong active lifestyles. We prospectively assessed long-term ART effects on the physical and mental statuses of aging men with LOH in Japan. The primary endpoint was health-related quality of life assessed by questionnaires. Secondary endpoints included glycemic control, lipid parameters, blood pressure, waist circumference, body composition, muscular strength, International Prostate Symptom Scores （IPSS）, International Index of Erectile Function-5 （IIEF-5） scores, and serum prostate-specific antigen levels. Of the 1637 eligible volunteers, 334 patients 〉 40 years with LOH were randomly assigned to either the ART （n = 169） or control groups （n = 165）. Fifty-two weeks after the initial treatment, ART significantly affected the role physical subdomain of the short form-36 health survey （SF-36） scale （P= 0.0318）. ART was also associated with significant decreases in waist circumstance （P = 0.002） and serum triglyceride （TG）（P = 0.013） and with significant increases in whole-body and leg muscle mass volumes （P= 0.071 and 0.0108, respectively）, serum hemoglobin （P 〈 0.001）, IPSS voiding subscore （P = 0.0418）, and the second question on I IEF-5 （P = 0.0049）. There was no significant difference between the groups in terms of severe adverse events. In conclusion, in patients with LOH, long-term ART exerted beneficial effects on Role Physical subdomain of the SF-36 scale, serum TG, waist circumstance, muscle mass volume, voiding subscore of IPSS, and the second question of IIEF-5. We hope our study will contribute to the future development of this area.

关键词： androgen replacement therapy health-related quality of life late-onset hypogonadism randomized controlled trial testosterone

Advances in inducing adaptive immunity using cell-based cancer vaccines: clinical applications in pancreatic cancer

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World Journal of Gastroenterology 2016年第18期22卷 4446-4458页

作者： mikio Kajihara Kazuki Takakura Tomoya Kanai Zensho Ito Yoshihiro Matsumoto Shigetaka Shimodaira Masato Okamoto Toshifumi Ohkusa Shigeo Koido Division of Gastroenterology and Hepatology Department of Internal Medicine the Jikei University School of Medicine (Kashiwa Hospital) Cell Processing Center Shinshu University Hospital Department of Advanced Immunotherapeutics Kitasato University School of Pharmacy Institute of Clinical Medicine and Research The Jikei University School of Medicine

The incidence of pancreatic ductal adenocarcinoma(PDA) is on the rise, and the prognosis is extremely poor because PDA is highly aggressive and notoriously difficult to treat. Although gemcitabine- or 5-fluorouracil-based chemotherapy is typically offered as a standard of care, most patients do not survive longer than 1 year. Therefore, the development of alternative therapeutic approaches for patients with PDA is imperative. As PDA cells express numerous tumor-associated antigens that are suitable vaccine targets, one promising treatment approach is cancer vaccines. During the last few decades, cell-based cancer vaccines have offered encouraging results in preclinical studies. Cell-based cancer vaccines are mainly generated by presenting whole tumor cells or dendritic cells to cells of the immune system. In particular, several clinical trials have explored cell-based cancer vaccines as a promising therapeutic approach for patients with PDA. Moreover, chemotherapy and cancer vaccines can synergize to result in increased efficacies in patients with PDA. In this review, we will discuss both the effect of cell-based cancer vaccines and advances in terms of future strategies of cancer vaccines for the treatment of PDA patients.

关键词： Pancreatic cancer Dendritic cell whole tumor cell Cancer vaccine Cytotoxic T lymphocyte

Didactic surgical experience of thyroid metastasis from renal cell carcinoma: A case report

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World Journal of Clinical Cases 2018年第15期6卷 1018-1023页

作者： Moriyasu Yamauchi Keita Kai Natsuko Shibamiya Rintaro Shimazu mikio Monji Kumiko Suzuki Hiroaki Kakinoki Shohei Tobu Yuichiro Kuratomi Department of Otolaryngology Head and Neck Surgery Saga University Faculty of Medicine Department of Pathology Saga University Hospital Department of Urology Saga University Faculty of Medicine

BACKGROUND The optimal therapeutic strategy in treating thyroid metastasis from renal cell carcinoma(RCC) has not been clearly established. Here we describe a case of didactic surgical experience of the disease which caused massive intraoperative *** SUMMARY A 59-year-old male patient presented with a thyroid left lobe soft mass detected by chest computed tomography scans prior to the surgical treatment of RCC of the left kidney. The thyroid mass was initially considered to be benign, then he underwent left radical nephrectomy. One year after the nephrectomy, stereotactic radiosurgery was performed for brain metastasis. During follow-up, the thyroid nodule gradually grew, and the patient manifested swallowing discomfort. Under a clinical diagnosis of thyroid follicular neoplasm, left hemithyroidectomy was performed. Although hemithyroidectomy is usually a safe and straightforward procedure, massive bleeding from markedly developed tumor vessels made the operation very difficult. The thyroid tumor was finally diagnosed as metastasis from clear cell RCC. CONCLUSION For proper timing of the surgery, a clinician should take into consideration the possibility of thyroid metastasis of RCC when a thyroid lesion is found in patients with RCC or in patients with a previous history of RCC. We recommend that thyroid metastasis of RCC should be resected as early as possible even if a patient has other metastatic sites.

关键词： Renal cell carcinoma Thyroid metastasis Hemorrhage Thyroidectomy Case report