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电子工业专用设备 2017年第1期46卷 8-13页

作者： Vincent Charbois Julie Lebreton Mylène Savoye Eric Labonne Antoine Labourier Benjamin Dumont Chet Lenox mike von den hof STMicroelectronics Crolles 2 SAS Crolles 法国 KLA-Tencor公司欧洲

介绍了20 nm平面技术生产线前端缺陷减少的方法、结果及改善。介绍的缺陷检测优化与缺陷减少方法是针对高性能逻辑器件所用的300 mm晶圆上的高介电常数金属栅极(HKMG)层叠模块而实施的。

关键词：缺陷检测与减少(DI) 成品率改善/学习(YE)

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Model-Based Control and Optimization of Large Scale Physical Systems-Challenges in Reservoir Engineering

Model-Based Control and Optimization of Large Scale Physical...

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2009中国控制与决策会议

作者： Paul M.J.Van den hof Jan-Dirk Jansen cijs van Essen Okko H.Bosgra Delft Center for Systems and Control Delft University of TechnologyMekelweg 22628 CD DelftThe Netherlands Department of Geotechnology Delft University of TechnologyThe Netherlands Shell International Exploration and Production RijswijkThe Netherlands

＜正＞Due to urgent needs to increase efficiency in oil recovery from subsurface reservoirs new technology is developed that allows more detailed sensing and actuation of multiphase flow properties in oil *** of the examples is the controlled injection of water through injection wells with the purpose to displace the oil in an appropriate direction. This technology enables the application of model-based optimization and control techniques to optimize production over the entire production period of a reservoir,which can be around 25 *** scale reservoir flow models are used for optimizing production settings,but suffer from high levels of uncertainty and limited validation *** of the challenges is the development of reduced complexity models that deliver accurate long-term predictions,and at the same time are not more complex than can be warranted by the amount of data that is *** this paper an overview will be given of the problems and opportunities for model-based control and optimization in this field aiming at the development of a closed-loop reservoir management system.

关键词： Oil reservoir production optimization optimal control parameter estimation dynamic optimization identifiability nonlinear observers

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Treatment adherence among sputum smear-positive pulmonary tuberculosis patients in mountainous areas in China

Treatment adherence among sputum smear-positive pulmonary tu...

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安徽省2011年度流行病与卫生统计学学术论坛

作者：姚嵩黄文辉 Susan van den hof 杨枢敏王晓林陈伟方雪晖潘海峰 Anhui Provincial TB Research Institute Jiangxi Provincial Center for Disease Control and Prevention KNCV Tuberculosis Foundation Center for Infection and Immunity Amsterdam (CINIMA) University of Amsterdam Gansu Provincial Center for Disease Control and Prevention Ningxia Provincial Center for Disease Control and Prevention Guizhou Provincial Center for Disease Control and Prevention Department of Epidemiology and Biostatistics School of Public Health Anhui Medical University

Background: We carried out an investigation in five provinces in China to assess treatment adherence and identify factors associated with insufficient treatment adherence in tuberculosis(TB) patients in mountainous, rural areas of China. Methods: In each of the five provinces, all counties with >80% mountainous area were stratified into three groups according to their gross domestic product. In each stratum, one county was randomly sampled. Study subjects were sampled from all smear positive TB cases registered in 2007 in the target counties. TB patients, village doctors, county doctors and directors of the TB prevention and control institutes were interviewed. Insufficient medication adherence was defined as taking less than 90% of anti-TB drug doses prescribed. Insufficient re-examination adherence was defined as having less than the recommended three sputum smear examinations during the treatment course. Results: A minority of patients took drugs under direct observation: on average 29% during the intensive phase of treatment. In total, 524 TB patients were included, of whom 49(9.4%) took less than 90% of all doses prescribed and 92(17.6%) did not have all sputum smear examinations, with substantial variations between the provinces. In multivariable analysis, no direct observation of treatment during the intensive phase and the presence of adverse events were associated both with insufficient medication adherence and insufficient re-examination adherence. Overall, 79% of patients were adherent both to treatment and re-examinations. Conclusions: In these remote and poor areas of China, the TB control program is not fully functioning according to the guidelines. The majority of patients are not treated under direct observation, while direct observation by health care staff was associated with better adherence, both to drug therapy and re-examinations. Insufficient adherence increases the risk of unsuccessful treatment outcomes and development of drug resistance. Me

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产科超声的生物学效应及安全性评价

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中国产前诊断杂志（电子版） 2008年第2期1卷 33-36页

作者： Stepl1enBly Michiel C. Van den hof Barbara Lewthwaite Robert Gagnon Lucie Morin Shia Salem 周文婷郭丽丽加拿大卫生部辐射防护局加拿大皇家外科医师学会 Halifax影像诊断委员会皇家内科医师学会加拿大的放射科医师协会

目的评估产科超声的生物学效应和安全性。结果:概述在何种情况下应当关注产科超声的安全性问题。证据我们检索了Medline数据库,回顾分析了加拿大卫生部的专门文件和其它相关文献。评估标准由主要作者及加拿大妇产科协会下属影像诊断委... 详细信息

目的评估产科超声的生物学效应和安全性。结果:概述在何种情况下应当关注产科超声的安全性问题。证据我们检索了Medline数据库,回顾分析了加拿大卫生部的专门文件和其它相关文献。评估标准由主要作者及加拿大妇产科协会下属影像诊断委员会对相关内容进行评估。证据等级由加拿大定期健康检查工作小组评定。利益,危害,以及代价仅出于医学原因时,方可行产科超声检查。因为超声检查过程中存在潜在的组织热损伤,所以在保证检查效果的前提下应尽量减少超声波的暴露(ALARA原则,下同)。我们还特别注意到以下情况可使超声波暴露量更大,即:使用脉冲式多普勒、彩色血流检查,妊娠早期经腹超声检查(径线大于5 cm),妊娠中、晚期超声检查胎儿骨骼发育情况,或者超声检查低灌注组织(胚胎组织)、发热孕妇的胎儿等。检查人员可以通过减少检查的时间,减少暴露于超声中的结构和仔细地分辨超声图像中的信息来减少上述风险。

关键词：安全性生物学效应超声产科胎儿热量指数

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Colonoscopic yield of colorectal neoplasia in daily clinical practice

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World Journal of Gastroenterology 2009年第9期15卷 1085-1092页

作者： Jochim S Terhaar sive Droste mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder Department of Gastroenterology and Hepatology VU University Medical CentrePO Box 70571007 MBAmsterdamThe Netherlands Gastroenterology and Hepatology Kennemer Gasthuis2000 AKHaarlemThe Netherlands Gastroenterology and Hepatology Academic Medical Centre1100 DDAmsterdamThe Netherlands Epidemiology and Biostatistics VU University Medical Centre1007 MBAmsterdamThe Netherlands Pathology VU University Medical Centre1007 MBAmsterdamThe Netherlands Gastroenterology and Hepatology Slotervaart Hospital1006 BKAmsterdamThe Netherlands Gastroenterology and Hepatology Medical Centre Alkmaar1800 AMAlkmaarThe Netherlands Gastroenterology and Hepatology Sint Lucas Andreas Hospital1061 AEAmsterdamThe Netherlands

AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per ***:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or ***:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients.

关键词： Colorectal cancer Screening Advanced neoplasia Colonoscopy Adenoma

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