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Progastrin-releasing peptide and gastrin-releasing peptide receptor mRNA expression in non-tumor tissues of the human gastrointestinal tract

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World Journal of Gastroenterology 2006年第16期12卷 2574-2578页

作者： Hans-Jürg Monstein Niclas Grahn mikael Truedsson Bodil Ohisson Molecular Biology Laboratory-LMC University HospitalDepartment of Biomedicine and SurgeryFaculty of Health SciencesS-581 85 LinkpingSweden Department of Clinical Sciences University Hospital MalmS-205 02 MalmSweden

瞄准：用分子的生物学技术在人的食管，胃肠道，胰和胆囊的非肿瘤纸巾调查释放 gastrin 肽(GRP ) 和 GRP 受体 mRNA 的表示。方法：多形核白细胞，(+) mRNA 用一个自动化 nucleic 抽出者从全部的 RNA 摘录被孤立并且随后，变换成搁浅单... 详细信息

瞄准：用分子的生物学技术在人的食管，胃肠道，胰和胆囊的非肿瘤纸巾调查释放 gastrin 肽(GRP ) 和 GRP 受体 mRNA 的表示。方法：多形核白细胞，(+) mRNA 用一个自动化 nucleic 抽出者从全部的 RNA 摘录被孤立并且随后，变换成搁浅单人赛的 cDNA (ss-cDNA ) 。PCR 扩大用基因特定的 GRP 和 GRP 受体教材被执行。PCR amplicons 的特性被南部的污点分析进一步用基因特定的 GRP 和 GRP 受体杂交探针证实。结果：GRP 和 GRP 受体 mRNA 的表示在将近非肿瘤标本的片断分析了的所有在各种各样的层次被检测，除了胆囊。在大多数活体检视标本， GRP 和 GRP 受体 mRNA 的合作表示看起来发生。然而， GRP mRNA 的表示比是 GRP 受体 mRNA 是更突出的。结论：GRP 和 GRP 受体 mRNAs 在整个胃肠道被表示并且在正常和肿瘤房间为印射的未来和它的生理的重要性的决心提供信息。

关键词：前胃液素胃泌激素肿瘤组织胃肠疾病

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踌躇的西行:中国大陆科幻的命运变迁

踌躇的西行:中国大陆科幻的命运变迁

Manufacture and characterization of graphene membranes with suspended silicon proof masses for MEMS and NEMS applications

作者：辛禄高郑军 mikael Huss

＜正＞科幻很可能是由鲁迅最先引介到中国的,他在1902年或1903年翻译了凡尔纳的《月界旅行》和《地心游记》。同时,鲁迅还写了《〈月界旅行〉弁言》,试图对科幻文学的原理进行界定。1917—1918年,另一名著名作家茅盾,和他弟弟沈德济合...

＜正＞科幻很可能是由鲁迅最先引介到中国的,他在1902年或1903年翻译了凡尔纳的《月界旅行》和《地心游记》。同时,鲁迅还写了《〈月界旅行〉弁言》,试图对科幻文学的原理进行界定。1917—1918年,另一名著名作家茅盾,和他弟弟沈德济合译了法国、英国、美国的科幻小说,凡尔纳和威尔斯依然排在榜首。鲁迅在译介《月界旅行》时,赞扬了他称之为"科学小说"（当时尚无"科幻"的说法）的可能性:"导中国人群以进行,必自科学小说始。"他希望通过"给科学小说

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Microsystems & Nanoengineering 2020年第1期6卷 1050-1066页

作者： Xuge Fan Anderson D.Smith Fredrik Forsberg Stefan Wagner Stephan Schroder Sayedeh Shirin Afyouni Akbari Andreas C.Fischer Luis Guillermo Villanueva mikael Ostling Max C.Lemme Frank Niklaus Division of Micro and Nanosystems School of Electrical Engineering and Computer ScienceKTH Royal Institute of TechnologySE-10044 StockholmSweden Division of Integrated Devices and Circuits School of Electrical Engineering and Computer ScienceKTH Royal Institute of TechnologySE-16440 KistaSweden Faculty of Electrical Engineering and Information Technology RWTH Aachen UniversityOtto-Blumenthal-Str.2552074 AachenGermany Advanced NEMS Group École Polytechnique Fédérale de Lausanne(EPFL)1015 LausanneSwitzerland Silex Microsystems AB 17526 JärfällaSweden AMO GmbH Advanced Microelectronic Center Aachen(AMICA)Otto-Blumnethal-Str.2552074 AachenGermany

Graphene’s unparalleled strength,chemical stability,ultimate surface-to-volume ratio and excellent electronic properties make it an ideal candidate as a material for membranes in micro-and nanoelectromechanical systems(MEMS and NEMS).However,the integration of graphene into MEMS or NEMS devices and suspended structures such as proof masses on graphene membranes raises several technological challenges,including collapse and rupture of the *** have developed a robust route for realizing membranes made of double-layer CVD graphene and suspending large silicon proof masses on membranes with high *** have demonstrated the manufacture of square graphene membranes with side lengths from 7µm to 110µm,and suspended proof masses consisting of solid silicon cubes that are from 5µm×5µm×16.4µm to 100µm×100µm×16.4µm in *** approach is compatible with wafer-scale MEMS and semiconductor manufacturing technologies,and the manufacturing yields of the graphene membranes with suspended proof masses were>90%,with>70%of the graphene membranes having>90%graphene area without visible *** measured resonance frequencies of the realized structures ranged from tens to hundreds of kHz,with quality factors ranging from 63 to *** graphene membranes with suspended proof masses were extremely robust,and were able to withstand indentation forces from an atomic force microscope(AFM)tip of up to~*** proposed approach for the reliable and large-scale manufacture of graphene membranes with suspended proof masses will enable the development and study of innovative NEMS devices with new functionalities and improved performances.

关键词： proof characterization hundreds

Preparation of High Percentage α-Calcium Sulfate Hemihydrate via a Hydrothermal Method

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Journal of Biomaterials and Nanobiotechnology 2017年第1期8卷 36-49页

作者： Le Fu Wei Xia Torbjorn Mellgren mikael Moge Hakan Engqvist Applied Materials Science Department of Engineering SciencesUppsala UniversityUppsalaSweden BioArctic Neuroscience AB StockholmSweden

α-calcium sulfate hemihydrate (α-HH) is known to be suitable for application as bone void filler. High percentage of α-HH is obviously needed for medical applications, especially for implantation. Three commercially available calcium sulfate dihydrates (DH, CaSO4·2H2O) with different sizes and surface morphologies were used as starting materials to synthesize high percentage α-HH via a hydrothermal method. The median particle sizes of the three types of DH were 946.7 μm, 162.4 μm and 62.4 μm, respectively. They were named as DH-L, DH-M and DH-S in this paper. The particle size distribution, morphology and phase composition of the raw materials were evaluated before synthesis. SEM results revealed that DH-L consisted of irregular large particles, while DH-M and DH-S were composed of plate-like particles with some small ones. High percentage HH can be obtained with proper synthesis parameters by hydrothermal method, specifically, 105 °C/90 min for DH-L (achieving 98.8% HH), 105°C/30 min for DH-M (achieving 96.7% HH) and 100°C/45 min for DH-S (achieving 98.4% HH). All the synthesized HH were hexagonal columns, demonstrating that they were α-phase HH. The particle size and morphology of starting material (DH) have significant influences on not only the rate of phase transition but also the morphology of the synthesized α-HH. Calcium sulfate dihydrate cements were prepared by the synthesized α-HH. The highest compressive strength of calcium sulfate dihydrate cement was 17.2 MPa. The results show that the preparation of high percentage α-HH is feasible via a hydrothermal method and the process can be further scaled up to industrial scale production.

关键词： α-Calcium Sulfate Hemihydrate High Percentage Hydrothermal Method Calcium Sulfate Dihydrate Cement

Rare Case of a Patient with Newly Diagnosed Thymoma Presenting with Paraneoplastic Systemic Lupus Erythematosus, Myasthenia Gravis, and Hypogammaglobulinemia

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Open Journal of Rheumatology and Autoimmune Diseases 2014年第3期4卷 146-152页

作者： Damien mikael Hansra Mario Ponce Francisco Socola Maria Helena Restrepo Department of Hematology/Oncology Sylvester Comprehensive Cancer Institute Jackson Memorial Hospit-al/University of Miami Miami Florida USA Department of Hematology/Oncology Sylvester Comprehensive Cancer Institute University of Miami Miami Florida USA Department of Medicine Jackson Memorial Hospital/University of Miami Miami Florida USA

A Pleural mass biopsy was performed showing an invasive thymoma. Computed tomography (CT) scan of the chest performed on admission revealed a left sided pleural mass, anterior mediastinal mass, lymphadenopathy and pericardial effusion. Pleural mass biopsy showed an invasive thymoma. Due to her clinical presentation, a complete work-up was performed revealing paraneoplastic systemic lupus erythematous (SLE), myasthenia gravis (MG) and hypogammaglobulinemia. We reviewed the literature regarding thymoma and its relationship with paraneoplastic SLE, MG and hypogammaglobulinemia.

关键词： Thymoma Paraneoplastic Systemic Lupus Erythematosus Myasthenia Gravis Hypogammaglobulinemia

Is there an optimal environment in which to learn clinical anatomy? One man’s view

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Forensic Medicine and Anatomy Research 2014年第1期2卷 11-16页

作者： Eng-Tat Ang Peter Abrahams Seow Choon Sheong mikael Hartman Department of Anatomy Yong Loo Lin School of Medicine National University of Singapore Singapore Department of Surgery Alexandra Hospital Jurong Health Singapore NUS Saw Swee Hock School of Public Health National University of Singapore Singapore Warwick Medical School West Midlands Surgical Training Centre Coventry CV4 7AL UK

Learning anatomy is essential in medical schools, and even more so for budding surgeons. Much has been discussed regarding the updated curriculum, and whether the pedagogies should be based upon cadaveric, and/or multimedia, or hybrid approaches. Much debate has also been centered on who is best qualified to teach. While all these are important, the setting is also critically important for the medical students and surgical trainees. Therefore the overarching issue is whether all these activities should be held in the dissection room, the operating theatre or the classical “Theatrum Anatomicum” ? What are the key experiential learning differences in picking up anatomical knowledge in the various venues listed above? This paper will provide some insights for teachers and students of human anatomy, and some ideas for the future planners and developers of anatomy learning centers internationally.

关键词： Learning Clinical Anatomy Optimal Environment Theatruman Atomicum Dissection Surgery

Eosinophil associated genes in the inflammatory bowel disease 4 region:Correlation to inflammatory bowel disease revealed

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World Journal of Gastroenterology 2012年第44期18卷 6409-6419页

作者： Kristin Blom Jenny Rubin Jonas Halfvarson Leif Trkvist Anders Rnnblom Per Sangfelt mikael Lrdal Ulla-Britt Jnsson Urban Sjqvist Lena Douhan Hkansson Per Venge Marie Carlson Department of Medical Sciences Clinical ChemistryUppsala University HospitalSE-75185 UppsalaSweden Division of Gastroenterology Department of Intestinal Medicinerebro University HospitalSE-70185 rebroSweden School of Health and Medical Sciences rebro UniversitySE-70185 rebroSweden IBD Clinical research group Karolinska University HospitalSE-17177 StockholmSweden Department for Clinical Science Intervention and TechnologyKarolinska University HospitalSE-17177 StockholmSweden Department of Medical Sciences Gastroenterology Research GroupUppsala UniversitySE-75185 UppsalaSweden Department of Medicine Karolinska InstitutetSE-17177 StockholmSweden

AIM:To study the association between inflammatory bowel disease(IBD) and genetic variations in eosinophil protein X(EPX) and eosinophil cationic protein(ECP).METHODS:DNA was extracted from ethylene diamine tetraacetic acid blood of 587 patients with Crohn's disease(CD),592 with ulcerative colitis(UC) and 300 healthy *** EPX405(G > C,rs2013109),ECP434(G > C,rs2073342) and ECP562(G > C,rs2233860) gene polymorphisms were analysed,by the 5'-nuclease allelic discrimination *** determination of intracellular content of EPX and ECP in granulocytes,39 blood samples was collected and extracted with a buffer containing cetyltrimethylammonium *** intracellular content of EPX was analysed using an enzyme-linked immunosorbent *** intracellular content of ECP was analysed with the UniCAP system as described by the *** tests for calculations of results were χ 2 test,Fisher's exact test,ANOVA,Student-Newman-Keuls test,and Kaplan-Meier survival curve with Log-rank test for trend,the probability values of P < 0.05 were considered statistically ***:The genotype frequency for males with UC and with an age of disease onset of ≥ 45 years(n = 57) was for ECP434 and ECP562,GG = 37%,GC = 60%,CC = 4% and GG = 51%,GC = 49%,CC = 0% *** was significantly different from the healthy subject's genotype frequencies of ECP434(GG = 57%,GC = 38%,CC = 5%;P = 0.010) and ECP562(GG = 68%,GC = 29%,CC = 3%;P = 0.009).The genotype frequencies for females,with an age of disease onset of ≥ 45 years with CD(n = 62),was for the ECP434 and ECP562 genotypes GG = 37%,GC =52%,CC = 11% and GG = 48%,GC = 47% and CC = 5% *** was also statistically different from healthy controls for both ECP434(P = 0.010) and ECP562(P = 0.013).The intracellular protein concentration of EPX and ECP was calculated in μg/10 6 eosinophils and then correlated to the EPX 405 *** protein content of EPX was highest in the patients with the C

关键词：嗜酸性粒细胞肠道疾病曲线显示炎症相关基因 Fisher精确检验基因型频率蛋白质含量

Role of radionuclide imaging for diagnosis of device and prosthetic valve infections

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World Journal of Cardiology 2016年第9期8卷 534-546页

作者： Jean-Fran?ois Sarrazin Francois Philippon mikael Trottier Michel Tessier Department of Cardiology Institut Universitaire de Cardiologie et Pneumologie de QuébecLaval University Department of Nuclear Medicine Institut Universitaire de Cardiologie et Pneumologie de QuébecLaval University

Cardiovascular implantable electronic device(CIED) infection and prosthetic valve endocarditis(PVE) remain a diagnostic *** imaging plays an important role in the diagnosis and management of patients with CIED infection or *** the past few years,cardiac radionuclide imaging has gained a key role in the diagnosis of these patients,and in assessing the need for surgery,mainly in the most difficult *** ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG PET/CT) and radiolabelled white blood cell single-photon emission computed tomography/computed tomography(WBC SPECT/CT) have been studied in these *** their 2015 guidelines for the management of infective endocarditis,the European Society of Cardiology incorporated cardiac nuclear imaging as part of their diagnostic algorithm for PVE,but not CIED infection since the data were judged insufficient at the *** article reviews the actual knowledge and recent studies on the use of ^(18)F-FDG PET/CT and WBC SPECT/CT in the context of CIED infection and PVE,and describes the technical aspects of cardiac radionuclide *** also discusses their accepted and potential indications for the diagnosis and management of CIED infection and PVE,the limitations of these tests,and potential areas of future research.

关键词： Device Endocarditis Fluorodeoxyglucose Imaging Infection Leukocytes Positron emission tomography/computed tomography Prosthetic valve Radionuclide Scintigraphy

Patient with Metastatic Breast Cancer Achieves Stable Disease for 5 Years on Graviola and Xeloda after Progressing on Multiple Lines of Therapy

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Advances in Breast Cancer Research 2014年第3期3卷 84-87页

作者： Damien mikael Hansra Orlando Silva Ashwin Mehta Eugene Ahn Department of Hematology and Oncology Sylvester Comprehensive Cancer Center at the University of Miami Miami USA

Breast cancer (BC) is the most common malignancy in women and is second to lung cancer in terms of cancer mortality. Treatment of BC remains a challenge as current therapies are limited by toxicity and drug resistance. Graviola (Annona muricata) is a tree that grows in the tropics of North and South America. Traditionally, the leaves and stems from the graviola tree have been used for a wide range of human diseases including cancer.?In vitro?and?in vivo?studies demonstrate anticancer activity in BC however clinical studies are lacking. We present the first case demonstrating clinical benefit without side effects using graviola in a patient with BC whose disease was refractory to multiple lines of chemotherapy including anthracyclines and taxanes.

关键词： Breast Cancer Graviola Therapy