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Linker phosphorylation of Smad3 promotes fibro-carcinogenesis in chronic viral hepatitis of hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第41期20卷 15018-15027页

作者： miki Murata Katsunori Yoshida Takashi Yamaguchi Koichi Matsuzaki Department of Gastroenterology and Hepatology Kansai Medical University

Epidemiological and clinical data point to a close association between chronic hepatitis B virus infection or chronic hepatitis C virus infection and development of hepatocellular carcinoma (HCC). HCC develops over several decades and is associated with fibrosis. This sequence suggests that persistent viral infection and chronic inflammation can synergistically induce liver fibrosis and hepatocarcinogenesis. The transforming growth factor-β (TGF-β) signaling pathway plays a pivotal role in diverse cellular processes and contributes to hepatic fibro-carcinogenesis under inflammatory microenvironments during chronic liver diseases. The biological activities of TGF-β are initiated by the binding of the ligand to TGF-β receptors, which phosphorylate Smad proteins. TGF-β type I receptor activates Smad3 to create COOH-terminally phosphorylated Smad3 (pSmad3C), while pro-inflammatory cytokine-activated kinases phosphorylates Smad3 to create the linker phosphorylated Smad3 (pSmad3L). During chronic liver disease progression, virus components, together with pro-inflammatory cytokines and somatic mutations, convert the Smad3 signal from tumor-suppressive pSmad3C to fibro-carcinogenic pSmad3L pathways, accelerating liver fibrosis and increasing the risk of HCC. The understanding of Smad3 phosphorylation profiles may provide new opportunities for effective chemoprevention and personalized therapy for patients with hepatitis virus-related HCC in the future.

关键词： Chronic viral hepatitis Transforming growth factor-β Smad3 Phosphorylation Fibro-carcinogenesis Hepatocellular carcinoma

Chronic atrophic gastritis detection with a convolutional neural network considering stomach regions

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World Journal of Gastroenterology 2020年第25期26卷 3650-3659页

作者： Misaki Kanai Ren Togo Takahiro Ogawa miki Haseyama Graduate School of Information Science and Technology Hokkaido UniversitySapporo 0600814HokkaidoJapan Education and Research Center for Mathematical and Data Science Hokkaido UniversitySapporo 0600812HokkaidoJapan Faculty of Information Science and Technology Hokkaido UniversitySapporo 0600814HokkaidoJapan

BACKGROUND The risk of gastric cancer increases in patients with Helicobacter pylori-associated chronic atrophic gastritis(CAG).X-ray examination can evaluate the condition of the stomach,and it can be used for gastric cancer mass ***,skilled doctors for interpretation of X-ray examination are decreasing due to the diverse of *** To evaluate the effectiveness of stomach regions that are automatically estimated by a deep learning-based model for CAG *** We used 815 gastric X-ray images(GXIs)obtained from 815 *** ground truth of this study was the diagnostic results in X-ray and endoscopic *** a part of GXIs for training,the stomach regions are manually annotated.A model for automatic estimation of the stomach regions is trained with the *** the rest of them,the stomach regions are automatically ***,a model for automatic CAG detection is trained with all GXIs for *** In the case that the stomach regions were manually annotated for only 10 GXIs and 30 GXIs,the harmonic mean of sensitivity and specificity of CAG detection were 0.955±0.002 and 0.963±0.004,*** By estimating stomach regions automatically,our method contributes to the reduction of the workload of manual annotation and the accurate detection of the CAG.

关键词： Gastric cancer risk Chronic atrophic gastritis Helicobacter pylori Gastric Xray images Deep learning Convolutional neural network Computer-aided diagnosis

Solution-based polycrystalline silicon transistors produced on a paper substrate

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npj Flexible Electronics 2017年第1期1卷 106-111页

作者： miki Trifunovic Paolo Maria Sberna Tatsuya Shimoda Ryoichi Ishihara Department of Electronic Components Technology and MaterialsDelft University of TechnologyBuilding 36Mekelweg 4Delft 2628 CDThe Netherlands School of Material and Science Japan Advanced Institute of Science and Technology1-1 AsahidaiNomiIshikawa 923-1292Japan

Printing of electronics is pursued as a low-cost alternative to conventional manufacturing *** addition,owing to relatively low process temperatures,flexible substrates can be used enabling novel *** flexible substrates,paper was found to be a particularly interesting candidate,since it has an order of magnitude lower price than low-cost polymer alternatives,and is *** ink materials,organic and metal-oxide semiconductors are thoroughly being investigated;however,they lack in electric performance compared to silicon in terms of device mobility,reliability,and energy *** recent years,liquid precursors for silicon were found and used to create polycrystalline silicon(poly-Si).However,fabrication of transistors on top of low-cost flexible substrates such as paper has remained an outstanding *** we demonstrate both p-channel and nchannel poly-Si thin-film transistors(TFTs)fabricated directly on top of paper with field-effect mobilities of 6.2 and 2.0 cm2/V s,*** fabrication challenges have been overcome by limiting the maximum process temperature to approximately 100℃,and avoiding liquid chemicals commonly used for etching and *** of poly-Si has been achieved by additive selective crystallization of the precursor film using an excimer *** work serves as a proof of concept,and has the potential to further improve device *** to the low-cost,biodegradable nature of paper,and the high performance,reliability,and energy efficiency of poly-Si TFTs,this work opens a pathway toward truly low-cost,low-power,recyclable applications including smart packages,biodegradable health monitoring units,flexible displays,and disposable sensor nodes.

关键词： polycrystalline film overcome

Gender differences in adolescent dry eye disease:a health problem in girls

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International Journal of Ophthalmology(English edition) 2018年第2期11卷 301-307页

作者： Masahiko Ayaki Motoko Kawashima miki Uchino Kazuo Tsubota Kazuno Negishi Department of Ophthalmology Keio University School of MedicineTokyoJapan.

AIM： To evaluate the signs and symptoms of dry eye disease（DED） in adolescents. METHODS： This was a cross-sectional, case-control study and outpatients aged 10 to 19y were recruited from six eye clinics of various practices and locations in Japan, and 253 non-DED subjects and 70 DED patients were enrolled. Participants were examined for DED-related signs. Patients were also interviewed to ascertain the presence or absence of six common DED-related symptoms： dryness, irritation, pain, eye fatigue, blurring, and photophobia. Main outcome measures were differences in signs and symptoms of dry eye disease between boys and ***： Of the 323 adolescents recruited, 70（21.7%） were diagnosed with DED. Significant differences between the non-DED and DED groups were found for short tear break-up time（BUT; ≤5s; P=0.000） and superficial punctate keratopathy（SPK; staining score ≥3; P=0.000）. Late adolescent girls reported fewer symptoms than late adolescent boys, although their DED-related signs were worse compared to other groups. The prevalence and severity of DED were similar in the Tokyo area compared with suburban and local areas but myopic errors were worse. CONCLUSION： We find that adolescents reported symptoms of DED similar to those found in adults, and the majority have short BUT-type DED. The prevalence and severity of DED in late adolescent girls is comparable with adults. Adolescents with DED are underserved and we believe that DED is a hidden but potentially serious health problem for this age group.

关键词： dry eye disease adolescence gender difference

Braking Performance of a Biomimetic Squid-Like Underwater Robot

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Journal of Bionic Engineering 2013年第3期10卷 265-273页

作者： Md. Mahbubar Rahman Sinpei Sugimori Hiroshi miki Risa Yamamoto Yugo Sanada Yasuyuki Toda Laboratory of Hull Form Design Department of Naval Architecture and Ocean Engineering Graduate School of Engineering Osaka University Osaka 565-0871 Japan

In this study, the braking performance of the undulating fin propulsion system ofa biomimetic squid-like underwater robot was investigated through free run experiment and simulation of the quasi-steady mathematical model. The quasi-steady equa- tions of motion were solved using the measured and calculated hydrodynamic forces and compared with free-run test results. Various braking strategies were tested and discussed in terms of stopping ability and the forces acting on the stopping stage. The stopping performance of the undulating fin propulsion system turned out to be excellent considering the short stopping time and short stopping distance. This is because of the large negative thrust produced by progressive wave in opposite direction. It was confirmed that the undulating fin propulsion system can effectively perform braking even in complex underwater explorations.

关键词： biomimetics squid-like underwater robot undulating fin propulsion system braking performance motion simulation

Combustion synthesis of YAG:Ce phosphors via the thermite reaction of aluminum

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Journal of Rare Earths 2018年第3期36卷 248-256页

作者： Junpei Ohyama Chunyu Zhu Genki Saito miki Haga Takahiro Nomura Norihito Sakaguchi Tomohiro Akiyama Center for Advanced Research of Energy and Materials Hokkaido UniversityKita 13 Nishi 8KitakuSapporo 060-8628Japan Division of Applied Chemistry&Frontier Chemistry Center Faculty of EngineeringHokkaido University5apporoHokkaido 060-8628Japan Graduate School of Chemical Sciences and Engineering Hokkaido University SapporoHokkaido 060-8628Japan

Cerium-doped yttrium aluminum garnet（YAG：Ce） as a yellow phosphor for white light-emitting diodes（LEDs） was synthesized via a facile combustion method using Y2 O3, CeO2, Al2 O3, Al,and NaClO4 as raw materials. The combustion synthesis approach utilizes the strong exothermic oxidation of aluminum to realize a self-sustaining reaction. In this study, we investigated the effects of the ratios of Al2 O3 to AI,fluxes, and coprecipitated materials as raw materials on the luminescence properties of the synthesized YAG：Ce phosphors. When the amount of Al2 O3 x is varied, the combustion reaction proceeds at x ≤ 1.8,with x = 1.725 being the optimum condition for producing a high-performance product. When 5 wt%BaF2 is added, the luminescence intensity is significantly improved owing to a decrease of YAP（YAlO3）formation with improved uniformity. However, the addition of CaF2 and NaF does not improve the luminescence properties. To suppress the segregation of CeO2, we used the coprecipitated material Y2 O3-CeO2 as a raw material. Unlike with separate addition of Y2 O3 and CeO2, Ce ions are uniformly distributed in the coprecipitated material, resulting in improved luminescence properties. The combination of BaF2 and coprecipitated material significantly improves the internal quantum efficiency to83.0%, which is close to that of commercial phosphors.

关键词： Phosphor Yttrium aluminum garnet Combustion synthesis Flux Coprecipitated material Rare earths

Association between tear film break up time and blink interval in visual display terminal users

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International Journal of Ophthalmology(English edition) 2018年第10期11卷 1691-1697页

作者： miki Uchino Motoko Kawashima Yuichi Uchino Kazuo Tsubota Norihiko Yokoi Department of Ophthalmology Keio University School of Medicine Department of Ophthalmology Kyoto Prefectural University School of Medicine

AIM：To investigate the association between tear film break up time（TBUT）and blinking interval in visual display terminal（VDT）***：Nine hundred and thirty VDT users underwent dry eye testing,and functional visual acuity（FVA）*** blinking interval during FVA was compared with *** with longer blinking interval than TBUT were considered as unstable tear *** regression analysis revealed the risk factors for unstable tear ***：Among 930 workers,858 subjects（92.3%）participated in this *** 80% of the subjects were categorized into the unstable tear *** tear group has significantly lower Schirmer values and TBUT（17.5±11.6 vs 21.1±11.5 mm,3.7±2.6 vs 5.7±2.7s,both P〈0.001）.There were no significant differences in epithelial staining or severity of *** regression showed that over 40y was a risk for being unstable tear group[odds ratio（OR）=1.53;95%confidence interval（CI）=1.06-2.20].Contact lens use was protective factor for being in the unstable tear group（OR=0.37;95%CI=0.26-0.53）.CONCLUSION：Subjects with shorter TBUT than blinking interval are prevalent among VDT *** over the age of 40 shows an increased risk for unstable tear film.

关键词： dry eye disease blink interval tear film break up time visual display terminal use

Effect of hydrogen peroxide on selective flotation of chalcocite and enargite

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International Journal of Mining Science and Technology 2023年第6期33卷 703-716页

作者： Gde Pandhe Wisnu Suyantara Daniyarov Berdakh Hajime miki Tsuyoshi Hirajima Keiko Sasaki Daishi Ochi Yuji Aoki Department of Earth Resources Engineering Faculty of EngineeringKyushu UniversityFukuoka 819-0395Japan Kyushu University Institute for Asian and Oceanian Studies Kyushu UniversityFukuoka 819-0395Japan Graduate School of Engineering Faculty of EngineeringKyushu UniversityFukuoka 819-0395Japan Uzbekistan-Japan Innovation Center of Youth Tashkent 100095Uzbekistan Sumitomo Metal Mining Co. Ltd.Tokyo 105-8716Japan Sumitomo Metal Mining Co. Ltd.Ehime 792-0002Japan

Enargite is typically associated with *** to the similarity in the flotation behaviors of these minerals,both minerals are reported to concentrate in the conventional flotation ***,inorganic arsenic in enargite can decrease the copper concentrate quality and increase the operating cost of processing this *** these minerals is important for cleaner copper production to avoid these *** this context,this study investigated the effect of hydrogen peroxide(H_(2)O_(2))treatment on the flotation behavior of chalcocite and *** tests of pure and mixed minerals indicated that H_(2)O_(2)treatment reduced the floatability of chalcocite and enargite by forming sulfate and copper hydroxide on their *** the detrimental effect of the H_(2)O_(2)treatment,there was a narrow window of H_(2)O_(2)concentration for separating both minerals,in which enargite floated and chalcocite was *** selective flotation behavior was caused by the rapid adsorption of potassium amyl xanthate(KAX)and lower surface oxidation of enargite compared with that of chalcocite.

关键词： Enargite Chalcocite Hydrogen peroxide Potassium amyl xanthate Selective flotation

Index of convexity:A novel liver function index using Tc-GSA scintigraphy

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World Journal of Gastroenterology 2013年第1期19卷 92-96页

作者： Kenji miki Yuichi Matsui Masanori Teruya Michio Kaminishi Norihiro Kokudo Department of Gastrointestinal Surgery Showa General HospitalTokyo187-8510Japan Hepato-Biliary-Pancreatic Surgery Division Artificial Organ and Transplantation DivisionDepartment of SurgeryGraduate School of MedicineUniversity of TokyoTokyo 113-8655Japan

AIM:To investigate the clinical usefulness of a newly developed index,the "index of convexity(IOC)",for evaluating liver functional reserve using technetium99m-diethylenetriaminepentaacetic acid-galactosylhuman serum albumin(Tc-GSA scintigraphy).METHODS:In total,349 patients underwent Tc-GSA *** planner images were obtained,and time activity curves of the liver and heart were generated and *** focus was on the convex shape of the liver accumulation *** developed a method for evaluating the extent of convexity and calculated an index that we named the *** index and receptor index were also *** correlations between each GSA index with other liver function tests and liver histopathology were ***:Among the 3 indices generated by TcGSA,the IOC had the highest correlation with all other liver function tests(indocyanine green R15,albumin,prothrombin time,cholinesterase level,platelet count,and total bilirubin level).IOC can also differentiate between normal liver,chronic hepatitis,and liver cirrhosis with highest F ratio among GSA indices as determined by one-way analysis of *** operating characteristic analysis demonstrated high diagnostic performance of IOC in the diagnosis of ***:IOC is a very simple and reliable index for assessing liver functional reserve,which may prove to be useful in combination with the indocyanine green test for preoperative assessment of hepatic resection.

关键词： Liver functional reserve Preoperative assessment Technetium-99m-diethylenetriaminepentaacetic acid-galactosyl-human serum albumin Liver cirrhosis Hepatectomy