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Staging the axilla in women with breast cancer: the utility of preoperative ultrasound-guided needle biopsy

Cancer Biology & Medicine 2014年第2期11卷 69-77页

作者： Nehmat Houssami Robin M. turner Screening and Test Evaluation Program (STEP) School of Public Health Sydney Medical School University of Sydney

Preoperative staging of the axilla in women with invasive breast cancer using ultrasound-guided needle biopsy(UNB) identifies approximately 50% of patients with axillary nodal metastases prior to surgical intervention. Although moderately sensitive, it is a highly specific staging strategy that is rarely falsely-positive, hence a positive UNB allows patients to be triaged to axillary lymph-node dissection(ALND) avoiding potentially unnecessary sentinel node biopsy(SNB). In this review, we extend our previous work through an updated literature search, focusing on studies that report data on UNB utility. Based on data for 10,934 breast cancer patients, sourced from 35 studies, a positive UNB allowed triage of 1,745 cases(simple proportion 16%) to axillary surgical treatment: the utility of UNB was a median 19.8% [interquartile range(IQR) 11.6%-26.7%] across these studies. We also modelled data from a subgroup of studies, and estimated that amongst patients with metastases to axillary nodes, the odds ratio(OR) for high nodal disease burden for a positive UNB versus a negative UNB was 4.38 [95% confidence interval(95% CI): 3.13, 6.13], P<0.001. From this model, the estimated proportion with high nodal disease burden was 58.9%(95% CI: 50.2%, 67.0%) for a positive UNB, whereas the estimated proportion with high nodal disease burden was 24.6%(95% CI: 17.7%, 33.2%) if UNB was negative. Overall, axillary UNB has good clinical utility and a positive UNB can effectively triage to ALND. However, the evolving landscape of axillary surgical treatment means that UNB will have relatively less utility where surgeons have modified their practice to omission of ALND for minimal nodal metastatic disease.

关键词： Breast cancer axillary staging node metastases test utility ultrasound-guided needle biopsy(UNB)

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Self-identification of electronically scanned signatures(ESS)and digitally constructed signatures(DCS)

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Forensic Sciences Research 2022年第2期7卷 261-264页

作者： Zuzanna Kazmierczyk Ian J.turner Centre for Excellence in Learning and Teaching University of DerbyDerbyUK

The use of electronic signatures as a form of identification is increasingly common,yet they have been shown to lack the dynamic features found in online *** this study,handwritten signatures were scanned to produce electronically scanned signatures(ESS)which were then digitally altered to produce digitally constructed signatures(DCS).The ESS and DCS were presented back to participants to identify which were *** 1%of participants correctly identified all signatures,with a mean score of 57.6%*** lack of self-recognition of ESS raises questions on their reliability and usefulness as means of personal identification.

关键词： Forensic sciences signature handwriting questioned document analysis electronic signature digital signature simulation

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The N-terminus of COX-1 and its effect on cyclooxygenase-1 catalytic activity

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Journal of Genetics and Genomics 2010年第2期37卷 117-123页

作者： Sean Phipps Michael J. turner Daniel L. Simmons Chemistry and Biochemistry Department Brigham Young University

Cyclooxygenases are encoded by COX-1 and COX-2. They share over sixty percent sequence identity in human and are similar to each other in their crystallographic structures. One major difference in the primary structure of these two isozymes is the presence of eight amino acids in the amino-terminal region of COX-1 that are not present in COX-2. The function of this amino acid sequence is unknown. In this study, a human COX-1 mutant （Δ7aa） with this sequence removed was studied in parallel with COX-1. Signal peptide cleavage, N-linked glycosylation, protein expression, distribution and dimerization were not affected by the mutation. The mutant was enzymati-cally active and showed the same sensitivity toward aspirin. The KM for the enzyme remained the same as COX-1. However, the Vmax of the COX-1 mutant decreased by 3.3-fold. We conclude that the COX-1 specific amino-terminal sequence has a subtle but detectable effect on COX-1 catalysis.

关键词： COX-1 COX-2 dimerization glycosylation aspirin KM Vmax

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The Newly Discovered Super-Large Wulashan-Hademengou Gold Metallogenic Belt in Inner Mongolia,China Has Gold Reserves of Over 100 Tons

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Acta Geologica Sinica(English Edition) 2014年第4期88卷 1332-1333页

作者： HAO Ziguo FEI Hongcai HAO Qingqing Susan turner Chinese Academy of Geological Sciences Editorial Office of Acta Geologica Sinica (English edition) Geological Society of China Editorial Office of Geology and Exploration Institute of Mineral Resources Research China Metallurgical Geology Bureau

The Wulashan-Hademengou gold ore district in Baotou city, Inner Mongolia, is a further newly discovered super-large gold metallogenic belt in northern China. The accumulated proven gold metal amount is 84.46 t, with an average grade of 3.53 g/t and a gold metal amount of 63.16 t, with an average grade of 3.30 g/t. The potential reserves are over 100 t.

关键词： Gold The Newly Discovered Super-Large Wulashan-Hademengou Gold Metallogenic Belt in Inner Mongolia,China Has Gold Reserves of Over 100 Tons

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Status of China's Land Resources in 2013

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Acta Geologica Sinica(English Edition) 2014年第3期88卷 1017-1018页

On 22nd April 2014,with the approach of the 45th World Earth Day,the Chinese Ministry of Land and Resources announced the status of China＇s land resources in 2013,putting forward the implementation of strict farmland protection measures to ensure the 1.8 billion acres of arable *** laid a solid foundation for achieving a ＂ten even increase＂ of food production and ensuring China＇s food security.

关键词： Status of China’s Land Resources in 2013

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Application of Multi-well Subsidence Analysis of the Beryl Embayment,Viking Graben,Northern North Sea

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Acta Geologica Sinica(English Edition) 2006年第5期80卷 693-704页

作者： DOU Lirong Jon D. turner Roger A. SCRUTTON China National Oil and Gas Exploration and Development Corporation CNPC Beijing 100034 China Department of Geology ＆ Geophysics The University of Edinburgh Edinburgh EH9 3JW Scotland UK

The Beryl Embayment is situated at the south end of the North Viking Graben in the North Sea. Three sets of normal faults, with N-S, NW-SE and NE-SW orientations, have been recognized in the Beryl Embayment. High-resolution subsidence analysis of 73 wells, combined with some seismic data, has been used to document Middle to Late Jurassic subsidence patterns in this area. The high temporal resolution achieved （1 to 2 million years per data point） has also allowed an assessment to be made of temporal evolution of faults with different orientations, and a study made of how and when the East Shetland Fault was linked and controlled sedimentary facies distributions. The results indicate that the East Shetland Fault can be divided into northern and southern parts which were linked together during the Early-Mid Oxfordian. The Mid-Late Jurassic syn-rift phase can be divided into four stages： minor active extension stage during the Bathonian-Middle Callovian, early syn-rotational stage during the Late Callovian-Early-Mid Oxfordian, syn-rotational climax stage during the Late Oxfordian-Early Volgian, and late syn-rotational stage during the Mid-Late Volgian. The results also show that there was a sequential variation of extension direction of active normal faults with different orientations, with an overall shift in the dominant orientation of active normal faults from N-S in the Bathonian-Middle Oxfordian, through NNW-SSE in the Late Oxfordian-Early Volgian （≈N30°E）, to NW-SE （≈N45°E） in the Mid-Late Volgian.

关键词： high-resolution subsidence analysis normal fault rift basin Beryl Embayment Viking Graben

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Carbon Isotope Discrimination is not Correlated with Transpiration Efficiency in Three Cool-Season Grain Legumes(Pulses)

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Journal of Integrative Plant Biology 2007年第10期49卷 1478-1483页

作者： Neil C.turner Jairo A.Palta Renuka Shrestha Christiane Ludwig Kadambot H.M.Siddique David W.turner Centre for Legumes in Mediterranean Agriculture M080The University of Western Australia35 Stirling HighwayCrawleyWA 6009Australia Centre for Legumes in Mediterranean Agriculture M080The University of Western Australia35 Stirling HighwayCrawleyWA 6009Australia CSIRO Plant IndustryPrivate Mail Bag No.5WembleyWA 6913Australia School of Plant Biology M084Institute of AgricultureThe University of Western Australia35 Stirling HighwayCrawleyWA 6009Australia CSIRO Plant Industry Private Mail Bag No.5WembleyWA 6913Australia Centre for Legumes in Mediterranean Agriculture M080The University of Western Australia35 Stirling HighwayCrawleyWA 6009Australia School of Plant BiologyM084Institute of AgricultureThe University of Western Australia35 Stirling HighwayCrawleyWA 6009Australia

The carbon isotope discrimination （δ^13C） of leaves has been shown to be correlated with the transpiration efficiency of leaves in a wide range of species. This has led to δ^13C being used in breeding programs to select for improved transpiration efficiency. The correlation between δ^13C and transpiration efficiency was determined under well-watered conditions during the vegetative phase in six genotypes of lentil （Lens culinaris Medikus）, six genotypes of chickpea （Cicerarietinum L.） and 10 cultivars of narrow-leafed lupin （Lupinus angustifolius L.）. Biomass （dry matter） accumulation and water use （transpiration） varied among the genotypes in all three species and transpiration efficiency was 40% to 75% higher in the most efficient compared with the least efficient genotypes. However, δ^13C and transpiration efficiency were not significantly correlated in any of the species. This suggests that the δ^13C technique cannot be used in selection for transpiration efficiency in the three grain legumes （pulses） studied.

关键词： biomass accumulation breeding chickpea lupin Cicer anetinum Lens culinans lentil Lupinus angustifofius water use.

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2015–2020 Geological Survey Program of China Geological Survey Bureau

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Acta Geologica Sinica(English Edition) 2014年第6期88卷 1917-1919页

作者： HAO Ziguo FEI Hongcai LIU Lian HAO Qingqing Susan turner Chinese Academy of Geological Sciences Editorial Office of Acta Geologica Sinica (English edition) Geological Society of China Editorial Office of Geology and Exploration Institute of Mineral Resources Research China Metallurgical Geology Bureau

On 1–5 September 2014,the China Geological Survey Bureau held a 2015–2020 Geology and Mineral Resources Investigation and Assessment Special Planning and Deployment Meeting to plan the next six years in order to invest nearly ten billion US dollars to implement 9 programs and 50 projects with the aim of developing geological survey work,and to play a leading role in ensuring sustained and stable development.

关键词： Bureau sustained Mines programs prospecting geology carrying tectonic geophysics sandstone

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Important Progress Made in the Study of Chinese Geological Carbon Sink Potential

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Acta Geologica Sinica(English Edition) 2013年第5期87卷 1472-1473页

作者： HAO Ziguo FEI Hongcai LIU Lian Susan turner Chinese Academy of Geological Sciences Editorial office of Acta Geologica Sinica (English edition)

From 2010 to 2012, geologists at the Institute of Karst Geology the Chinese Academy of Geological Sciences carried out the ＂Chinese Geological Carbon Sink Projects Research＂. They did investigation and research work... 详细信息

关键词： Important Progress Made in the Study of Chinese Geological Carbon Sink Potential

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Status of China's Mineral Resources in 2013

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Acta Geologica Sinica(English Edition) 2014年第3期88卷 1018-1019页

On 22nd April 2014,with the approach of the 45th World Earth Day,China＇s Ministry of Land and resources issued the status of China＇s mineral resources in *** first task of the prospecting breakthrough strategy action implemented in the last five years has been completed,and China＇s security capacity for mineral resources has been significantly *** the future,the enforcement of the economical and intensive utilization of mineral resources will be strengthened,and economic transformation and upgrading will be promoted to ensure sustained and stable development of China＇s economy.

关键词： mineral resources economic transformation

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