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Atherosclerosis originating from childhood:Specific features

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Journal of Biomedical Research 2024年第3期38卷 233-240页

作者： Anastasia V.Poznyak Alexey A.Yakovlev mikhailА.popov Elena B.Zhigmitova Vasily N.Sukhorukov Alexander N.Orekhov Institute for Atherosclerosis Research Moscow 121609Russia Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology Moscow 109240Russia Department of Cardiac Surgery Moscow Regional Research and Clinical InstituteMoscow 129110Russia Laboratory of Angiopathology Institute of General Pathology and PathophysiologyMoscow 125315Russia

Atherosclerosis is extremely ***,it is considered a disease of older people,who most often experience problems with the heart and blood *** much attention from the scientific community has been paid to studying the association between aging and atherosclerosis,as well as its consequences,there is evidence that atherosclerosis occurs at an early *** may form both during intrauterine development and in *** plays an important role in childhood atherosclerosis,along with previous infectious diseases and excess weight of both the child and the *** the present review,we examined the development of atherosclerosis and the prerequisites in childhood.

关键词： atherosclerosis childhood pediatrics cardiovascular disease

Web service for biodiversity estimation using remote sensing data

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International Journal of Digital Earth 2008年第4期1卷 367-376页

作者： mikhail A.popov Nataliia N.Kussul Sergey A.Stankevich Anna A.Kozlova Andrii Yu.Shelestov Oleksii M.Kravchenko Mykhailo B.Korbakov Serhiy V.Skakun Scientific Centre for Aerospace Research of the Earth KievUkraine Department of Space Information Technologies and Systems Space Research Institute NASU-NSAUKievUkraine

This paper presents a technique for the assessment and mapping of land biodiversity by using remote sensing *** proposed approach uses a fuzzy model that encapsulates different ecological factors influencing *** imple... 详细信息

关键词： potential biodiversity index remote sensing data product pre-Black Sea region of the Ukraine web service

Microtubular solid oxide fuel cells with a two-layer LSCF/BSCFM5 cathode

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Green Carbon 2023年第2期1卷 154-159页

作者： Vladislav Sivtsev Elizaveta Lapushkina Ivan Kovalev Rostislav Guskov mikhail popov Alexander Nemudry Institute of Solid State Chemistry and Mechanochemistry SB RAS NovosibirskRussia

In this study,we present the development of microtubular solid oxide fuel cells(MT-SOFC)with a two-layer cathode:a composite cathode functional layer(CFL)adjacent to the buffer layer(BL)and a cathode current-collecting layer(CCCL).CFL consists of a mixture of BL material Ce_(0.9)Sm_(0.2)O_(1.95)(SDC)and perovskite Ba_(0.5)Sr_(0.5)Co_(0.75)Fe_(0.2)Mo_(0.05)O_(3-δ)(BSCFM5),which has a high exchange rate with *** widely used cathode material La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3-δ)(LSCF)with high electrical conductivity was used as the CCCL.A significant increase in the peak power density of the MT-SOFC to 1.2 W/cm^(2)at 850℃ was achieved using the proposed two-layer cathode.

关键词： Microtubular solid oxide fuel cells Cathode Perovskites Oxygen exchange

Transient expression of inactive RB in mesenchymal stem cells impairs their adipogenic potential and is associated with hypermethylation of the PPARγ2 promoter

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Genes & Diseases 2022年第1期9卷 165-175页

作者： mikhail Baryshev Nikolai Petrov Vladimir Ryabov Boris popov Institute of Cytology Russian Academy of Sciences St.Petersburg4Tikhoretsky Av.194064St.PetersburgRussia Institute of Microbiology and Virology Riga Stradins UniversityRatsupites 5LV-1067RigaLatvia Developmental Therapeutics Branch National Cancer InstituteNational Institutes of HealthBethesdaMaryland 20892USA

The retinoblastoma gene product(pRb)is a chromatin-associated protein that can either suppress or promote activity of key regulators of tissue-specific *** found that twelve weeks after transfection of the exogenous active(ΔB/X andΔр34)or inactive(ΔS/N)forms of RB into the 10T1/2 mesenchymal stem cells and clonal selection not a single cell line did contain exogenous RB,despite being G-418 ***,the consequences of the transient production of exogenous RB had different effects on the cell ***ΔB/X andΔр34 cells transfected with active form of RB showed elevated levels of inducible adipocyte differentiation(AD).On the contrary,theΔS/N cells transfected with inactive RB mutant were insensitive to induction of AD associated with abolishing of expression of the PPARγ***,the PPARγ2 promoter in undifferentiatedΔS/N cells was hypermethylated,but all except−60 position CpG became mostly demethylated after cells exposure to *** conclude that while transient expression of inactive exogenous RB induces long term epigenetic alterations that prevent adipogenesis,production of active exogenous RBs results in an AD-promoting epigenetic *** results indicate that pRb is involved in the establishment of hereditary epigenetic memory at least by creating a methylation pattern of PPARγ2.

关键词： Adipogenic differentiation DNA methyltransferase 1 Mesenchymal stem cells MSCs RB Retinoblastoma susceptibility gene

Gazeau–Klauder coherent states examined from the viewpoint of diagonal ordering operation technique

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Chinese Physics B 2016年第7期25卷 114-123页

作者： Dusan popov Romeo Negrea Miodrag popov Politehnica University Timisoara Department of Physical Foundations of Engineering 300223 Timisoara Romania Politehnica University of Timisoara Department of Mathematics 300006 Timisoara Romania politehnica University Timisoara Department of Architecture and Urban Planning 300223 Timisoara Romania

In this paper we investigate the Gazeau–Klauder coherent states using a newly introduced diagonal ordering operation technique, in order to examine some of the properties of these coherent states. The results coincide with those obtained from other purely algebraic methods, but the calculations are greatly simplified. We apply the general theory to two cases of Gazeau–Klauder coherent states： pseudoharmonic as well as the Morse oscillators.

关键词： coherent states operator technique density operator

Reduction of friction by normal *** of contact stiffness

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Friction 2017年第1期5卷 45-55页

作者： M.popov V.L.popov N.V.popov Berlin University of Technology Berlin 10623 GermanyTomsk Polytechnic University Tomsk 634050 RussiaTomsk State University Tomsk 634050 Russia Berlin University of Technology Berlin 10623 Germany

The present paper is devoted to a theoretical analysis of sliding friction under the influence of oscillations perpendicular to the sliding *** contrast to previous works we analyze the influence of the stiffness of the tribological contact in detail and also consider the case of large oscillation amplitudes at which the contact is lost during a part of the oscillation period,so that the sample starts to 'jump'.It is shown that the macroscopic coefficient of friction is a function of only two dimensionless parameters-a dimensionless sliding velocity and dimensionless oscillation *** function in turn depends on the shape of the contacting *** the present paper,analysis is carried out for two shapes:a flat cylindrical punch and a parabolic *** we consider 'stiff systems',where the contact stiffness is small compared with the stiffness of the *** role of the system stiffness will be studied in more detail in a separate paper.

关键词： sliding friction out-of-plane oscillation contact stiffness coefficient of friction active control of friction

Non-adhesive and adhesive contacts of an elastic quarter-or eighth-space with freely sliding sides

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Friction 2024年第9期12卷 2052-2063页

作者： Qiang LI Valentin L.popov Technische Universität Berlin Berlin 10623Germany

The contact of an elastic quarter-or eighth-space is studied under the condition that the movement of the side surface of the quarter-space is constrained:It can slide freely along the plane of the side surface but its normal movement is blocked(for example,by a rigid wall).The solution of this contact problem can be easily achieved by additionally applying a mirrored load to an elastic ***-adhesive contact and the Johnson–Kendall–Roberts(JKR)-type adhesive contact between a rigid sphere and an elastic quarter-space under such a boundary condition is numerically simulated using the fast Fourier transform(FFT)-assisted boundary element method(BEM).Contacts of an elastic eighth-space are investigated using the same *** on the position of the sphere relative to the side edge,different contact behavior is *** the case of adhesive contact,the force of adhesion first increases with increasing the distance from the edge of the quarter-space,achieves a maximum,and decreases further to the JKR-value in large distance from the *** enhancement of the force of adhesion compared to the half-space-contact is associated with the pinning of the contact area at the *** provide the maps of the force of adhesion and their analytical approximations,as well as pressure distributions in the contact plane and inside the quarter-/eighth-space.

关键词： quarter-space eighth-space adhesion edge effect boundary element method(BEM)

Method of reduction of dimensionality in contact and friction mechanics:A linkage between micro and macro scales

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Friction 2013年第1期1卷 41-62页

作者： Valentin L.popov Berlin University of Technology Berlin 10623Germany

Computer simulations have been an integral part of the technical development process for a long time *** tribology is one of the last fields in which computer simulations have,until now,played no significant *** is primarily due to the fact that investigating tribological phenomena requires considering all spatial scales from the macroscopic shape of the contact system down to the *** the present paper,we give an overview of the previous work on the so-called method of reduction of dimensionality(MRD),which in our opinion,gives a key for the linking of the micro-and macro-scales in tribological *** in contact mechanics is based on the mapping of some classes of three-dimensional contact problems onto one-dimensional contacts with elastic *** equivalence of three-dimensional systems to those of one-dimension is valid for relations of the indentation depth and the contact force and in some cases for the contact *** arbitrary bodies of revolution,MRD is exact and provides a sort of“pocket edition”of contact mechanics,giving the possibility of deriving any result of classical contact mechanics with or without adhesion in a very simple way.A tangential contact problem with and without creep can also be mapped exactly to a one-dimensional *** can be shown that the reduction method is applicable to contacts of linear visco-elastic bodies as well as to thermal effects in *** method was further validated for randomly rough self-affine surfaces through comparison with direct 3D *** means a huge reduction of computational time for the simulation of contact and friction between rough surfaces accounting for complicated rheology and *** MRD,not only is the dimension of the space reduced from three to one,but the resulting degrees of freedom are independent(like normal modes in the theory of oscillations).Because of this independence,the method is predestinated for parallel calculation on

关键词： contact mechanics rough surfaces static friction sliding friction elastomers adhesion rolling dynamic tangential contacts reduction of dimensionality scale linkage

Active control of friction by transverse oscillations

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Friction 2019年第1期7卷 74-85页

作者： J.BENAD K.NAKANO V.L.popov M.popov Technische Universit?t Berlin Yokohama National University National Research Tomsk Polytechnic University National Research Tomsk State University

The present paper is devoted to a theoretical analysis of sliding friction under the influence of in-plane oscillations perpendicular to the sliding direction. Contrary to previous studies of this mode of active control of friction, we consider the influence of the stiffness of the tribological contact in detail and show that the contact stiffness plays a central role for small oscillation amplitudes. In the present paper we consider the case of a displacement-controlled system, where the contact stiffness is small compared to the stiffness of the measuring system. It is shown that in this case the macroscopic coefficient of friction is a function of two dimensionless parameters— a dimensionless sliding velocity and dimensionless oscillation amplitude. In the limit of very large oscillation amplitudes, known solutions previously reported in the literature are reproduced. The region of small amplitudes is described for the first time in this paper.

关键词： sliding friction in-plane oscillation contact stiffness coefficient of friction active control of friction