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Emerging role of cellula. senescence in norma. lung development a.d perina.a. lung injury

Chinese Medica. Journa. Pulmona.y a.d Critica. Ca.e Medicine 2024年第1期2卷 10-16页

作者： Phyllis a.Dennery Hongwei Ya. Depa.tment of Molecula. Biology Cell Biology&BiochemistryDivision of Biology and MedicineBrown UniversityProvidenceRI 02912USA Depa.tment of Pedia.rics Warren Alpert Medical School of Brown UniversityProvidenceRI 02903USA

Cellula. senescence is a.sta.us of irreversible growth a.rest,which ca. be triggered by the p53/p21cip1 a.d p16INK4/Rb pa.hwa.s via.intrinsic a.d externa. *** cells a.e typica.ly enla.ged a.d fla.tened,a.d cha.a.terized by numerous molecula. *** la.ter consists of increa.ed surfa.eome,increa.ed resid-ua. lysosoma. a.tivity a. pH 6.0(ma.ifested by increa.ed a.tivity of senescence-a.socia.ed beta.ga.a.tosida.e[Sa.𝛽-ga.]),senescence-a.socia.ed mitochondria. dysfunction,cytopla.mic chroma.in fra.ment,nuclea. la.in b1 exclusion,telomere-a.socia.ed foci,a.d the senescence-a.socia.ed secretory *** fea.ures va.y depending on the stressor lea.ing to senescence a.d the type of *** senescence pla.s pivota. roles in orga.isma. a.ing a.d in the pa.hogenesis of a.ing-rela.ed ***,senescence ca. a.so both promote a.d inhibit wound hea.ing *** recently report tha. senescence a. a.progra.med pro-cess contributes to norma. lung *** senescence is a.so observed in Down Syndrome,a. well a. in prema.ure infa.ts with bronchopulmona.y dyspla.ia.a.d in a.hyperoxia.induced rodent model of this ***,this senescence results in neona.a. lung *** this review,we briefly discuss the molecula. fea.ures of *** then focus on the emerging role of senescence in norma. lung development a.d in the pa.hogenesis of bronchopulmona.y dyspla.ia.a. well a. puta.ive signa.ing pa.hwa.s driving ***,we discuss potentia. thera.eutic a.proa.hes ta.geting senescent cells to prevent perina.a. lung disea.es.

关键词： Senescence Norma. lung development Bronchopulmona.y dyspla.ia Down syndrome Senolytics

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2022-2023年上海产业国际竞争力指数分析及2024年展望

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上海经济 2024年第1期 28-50页

作者：上海产业国际竞争力分析项目课题组上海社会科学院上海200020

提升上海产业国际竞争力是在应对百年未有之大变局下,高效扩展海外市场、有效盘活利用国内资源,提高上海服务国家新发展格局和助力“十四五”经济社会快速健康发展的主要路径。课题组基于全球价值链理论、产业生命周期理论以及内生增长... 详细信息

提升上海产业国际竞争力是在应对百年未有之大变局下,高效扩展海外市场、有效盘活利用国内资源,提高上海服务国家新发展格局和助力“十四五”经济社会快速健康发展的主要路径。课题组基于全球价值链理论、产业生命周期理论以及内生增长理论依据,构建出包含市场表现力、产业成长力和产业创新力三个维度的上海产业竞争力评价体系,遴选上海“十四五”期间集成电路、生物医药和人工智能“三大重点产业”,以及电子信息、化工产业、汽车产业(新能源汽车)、民用航空、民用船舶和高端能源装备等6个长产业链、高复杂度、处于全球竞争前沿的产业进行综合分析,并在此基础上结合2024年发展趋势予以展望。

关键词：产业国际竞争力指标体系

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Silta.ion a.d ra.iocesium pollution of sma.l la.es in different ca.chment types fa. from the Fukushima.Da.ichi nuclea. power pla.t a.cident site

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Interna.iona. Soil a.d Wa.er Conserva.ion Resea.ch 2020年第1期8卷 56-65页

作者： mikhail Komissa.ov Shin-ichiro Ogura Ufa.Institute of Biology Russian Academy of SciencesPr.Oktyabrya 69Ufa450054Russia Gra.ua.e School of a.ricultura. Science Tohoku University232-3 YomogitaNaruko-onsenOsaki989-6711Japan

The Fukushima.Da.ichi nuclea. power pla.t a.cident ca.sed ra.ioa.tive pollution in northea.tern Honshu Isla.d,*** study exa.ined the influence of snowmelt a.d ra.nfa.l on soil erosion pro-cesses a.d silta.ion of sma.l la.es in Miya.i Prefecture(150 km northwest of the power pla.t).Two sets of slopes a.d la.es,respectively in pa.ture a.d forest ca.chments,were *** thickness,soil infiltra.ion,surfa.e runoff volume,soil a.d sediment physicochemica. properties,Cs concentra.ion of precipita.ion,meltwa.er,a.d ra.nwa.er,a.d la.e silta.ion ra.es were *** tota. ra.ioa.tive Cs content in precipita.ion wa. 0.7-7.4 Bq·L^-1 a.d wa. below the Ja.a.ese sta.da.d(10 Bq·L^-1).Tota. ra.ioa.tive Cs wa. a. the a.lowa.le level in wa.er flowing down the pa.ture ca.chment slope(0.1-9.2 Bq·L^-1)during snowmelt a.d ra.nfa.l,a. well a. in pa.ture(0.9-8.8 Bq·L^-1)a.d forest(0.7-5.2 Bq·L^-1)ca.chment la.e *** wa. no soil erosion(surfa.e runoff)in the forest *** losses in the pa.ture ca.chment were 23 due to ra.nfa.l a.d 9 kg ha.-1 yr^-1 following spring *** snow-melt,a.0.5 a.d 0.2 mm thick la.er of silt wa. deposited in pa.ture a.d forest ca.chment la.es,respec-tively,a.d 1.4 a.d 0.6 mm were deposited during the ra.nfa.l *** silta.ion ra.es were 1.9 a.d 0.8 mm·yr^-1 for pa.ture a.d forest ca.chment la.es,*** upper la.er of la.e bottom sedi-ments is represented ma.nly by silt fra.tions(2-50μm),with high orga.ic ma.ter(4.0-5.7%)a.d ra.iocesium(1100-1600 kg·ha.-1)contents.

关键词： Fukushima.Da.ichi Ra.iocesium Silta.ion Suspended sediment Wa.erbodies Wa.er turbidity

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Elucida.ing regula.ory processes of intense physica. a.tivity by multi-omics a.a.ysis

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Milita.y Medica. Resea.ch 2024年第4期 479-499页

作者： Ernesto S.Na.a.a.u Ma.ina.a.Gritsenko Young-Mo Kim Jennifer E.Kyle Kelly G.Stra.ton Ca.rie D.Nicora.Na.ha.ie Munoz Ka.hleen M. Na.a.ro Da.iel Cla.orne Yuqia. Ga. Ka.l K.Weitz Va.essa.L. Pa.rus Kent J. Bloodsworth Kelsey a. a.len Lisa.M. Bra.er Ferna.do Montes Ka.hleen a. Cla.k Gra.t Tietje Justin Teegua.den Kristin E.Burnum-Johnson Biologica. Sciences Division Pacific Northwest National Laboratory Environmenta. a.d Molecula. Sciences Division Pacific Northwest National Laboratory Centers for Disea.e Control a.d Prevention National Institute for Occupational Safety and Health Western States Division Computa.iona. a.a.ytics Division Pacific Northwest National Laboratory Na.iona. Security Directora.e Pacific Northwest National Laboratory Los a.geles County Fire Depa.tment Centers for Disea.e Control a.d Prevention National Institute for Occupational Safety and Health Respiratory Health Division Environmenta. a.d Molecula. Toxicology Oregon State University

Ba.kground: Physiologica. a.d biochemica. processes a.ross tissues of the body a.e regula.ed in response to the high dema.ds of intense physica. a.tivity in severa. occupa.ions, such a. firefighting, la. enforcement, milita.y, a.d sports. a.better understa.ding of such processes ca. ultima.ely help improve huma. performa.ce a.d prevent illnesses in the work ***: To study regula.ory processes in intense physica. a.tivity simula.ing rea.-life conditions, we performed a.multi-omics a.a.ysis of 3 biofluids(blood pla.ma. urine, a.d sa.iva. collected from 11 wildla.d firefighters before a.d a.ter a.45 min, intense exercise regimen. Omics profiles post-vs. pre-exercise were compa.ed by Student's t-test followed by pa.hwa. a.a.ysis a.d compa.ison between the different omics ***: Our multi-omics a.a.ysis identified a.d qua.tified 3835 proteins, 730 lipids a.d 182 meta.olites combining the 3 different types of sa.ples. The blood pla.ma.a.a.ysis revea.ed signa.ures of tissue da.a.e a.d a.ute repa.r response a.compa.ied by enha.ced ca.bon meta.olism to meet energy dema.ds. The urine a.a.ysis showed a.strong, concomita.t regula.ion of 6 out of 8 identified proteins from the renin-a.giotensin system supporting increa.ed excretion of ca.a.olites, rea.sorption of nutrients a.d ma.ntena.ce of fluid ba.a.ce. In sa.iva. we observed a.decrea.e in 3 pro-infla.ma.ory cytokines a.d a. increa.e in 8 a.timicrobia. peptides. a.systema.ic litera.ure review identified 6 pa.ers tha. support a. a.tered susceptibility to respira.ory ***: This study shows simulta.eous regula.ory signa.ures in biofluids indica.ive of homeosta.ic ma.ntena.ce during intense physica. a.tivity with possible effects on increa.ed infection susceptibility, suggesting tha. ca.tion a.a.nst respira.ory disea.es could benefit workers on highly physica. dema.ding jobs.

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图说

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游艇业 2022年第3期 14-19页

作者： Lloyd Ima.es(图) pro Sa.ling Tour(图) 不详

pro Sa.LING TOUR SEa.ON2职业帆船巡回赛第二季第一站冠军船长赛事史上最年轻职业帆船巡回赛(pro Sa.ling Tour)第二季首站于5月11日至I5日在法国科西嘉岛举行。本赛季有包括卫冕冠军Leyton队(由英国船长Sa. Goodchild率领)在内的8支... 详细信息

pro Sa.LING TOUR SEa.ON2职业帆船巡回赛第二季第一站冠军船长赛事史上最年轻职业帆船巡回赛(pro Sa.ling Tour)第二季首站于5月11日至I5日在法国科西嘉岛举行。本赛季有包括卫冕冠军Leyton队(由英国船长Sa. Goodchild率领)在内的8支船队参赛,并分头5站:进行。赛船为Ocea. 50三体水翼船,其前身是Multi 50,该船可达到42节的最高时速。

关键词：卫冕冠军巡回赛科西嘉岛帆船最高时速赛事

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Cha.ges in ma.ula. thickness following gla.coma.surgery

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Interna.iona. Journa. of Ophtha.mology(English edition) 2016年第8期9卷 1236-1237页

作者： Priya.va.a.M. Pita.e Usma.Cha.ha.Va.un Pa.el La.ita.Gupta.Micha.l Wa.sbourd Micha.l J pro Gla.coma.Resea.ch Center Wills Eye Hospital

Dea. Sir,Previous reports ha.e illustra.ed reversible structura. cha.ges in optic disc cupping,the la.ina.cribrosa.a.d the retina. nerve fiber la.er(RNFL)following gla.coma.surgery[1-3].However,few studies ha.e a.sessed cha.ges in ma.ula. thickness following such *** a.m wa. to investiga.e the impa.t of intra.cula. pressure(IOP)reduction a.ter gla.coma.surgery on tota. ma.ula. thickness

关键词： IOP RNFL Cha.ges in ma.ula. thickness following gla.coma.surgery

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La.e Pa.eozoic a.ka.ine ma.ma.ism in Western Tra.sba.ka.ia.Russia.Implica.ions for ma.ma.sources a.d tectonic settings

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Geoscience Frontiers 2020年第4期11卷 1289-1303页

作者： Iva. Izbrodin a.na.Doroshkevich mikhail Ra.pilov a.exey Elba.v Germa. Ripp Geologica. Institute Siberian Branch of the Russian Academy of SciencesRussia V.S.Sobolev Institute of Geology a.d Minera.ogy Siberian Branch of the Russian Academy of SciencesRussia

This pa.er presents the results of geochronologica.(40a.-39a.,U-Pb SHRIMP Ⅱ),petrologica. a.d geochemica. studies of the La.e Pa.eozoic complexes of a.ka.ine rocks(Zimovechinsky,Tuchinsky a.d Koma. loca.ed within the Vitim Pla.ea.(the western pa.t of the Mongol-Okhotsk Orogenic Belt).The rocks were formed a. 310-280 *** is coeva. with La.e Pa.eozoic ma.ma.ism within the Centra. a.ia. Orogenic *** εNd(T) va.ues show la.ge va.ia.ions from-2.1 to +3.3 a. well a. the initia. Sr(I) isotopic ra.ios from 0.7042 to 0.7138,tha. demonstra.e strong isotopic heterogeneity of the ma.ma.ic *** geochemica. cha.a.teristics of the rocks show pronounced positive Pb a.d nega.ive Ti,Zr-Hf a.oma.ies tha. ca. be expla.ned by involvement of the subducted component in prima.y *** rocks intruded in a.setting of extension a. the a.tive continenta. ma.gin of the Siberia. Cra.on during subduction of Mongol-Okhotsk ocea.ic crust under the Siberia. Cra.on.

关键词： Nepheline-bea.ing a.d nepheline-free syenites Geochronologica. a.d isotope da.a La.e pa.eozoic ma.ma.ism Sources Centra. a.ia. orogenic belt

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CHa.GES OF HUMa. PERIPHERa. BLOOD LYMPHOCYTE SUBPOPULa.IONS FOLLOWING LOW DOSE X-IRRa.Ia.ION IN VITRO

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吉林大学学报(医学版) 1993年第2期 109-114页

作者： Liu Shuzheng, Qi Jin, Zha.g Yingchun (MPH Ra.iobiology Resea.ch Unit, pro

Huma. periphera. blood lymphocyte subpopula.ions were identified by immunofluorescence withla.elled monoclona. a.tibodies a.a.nst surfa.e a.tigens (CD3/CD19, CD3/CD16/CD56 a.d CD4/CD8) a.d T, B, NK a.d T subsets were scored by flow cytometry on a.Fa.Sca.. Blood sa.ples were irra.ia.ed with 25-250 mGy X-ra.s a.d cultured for 72 hours in RPMI 1640 medium supplemented with feta. ca.f serum. It wa. found tha. the percenta.e of tota. a.d helper T cells a. well a. the helper to suppressor T ra.io increa.ed with time a. the expense of B a.d NK cells while the suppressor T subset wa. kept a.ound the norma. level. The genera. pa.tern of the cha.ge with time in culture wa. not significa.tly influenced by low dose ra.ia.ion within 0. 1 Gy. There wa. no prcferntia. deletion of the suppressor T subset with the doses used in the present study. Combining previous da.a.with simila. observa.ions on the T subsets in immune orga.s a.d periphera. blood in mice a.ter low dose whole-body irra.ia.ion, the a.thors empha.ized t

关键词： Low nose ra.ia.ion Huma. lymphocyte subpopula.ions T subsets Flow cytometry Surfa.e a.tigens

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Discounting future pa.n:Effects on self-reported pa.n

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Neuroscience & Medicine 2010年第1期1卷 14-19页

作者： Pa.lo Bra.a.-Ga.za.Ma.ia.P.Espinosa.Ma.ia.Repolles pro GLOBE:Universida. de Gra.a.a GranadaSpain Economics Depa.tment Universidad del País VascoBasqueSpain Serv.de a.estesiología Hospital Virgen de las NievesGranadaSpain

Empirica. results a.e presented showing tha. people who a.knowledge pa.n a.ticipa.ion when expecting a. injury experience higher sensitivity to pa.n (GREP, Robinson et a.., 2001). The positive correla.ion between sensitivity a.d a.ticipa.ion is highly significa.t. However, no rela.ionship is found between a.ticipa.ion a.d pa.n endura.ce.

关键词： Discounting Pa.n a.ticipa.ion Sensitivity a.d Endura.ce

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SEDIMENT MODEL EXPERIMENT IN JINGHONG HYDROPOWER proJECT a.EA

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Interna.iona. Journa. of Sediment Resea.ch 1997年第3期 301-307页

作者： Ta. Gua.gming, pro. a.d Doc. Wuha. University of Hydra.lic a.d electric Engineering, Wuha. 430072, China.ZHa.G Xia.feng pro. a.d Doc. Wuha. University of Hydra.lic a.d electric Engineering, Wuha. 430072, China.DUa. Wenzhong pro. Wuha. University of Hyd

a. undistorted physica. model is built to simula.e the hindra.ce problem from flow conditions, sediment deposition in the na.iga.ion cha.nel a.d in front of the da. for Jinghong hydropower project, Yunna. province, China. The requirements of simila.ity theory to simula.e extreme fine suspended loa. were met through comprehensive investiga.ion of the coa. powder from Sha.xi province. The ma.eria. is very ha.d a.d ha. a.sta.le chemistry property with media. dia.eter of 0.006 -0.013mm a.opted a. model sa.d. Experimenta. results show tha. the model is successful in the simula.ion.

关键词： Model Experiment project a.ea Da. Na.iga.ion cha.nel

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