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TC10 as an essential molecule in axon regeneration through membrane supply and microtubule stabilization

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Neural Regeneration Research 2022年第1期17卷 87-88页

作者： Takeshi nakamura Shingo Koinuma Division of Cell Signaling Research Institute for Biomedical SciencesTokyo University of ScienceNodaJapan

Mammalian central nervous system(CNS)neurons lose axon regenerative ability as they *** failure to regenerate shows a clear contrast to a remarkable potential of axon growth during embryonic development and after an injury in the peripheral nervous system(PNS)(Hilton and Bradke,2017).The absence of regeneration in the mature CNS neurons is caused by an inhibitory influence of the environment of the injured axons and the deficit of intrinsic factors that enable regeneration in the PNS(He and Jin,2016).

关键词： stabilization enable axon

从诉讼法学的立场对实体法学的学术方法及其构造质疑

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河北法学 2024年第3期42卷 2-34页

作者： [日]中村宗雄冯祝恒(译) 张卫平(校) 早稻田大学东京清华大学法学院北京100084 烟台大学山东烟台264005

在现代法学之下,民事实体法学与诉讼法学虽然都取得了飞速发展,但直到现在两者之间也没有建立起充分的学术联系。实体法学现阶段仍然是从罗马法继受而来的潘德克顿法学的一元自足体系,其对已形成独立法律体系的诉讼法理论毫不关心。也因... 详细信息

在现代法学之下,民事实体法学与诉讼法学虽然都取得了飞速发展,但直到现在两者之间也没有建立起充分的学术联系。实体法学现阶段仍然是从罗马法继受而来的潘德克顿法学的一元自足体系,其对已形成独立法律体系的诉讼法理论毫不关心。也因此,实体法理论存在缺陷、曲解以及学术范围不当扩大等问题。这些问题的主要成因可细分为:其一,现代私法学舍弃了实体法作为裁判规范的一面,完全沦为了社会规范理论;其二,现代私法学以具有私法性质的“请求权”概念继承了actio理论,舍弃了其诉讼性质;其三,现代私法学没有将对私法关系产生影响的“裁判效力”纳入其理论;其四,实体法学者对通过诉讼进行“权利确定”缺乏明确的认识。法的世界由实体法与诉讼法组成,二者应当分别划分学术领域,在互补关系上相互融合,从而构成法学的整个体系。为此,应首先打破实体法学与诉讼法学的自足体系,一方面需要将实体法理论引入到诉讼法学领域,提倡“实体法与诉讼法并立二元观”的诉讼法学理论构造,另一方面也需要在实体法学中建立与诉讼法学相融合的理论构造。

关键词：实体法学诉讼法学学术方法学术构造学术联系

A NEW APPROACH AND ERROR ANALYSIS FOR RECONSTRUCTING THE SCATTERED WAVE BY THE POINT SOURCE METHOD

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Journal of Computational Mathematics 2007年第2期25卷 113-130页

作者： Jijun Liu Gen nakamura Roland Potthast Department of Mathematics Southeast University Nanjing 210096 China Department of Mathematics Graduate School of Science Hokkaido University Sapporo 060-0810 Japan Institute for Numerical and Applied Mathematics University of Gottingen Lotzestr 16-1837085 Gottingen Germany

Consider an inverse scattering problem by an obstacle D belong to R^2 with impedance boundary. We investigate the reconstruction of the scattered field u^s from its far field pattern u^∞ using the point source method. First, by applying the boundary integral equation method, we provide a new approach to the point-source method of Potthast by classical potential theory. This extends the range of the point source method from plane waves to scattering of arbitrary waves. Second, by analyzing the behavior of the Hankel function, we obtain an improved strategy for the choice of the regularizing parameter from which an improved convergence rate （compared to the result of [15]） is achieved for the reconstruc- tion of the scattered wave. Third, numerical implementations are given to test the validity and stability of the inversion method for the impedance obstacle.

关键词： Inverse scattering Regularization Error estimate Numerics

RECONSTRUCTION OF SCATTERED FIELD FROM FAR-FIELD BY REGULARIZATION

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Journal of Computational Mathematics 2004年第3期22卷 389-402页

作者： Ji-junLiu JinCheng G.nakamura DepartmentofMathematics SoutheastUniversityNanjing210096China DepartmentofMathematics FudanUniversityShanghai200433China DepartmentofMathematics HokkaidoUniversitySapporo060-0810Japan

In this paper, we consider an inverse scattering problem for an obstacle D R^2 with Robin boundary condition. By applying the point source, we give a regularizing method to recover the scattered field from the far-fie... 详细信息

关键词： Inverse scattering Numerics Point source Regularization

THE LOCAL WELL-POSEDNESS OF A CHEMOTAXIS-SHALLOW WATER SYSTEM WITH VACUUM

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Acta Mathematica Scientia 2021年第1期41卷 231-240页

作者： Jishan FAN Fucai LI Gen nakamura Department of Applied Mathematics Nanjing Forestry UniversityNanjing 210037China Department of Mathematics Nanjing UniversityNanjing 210093China Department of Mathematics Hokkaido UniversitySapporo 060-0810Japan

In this paper we prove the local well-posedness of strong solutions to a chemotaxisshallow water system with initial vacuum in a bounded domainΩ■R^(2)without the standard compatibility condition for the initial *** ... 详细信息

关键词： chemotaxis shallow water vacuum local well-posedness strong solution

Attenuation and Distortion of Compression Waves Propagating in Very Long Tube

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Journal of Thermal Science 2011年第1期20卷 53-57页

作者： Shinya nakamura Daisuke SASA Toshiyuki AOKI Graduate School of Engineering Sciences Kyushu UniversityKasugaFukuoka816-8580Japan

A lot of phenomena related to propagating various waves are seen when the high-speed train goes through the tunnel,the gas pipeline is broken due to an accident or the air brake of the wagon *** instance,a compression wave generated ahead of a high-speed train entering a tunnel propagates to the tunnel exit and spouts as a micro pressure wave,which causes an exploding *** order to estimate the magnitude correctly,the mechanism of the attenuation and distortion of a compression wave propagating along a very long tunnel must be understood and the experimental information on these phenomena is *** experimental investigation is carried out to clarify the attenuation and distortion of the propagating compression wave in a very long *** results show that the strength of a compression wave decreases with *** attenuation and distortion of compression waves are affected by the initial waveform of the compression wave and by the unsteady boundary layer induced by the propagating *** shape of a compression wave becomes different with the propagating distance;that is,a shock wave appears just head of a wavefront and an overshoot on pressure distribution is observed behind a shock wave due to the transition of the unsteady boundary layer.

关键词： Propagating Compression Wave Very Long Tube Micro-pressure Wave High-Speed Train

A new cascade-less engine operated from subsonic to hypersonic conditions: designed by computational fluid dynamics of compressible turbulence with chemical reactions

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Journal of Thermal Science 2010年第6期19卷 481-485页

作者： Ken Naitoh Kazushi nakamura Takehiro Emoto Waseda University Faculty of Science and Engineering

By using our computational fluid dynamic models, a new type of single engine capable of operating over a wide range of Mach numbers from subsonic to hypersonic regimes is proposed for airplanes, whereas traditional piston engines, turbojet engines, and scram engines work only under a narrower range of operating conditions. The new engine has no compressors or turbines such as those used in conventional turbojet engines. An important point is its system of super multijets that collide to compress gas for the transonic regime. Computational fluid dynamics is applied to clarify the potential of this engine. The peak pressure at the combustion center is over 2.5 MPa, while that just before ignition is over 1.0 MPa. The maximum power of this engine will be sufficient for actual use. Under the conditions of higher Mach numbers, the main intake passage located in front of the super multijet nozzles, takes in air more. That results in a ram or scramjet engine for supersonic and hypersonic conditions.

关键词： Aircraft engine multijets twister system compressible flow

Silicon photonics for telecom and data‐com applications

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Opto-Electronic Advances 2020年第10期3卷 31-56页

作者： Kiyoshi Asakawa Yoshimasa Sugimoto Shigeru nakamura Associate Program University of TsukubaTsukubaIbaraki 305-8571Japan. Nanotechnology Innovation Station National Institute for Materials Science(NIMS)1-2-1 SengenTsukubaIbaraki 305-0047Japan. Biometrics Research Laboratories NEC Corporation1131HinodeAbikoChiba 270-1198Japan.

In recent decades,silicon photonics has attracted much attention in telecom and data-com *** of high refractive-index contrast waveguides on silicon-on-insulator(SOI),a variety of integrated photonic passive and active devices have been implemented supported by excellent optical properties of silicon in the mid-infrared *** main advantage of the silicon photonics is the ability to use complementary metal oxide semiconductor(CMOS)process-compatible fabrication technologies,resulting in high-volume production at low *** the other hand,explosively growing traffic in the telecom,data center and high-performance computer demands the data flow to have high speed,wide bandwidth,low cost,and high energy-efficiency,as well as the photonics and electronics to be integrated for ultra-fast data transfer in *** practical applications,silicon photonics started with optical interconnect transceivers in the data-com first,and has been now extended to innovative applications such as multi-port optical switches in the telecom network node and integrated optical phased arrays(OPAs)in light detection and ranging(LiDAR).This paper overviews the progresses of silicon photonics from four points reflecting the recent advances mentioned ***-based silicon photonic platform technologies,applications to optical transceiver in the data-com network,applications to multi-port optical switches in the telecom network and applications to OPA in LiDAR system.

关键词： silicon photonics integration of photonics and electronics CMOS process-compatible fabrication optical interconnect transceiver optical multi-port switch optical phased array

Personalized immunotherapy in cancer precision medicine

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Cancer Biology & Medicine 2021年第4期18卷 955-965页

作者： Kazuma Kiyotani Yujiro Toyoshima Yusuke nakamura Project for Immunogenomics Cancer Precision Medicine CenterJapanese Foundation for Cancer ResearchTokyo 135-8550Japan

With the significant advances in cancer genomics using next-generation sequencing technologies,genomic and molecular profilingbased precision medicine is used as a part of routine clinical test for guiding and selecting the most appropriate treatments for individual cancer *** many molecular-targeted therapies for a number of actionable genomic alterations have been developed,the clinical application of such information is still limited to a small proportion of cancer *** this review,we summarize the current status of personalized drug selection based on genomic and molecular profiling and highlight the challenges how we can further utilize the individual genomic *** immunotherapies,including immune checkpoint inhibitors,would be one of the potential approaches to apply the results of genomic sequencing most *** cancer-specific antigens derived from somatic mutations,the so-called neoantigens,occurring in individual cancers have been in focus *** immunotherapies,which target neoantigens,could lead to a precise treatment for cancer patients,despite the challenge in accurately predicting neoantigens that can induce cytotoxic T cells in individual *** prediction of neoantigens should accelerate the development of personalized immunotherapy including cancer vaccines and T-cell receptor-engineered T-cell therapy for a broader range of cancer patients.

关键词： Personalized medicine cancer precision medicine neoantigen personalized immunotherapy immune checkpoint blockade cancer vaccine adoptive T cell therapy