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Integrative Zoology 2011年第4期6卷 399-408页

作者： Carolina santos-HEREDIA Ellen ANDRESEN Pablo STEVENSON Department of Biological Sciences University of the AndesBogotaColombia Center for Ecosystem Research at the National Autonomous University of Mexico MoreliaMexico

Seeds of many plant species are secondarily dispersed by dung beetles,but the outcome of this interaction is highly *** is known about how certain anthropogenic disturbances affect this plant-animal *** aims of this study were to assess the effect of dung type on secondary dispersal by dung beetles in a forest fragment,and to determine whether this interaction is affected by edge *** pitfall traps,we captured dung beetles attracted to dung of 2 frugivorous mammals:woolly monkeys and howler *** found differences between both dung beetle assemblages,but these differences were not consistent in *** seeds surrounded by both dung types,we carried out a field experiment using seeds of 2 plant *** found that the probability of secondary dispersal by dung beetles was higher for seeds placed in woolly monkey ***,we carried out a field experiment using plastic beads as seed mimics to assess edge *** found that secondary seed dispersal by dung beetles was negatively affected by *** disruption of plant-animal interactions along anthropogenic forest edges could have long-term negative effects on forest dynamics by affecting processes of regeneration.

关键词： fragmentation plant-animal interaction Scarabaeidae seed fate

Learning to combine multiple string similarity metrics for effective toponym matching

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International Journal of Digital Earth 2018年第9期11卷 913-938页

作者： Rui santos Patricia Murrieta-Flores Bruno Martins Instituto Superior Técnico and INESC-ID University of LisbonLisbonPortugal Digital Humanities Research Center University of ChesterChesterUK

Several tasks related to geographical information retrieval and to the geographical information sciences involve toponym matching,that is,the problem of matching place names that share a common *** this article,we present the results of a wide-ranging evaluation on the performance of different string similarity metrics over the toponym matching *** also report on experiments involving the usage of supervised machine learning for combining multiple similarity metrics,which has the natural advantage of avoiding the manual tuning of similarity *** with a very large dataset show that the performance differences for the individual similarity metrics are relatively small,and that carefully tuning the similarity threshold is important for achieving good *** methods based on supervised machine learning,particularly when considering ensembles of decision trees,can achieve good results on this task,significantly outperforming the individual similarity metrics.

关键词： Toponym matching supervised learning string similarity metrics duplicate detection ensemble learning geographic information retrieval

Glycoproteogenomics: Setting the Course for Next-generation Cancer Neoantigen Discovery for Cancer Vaccines

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Genomics, Proteomics & Bioinformatics 2021年第1期19卷 25-43页

作者： José Alexandre Ferreira Marta Relvas-santos Andreia Peixoto AndréM.N.Silva Lúcio Lara santos Experimental Pathology and Therapeutics Group Portuguese Institute of OncologyPorto 4200-072Portugal Institute of Biomedical Sciences Abel Salazar University of PortoPorto 4050-313Portugal Porto Comprehensive Cancer Center(P.ccc) Porto 4200-072Portugal REQUIMTE-LAQV Department of Chemistry and BiochemistryFaculty of Sciences of the University of PortoPorto 4169-007Portugal

Molecular-assisted precision oncology gained tremendous ground with high-throughput next-generation sequencing(NGS),supported by robust *** quest for genomicsbased cancer medicine set the foundations for improved patient stratification,while unveiling a wide array of neoantigens for *** pre-clinical and clinical studies have successfully used tumor-specific peptides in vaccines with minimal off-target ***,the low mutational burden presented by many lesions challenges the generalization of these solutions,requiring the diversification of neoantigen *** utilizing customized databases for protein annotation by mass spectrometry(MS)is a powerful tool toward this *** the concept toward exploring proteoforms originated from post-translational modifications(PTMs)will be decisive to improve molecular subtyping and provide potentially targetable functional nodes with increased cancer *** through the path of systems biology,we highlight that alterations in protein glycosylation at the cell surface not only have functional impact on cancer progression and dissemination but also originate unique molecular fingerprints for targeted ***,we discuss the outstanding challenges required to accommodate glycoproteomics in oncoproteogenomics *** envisage that such rationale may flag a rather neglected research field,generating novel paradigms for precision oncology and immunotherapy.

关键词： Glycoproteogenomics Oncoproteogenomics Cancer neoantigens Glycosylation Precision oncology

Characteristics of lightning‐induced voltages based on experimental data

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High Voltage 2021年第3期6卷 555-561页

作者： Michele N.N.santos Alexandre Piantini Technological and Exact Sciences Department Federal University of AmapáMacapá‐APBrazil Institute of Energy and Environment University of São PauloSão Paulo‐SPBrazil

This paper presents an analysis of 64 lightning‐induced voltage waveforms recorded in an experimental system implemented in the campus of the University of São Paulo,*** voltages were measured on a 10 m high,2.7 km long un‐energized overhead line consisting of two conductors installed on 6 m *** of the conductors had surge arresters,while the other one was left *** speaking,all the recorded voltages on the unprotected conductor were bipolar,but in many cases only one semi‐cycle could be considered important for practical *** criteria are discussed for the determination of the waveshape parameters,which may differ signifi-cantly from those of the standard lightning impulse voltage(1.2/50μs).Based on the proposed criterion for classifying the induced voltages,unipolar waveforms accounted for 67%of the total and,except for one case,all of them had positive *** median values of the front time and time‐to‐half‐value were,respectively,5.2μs and 15.8μ*** waveforms were 33%of the total and in approximately 62%of the cases the first semi‐cycle was of positive *** 91%of the cases the voltage peak occurred either in the first or the second semi‐cycle.

关键词： lightning bipolar protected

Saturated anisotropic hydraulic conductivity of a compacted lateritic soil

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第5期10卷 986-991页

作者： Roberto Aguiar dos santos Edmundo Rogerio Esquivel Varzea Grande Institute of Engineering Federal University of Mato Grosso Cuiaba Mato Grosso Brazil Sao Carlos School of Engineering University of Sao Paulo Sao Carlos Sao Paulo Brazil

This study focuses on the saturated anisotropic hydraulic conductivity of a compacted lateritic clayey sandy soil. The effects of the molding water content and the confining stress on the anisotropic hydraulic conductivity are investigated. The hydraulic conductivity is measured with a flexible-wall permeameter. Samples are dynamically compacted into the three compaction states of a standard Proctor compaction curve： the dry branch, optimum water content and wet branch. Depending on the molding water content and confining stress, the hydraulic conductivity may increase or decrease. In addition, the results indicate that, when the samples are compacted to the optimum water content, lower hydraulic conductivity is obtained, except at a confining stress equal to 50 kPa. The increase of the confining stress decreases the hydraulic conductivity for each of the evaluated compaction states. In the wet branch, horizontal hy- draulic conductivity is about 8 times higher than the vertical value. The anisotropic hydraulic conduc- tivities of the dry and wet branches decrease when the confining stress increases, and the opposite is observed in the optimum water content state.

关键词： Hydraulic conductivity Anisotropic behavior Lateritic soil Tropical soil Compacted soil

Fluorescent probes for the detection of reactive oxygen species in human spermatozoa

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Asian Journal of Andrology 2020年第5期22卷 465-471页

作者： Sara Escada-Rebelo Francisca G Mora Ana P Sousa Teresa Almeida-santos Artur Paiva Joao Ramalho-santos phD Programme in Experimental Biology and Biomedicine CNC-Center for Neuroscience and Cell BiologyUniversity of CoimbraCoimbra 3004-504Portugal Biology of Reproduction and Stem Cell Group CNC-Center for Neuroscience and Cell BiologyUniversity of CoimbraCoimbra 3004-504Portugal IIIUC-Institute for Interdisciplinary Research Casa Costa AlemaoUniversity of CoimbraCoimbra 3030-789Portugal Reproductive Medicine Unit University Hospitals of CoimbraCoimbra 3004-561Portugal Faculty of Medicine University of CoimbraCoimbra 3000-370Portugal Clinical Pathology Unit University Hospitals of CoimbraCoimbra 3004-561Portugal Department of Life Sciences University of CoimbraCoimbra 3000-456Portugal

Reactive oxygen species(ROS)production is a by-product of mitochondrial activity and is necessary for the acquisition of the capacitated state,a requirement for functional ***,an increase in oxidative stress,due to an abnormal production of ROS,has been shown to be related to loss of sperm function,highlighting the importance of an accurate detection of sperm ROS,given the specific nature of this *** this work,we tested a variety of commercially available fluorescent probes to detect ROS and reactive nitrogen species(RNS)in human sperm,to define their *** both flow cytometry(FC)and fluorescence microscopy(FM),we confirmed that MitoSOX™Red and dihydroethidium(DHE)detect superoxide anion(as determined using antimycin A as a positive control),while DAF-2A detects reactive nitrogen species(namely,nitric oxide).For the first time,we also report that RedoxSensor™Red CC-1,CellROX®Orange Reagent,and MitoPYl seem to be mostly sensitive to hydrogen peroxide,but not ***,mean fluorescence intensity(and not percentage of labeled cells)is the main parameter that can be reproducibly monitored using this type of methodology.

关键词： flow cytometry fluorescent probes human spermatozoa oxidative stress reactive oxygen species

Ultrafast laser-driven topological spin textures on a 2D magnet

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npj Computational Materials 2022年第1期8卷 1630-1635页

作者： Mara Strungaru Mathias Augustin Elton J.G.santos Institute for Condensed Matter Physics and Complex Systems School of Physics and AstronomyThe University of EdinburghEdinburghEH93FDUK Donostia International Physics Center(DIPC) 20018Donostia-San SebastiánBasque CountrySpain Higgs Centre for Theoretical Physics The University of EdinburghEdinburghEH93FDUK

Ultrafast laser excitations provide an efficient and low-power consumption alternative since different magnetic properties and topological spin states can be triggered and manipulated at the femtosecond(fs)***,it is largely unknown whether laser excitations already used in data information platforms can manipulate the magnetic properties of recently discovered two-dimensional(2D)van der Waals(vdW)*** we show that ultrashort laser pulses(30−85 fs)can not only manipulate magnetic domains of 2D-XY CrCl_(3)ferromagnets,but also induce the formation and control of topological nontrivial meron and antimeron spin *** observed that these spin quasiparticles are created within~100 ps after the excitation displaying rich dynamics through motion,collision and annihilation with emission of spin waves throughout the *** findings highlight substantial opportunities of using photonic driving forces for the exploration of spin textures on 2D magnetic materials towards magneto-optical topological applications.

关键词： laser excitation topological

Exploring spatial relationships between stream channel features,water depths and flow velocities during flash floods using HEC-GeoRAS and Geographic Information Systems

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Journal of Geographical Sciences 2022年第4期32卷 757-782页

作者： Miguel LEAL Eusébio REIS Pedro Pinto santos Centre of Geographical Studies and Associated Laboratory TERRA Institute of Geography and Spatial PlanningUniversidade de Lisboa1600-276 LisbonPortugal Forest Research Centre and Associated Laboratory TERRA School of AgricultureUniversidade de LisboaTapada da Ajuda1349-017 LisbonPortugal

Water depths and flow velocities decisively influence the damage caused by flash *** Information System(GIS)is a powerful and useful tool,allowing the spatial analysis of results obtained by hydraulic modelling,namely from the HEC-RAS/HEC-GeoRAS *** GIS spatial analysis performed in this study seeks to explain and quantify the spatial relationships between the stream channel features and flow components during flash flood *** these relationships are generically known,there are few studies exploring this subject in different geographic contexts.A 1D hydraulic model was applied in a small watershed in Portugal,providing good results in the definition of floodable areas,water depths and longitudinal *** direct relationship was found between water depths and velocities in the floodable areas;however,negative strong correlations were found between the two flow components along the stream *** slope,channel and flood width,and roughness prove to be highly relevant on the longitudinal variations of water depths and velocities and on the location of maximum *** peak discharges and return periods(R;)can change the relationships between water depths and velocities at the same *** can be improved with more accurate elevation data for stream channels and floodplains.

关键词： flash floods water depth flow velocity geographic information systems(GIS) spatial analysis

Influence of a non-rotating shoulder on heat generation,microstructure and mechanical properties of dissimilar AA2024/AA7050 FSW joints

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Journal of Materials Science & Technology 2018年第1期34卷 119-127页

作者： Alessandro Barbini Jan Carstensen Jorge F.dos santos Helmholtz-Zentrum Geesthacht Institute of Materials Research Materials Mechanics Solid-State Joining Processes (WMP)

Friction stir welding （FSW） and stationary shoulder friction stir welding （SSFSW） were carried out for the butt joining of dissimilar AA2024-T3 and AA7050-T7651 aluminium alloys with thicknesses of 2 mm. A comparison between the two processes was performed by varying the welding speed while keeping the rotational speed constant, Through the analysis of the force and torque produced during welding and a simple analytical model, it was possible to show that in SSFSW there is more effective coupling with the tool and the heat produced is more efficiently distributed. This process decreases both the welding area and the diffusion at the interface of the two alloys compared with FSW. The minimum microhardness occurred at the advancing side （AS） at the interface between the thermo-mechanically affected zone （TMAZ） and the stir zone （SZ） in both processes, although the decrease was more gradual in SSFSW. This interface is also where all specimens failed for both welding technologies. An increase in tensile strength was measured in SSFSW compared with standard FSW. Furthermore, it was possible to establish the mechanical performance of the material in the fracture zone using digital image correlation.

关键词： Stationary shoulder friction stir welding Friction stir welding Dissimilar welded joints Process analysis Microstructure analysis Mechanical behaviour

Evaluation and modeling of runoff and sediment yield for different land covers under simulated rain in a semiarid region of Brazil

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International Journal of Sediment Research 2018年第2期33卷 117-125页

作者： Richarde Marques da Silva Celso Augusto Guimares santos José Yure Gomes dos santos Department of Geosaences Federal University of Paraíba Department of Civil and Environmental Engineering Federal University of Paraíba Federal University of Western Bahia Center for Humanities

This paper quantifies the runoff and sediment yield for four different land covers in a semiarid region of Brazil. The WESP model, a distributed, event-oriented runoff-erosion model, was applied and its physical parameters, NSand KR, were adjusted based on observed runoff and sediment yield data using simulated rainfall with an average intensity of 53 mm h-1. The sediment yield obtained was 53.02 kg ha-1(caatinga vegetation), 231.96 kg ha-1(bare soil), 309.75 kg ha-1(beans), and 847.38 kg ha-1(corn). The results showed that caatinga cover yields the lowest erosion and runoff when compared to the other *** results also show that the sediment yield and runoff values simulated with NS, KI, and KR parameters were well calibrated, within acceptable deviations. The caatinga vegetation was more effective in protecting the soil, when compared to the other types of coverage. The beans and corn covers had the highest values of runoff and sediment yield, even higher than those observed for bare soil.

关键词： Runoff Erosion Semiarid region WESP model