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Impact of diabetes on long term follow-up of elderly patients with chronic total occlusion post percutaneous coronary intervention

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Journal of Geriatric Cardiology 2013年第1期10卷 16-20页

作者： Wei Liu Kenji Wagatsuma Hideo Nii mikihito toda Hideo Amano Yasuto Uchida Division of Interventional Cardiology Cardiovascular Center Toho University 6-11-1 Omori-Nishi Ota-K Tokyo 143-8541 Japan Department of Cardiology Beijing An Zhen Hospital Capital Medical University Chao Yang District Beijing 100029 China Division of Interventional Cardiology Cardiovascular Center Toho University 6-11-1 Omori-Nishi Ota-K Tokyo 143-8541 Japan

Ba ckground The prognosis of elderly patients with chronic total occlusion (CTO) and diabetes mellitus (DM) treated with percutaneous coronary intervention (PCI) is not known. Objective To investigate the effect of diabetes on long-term follow-up of CTO after PCI in elderly *** A total of 153 elderly patients (age > 65 years old) with CTO lesions which were successfully treated with PCI were enrolled. Fifty one patients with diabetes and 102 without diabetes were compared for long-term outcomes (mean follow up: 36 ±12 months). Major adverse cardiac events (MACE) which include death, myocardial infarction or target lesion revascularization (TLR) were considered as a combined endpoint. Results The combined endpoint occurred in 29.4% of diabetes patients, and 11.3% of the patients without diabetes (P < 0.05). The Cox proportional hazards model identified: drug eluting stent (DES) or bare metal stent (BMS) (HR: 0.13, 95% confidence interval (95%CI): 0.03–0.62, P = 0.004), DM(HR: 6.69, 95% CI: 1.62–15.81, P = 0.01) and final minimal lumen diameter (MLD) (HR: 0.37, 95% CI: 0.13–0.90, P = 0.03 ) as independent predictors of MACE, DM with renal impairment (HR: 6.64, 95% CI: 1.32–33.36, P = 0.02), HBA1C on admission (HR: 1.79, 95% CI: 1.09–2.94, P = 0.02), as independent predictors of MACE at long term follow-up. Conclusions The study demonstrates that DMis a predictive factor for MACE in elderly CTOpatients treatedwith PCI, type of stent, final minimal lumen diameter and DMwith renal impairment, and HBA1C level on admission are predictors of MACE.

关键词： Chronic total occlusion Diabetes Drug eluting stent Elderly patient Percutaneous coronary intervention

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How Convolutional Neural Networks Diagnose Plant Disease

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Plant Phenomics 2019年第1期1卷 223-236页

作者： Yosuke toda Fumio Okura Japan Science and Technology Agency 4-1-8 HonchoKawaguchiSaitama 332-0012Japan Institute of Transformative Bio-Molecules(WPI-ITbM) Nagoya UniversityChikusaNagoya 464-8602Japan Department of Intelligent Media Institute of Scientific and Industrial ResearchOsaka University8-1MihogaokaIbarakiOsaka 567-0047Japan

Deep learning with convolutional neural networks(CNNs)has achieved great success in the classification of various plant ***,a limited number of studies have elucidated the process of inference,leaving it as an untouchable black *** the CNN to extract the learned feature as an interpretable form not only ensures its reliability but also enables the validation of the model authenticity and the training dataset by human *** this study,a variety of neuron-wise and layer-wise visualization methods were applied using a CNN,trained with a publicly available plant disease image *** showed that neural networks can capture the colors and textures of lesions specific to respective diseases upon diagnosis,which resembles human *** several visualizationmethods were used as they are,others had to be optimized to target a specific layer that fully captures the features to generate consequential ***,by interpreting the generated attention maps,we identified several layers that were not contributing to inference and removed such layers inside the network,decreasing the number of parameters by 75%without affecting the classification *** results provide an impetus for the CNN black box users in the field of plant science to better understand the diagnosis process and lead to further efficient use of deep learning for plant disease diagnosis.

关键词： diagnosis removed interpreting

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Adaptive dynamic range shift (ADRIFT) quantitative phase imaging

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Light(Science & Applications) 2021年第1期10卷 19-28页

作者： Keiichiro toda Miu Tamamitsu Takuro Ideguchi Department of Physics The University of TokyoTokyo 113-0033Japan Institute for Photon Science and Technology The University of TokyoTokyo 113-0033Japan PRESTO Japan Science and Technology AgencySaitama 332-0012Japan

Quantitative phase imaging(QPI)with its high-contrast images of optical phase delay(OPD)maps is often used for label-free single-cell *** to other imaging methods,sensitivity improvement has not been intensively explored because conventional QPI is sensitive enough to observe the surface roughness of a substrate that restricts the minimum measurable ***,emerging QPI techniques that utilize,for example,differential image analysis of consecutive temporal frames,such as mid-infrared photothermal QPI,mitigate the minimum OPD limit by decoupling the static OPD contribution and allow measurement of much smaller ***,we propose and demonstrate supersensitive QPI with an expanded dynamic *** is enabled by adaptive dynamic range shift through a combination of wavefront shaping and dark-field QPI *** a proof-of-concept demonstration,we show dynamic range expansion(sensitivity improvement)of QPI by a factor of 6.6 and its utility in improving the sensitivity of mid-infrared photothermal *** technique can also be applied for wide-field scattering imaging of dynamically changing nanoscale objects inside and outside a biological cell without losing global cellular morphological image information.

关键词： scattering dynamic phase

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Validation and Application of Skeletochronology for Age Determination of the Ryukyu Ground Gecko, Goniurosaurus kuroiwae(Squamata: Eublepharidae)

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Asian Herpetological Research 2013年第4期4卷 233-241页

作者： Takaki KURITA Mamoru toda Graduate School of Engineering and Science University of the Ryukyus Tropical Biosphere Research Center University of the Ryukyus

Skeletochronology is a method commonly used for estimating the age of amphibians and reptiles in the wild. However, the number of lines of arrested growth （LAGs） does not necessarily reflect age in some species. We validated the applicability of this method to an endangered eublepharid gecko, Goniurosaurus kuroiwae, then inferred its longevity and age structures in wild populations. We classified young geckos into three groups using previously published data for early growth： Group 1 contained hatchlings before the first winter, Group 2 contained hatchlings after the first win- ter, and Group 3 included yearlings after the second winter. LAG numbers in these groups were then compared. All individuals in Group 1 possessed a single LAG, which was considered as a hatching line. Most individuals in Groups 2 and 3 possessed one and two additional LAGs, respectively （LAG1 and LAG2）, corroborating the notion that LAGs are formed annually. A few geckos exhibited fewer LAGs than expected. Analysis of variations in LAG and marrow cavity diameter demonstrated that in animals with fewer LAGs, endosteal resorption or fusion of hatching line and LAG1 had occurred. LAG2 was never lost by endosteal resorption and was identifiable by its diameter. Thus, the age of adult geckos could be determined by counting LAGs outward from LAG2. Application of this method to wild populations re- vealed that the longevity of this species is not less than 83 months, but that almost all individuals in fragmented habitats die before 50 months, suggesting lower population sustainability in such habitats.

关键词： age structure endosteal resorption hatching line longevity rapprochement Ryukyu Archipelago

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Coulomb Stress Evolution History as Implication on the Pattern of Strong Earthquakes along the Xianshuihe-Xiaojiang Fault System, China

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Journal of Earth Science 2018年第2期29卷 427-440页

作者： Bing Yan Shinji toda Aiming Lin School of Earth Sciences and Engineering Nanjing University Department of Geophysics Graduate School of Science Kyoto University International Research Institute of Disaster Science Tohoku University

Coulomb stress accumulation and releasing history and its relationship with the occur- rence of strong historical earthquakes could deepen our understanding of the occurrence pattern of strong earthquakes and hence its seismic potential in future. The sinistral strike-slip Xianshuihe- Xiaojiang fault zone （XXFS） is one of the most dangerous fault zones in China, extending 1 500-km- long from the central Tibetan Plateau to the Red River fault zone. There are 35 M≥6.5 historical earth- quakes occurred since 1327, hence it is an ideal site for studying the Coulomb stress evolution history and its relationship with the occurrences of strong earthquakes. In this study, we evaluated the Cou- lomb stress change history along the XXFS by synthesizing fault geometry, GPS data and historical earthquakes. Coulomb stress change history also revealed different patterns of historical earthquakes on different segments of the XXFS, such as characteristic recurrence intervals along the Salaha-Moxi fault and super-cycles along the Xianshuihe fault. Based on the occurrence pattern of past historical earthquakes and current Coulomb stress field obtained in this study, we suggest positive ACFS and hence high seismic potential along the Salaha-Moxi fault and the Anninghe fault.

关键词： Tibetan Plateau Xianshuihe-Xiaojiang fault system Coulomb stress triggering theory recurrence interval seismic hazard.

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Computational Study on a Squid-Like Underwater Robot with Two Undulating Side Fins

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Journal of Bionic Engineering 2011年第1期8卷 25-32页

作者： Md. Mahbubar Rahman Yasuyuki toda Hiroshi Miki Department of Naval Architecture and Ocean Engineering Graduate School of Engineering Osaka University 2-1 Yamadaoka Suita City Osaka 565-0871 Japan

The undulating fin propulsion system is an instance of the bio-inspired propulsion systems. In the current study, the swimming motion of a squid-like robot with two undulating side fins, mimicking those of a Stingray or a Cuttlefish, was investigated through flow computation around the body. We used the finite analytic method for space discretization and Euler implicit scheme for time discretization along with the PISO algorithm for velocity pressure coupling. A body-fitted moving grid was generated using the Poisson equation at each time step. Based on the computed results, we discussed the features of the flow field and hydrodynamic forces acting on the body and fin. A simple relationship among the fin＇s principal dimensions was established. Numerical computation was done for various aspect ratios, fin angles and frequencies in order to validate the proposed relationship among principal dimensions. Subsequently, the relationship was examined base on the distribution of pressure difference between upper and lower surfaces and the distribution of the thrust force. In efficiency calculations, the undulating fins showed promising results. Finally, for the fin, the open characteristics from computed data showed satisfactory conformity with the experimental results.

关键词： biomimetics squid robot undulating fin propulsion efficiency hydrodynamics CFD

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Super-High Heat Flux Removal Using Sintered Metal Porous Media

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Journal of Thermal Science 2005年第3期14卷 272-280页

作者： Kazuhisa YUKI Jun ABEI Hidetoshi HASHIZUME Saburo toda Dept. of Quantum Sci. and Energy Eng. Tohoku University Aramaki-Aoba Aoba Sendai 980-8579 Japan DENSO Corporation 1-1 Showa-cho Kariya Aichi 448-8661 JAPANDept. of Quantum Sci. and Energy Eng. Tohoku University Aramaki-Aoba Aoba Sendai 980-8579 JapanTohoku Radiological Science Center 1-1-30 Ichibancho Aoba Sendai 980-1811 Japan

Heat transfer experiments using various porous materials are performed to verify the possibility of extremely high heat flux removal （several dozens of MW/m^2）. The porous media introduced in this experiment are bronze particle-sintered ones and copper fibers-sintered ones that have high thermal conductivity, each of which can enhance the thermal diffusion in the porous material. From the heat transfer experiments using a non-transferred type of plasma arcjet as a high heat flux source, the steady heat removal of 66.0 MV~/m2 is proved by using the bronze porous medium whose pore size and porosity are 100 μm and 0.38, respectively. Furthermore, as the result of evaluating the heat removal performance for various copper fiber porous media with the porosity from 0.5 to 0.7 and the fiber diameter from 30 to 90 μm, it is clarified that the maximum cooling performance exceeds 70.0 MW/m^2 at the porosity of 0.7 and the fiber diameter of 90μm, and that using the lower porosity material is useful for improving an evaporation rate in the porous media.

关键词： heat transfer porous media

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FEM Modeling of Crack Propagation in a Model Multiphase Alloy

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Journal of Materials Science & Technology 2006年第1期22卷 59-65页

作者： Lihe QIAN Seishi NISHIDO Hiroyuki toda Toshiro KOBA YASHI Department of Production Systems Engineering Toyohashi University of Technology Toyohashi 441-8580 Japan IT Promotion Department Aisin Takaoka Co. Ltd. 1 Tennoh Takaokashin-machi Toyota 473-8501 Japan

In this paper, several widely applied fracture criteria were first numerically examined and the crack-tip-region Jntegral criterion was confirmed to be more applicable to predict fracture angle in an elastic-plastic multiphase material. Then, the crack propagation in an idealized an elastic-plastic finite element method. The variation dendritic two-phase AI-7%Si alloy was modeled using of crack growth driving force with crack extension was also demonstrated. It is found that the crack path is significantly influenced by the presence of α-phase near the crack tip, and the crack growth driving force varies drastically from place to place. Lastly, the simulated fracture path in the two-phase model alloy was compared with the experimentally observed fracture path.

关键词： Al-Si alloys Fracture criterion Fracture path Numerical simulation Finite element method (FEM) Multiphase microstructure

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Seismicity,structure and tectonics in the Arctic region

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Geoscience Frontiers 2015年第5期6卷 665-677页

作者： Masaki Kanao Vladimir D.Suvorov Shigeru toda Seiji Tsuboi National Institute of Polar Research.Research Organization of Information and Systems Trofimuk Institute of Petroleum Geology and Geophysics of Siberian Branch Russian Academy of Sciences Department of Earth Sciences Faculty of EducationAichi University of Education Institute for Research on Earth Evolution Japan Agency for Marine-Earth Science and Technology

The "Arctic" region,where the North Pole occupies the center of the Arctic Ocean,has been affecting the environmental variation of the Earth from geological time to the ***,the seismic activities in the area are not adequately ***,by conducting long term monitoring of seismic phenomenon as sustainable parameters,our understanding of both the tectonic evolution of the Earth and the dynamic interaction between the cryosphere and geosphere in surface layers of the Earth will *** this paper,the association of the seismicity and structure of the Arctic region,particularly focused on Eurasian continent and surrounding oceans,and its relationship with regional evolution during the Earth’s history is *** target areas cover representative tectonic provinces in the Eurasian Arctic,such as the wide area of Siberia,Baikal Rift *** East Russia,Arctic Ocean together with Greenland and Northern *** on discussion including characteristics of seismicity,heterogeneous structure of the crust and upper mantle,tectonic history and recent dynamic features of the Earth’s surface in the Arctic are summarized.

关键词： Arctic region Seismicity Tectonics Earth’s structu

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Label-free mid-infrared photothermal live-cell imaging beyond video rate

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Light(Science & Applications) 2023年第8期12卷 1661-1674页

作者： Genki Ishigane Keiichiro toda Miu Tamamitsu Hiroyuki Shimada Venkata Ramaiah Badarla Takuro Ideguchi Department of Physics The University of TokyoTokyoJapan Institute for Photon Science and Technology The University of TokyoTokyoJapan

Advancement in mid-infrared(MIR)technology has led to promising biomedical applications of MIR spectroscopy,such as liquid biopsy or breath *** the contrary,MIR microscopy has been rarely used for live biological samples in an aqueous environment due to the lack of spatial resolution and the large water absorption ***,mid-infrared photothermal(MIP)imaging has proven to be applicable to 2D and 3D single-cell imaging with high spatial resolution inherited from visible ***,the maximum measurement rate has been limited to several frames s-1,limiting its range of ***,we develop a significantly improved wide-field MIP quantitative phase microscope with two orders-of-magnitude higher signal-to-noise ratio than previous MIP imaging techniques and demonstrate live-cell imaging beyond video *** first derive optimal system design by numerically simulating thermal conduction following the photothermal ***,we develop the designed system with a homemade nanosecond MIR optical parametric oscillator and a high full-well-capacity image *** high-speed and high-spatial-resolution MIR microscope has great potential to become a new tool for life science,in particular for live-cell analysis.

关键词： beyond conduction limiting

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