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Extreme biomimetic approach for developing novel chitin-GeO2 nanocomposites with photoluminescent properties

Nano Research 2015年第7期8卷 2288-2301页

作者： Marcin Wysokowski Mykhailo Motylenko Jan Beyer Anna Makarova Hartmut Stocker Juliane Walter Roberta Galli Sabine Kaiser Denis vyalikh vasilii v. Bazhenov laroslav Petrenko Allison L Stelling Serguei L. Molodtsovs Dawid Stawski Krzysztof J.Kurzydfowski Enrico Langer mikhail v tsurkan Teofil Jesionowski Johannes Heitmann Dirk C. Meyer Hermann Ehrlich Institute of Chemical Technology and Engineering Poznan University of Technology 60965 Poznan Poland Institute of Materials Science TU Bergakademie Freiberg 09599 Freiberg Germany Institute of Applied Physics TU Bergakademie Freiberg 09599 Freiberg Germany Institute of Solid State Physics Dresden University of Technology 01069 Dresden Germany Institute of Experimental Physics TU Bergakademie Freiberg 09599 Freiberg Germany Faculty of Medicine Carl Gustav Carus Department of Anaesthesiology and Intensive Care Medicine Clinical Sensoring and Monitoring TU Dresden 01069 Dresden Germany epartment of Physics St. Petersburg State University 198504 St. Petersburg Russia Department of Mechanical Engineering and Materials Science Duke University 27708 Durham NC USA European X-Ray Free-Electron Laser Facility (XFEL) GmbH 22761 Hamburg Germany ITMO University 197101 St. Petersburg Russia Department of Commodity and Material Sciences and Textile Metrology Technical University of Lodz 90924 LSdz Poland Materials Design Group Faculty of Materials Science and Engineering Warsaw University of Technology PL-02507 Warsaw Poland Institute of Semiconductors and Microsystems TU Dresden 01062 Dresden Germany Leibniz Institute of Polymer Research Max Bergmann Centre for Biomaterials 01062 Dresden Germany

This work presents an extreme biomimetics route for the creation of nano- structured biocomposites utilizing a chitinous template of poriferan origin. The specific thermal stability of the nanostructured chitinous template allowed for the formation under hydrothermal conditions of a novel germanium oxide- chitin composite with a defined nanoscale structure. Using a variety of analytical techniques （FTIR, Raman, energy dispersive X-ray （EDX）, near-edge X-ray absorption fine structure （NEXAFS）, and photoluminescence （PL） spectroscopy, EDS-mapping, selected area for the electron diffraction pattern （SAEDP）, and transmission electron microscopy （TEM））, we showed that this bioorganic scaffold induces the growth of GeO2 nanocrystals with a narrow （150-300 nm） size distri- bution and predominantly hexagonal phase, demonstrating the chitin template＇s control over the crystal morphology. The formed GeO2-chitin composite showed several specific physical properties, such as a striking enhancement in photo- luminescence exceeding values previously reported in GeOR-based biomaterials. These data demonstrate the potential of extreme biomimetics for developing new-generation nanostructured materials.

关键词： extreme biomimetics, chitin-GeO2 photoluminescence, near-edge X-ray absorption fine structure (NEXAFS) spectroscopy

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Decline of Eulia ministrana(Lepidoptera:Tortricidae)in polluted habitats is not accompanied by phenotypic stress responses

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Insect Science 2021年第5期28卷 1482-1490页

作者： vitali Zverev mikhail v.Kozlov Department of Biology University of TurkuTurkuFinland

Env ironmental pollution is currently identified as one of the major drivers of rapid decline of insect populations,and this finding has revitalized interest in insect responses to *** tested the hypothesis that the pollution-induced decline of insect populations can be predicted from phenotypic stress responses expressed as morphological differences between populations inhabiting polluted and unpolluted *** explored populations of the brassy tortrix Eulia ministrana in subarctic forests along an environmental disturbance gradient created by long-lasting severe impacts of aerial emissions of the copper-nickel smelter in Monchegorsk,northwestern *** used pheromone traps to measure the population densities of this leafrolling moth and to collect specimens for assessment of three morphological stress indices:size,forewing melanization,and fluctuating asymmetry in wing *** length of *** increased by 10%,and neither forewing melanization nor fluctuating asymmetry changed from the unpolluted forest to the heavily polluted industrial ***,the population density of *** decreased 5 to 10 fold in the same pollution ***,none of the studied potential morphological stress indicators signaled vulnerability of *** to environmental pollution and/or to pollution-induced environmental *** conclude that insect populations can decline without any visible signs of *** use of morphological proxies of insect fitness to predict the consequences of human impact on insect populations is therefore risky until causal relationships between these proxies and insect abundance are deciphered.

关键词： copper-nickel smelter fluctuating asymmetry industrial melanism Kola Peninsula moth size pheromone trapping

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Autism spectrum disorder:difficulties in diagnosis and microRNA biomarkers

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Neural Regeneration Research 2025年第10期20卷 2776-2786页

作者： Bridget Martinez Philip v.Peplow Department of Pharmacology University of Nevada-RenoRenoNVUSA Department of Medicine University of Nevada-RenoRenoNVUSA Department of Anatomy University of OtagoDunedinNew Zealand

We performed a PubMed search for microRNAs in autism spectrum disorder that could serve as diagnostic biomarkers in patients and selected 17 articles published from January 2008 to December 2023,of which 4 studies were performed with whole blood,4 with blood plasma,5 with blood serum,1 with serum neural cell adhesion molecule L1-captured extracellular vesicles,1 with blood cells,and 2 with peripheral blood mononuclear *** of the studies involved children and the study cohorts were largely *** of the studies had performed microRNA sequencing or quantitative polymerase chain reaction assays to measure microRNA *** five studies had used real-time polymerase chain reaction assay to validate microRNA expression in autism spectrum disorder subjects compared to *** microRNAs that were validated in these studies may be considered as potential candidate biomarkers for autism spectrum disorder and include miR-500a-5p,-197-5p,-424-5p,-664a-3p,-365a-3p,-619-5p,-664a-3p,-3135a,-328-3p,and-500a-5p in blood plasma and miR-151a-3p,-181b-5p,-320a,-328,-433,-489,-572,-663a,-101-3p,-106b-5p,-19b-3p,-195-5p,and-130a-3p in blood serum of children,and miR-15b-5p and-6126 in whole blood of *** important limitations were identified in the studies reviewed,and need to be taken into account in future *** studies are warranted with children and adults having different levels of autism spectrum disorder severity and consideration should be given to using animal models of autism spectrum disorder to investigate the effects of suppressing or overexpressing specific microRNAs as a novel therapy.

关键词： autism spectrum disorder biomarker blood cells blood plasma blood serum diagnosis microRNA peripheral blood mononuclear cells serum neural cell adhesion molecule L1-captured extracellular vesicles whole blood

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MicroRNAs as potential diagnostic biomarkers for bipolar disorder

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Neural Regeneration Research 2025年第6期20卷 1681-1695页

Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed i

关键词： biomarker bipolar disorder blood leukocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines microRNA neural progenitor cells whole blood

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MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder

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Neural Regeneration Research 2025年第7期20卷 1957-1970页

Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life ***,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic stress *** addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the overlap of symptoms with other conditions can lead to misdiagnosis and inappropriate *** suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress *** performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSD)that could serve as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to December *** included four studies with whole blood,seven with peripheral blood mononuclear cells,four with plasma extracellular vesicles/exosomes,and one with serum *** of these studies had also used whole *** studies were excluded as they did not involve microRNA *** of the studies had collected samples from adult male veterans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult *** measuring miRNA expression levels,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString *** six studies had used real time polymerase chain reaction assay to determine/validate miRNA expression in PTSD subjects compared to *** miRNAs that were found/validated in these studies may be considered as potential candidate biomarkers for PTSD and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular vesicles/

关键词： biomarker diagnosis microRNA peripheral blood mononuclear cells plasma extracellular vesicles/exosomes post-traumatic stress disorder serum exosomes whole blood whole plasma

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Magnetic nanoparticles and concentrated magnetic nanofluids:Synthesis,properties and some applications

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China Particuology 2007年第1期5卷 43-49页

作者： Ladislau vks Doina Bica mikhail v. Avdeev Lab Magnetic Fluids CFATR Romanian Academy-Timisoara Division Timisoara Romania National Center for Engineering of Systems with Complex Fluids Univ. Politehnica Timisoara Timisoara Romania Lab Magnetic Fluids CFATR Romanian Academy-Timisoara Division Timisoara Romania Frank Laboratory of Neutron Physics Joint Institute for Nuclear Research Dubna Russia

This paper reviews some recent results concerning chemical synthesis of magnetic nanoparticles and preparation of various types of magnetic nanofluids. Structural properties and behaviour in external magnetic field of magnetic nanofluids will be emphasized with relation to their use in leakage-free rotating seals and in biomedical applications.

关键词： Magnetic nanoparticle Magnetic nanofluid Rotating seal Biomedical application Chemical co-precipitation Structural characterization

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High tolerance to simulated root herbivory in hydroponically grown cuttings of Salix phylicifolia

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Journal of Forestry Research 2021年第6期32卷 2661-2668页

作者： mikhail v.Kozlov Elena L.Zvereva Department of Biology University of Turku20014TurkuFinland

The shortage of information regarding the effects of root damage on forest plants,especially trees and shrubs,is the most critical gap in our knowledge of belowground insect *** study examines how the tea-leaved willow,Salix phylicifolia,responds to simulated root herbivory and how nutrient availability affects these *** grown cuttings were used to precisely apply the desired levels of root ***:shoot ratios increased proportionally to the intensity of root damage,whereas specific leaf area,leaf water content and chlorophyll fluorescence were not *** removal of 2-64%of roots once in early summer and the removal of 25%of roots three times during the summer did not change biomass production by *** repeated removal of 50 and 75%of roots decreased shoot biomass and,to a lesser extent,total root *** tolerance of tea-leaved willow to root damage was greater in low nutrient treatment than in high nutrient treatment,thus supporting the Growth Rate *** to this model,in low resource conditions plants do not attain their maximum growth rate and therefore have a higher capacity for regrowth after *** conclude that,in the absence of water limitations,tea-leaved willow shows high tolerance to root losses and is unlikely to be affected by realistic levels of root herbivory.

关键词： Belowground herbivory Chlorophyll fluorescence Leaf water content Plant growth

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Thermal radiation and natural convection in a large-scale enclosure heated from below:Building application

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Building Simulation 2021年第3期14卷 681-691页

作者： Stepan A.mikhailenko Igor v.Miroshnichenko mikhail A.Sheremet Laboratory on Convective Heat and Mass Transfer Tomsk State University634050 TomskRussia Regional Scientific and Educational Mathematical Centre Tomsk State University634050 TomskRussia

A computational research of radiative-convective energy transport in large-scale enclosure with a heat-generating heater under normal room conditions has been *** heater(underfloor heating system)is located at the bottom of the *** the Boussinesq assumption,the control equations have been solved contemporaneously to receive both the velocity fields and temperature *** generate the systems of linear equations using vorticity and stream function,the finite difference technique has been *** developed convective-radiative model has been validated through a comparison with several *** influence of heater size and location,internal surfaces emissivity from 0 to 1,Ostrogradsky number for a wide range from 0 to 5 on Nusselt numbers and both stream function and temperature distributions has been *** results demonstrate that the influence of the thermal radiation on total heat transfer increases with surface emissivity of walls and heater surfaces.

关键词： indoor environment natural convection thermal radiation large-scale cabinet local heater finite difference method

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Detrimental and synergistic role of epilepsy——Alzheimer’s disease risk factors

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Neural Regeneration Research 2019年第8期14卷 1376-1377页

作者： mikhail A. Filippov vasily v. vorobyov International Medical Cluster Skolkovo Moscow Region Russia Institute of Cell Biophysics Russian Academy of Sciences Pushchino Moscow Region Russia

Identification of individuals at risk for developing Alzheimers disease (AD) is an important issue for its pretreatment. Perspective studies predicting the disease are based on the genetic approaches emerging from the nucleotide polymorphism analysis in different loci through the entire genome in AD patients. Considerable diversity of genes located in these regions raise the question of this diversity's peculiar role in the disease development. The mechanisms of AD have been shown to be associated with the gene variation, increased beta-amyloid production and concomitant epileptiform activity/epilepsy in particular (Palop and Mucke, 2009).

关键词： Detrimental synergistic role disease risk factors

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Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.v.P.Sakamuri Anil Sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

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