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国际医学放射学杂志 2015年第2期 170-170页

作者： Z.L.Zhang W.G.Li D.Proc.ssi K.Li A.Y.sheu A.c.Gordon 卢忠飞 Department of Radiology Northwestern University 737 N Michigan Ave 16th Floor Chicago IL 60611

摘要目的检验以下关于胰腺癌小鼠模型的假说:接种负载抗原的铁标记树突状细胞降低MR T2WI中淋巴结(LN)外围引流的信号强度,而且这种信号降低与接种树突状细胞

关键词：树突状细胞胰腺癌淋巴结淋巴组织 MR 抗原

Spinal Motion Segments-Ⅱ:Tuning and Optimisation for Biofidelic.Performanc.

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Journal of Bionic.Engineering 2020年第4期17卷 757-766页

作者： c.nstantinos Franc.skides Emily Arnold Ian Horsfall Gianluc. Tozzi Mic.ael c.ibson Peter Zioupos Musc.loskeletal and Medic.legal Researc. Group Cranfield Forensic InstituteCranfield UniversityDefence Academy of the UKShrivenhamSN68LAUK c.ntre for Defenc. Engineering Cranfield UniversityDefence Academy of the UKShrivenhamSN68LAUK Sc.ool of Engineering University of PortsmouthPortsmouthPO13DJUK c.ntre for Simulation&Analytic. Cranfield UniversityDefence Academy of the UKShrivenhamSN68LAUK

Most c.mmerc.ally available spine analogues are not intended for biomec.anic.l testing,and the few that are suitable for using in c.njunc.ion with implants and devic.s to allow a hands-on prac.ic. on operative proc.dures are very expensive and still none of these offers patient-spec.fic.analogues that c.n be ac.essed within reasonable time and pric. ***-made spine analogues would also avoid the ethic.l restric.ions surrounding the use of biologic.l spec.mens and c.mplic.tions arising from their inherent biologic.l *** we sought to improve the biofidelity and ac.urac. of a patient-spec.fic.motion segment analogue that we presented *** models were made by ac.ylonitrile butadiene styrene(ABS)in 3D printing of porc.ne spine segments(T12-L5)from mic.oc. sc.n data,and were tested in axial loading at 0.6 ***-1(strain rate range 6×10^-4 s^-1-10×10^-4 s^-1).In this paper we have sought to improve the biofidelity of these analogue models by c.nc.ntrating in improving the two most c.itic.l aspec.s of the mec.anic.l behaviour:the material used for the intervertebral disc.and the influenc. of the fac.t *** deformations were followed by use of Digital Image c.rrelation(DIc.and c.nsequently different sc.nning resolutions and data ac.uisition tec.niques were also explored and c.mpared to determine their *** found that the selec.ion of an appropriate intervertebral disc.simulant(PT Flex 85)ac.ieved a realistic.forc./displac.ment response and also that the fac.t joints play a key role in ac.ieving a biofidelic.behaviour for the entire motion *** have therefore overall c.nfirmed the feasibility of produc.ng,by rapid and inexpensive 3D-printing methods,high-quality patient-spec.fic.spine analogue models suitable for biomec.anic.l testing and prac.ic..

关键词： spine bone analogue mic.o-c. 3D printing Digital Image c.rrelation(DIc.

Spinal Motion Segments-Ⅰ:c.nc.pt for a Subjec.-spec.fic.Analogue Model

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Journal of Bionic.Engineering 2020年第4期17卷 747-756页

作者： c.nstantinos Franc.skides Emily Arnold Ian Horsfall Gianluc. Tozzi Mic.ael c.ibson Peter Zioupos Musc.loskeletal and Medic.legal Researc. Group Cranfield Forensic InstituteCranfield UniversityDefence Academy of the UKShrivenhamSN68LAUK Impac. and Armour Group Centre for Defence EngineeringCranfield UniversityDefence Academy of the UKShrivenhamSN68LAUK Sc.ool of Engineering University of PortsmouthPortsmouthPO13DJUK c.ntre for Simulation&Analytic. Cranfield UniversityDefence Academy of the UKShrivenhamSN68LAUK

Most c.mmerc.al spine analogues are not intended for biomec.anic.l testing,and those developed for this purpose are expensive and yet still fail to replic.te the mec.anic.l performanc. of biologic.l ***-spec.fic.analogues that address these limitations and avoid the ethic.l restric.ions surrounding the use of human c.davers are therefore *** present a method for the produc.ion and c.arac.erisation of biofidelic.patient-spec.fic.Spine Motion Segment(SMS=2 vertebrae and the disk in between)analogues that allow for the biologic.l variability enc.untered when dealing with real *** spine segments(L1-LA)were sc.nned by c.mputed tomography,and 3D models were printed in ac.ylonitrile butadiene styrene(ABS).Four biologic.l spec.mens and four ABS motion segments were tested,three of whic. were further segmented into two Vertebral Bodies(VBs)with their intervertebral disc.IVD).All segments were loaded axially at 0.6 mm·min-1(strain-rate range 6×10-4 s-1-10×10-4 s-1).The artific.al VBs behaved like biologic.l segments within the elastic.region,but the best two-part artific.al IVD were^15%less stiffthan the biologic.l ***-speed images rec.rded during c.mpressive loading allowed full-field strains to be *** c.mpression of the spine motion segments,IVDs experienc.d higher strains than VBs as *** method allows the rapid,inexpensive and reliable produc.ion of patient-spec.fic.3D-printed analogues,whic. morphologic.lly resemble the real ones,and whose mec.anic.l behaviour is c.mparable to real biologic.l spine motion segments and this is their biggest asset.

关键词： spine bone analogue mic.o-c. 3D printing Digital Image c.rrelation(DIc.

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创新教学报告2016

开放学习研究 2017年第1期22卷 1-21页

作者： M.沙普尔斯 R.洛克 R.弗格森 M.加伟达 c.赫瑞德杜高瑞琳 A.库库拉斯卡-休姆吕赐杰 P.麦克安德鲁 B.赖迪厄斯 M.韦勒黄龙翔高茜周晖英国开放大学教育技术研究所新加坡南洋理工大学国立教育学院学习科学研究所北京开放大学

本报告提出了现代社会中改变或创新教学、学习和评价的理论与实践的十种"创新教学法",包括基于社交媒体的学习、有效失败、回授法、设计思维、众包学习、电子游戏学习、形成性分析、为未来而学、超用语以及学习区块链,它们将在未来不同... 详细信息

本报告提出了现代社会中改变或创新教学、学习和评价的理论与实践的十种"创新教学法",包括基于社交媒体的学习、有效失败、回授法、设计思维、众包学习、电子游戏学习、形成性分析、为未来而学、超用语以及学习区块链,它们将在未来不同时期内,对教育教学变革产生不同程度的影响。

关键词：创新教学学习科学设计思维形成性分析学习区块链

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麦克·凯利的后现代主义

东方艺术 2011年第7期 122-127页

作者： John c.Welc.man 周雪松

如果麦克·凯利（mike Kelley）生活在伦勃朗时代的荷兰,他可能会是一个郁金香杂交种植的专家,至少可以上日班。凯利比我们眼里看到的这个凯利要丰富得多。在1993年美国惠特尼美术馆,凯利的＂天主教品味＂个人回顾展上,无数的凯利被挨... 详细信息

如果麦克·凯利（mike Kelley）生活在伦勃朗时代的荷兰,他可能会是一个郁金香杂交种植的专家,至少可以上日班。凯利比我们眼里看到的这个凯利要丰富得多。在1993年美国惠特尼美术馆,凯利的＂天主教品味＂个人回顾展上,无数的凯利被挨个堆放在一起：

关键词：后现代主义凯利麦克伦勃朗郁金香美术馆天主教

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Molec.lar bridge-mediated ultralow-power gas sensing

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Mic.osystems & Nanoengineering 2021年第2期7卷 143-153页

作者： Aishwaryadev Banerjee Shakir-Ul Haque Khan Samuel Broadbent Ashrafuzzaman Bulbul Kyeong Heon Kim Seungbeom Noh R.Looper c.H.Mastrangelo H.Kim Department of Elec.ric.l and c.mputer Engineering University of UtahSalt Lake CityUT84112USA Department of c.emistry University of UtahSalt Lake CityUT84112USA Gyeongsang National University JinjuSouth Korea

We report the elec.ric.l detec.ion of c.ptured gases through measurement of the quantum tunneling c.arac.eristic. of gas-mediated molec.lar junc.ions formed ac.oss *** gas-sensing nanogap devic. c.nsists of a pair of vertic.lly stac.ed gold elec.rodes separated by an insulating 6 nm spac.r(~1.5 nm of sputteredα-Si and~4.5 nm ALD SiO2),whic. is notc.ed~10 nm into the stac. between the gold *** exposed gold surfac. is func.ionalized with a self-assembled monolayer(SAM)of c.njugated thiol linker *** the devic. is exposed to a target gas(1,5-diaminopentane),the SAM layer elec.rostatic.lly c.ptures the target gas molec.les,forming a molec.lar bridge ac.oss the *** gas c.pture lowers the barrier potential for elec.ron tunneling ac.oss the notc.ed edge region,from~5 eV to~0.9 eV and establishes additional c.nduc.ing paths for c.arge transport between the gold elec.rodes,leading to a substantial dec.ease in junc.ion *** demonstrated an output resistanc. c.ange of>108 times upon exposure to 80 ppm diamine target gas as well as ultralow standby power c.nsumption ofc.nfirming elec.ron tunneling through molec.lar bridges for ultralow-power gas sensing.

关键词： tunneling bridge bridges

硫酸镁通过Toll样受体4/核转录因子-κB通路抑制慢性肾衰竭大鼠血管钙化的机制研究

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临床肾脏病杂志 2022年第10期22卷 840-846页

作者：董丽明李寅辉米克热衣·艾孜买提李莉新疆医科大学第一附属医院临床营养科乌鲁木齐830000 新疆医科大学附属中医医院内分泌科乌鲁木齐830000 新疆医科大学第一附属医院肾脏疾病中心肾病一科乌鲁木齐830000

目的探究硫酸镁通过Toll样受体4(toll-like rec.ptor 4,TLR4)/核转录因子-κB(nuc.ear transc.iption fac.or-κB,NF-κB)通路对慢性肾衰竭(c.ronic.renal failure,c.F)大鼠血管钙化(vasc.lar c.lc.fic.tion,Vc.的影响。方法将SD大鼠按照随机数字法随机分为对照组、模型组、硫酸镁-L组(25%硫酸镁2 mL)、硫酸镁-H组(25%硫酸镁4 mL)、硫酸镁-H+吡咯烷二硫代氨基甲酸酯(pyrrolidine dithioc.rbamate,PDTc.组(25%硫酸镁4 mL+100 mg/kg NF-κB抑制剂PDTc.,10只/组;除对照组外,造模大鼠使用硫酸腺嘌呤混悬液灌胃3周,于4~12周,硫酸镁-L组、硫酸镁-H组、硫酸镁H+PDTc.灌胃相应剂量药物,模型组使用等体积生理盐水灌胃(1次/d),全程用高磷饲料饲喂;对照组于1~3周进行1.5%甲基纤维素灌胃,4~12周使用等量生理盐水灌胃,整个试用期均使用基础饲料喂养;全自动生化分析仪检测大鼠血清生化指标;HE染色观察大鼠肾组织病理学情况;钙盐染色液染色观察腹主动脉钙化情况;邻甲酚酞络合酮比色法检测大鼠腹主动脉血管壁钙含量;蛋白质印迹法检测大鼠腹主动脉核心结合因子α1(c.re binding fac.orα1,c.fα1)、骨形态发生蛋白2(bone morpho⁃genic.protein2,BMP2)及TLR4/NF-κB通路蛋白表达情况。结果与对照组相比,模型组大鼠血清中血尿素氮(blood urea nitrogen,BUN)、血肌酐(serum c.eatinine,Sc.)、血磷、钙水平、肾组织病理损伤程度、腹主动脉钙化程度、c.fα1、BMP2、TLR4、p-NF-κB p56/NF-κB p56表达显著增加,血清中镁水平显著降低(Pc.BUN、Sc.、血磷、钙水平、肾组织病理学程度、腹主动脉钙化程度、c.fα1、BMP2、TLR4、p-NF-κB p56/NF-κB p56表达显著降低,镁水平显著增加(Pc.BUN、Sc.、血磷、钙水平、肾组织病理损伤程度、腹主动脉钙化程度、c.fα1、BMP2、TLR4、p-NF-κB p56/NF-κB p56表达显著降低,镁水平显著增加(Pc.BUN、Sc.、血磷、钙水平、肾组织病理学程度、腹主动脉钙化程度、c.fα1、BMP2、TLR4、p-NF-κB p56/NF-κB p56表达显著降低,镁水平显著增加(Pc.F大鼠Vc.

关键词：硫酸镁 Toll样受体4 核转录因子-κB 慢性肾衰竭血管钙化

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