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The Chengdu system for recurrent hepatocellular carcinoma: A step in the right direction

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Hepatobiliary Surgery and Nutrition 2019年第3期8卷 298-300页

作者： Simon Erridge mikael H.sodergren Department of Surgery and Cancer Imperial College LondonLondonUK

Liver cancer is the fourth leading cause of cancer-related death *** carcinoma(HCC),the most prevalent cause of primary liver cancer,is observed highest in the Far East,South-Eastern Asia and East Africa(1).In most endemic regions this is secondary to the prevalence of specific risk factors including chronic hepatitis B virus(HBV)infection,hepatitis C virus(HCV)infection and aflatoxin-exposure(1,2).The development of HBV vaccination and programmes to reduce HBV transmission has reduced the risk of HCC in high-risk Asian countries(1).Global incidence of HCC however continues to rise and major contributory factors to this are alcohol misuse and the obesity epidemic,resulting in non-alcoholic fatty liver disease,in Western nations(1,2).

关键词： Liver Eastern alcohol

Laparoscopic vs open approach to resection of hepatocellular carcinoma in patients with known cirrhosis:Systematic review and meta-analysis

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World Journal of Gastroenterology 2014年第25期20卷 8274-8281页

作者： Ahmed Twaij Philip H Pucher mikael H sodergren Tamara Gall Ara Darzi Long R Jiao Department of Surgery and Cancer QEQM BuildingSt Mary’s HospitalImperial CollegeLondon W2 1NY United Kingdom Department of Surgery Hammersmith HospitalImperial College LondonLondon SW7 2AZUnited Kingdom

AIM: To review the currently available literature comparing laparoscopic to open resection of hepatocellular carcinoma (HCC) in patients with known liver cirrhosis.

关键词： Laparoscopic Hepatocellular carcinoma Cirrhosis Hepatic resection Surgery Hepatobiliary Surgical oncology

Radiofrequency combined with immunomodulation for hepatocellular carcinoma: State of the art and innovations

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World Journal of Gastroenterology 2020年第17期26卷 2040-2048页

作者： Adriano Carneiro da Costa mikael sodergren Kumar Jayant Fernando Santa Cruz Duncan Spalding Madhava Pai Nagy Habib Department of Surgery and Cancer Faculty of MedicineHammersmith HospitalImperial College LondonLondon W120NNUnited Kingdom

Hepatocellular carcinoma(HCC)is the most common primary liver tumor and has been considered a very immunogenic *** treatment with radiofrequency ablation(RFA)has been established as the standard ablative therapy for early HCC,and is currently recognized as the main ablative tool for HCC tumors<5 cm in size;however,progression and local recurrence remain the main disadvantages of this *** solve this clinical problem,recent efforts were concentrated on multimodal treatment,combining different strategies,including the combination of RFA and *** article reviewed the combination treatment of RFA with immunotherapy and found that this treatment strategy leads to an increased response of anti-tumor T cells,significantly reduces the risk of recurrence and improves survival rates compared to RFA *** review highlighted scientific evidence that supports the current recommendations for pre-clinical studies,and discuss the need for further research on this topic.

关键词： Hepatocellular carcinoma Radiofrequency ablation Immunotherapy Liver cancer Combined modality therapy State-of-the-art review

No difference in mortality among ALPPS,two-staged hepatectomy,and portal vein embolization/ligation:A systematic review by updated traditional and network meta-analyses

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Hepatobiliary & Pancreatic Diseases International 2020年第5期19卷 411-419页

作者： Paschalis Gavriilidis Robert P Sutcliffe Keith J Roberts Madhava Pai Duncan Spalding Nagy Habib Long R Jiao mikael H sodergren Department of Hepatopanceaticobiliary Surgery Imperial College Healthcare NHS TrustHammersmith HospitalLondon W120HSUK Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery Queen Elizabeth University Hospitals Birmingham NHS Foundation TrustBirmingham B152THUK

Background:There is an ongoing debate on the feasibility,safety,and oncological efficacy of the associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)*** aim of this study was to compare ALPPS,two-staged hepatectomy(TSH),and portal vein embolization(PVE)/ligation(PVL)using updated traditional meta-analysis and network meta-analysis(NMA).Data sources:Electronic databases were used in a systematic literature *** traditional metaanalysis and NMA were performed and *** and major morbidity were selected as primary ***:Nineteen studies including 1200 patients were selected from the pool of 436 *** these patients,315(31%)and 702(69%)underwent ALPPS and portal vein occlusion(PVO),*** mortality based on updated traditional meta-analysis,subgroup analysis of the randomized controlled trials(RCTs),and both Bayesian and frequentist NMA did not demonstrate significant differences between the ALPPS cohort and the PVE,PVL,and TSH ***,analysis of RCTs did not demonstrate significant differences of major morbidity between the ALPPS and PVO *** ALPPS cohort demonstrated significantly more favorable outcomes in hypertrophy parameters,time to operation,definitive hepatectomy,and R0 margins rates compared with the PVO *** contrast,1-year disease-free survival was significantly higher in the PVO cohort compared to the ALPPS ***:This study is the first to use updated traditional meta-analysis and both Bayesian and frequentist NMA and demonstrated no significant differences in 90-day mortality between the ALPPS and other hepatic hypertrophy ***,two high quality RCTs including 147 patients demonstrated no significant differences in major morbidity between the ALPPS and PVO cohorts.

关键词： ALPPS Hepatectomy Portal vein embolization Portal vein ligation Network meta-analysis

Natural orifice translumenal endoscopic surgery applications in clinical practice

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World Journal of Gastrointestinal Endoscopy 2012年第3期4卷 65-74页

作者： Ross S Coomber mikael H sodergren James Clark Julian Teare Ara Darzi Division of Surgery Department of Surgery and CancerImperial College LondonSt.Mary's Hospital

To review natural orifice translumenal endoscopic surgery (NOTES) applications in clinical practice and assess the evidence base for each application as reported in the *** electronic literature search was *** criteria were publications relating to NOTES applications in *** each type of operation the highest level of evidence available for clinical NOTES publications was *** and short-term operative outcomes were compared with gold standard published evidence where ***,registered trials recruiting patients for NOTES applications were *** NOTES publications with the highest level of evidence in each application are *** were no RCTs in the literature to *** strongest evidence came in the form of large,multi-centre trials with 300-500 *** results are encouraging,comparable with gold standard techniques on morbidity and *** short-term operative outcomes were also simi-lar when compared to the gold standard techniques,other than improved cosmesis little else can definitely be concluded as a clear benefit of a NOTES *** most common procedures are cholecystectomy,appendicectomy and peritoneoscopy mainly performed via transvaginal *** is evident that morbidity appears to be higher when the transgastric route is *** safety profile of hybrid NOTES transvaginal procedures is beginning to be confirmed as is evident from the large number of procedures presented in this review.A number of authors have presented work on pure NOTES procedures but the results are inconsistent and thus the vast majority of NOTES procedures worldwide are performed in a hybrid fashion with a variable amount of *** review of the clinical applications of NOTES summarises the growing evidence behind this surgical discipline and highlights NOTES procedures with an acceptable safety profile.

关键词： Natural orifice translumenal endoscopic surgery Humans Clinical practice