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Preserving cognitive function in patients with Alzheimer's disease:The Alzheimer's disease neuroprotection research initiative(ADNRI)

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Neuroprotection 2023年第2期1卷 84-98页

作者： Jie Liu Heleen van Beusekom Xian-Le Bu Gong Chen Paulo Henrique Rosado de Castro Xiaochun Chen Xiaowei Chen Andrew N.Clarkson Tracy D.Farr Yuhong Fu Jianping Jia Jukka Jolkkonen Woojin Scott Kim Paula Korhonen Shen Li Yajie Liang Guang-Hui Liu Guiyou Liu Yu-Hui Liu Tarja malm Xiaobo mao Joaquim miguel Oliveira mike m.modo Pedro Ramos-Cabrer Karsten Ruscher Weihong Song Jun Wang Xuanyue Wang Yun Wang Haitao Wu Lize Xiong Yi Yang Keqiang Ye Jin-Tai Yu Xin-Fu Zhou marietta Zille Colin L.masters Piotr Walczak Boltze Johannes Xunming Ji Yan-Jiang Wang Department of Neurology Daping HospitalThird Military Medical UniversityChongqingChina Chongqing Key Laboratory of Ageing and Brain Diseases ChongqingChina Division of Experimental Cardiology Department of CardiologyErasmus MCUniversity Medical CenterRotterdamThe Netherlands Institute of Brain and Intelligence Third Military Medical UniversityChongqingChina Guangdong-HongKong-macao Institute of CNS Regeneration(GHmICR) Jinan UniversityGuangzhouGuangdongChina Institute of Biomedical Sciences Federal University of Rio de JaneiroRio de JaneiroRio de JaneiroBrazil Fujian Key Laboratory of molecular Neurology Department of Neurology and GeriatricsFujian Institute of GeriatricsFujian Medical University Union HospitalInstitute of NeuroscienceFujian Medical UniversityFuzhouFujianChina Guangyang Bay Laboratory Chongqing Institute for Brain and IntelligenceChongqingChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina Department of Anatomy Brain Health Research Centre and Brain Research New ZealandUniversity of OtagoDunedinNew Zealand School of Life Sciences University of NottinghamNottinghamUK Brain and mind Centre&School of medical Sciences The University of SydneySydneyNew South WalesAustralia Innovation Center for Neurological Disorders and Department of Neurology Xuanwu HospitalNational Clinical Research Center for Geriatric DiseasesCapital Medical UniversityBeijingChina A.I.Virtanen Institute for molecular Sciences University of Eastern FinlandKuopioFinland Department of Neurology and Psychiatry Beijing Shijitan HospitalCapital Medical UniversityBeijingChina Department of Diagnostic Radiology and Nuclear medicine University of Maryland School of MedicineBaltimoreMarylandUSA University of Chinese Academy of Sciences BeijingChina State Key Laboratory of membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Sci

The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease(AD)and associated socioeconomic *** metabolism of amyloid-β(Aβ)has been proposed as a significant pathomechanism in AD,supported by results of recent clinical trials using anti-Aβ***,the cognitive benefits of the current treatments are *** etiology of AD is multifactorial,encompassing Aβand tau accumulation,neuroinflammation,demyelination,vascular dysfunction,and comorbidities,which collectively lead to widespread neurodegeneration in the brain and cognitive ***,solely removing Aβfrom the brain may be insufficient to combat neurodegeneration and preserve *** attain effective treatment for AD,it is necessary to(1)conduct extensive research on various mechanisms that cause neurodegeneration,including advances in neuroimaging techniques for earlier detection and a more precise characterization of molecular events at scales ranging from cellular to the full system level;(2)identify neuroprotective intervention targets against different neurodegeneration mechanisms;and(3)discover novel and optimal combinations of neuroprotective intervention strategies to maintain cognitive function in AD *** Alzheimer's Disease Neuroprotection Research Initiative's objective is to facilitate coordinated,multidisciplinary efforts to develop systemic neuroprotective strategies to combat *** aim is to achieve mitigation of the full spectrum of pathological processes underlying AD,with the goal of halting or even reversing cognitive decline.

关键词： Alzheimer's disease early intervention neural regeneration neuroprotection systematic perspective

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Regional tectonics, geology, magma chamber processes and mineralisation of the Jinchuan nickel-copper-PGE deposit, Gansu Province, China： A review

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Geoscience Frontiers 2016年第3期7卷 431-451页

作者： T.m. (mike) Porter Porter GeoConsultancy Pry Ltd. Linden Park 5065 SA Australia

The Jinchuan Ni-Cu-PGE deposit（〉500 mt @1.2%Ni,0.7%Cu,～0.4 g/t PGE）,one of the largest magmatic sulphide deposits in the world,is located within the westernmost terrane of the North China *** is hosted within the 6.5 km long,Neoproterozoic（～0.83 Ga） Jinchuan ultramafic intrusion,emplaced as a sill-like body into a Palaeoproterozoic suite of gneisses,migmatites,marbles and amphibolites,below an active intracratonic *** parental magma was high-mg basalt,generated through melting of subcrustal lithospheric mantle by a mantle plume during the initiation of Rodinia supercontinent *** lower Palaeozoic collision of the exotic Qilian Block with the breakup-related southern margin of the craton accreted a subduction complex,and emplaced voluminous granitic intrusions and foreland basin sequences within the craton,to as far north as *** the Cainozoic,allochthonous lower Palaeozoic rocks were thrust up to 300 km to the northeast over cratonic basement,to within 25 km of the Jinchuan *** Jinchuan ultramafic intrusion was injected into three interconnected sub-chambers,each containing a separate *** essentially comprises an olivine-orthopyroxene-chromite cumulate,with interstitial orthopyroxene,clinopyroxene,plagioclase and phlogopite,and is predominantly composed of lherzolite（～80%）,with an outer rim of olivine pyroxenite and cores of mineralised *** occurs as disseminated and net-textured sulphides,predominantly within the dunite,with lesser,PGE rich lenses,late massive sulphide accumulations,small copper rich pods and limited mineralised diopside skarn in wall rock *** principal ore minerals are pyrrhotite（the dominant sulphide）,pentlandite,chalcopyrite,cubanite,mackinawite and pyrite,with a variety of platinum group minerals and minor *** deposit underwent significant post-magmatic tremolite-actinolite,chlorite,serpentine and magnetite *** volume of thejinchuan intrusion accounts for 〈3%

关键词： Rodinia break-up rifting Plume related Deep staging chamber Olivine-orthopyroxene-chromite cumulate Net textured and disseminated sulphides Post-magmatic alteration

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The geology, structure and mineralisation of the Oyu Tolgoi porphyry copper-gold-molybdenum deposits, mongolia： A review

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Geoscience Frontiers 2016年第3期7卷 375-407页

作者： T.m.(mike) Porter Porter CeoConsultancy Ply Ltd. Linden Park 5065 SA Australia

The Oyu Tolgoi cluster of seven porphyry Cu-Au-mo deposits in southern mongolia,define a narrow,linear,12 km long,almost continuously mineralised trend,which contains in excess of 42 mt of Cu and1850 t of Au,and is among the largest high grade porphyry Cu-Au deposits in the *** deposits lie within the Gurvansayhan island-arc terrane,a fault bounded segment of the broader Silurian to Carboniferous Kazakh-mongol arc,located towards the southern margin of the Central Asian Orogenic Belt,a collage of magmatic arcs that were periodically active from the late Neoproterozoic to PermoTriassic,extending from the Urals mountains to the Pacific *** at Oyu Tolgoi is associated with multiple,overlapping,intrusions of late Devonian（～372 to 370 ma） quartzmonzodiorite intruding Devonian（or older） juvenile,probably intra-oceanic arc-related,basaltic lavas and lesser volcaniclastic rocks,unconformably overlain by late Devonian（～370 ma） basaltic to dacitic pyroclastic and volcano sedimentary *** quartz-monzodiorite intrusions range from earlymineral porphyritic dykes,to larger,linear,syn-,late- and post-mineral dykes and *** was deposited within syn-mineral quartz-monzodiorites,but is dominantly hosted by augite basalts and to a lesser degree by overlying dacitic pyroclastic *** ore deposition,an allochthonous plate of older Devonian（or pre-Devonian） rocks was overthrust and a post-ore biotite granodiorite intruded at～365 *** is characterised by varying,telescoped stages of intrusion and *** A-type quartz veined dykes were followed by Cu-Au mineralisation associated with potassic alteration,mainly K-feldspar in quartz-monzodiorite and biotite-magnetite in basaltic *** reflux of cooled,late-magmatic hydrothermal fluid resulted in intense quartz-sericite retrograde alteration in the upper parts of the main syn-mineral intrusions,and an equivalent chlorite-muscovite/illite-hematite assemblage in bas

关键词： Tectonic setting Porphyry copper-gold-molybdenum deposit High sulphidation Geology Alteration Structure

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Improvements in Inversion of magnetic Resonance Exploration-Water Content, Decay Time, and Resistivity

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Journal of China University of Geosciences 2009年第3期20卷 592-605页

作者： Ugur Yaramanci mike müller-Petke Leibniz Institute of Applied Geophysics Stilleweg 2 Hannover D-30655 Germany Berlin University of Technology Ackerstrasse 71-76 Berlin D-13355 Germany

In this review article, we present recent developments and improvements in magnetic resonance sounding （mRS）, a newly established geophysical exploration method that provides unique information about hydrogeophysical properties due to its direct sensitivity to hydrogen protons and proton dynamics. Starting with the most sophisticated and complete mRS formulation, we give a detailed view on how to solve the equation, i.e., inverting exactly for all model parameters： water content, decay time, and resistivity. Giving a short review of general inversion schemes used in geophysics, the special properties of mRS inversion are evaluated and the development of mRS inversion over recent years is shown. We present the extension of mRS to magnetic resonance tomography （mRT）, i.e., the extension to two-dimensional investigations and appropriate inversions. Finally, we address restrictions, limitations, and inconsistencies as well as future developments.

关键词： magnetic resonance sounding (mRS) magnetic resonance tomography (mRT) inversion modeling water content decay time resistivity.

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mortality associated with gastrointestinal bleeding in children: A retrospective cohort study

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World Journal of Gastroenterology 2017年第9期23卷 1608-1617页

作者： Thomas m Attard mikaela miller Chaitanya Pant Ashwath Kumar mike Thomson Department of Gastroenterology Children’s Mercy Hospital Clinical Decision Support Children’s Mercy Hospital Department of Gastroenterology The University of Kansas Hospital University of missouri medical School Sheffield Children’s Hospital Western Bank

To determine the clinical characteristics of children with gastrointestinal bleeding (GIB) who died during the course of their *** interrogated the Pediatric Hospital Information System database, including International Classification of Diseases, Current Procedural Terminology and Clinical Transaction Classification coding from 47 pediatric tertiary centers extracting the population of patients (1-21 years of age) admitted (inpatient or observation) with acute, upper or indeterminate GIB (1/2007-9/2015). Descriptive statistics, unadjusted univariate and adjusted multivariate analysis of the associations between patient characteristics and treatment course with mortality was performed with mortality as primary and endoscopy a secondary outcome of interest. All analyses were performed using the R statistical package, *** population with GIB was 19528; 54.6% were male, overall mortality was 2.07%; (0.37% in patients with the principal diagnosis of GIB). When considering only the mortalities in which GIB was the principal diagnosis, 48% (12 of 25 principal diagnosis GIB mortalities) died within the first 3 d of admission, whereas 19.8% of secondary diagnosis GIB patients died with 3 d of admission. Patients who died were more likely to have received octreotide (19.8% c.f. 4.04%) but tended to have not received proton pump inhibitor therapy in the first 48 h, and far less likely to have undergone endoscopy during their admission (OR = 0.489, P mortalities were significantly more likely to have multiple complex chronic *** associated mortality in children is highest within 7 d of admission. multiple comorbidities are a risk factor whereas early endoscopy during the admission is protective.

关键词： Pediatrics Gastrointestinal hemorrhage Endoscopy Proton pump inhibitors mortality Liver disease Hospital Information Systems Octreotide

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Advanced surface coil layout with intrinsic noise cancellation properties for surface-NmR applications

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magnetic Resonance Letters 2023年第2期3卷 140-149,I0004页

作者： Thomas Hiller Stephan Costabel Raphael Dlugosch Tobias Splith mike müller-Petke Federal Institute for Geosciences and Natural Resources Wilhelmstr.25-30Berlin13595Germany Federal Institute for Geosciences and Natural Resources Stilleweg 2Hannover3655Germany Leibniz Institute for Applied Geophysics Stilleweg 2Hannover30655Germany

A recent study demonstrated that in small-scale prepolarized surface nuclear magnetic resonance(SNmR-PP)measurements with a footprint of a few square meters,customized PP switch-off ramps can serve as an efficient excitation mechanism,eliminating the requirement for a conventional oscillating excitation *** approach enables the detection of short relaxation signals from the unsaturated soil zone and can,therefore,be used to directly provide soil moisture and pore geometry *** ultimately such small-scale SNmR-PP setups are intended for a mobile application,it is necessary to develop strategies that allow for speedy measurement progress and do not require noise cancellation protocols based on reference ***,we developed a new concentric figure-of-eight(cFOE)loop layout that combines the direction independence of a circular loop with the intrinsic noise cancellation properties of a classical *** approach significantly decreases the measurement time because suitable signal-to-noise ratios are reached much faster compared to a classical circular loop and will bring us one step further toward fast and non-invasive soil moisture mapping applications.

关键词： Surface-NmR Prepolarization Noise cancellation Loop layout

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Large-scale destress blasting for seismicity control in hard rock mines:A case study

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International Journal of mining Science and Technology 2020年第2期30卷 141-149页

作者： Isaac Vennes Hani mitri Damodara Reddy Chinnasane mike Yao Department of mining and materials Engineering McGill UniversityMontrealQuebec H3A 0E8Canada Copper Cliff mine Vale Canada LtdSudbury P0M 1N0Canada

Destress blasting is a rockburst control technique where highly stressed rock is blasted to reduce the local stress and stiffness of the rock,thereby reducing its burst *** technique is commonly practiced in deep hard rock mines in burst prone developments,as well as in sill or crown pillars which become burst-prone as the orebody is ***-scale destressing is a variant of destress blasting where panels are created parallel to the orebody strike with a longhole,fanning blast pattern from cross cut drifts situated in the host *** aim of panel destressing is to reduce the stress concentration in the ore blocks or pillars to be *** paper focuses on the large-scale destress blasting program conducted at Vale's Copper Cliff mine(CCm)in Ontario,*** merits of panel destressing are examined through field measurements of mining induced stress changes in the *** destressing mechanism is simulated with a rock fragmentation factor(a)and stress reduction/dissipation factor(b).A 3D model is built and validated with measured induced stress *** is shown that the best correlation between the numerical model and field measurements is obtained when the combination of a and b indicates that the blast causes high fragmentation(a=0.05)and high stress release(b=0.95)in the destress *** is demonstrated that the burst proneness of the ore blocks in the panel stress shadow is reduced in terms of the brittle shear ratio(BSR)and the burst potential index(BPI).

关键词： Destress blasting Preconditioning Rockbursts Strainbursts Numerical modeling

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microbial Diversity of Planctomycetes and Related Bacteria in Wetlands with Different Anthropogenic Disturbances

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湿地科学 2013年第2期11卷 158-166页

作者： Yu Wang Guibing Zhu Erwin van der Biezen mike S m Jetten Chengqing Yin State Key Laboratory of Environmental Aquatic Quality Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences Department of microbiology Institute for Water and Wetland Research (IWWR) Radboud University Nijmegen

The diversity of Planctomycetes and related bacteria in 3 types of freshwater wetlands with different anthropogenic disturbances were investigated by cloning and sequencing PCR-amplified partial 16S rRNA genes. Three clone libraries were constructed using 16S rRNA-targeted forward PCR primer specific for Planctomycetales and general bacterial reverse primer. Phylogenetic analysis of the 16S rRNA gene sequences defined 95 operational taxonomic units (OTUs) with 163 sequences. The clone libraries covered a wide microbial diversity of Proteobacteria and the Planctomycetes-Verrucomicrobia-Chlamydiales (PVC) superphylum. The majority of the OTUs were related to the phylum of Planctomycetes (33 OTUs), Proteobacteria (22 OTUs) and Verrucomicrobia (22 OTUs). Four known genera from the Planctomycetes phylum were all detected. The genus Pirellula (18 OTUs) dominated the Planctomycetes community, but different patterns of distribution were observed in the wetlands. The littoral wetlands of Baiyangdian Lake with the least anthropogenic disturbances covered more species and showed the highest biodiversity. However, the Jiaxing paddy fields with the highest anthropogenic disturbances showed a higher biodiversity than that in the riparian wetlands of the North Canal. Bacteria distantly related to anammox bacteria were also detected with a small proportion (4 OTUs). It showed that wetlands hold a great biodiversity of phyla Planctomycetes and related bacteria; furthermore, there is ample opportunity to discover novel phylotypes of Planctomycetes in the wetland ecosystems.

关键词： Planctomycetes biodiversity PVC superphylum anthropogenic disturbances freshwater wetlands

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Regeneration status of riparian tree species in two sites that differ in land-use in the Okavango Delta,Botswana

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Journal of Forestry Research 2017年第5期28卷 1073-1082页

作者： Gaolathe Tsheboeng mike murray-Hudson Keotshephile Kashe Okavango Research Institute

Human communities from the Okavango Delta benefit from the services and goods provided by the wetland ecosystem through its riparian vegetation. These include food and timber products used for the construction of shelter and canoes. Despite the importance of riparian tree species in the Delta, their regeneration structure is currently unknown. For riparian trees to be managed sustainably, information on the current regeneration status of the trees under different land uses is needed. The moremi game reserve (protected area) and Seronga (communal area) were selected for this study on the regeneration of riparian tree species of Croton megalobotrys müll. Arg, Philenoptera violacea (Klotzsch) Schrire, Senegalia nigrescens (Acacia nigrescens) Oliv and Diospyros mespiliformis Hochst. ex A. Dc. The height of each individual tree was estimated in randomly selected 30 plots (15 from each site) of 20 × 50 m for assignment to five regeneration classes: 0-0.5, 0.5-1, 1-2, 2-4 and >4 m. Linear regression was used to infer regeneration status of each species. An independent-sample Student’s t test was used to determine any significance differences in seedling density/ha and sapling density/ha between different sites at p mespiliformis populations had an unstable regeneration structure in both sites, while P. violacea regeneration was stable regardless of land-use type. Croton megalobotrys and S. nigrescens had an unstable regeneration pattern in Seronga, while in moremi it was stable; thus, the regeneration structure of C. megalobotrys and S. nigrescens is affected by land-use. This result implies that intervention is needed to conserve the two species in Seronga where the current land-use appears to be incompatible with regeneration; D. mespiliformis also needs to be conserved in both moremi and Seronga.

关键词： Conservation Regeneration Riparian Okavango and wetlands

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Role of the intestinal barrier in inflammatory bowel disease

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World Journal of Gastroenterology 2008年第3期14卷 401-407页

作者： mike G Laukoetter Porfirio Nava Asma Nusrat Epithelial Pathobiology Research Unit Department of Pathology and Laboratory Medicine Emory University Atlanta GA 30322 United States Department of General Surgery University of Muenster Muenster 48149 Germany Epithelial Pathobiology Research Unit Department of Pathology and Laboratory Medicine Emory University Atlanta GA 30322 United States

A critical function of the intestinal mucosa is to form a barrier that separates luminal contents from the interstitium. The single layer of intestinal epithelial cells (IECs) serves as a dynamic interface between the host and its environment. Cell polarity and structural properties of the epithelium is complex and is important in the development of epithelial barrier function. Epithelial cells associate with each other via a series of intercellular junctions. The apical most intercellular junctional complex referred to as the Apical Junction Complex (AJC) is important in not only cell-cell recognition, but also in the regulation of paracellular movement of fluid and solutes. Defects in the intestinal epithelial barrier function have been observed in a number of intestinal disorders such as inflammatory bowel disease (IBD). It is now becoming evident that an aberrant epithelial barrier function plays a central role in the pathophysiology of IBD. Thus, a better understanding of the intestinal epithelial barrier structure and function in healthy and disease states such as IBD will foster new ideas for the development of therapies for such chronic disorders.

关键词： Intestine Barrier function Tight Junction InflammatorY bowel disease Crohn's disease Ulcerativecolitis

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